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| Number | Title | Issue Date |
| 8148398 | Intermediate duration neuromuscular blocking agents and antagonists thereof The invention provides novel neuromuscular blocking agents, methods of using the neuromuscular blocking agents as well as reagents, methods and kits for reversing the effects of the neuromuscular blocking agents. ... | 04/03/2012 |
| 7932266 | Isoquinoline derivatives as calpain inhibitors The invention relates to derivative compounds of partially-reduced isoquinoline with substitution of a sec-butyl group at position 3 with calpain inhibitor activity. The inventive compound comprises an ester or amide derived from (3-sec-butyl-1-oxo-2,3-dihydro-1H-is... | 04/26/2011 |
| 7816370 | Use of epothilones in the treatment of neuronal connectivity defects such as schizophrenia and autism The present invention is about the use of at least one epothilone or derivative thereof as an active ingredient for manufacturing a medicament for use in the treatment of disease(s) involving a neuronal connectivity defect, such as schizophrenia or autism. ... | 10/19/2010 |
| RE40558 | Therapeutic uses of di-aryl acid derivatives The use of diaryl acid derivatives of formula (I) or pharmaceutically acceptable salts, N-oxides, hydrates or solvates thereof, wherein the variables shown are defined in the disclosure, and their pharmaceutical compositions as P... | 10/28/2008 |
| 7342028 | Medical use for tachykinin antagonists The present invention relates to the use of tachykinin antagonists, including substance P antagonists and other neurokinin antagonists, in the treatment of emesis. Also described are novel tachykinin antagonists of formula (I), processes for their preparation, pharm... | 03/11/2008 |
| 7268142 | Tetrahydroisoquinolinyl derivatives of quinazoline and isoquinoline The invention pertains to substituted quinazoline and isoquinoline compounds that serve as effective phosphodiesterase (PDE) inhibitors. In particular, the invention relates to said compounds which are selective inhibitors of PDE-10. The invention also relates to in... | 09/11/2007 |
| 7265099 | Use of chemical chelators as reversal agents for drug-induced neuromuscular block The invention relates to the use of chemical chelators for the preparation of a medicament for the reversal of drug-induced neuromuscular block, to a kit for providing neuromuscular block and its reversal, and to cyclophane derivatives having general formula (A) whe... | 09/04/2007 |
| 7157463 | Substituted piperidines/piperazines as melanocortin receptor agonists The present invention relates to melanocortin receptor agonists of formula I, which is useful in the treatment of obesity, diabetes and male and/or female sexual dysfunction ... | 01/02/2007 |
| 7078413 | Compositions and methods of use for a bombesin peptide The present invention discloses a seven amino acid peptide (7AA) of bombesin. Methods for reducing the impairment respiratory tract mucosal immunity, reducing the rate of infection of the respiratory tract by pathogenic microorganisms and reducing the atrophy or dys... | 07/18/2006 |
| 6962927 | Method for potentiating primary drugs in treating multidrug resistant disease The specification discloses a method for enhancing the inhibiting action of drugs against multidrug resistant cells, apparently by reversing or inhibiting the glycoprotein “pumps” associated with such cells. ... | 11/08/2005 |
| 6911455 | Methods for preparing pharmaceutical formulations The invention relates to pharmaceutical formulations and methods for preparing pharmaceutical formulations of histamine releasers. The present invention provides methods for determining the concentration of physiologically acceptable excipients for use in the formul... | 06/28/2005 |
| 6911454 | Method for potentiating primary drugs in treating multidrug resistant disease The specification discloses a method for enhancing the inhibiting action of drugs against multidrug resistant cells, apparently by reversing or inhibiting the glycoprotein “pumps” associated with such cells. ... | 06/28/2005 |
