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| Number | Title | Issue Date |
| 8163773 | Organic compounds The invention relates to 3,5-substituted piperidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on activity of renin; the use of a compoun... | 04/24/2012 |
| 8143280 | Glucocorticoid receptor antagonists The present invention relates to compounds of formula I wherein A, n, R1a to R1e and R2 to R5 are as defined in the description and claims, and pharmaceutically acceptable salts t... | 03/27/2012 |
| 8138206 | Piperidine derivative Disclosed is a substance having an antagonistic effect on the binding of histamine to a histamine H3 receptor or an inhibitory effect on the activity which a histamine H3 receptor constantly exhibits. A compound represented by the formula (I) or a pharmaceutically a... | 03/20/2012 |
| 8133904 | Cannabinoid receptor antagonists/inverse agonists useful for treating obesity The present invention provides novel pyrazoles that are useful as cannabinoid receptor antagonists and pharmaceutical compositions thereof and methods of using the same for treating obesity, diabetes, and/or cardiometabolic disorders. ... | 03/13/2012 |
| RE43244 | Phenylethylamines and condensed rings variants as prodrugs of catecholamines, and their use Compounds of the general formula I wherein rings B, C, D and E may be present or not and, when present, are combined with A as A+C, A+E, A+B+C, A+B+D, A+B+E, A+C+E, A+B+C+D or A+B+C+D+E, rings B, C and E being aliphatic whe... | 03/13/2012 |
| 8129409 | Piperidine derivatives and cosmetic compositions thereof The present invention provides piperidine derivatives of formula (I): salts and optical isomers thereof and cosmetic compositions containing them. ... | 03/06/2012 |
| 8129408 | Pharmaceutical composition for piperidinoalkanol compounds The invention provides a pharmaceutical composition in solid unit dosage form, comprising, a) a therapeutically effective amount of a piperidinoalkanol compound or a pharmaceutically acceptable salt thereof; and, b) at least one inert ingredient. ... | 03/06/2012 |
| 8101635 | Calcium blockers to treat proliferative vitreoretinopathy Glutamate causes migration and proliferation of retinal pigment epithelium and/or glial cells, and glutamate antagonists can prevent, treat or reduce retinal pigment epithelium and/or glial migration and the subsequent development of proliferative vitreoretinopathy.... | 01/24/2012 |
| 8048895 | Kappa opioid receptor ligands Kappa opioid receptor antagonists are provided that yield significant improvements in functional binding assays to kappa opioid receptors, and the use of these antagonists in treatment of disease states that are ameliorated by binding of the kappa opioid receptor su... | 11/01/2011 |
| 8044069 | Compounds as calcium channel blockers The present application relates to calcium channel inhibitors containing compounds of formula (I) wherein Ar1, Ar2, L1, L2, n, R1, R4, X and Y are as defined... | 10/25/2011 |
| 8026255 | Substituted piperidines as somatostatin receptor subtype 5 (SSTR5) antagonists This invention is concerned with compounds of the formula and pharmaceutically acceptable salts thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their prepara... | 09/27/2011 |
| 8017627 | Fentanyl composition for nasal administration The treatment of acute pain with a sufficient dosage by intranasal administration of fentanyl results in a time to onset of action comparable to intravenous administration and a significantly faster onset of action than nasal titration of fentanyl. The nasal adminis... | 09/13/2011 |
| 7994195 | Therapeutic substituted piperidone compounds Compounds comprising or a pharmaceutically acceptable salt or a prodrug thereof are disclosed herein. Details are provided herein. Compositions, methods, and medicaments related thereto are also disclosed. ... | 08/09/2011 |
| 7985758 | Piperidine derivatives for treatment of Alzheimer's disease Compounds of formula (I) modulate the activity of gamma secretase and hence find use in treatment or prevention of Alzheimer's disease and related conditions. ... | 07/26/2011 |
| 7981907 | Thio-substituted biarylmethanesulfinyl derivatives The present invention is related to chemical compositions, processes for the preparation thereof and uses of the composition. Particularly, the present invention relates to compositions that include substituted biaryl-methanesulfinyl acetamides of Formula (I): | 07/19/2011 |
| 7973055 | Crystalline forms of a biphenyl compound The invention provides crystalline forms of biphenyl-2-ylcarbamic acid 1-[2-({3-[2-(4-hydroxybenzylamino)ethylcarbamoyl]benzoyl}methylamino)ethyl]piperidin-4-yl ester, and pharmaceutically acceptable solvates thereof. The crystalline form can be a freebase (Form I o... | 07/05/2011 |
| 7951821 | N-[phenyl(piperidin-2-yl)methyl]benzamide derivatives, preparation thereof, and use thereof in therapy This invention discloses and claims a compound of general formula (I) in which R1 represents either a hydrogen atom, or an optionally substituted alkyl group, or a cycloalkylalkyl group, or an optionally substitu... | 05/31/2011 |
| 7923459 | Process for the synthesis of 4-(3-methanesulfonylphenyl)-1-N-propyl-piperidine The present invention is directed to processes for the preparation of 4-(3-methanesulfonyl-phenyl)-1-N-propylpiperidine (I) or a pharmaceutically acceptable salt thereof, which comprises: oxidizing a sulfide of the formula (II): with a catalytic oxidizing agent and ... | 04/12/2011 |
| 7910605 | Non-imidazole alkylamines as histamine H- receptor ligands and their therapeutic applications Use of a compound of formula (A), wherein: W is a residue which imparts antagonistic and/or agonistic activity at histamine H3-receptors when attached to an imidazole ring in 4(5) position; R1 and R | 03/22/2011 |
| 7893089 | IL-8 receptor antagonists This invention relates to novel compounds and compositions thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8). ... | 02/22/2011 |
| 7888373 | Heterocyclic sulfonamides as modulators of cardiac sarcomeres Certain substituted sulfonamide derivatives of Formula (I) selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure. | 02/15/2011 |
| 7879879 | Biphenyl derivatives This invention provides biphenyl derivatives of formula I: wherein R1, R2, R3, R4, R5, R6, R7, W, a, b and c are as defin... | 02/01/2011 |
| 7875632 | Selective serotonin receptor inverse agonists as therapeutics for disease Disclosed herein are pharmaceutical compositions comprising an inverse serotonin receptor agonist or a serotonin receptor antagonist and an anti-psychotic agent. Disclosed herein are also methods of treating psychotic disorders using the disclosed pharmaceutical com... | 01/25/2011 |
| 7872021 | LXR receptor modulators Benzenesulfonamide derivative compounds corresponding to the general formula (I): and their pharmaceutically acceptable addition salts; a process for preparation of such compounds; pharmaceutical compositions containing suc... | 01/18/2011 |
| 7872022 | Serotonin transporter (SERT) inhibitors for the treatment of depression and anxiety The present invention relates to trans-derivatives of formula wherein R1, R2, R3, and the dotted line are as defined herein and to pharmaceutically acceptable acid addition salts thereof. | 01/18/2011 |
| 7863296 | Selective serotonin receptor inverse agonists as therapeutics for disease Disclosed herein are pharmaceutical compositions comprising an inverse serotonin receptor agonist or a serotonin receptor antagonist and an anti-insomnia agent. Disclosed herein are also methods of treating insomnia using the disclosed pharmaceutical compositions. | 01/04/2011 |
| 7851488 | Tetrahydropyridines with central nervous system activity Provided are novel tetrahydropyridine derivatives bearing substituents. These compounds can be used for alleviating the symptoms of CNS disorders. ... | 12/14/2010 |
| 7851487 | Use of tetrahydropyridines in the treatment of central nervous system disorders Disclosed are methods for alleviating symptoms of neuropsychiatric disorders using tetrahydropyridine derivatives bearing aromatic substituents. The method comprises administering to an individual a tetrahydropyridine derivative bearing aromatic substituents in an a... | 12/14/2010 |