| 6903075 | Heterocyclic amide compounds as cell adhesion inhibitors Compounds of Formula I are antagonists of VLA-4 and/or α4β7, and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These compounds may be formulated into pharmaceutical compositions an... | 06/07/2005 |
| 6800645 | Substituted azabicyclic compounds This invention is directed to physiologically active compounds of formula (I) wherein represents a bicyclic ring system, of about 10 to about 13 ring members, in which the ri... | 10/05/2004 |
| 6686351 | Compounds and methods for modulation of estrogen receptors Compounds that modulate the estrogen receptor (ER) are disclosed, as well as pharmaceutical compositions containing the same. In a specific embodiment, the compounds are selective modulators for ER-ଲ over ER-. Methods are disclosed for modula... | 02/03/2004 |
| 6645957 | Cyclic amide compound The invention relates to compounds represented by the following general formula (1): ##STR1## wherein A is an aromatic compound which may be substituted, or the like, B is a nitrogen atom or CH, X is a lower alkylene group which may be substituted, o... | 11/11/2003 |
| 6627641 | Antimalarial naphthylisoquinoline alkaloids and pharmaceutical compositions and medical uses thereof The present invention provides antimalarial pharmaceutical compositions containing antimalarial naphthylisoquinoline alkaloids or antimalarial derivatives thereof, useful new antimalarial naphthylisoquinoline alkaloid derivatives, methods for obtaining su... | 09/30/2003 |
| 6617335 | Preparation and drug composition of bis-benzyl-isoquinoline class alkaloids This invention relates to the preparation of bis-isoquinoline derivatives of general formula (I) and salts thereof, which possesses multi-drug resistance (MDR) reversal activities. Drug compositions and formulations comprising bis-isoquinoline derivatives... | 09/09/2003 |
| 6593322 | Compounds and methods for modulation of estrogen receptors Compounds that modulate the estrogen receptor (ER) are disclosed, as well as pharmaceutical compositions containing the same. In a specific embodiment, the compounds are selective for ER-ଲ over ER-. Methods are disclosed for modulating ER-&#x... | 07/15/2003 |
| 6579885 | Aryl and heteroaryl substituted tetrahydroisoquinolines and use thereof Provided herein are compounds of the formula (I): ##STR1## wherein R1 -R8 are as described herein, R4 being aryl or heteroaryl Such compounds are particularly useful in the treatment of a disorder which is created by or is... | 06/17/2003 |
| 6576642 | Diamide compounds and compositions containing the same Compounds having the formula (1): ##STR1## wherein A is a phenyl, naphthyl, dihydronaphthyindeny, pyridyl, indolyl,isoindolyl, quinolyl or isoquinolyl group which are optionally substituted; X is optionally substituted alicyclic, aromatic, imino or h... | 06/10/2003 |
| 6573279 | Isoquinoline derivatives or salts thereof The compound of the present invention relates to a drug, particularly to a novel isoquinoline derivative or its salt having an If current inhibitory effect without serious side effects such as convulsion and also to a drug, particularly a cardi... | 06/03/2003 |
| 6562836 | Methods and compounds for inhibiting amyloid deposits Methods and compositions which are useful in the treatment of amyloidosis. In particular, methods and compositions are provided for inhibiting, preventing and treating amyloid deposition, e.g., in pancreatic islets, wherein the amyloidotic deposits are is... | 05/13/2003 |
| 6548520 | Substituted imidazoles having anti-cancer and cytokine inhibitory activity The present invention is related to novel 2-alkyl substituted imidazoles of formula (I) useful for the treatment of CSBP kinase mediated diseases. ##STR1##... | 04/15/2003 |