| 7846945 | Piperdine-based inhibitors of sodium glucose co-transporter 2 and methods of their use Compounds and pharmaceutical compositions comprising them are disclosed that may be useful for the treatment of diseases and disorders such as diabetes and obesity. ... | 12/07/2010 |
| 7829580 | Cyclic amine derivative having heteroaryl ring A compound having the general formula (I) wherein R1 represents C1-C6 alkyl, etc., R2 represents hydrogen, C2-C7 alkanoyl, C7-C11 arylcarbonyl, the formula R4—(CH2)l... | 11/09/2010 |
| 7816375 | Ligands for monoamine receptors and transporters, and methods of use thereof One aspect of the present invention relates to heterocyclic compounds. A second aspect of the present invention relates to the use of the heterocyclic compounds as ligands for various mammalian cellular receptors, including dopamine, serotonin, or norepinephrine tra... | 10/19/2010 |
| 7799804 | Therapeutic agents The present invention relates to compounds of formula (I) and processes for preparing such compounds, their use in the treatment of obesity, psychiatric and neurological disorders, to methods for their therapeutic use and to pharmaceutical compositions containing th... | 09/21/2010 |
| 7786140 | Piperidine derivative having NMDA receptor antagonistic activity A piperidine derivative of the formula (I) is found to bind specifically with the NR1/NR2B receptor and usable as an analgesic (pain treatment drug). wherein X is OH or lower alkylsulfonyloxy; Ar is optionally substituted a... | 08/31/2010 |
| 7786141 | Dihydrospiroindene modulators of muscarinic receptors The present invention relates to dihydrospiroindene modulators of muscarinic receptors. The present invention also provides compositions comprising such dihydrospiroindene modulators, and methods therewith for treating muscarinic receptor mediated diseases. ... | 08/31/2010 |
| 7772253 | Amide derivatives as somatostatin receptor 5 antagonists This invention is concerned with compounds of the formula wherein R1 to R5, R5′ and A are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The inven... | 08/10/2010 |
| 7763639 | Disubstituted phenylpiperidines/piperazines as modulators of dopamine neurotransmission The present invention relates to compounds which have therapeutic effects against disorders in the central nervous system, and in particular new 4-(ortho, meta-disubstituted phenyl)-1-alkypiperidines and piperazines. wherei... | 07/27/2010 |
| 7759364 | Method for producing non-hydrated fexofenadine hydrochloride and a novel crystalline form obtained thereby The invention relates to non-hydrated fexofenadine hydrochloride which can be obtained from a fexofenadine base and hydrogen chloride, according to the reaction conditions, either in the form of a novel polymorph (“form A”), in an amorphous form, or in the form ... | 07/20/2010 |
| 7732463 | 4-(2-phenylsulfanyl-phenyl)-piperidine derivatives as serotonin reuptake inhibitors The invention provides compounds represented by the general formula (I) wherein the substituents are defined in the application. The compounds are useful in the treatment of an affective disorder, including depression, anxiety disorders including general anxiety dis... | 06/08/2010 |
| 7728009 | Thiazole amides, imidazole amides and related analogues Thiazole amides, imidazole amides and related analogues of the Formula: are provided, in which variables are as described herein. Such compounds may be used to modulate ligand binding to histamine H3 receptors in vivo or in... | 06/01/2010 |
| 7728008 | N-linked heterocyclic antagonists of P2Yreceptor useful in the treatment of thrombotic conditions The present invention provides novel ureas containing N-aryl or N-heteroaryl substituted heterocycles of Formula (I): or a stereoisomer, tautomer, pharmaceutically acceptable salt or solvate form thereof, wherein the variab... | 06/01/2010 |