| 6531487 | Indolo[2,1-b] quinazole-6, 12-dione antimalarial compounds and methods of treating malaria therewith Compounds, compositions and methods are provided for treating malaria parasites in vitro and in vivo by administering indolo[2,1-b]quinazoline-6,12-dione compounds of Formula I. ##STR1## wherein A, B, C, D, E, F, G and H are independently selected from ca... | 03/11/2003 |
| 6436923 | Compounds and methods for modulation of estrogen receptors Compounds that modulate the estrogen receptor (ER) are disclosed, as well as pharmaceutical compositions containing the same. In a specific embodiment, the compounds are selective modulators for ER-ଲ over ER-. Methods are disclosed for modula... | 08/20/2002 |
| 6429211 | Praziquantel compounds for treating diseases due to Sarcocystis Neospora Toxoplasma and Isospora Disclosed herein are compositions and methods of treating therapeutically, or metaphylactically infected mammals susceptible to, or infected mammals suffering from parasitic neurologic or abortigenic diseases such as Sarcocystis, Neosporosis or Toxoplasmo... | 08/06/2002 |
| 6417178 | Amyloid binding nitrogen-linked compounds for the antemortem diagnosis of alzheimer's disease, in vivo imaging and prevention of amyloid deposits Amyloid binding compounds which are derivatives of Chrysamine G, pharmaceutical compositions containing, and methods using such compounds to identify Alzheimer's brain in vivo and to diagnose other pathological conditions characterized by amyloidosis, suc... | 07/09/2002 |
| 6384028 | N-acylpiperidinylcarbonylaminocarboxylic acids and their use as glycoprotein IIb/IIIa antagonists and fibrinogen-blood platelets binding inhibitors ଲ-alanine compounds or a pharmaceutically acceptable salt thereof, which is useful as a glycoprotein IIB/IIIa antagonist, inhibitor of blood platelet aggregation and inhibitor of the binding of fibrinogen to blood platelet; a composition containing ... | 05/07/2002 |
| 6329390 | 5-Bicycloindole compounds Disclosed herein are compounds selective for a 5-HT1D receptor, the compounds having the general formula (I): ##STR1## Also disclosed is the use of these compounds as pharmaceuticals to treat indications where stimulation of a 5-HT1D... | 12/11/2001 |
| 6297283 | Diamide compounds and compositions containing the same The present invention relates to compounds represented by the following general formula (1): ##STR1## wherein A is a phenyl, naphthyl, dihydronaphthyl, indenyl, pyridyl, indolyl, isoindolyl, quinolyl or isoquinolyl group which may be substituted; X i... | 10/02/2001 |
| 6284772 | Indolo[2,1-B] quinazole-6,12-dione antimalarial compounds and methods of treating malaria therewith Compounds, compositions and methods are provided for treating malaria parasites in vitro and in vivo by administering indolo[2,1-b]quinazoline-6,12-dione compounds of Formula I. ##STR1## wherein A, B, C, D, E, F, G and H are independently selected from ca... | 09/04/2001 |
| 6274594 | Isoquinoline derivatives and their therapeutical use Novel isoquinoline derivatives and methods of using them to treat various neurological indications are disclosed.... | 08/14/2001 |
| 6242450 | 5-HT1F antagonists This invention provides 5-HT1f antagonists of Formula I: ##STR1## where AR1, AR2, R, and R' are as defined in the specification.... | 06/05/2001 |
| 6218393 | Anthranilic acid derivatives as multi drug resistance modulators Anthranilic acids of formula (I): ##STR1## wherein each of R to R9 is an organic substituent, n is 0 or 1, m is 0 or an integer of 1 to 6, q is 0 or 1, X is a direct bond, O, S, --S--(CH2)p or --O--(CHO2)p | 04/17/2001 |
| 6187789 | Substituted isoquinolines as ultra short acting neuromuscular blockers Ultrashort acting neuromuscular blocking agents of Formula (I) which are useful as skeletal muscle relaxants during emergency intubation procedures, routine surgery and post-operative settings are disclosed, wherein: X is a halogen; h is from 1 to 2; Y is... | 02/13/2001 |
| 6177445 | Substituted isoquinolines as ultra short acting neuromuscular blockers Ultra short acting neuromuscular blocking agents of Formula (I) which are useful as skeletal muscle relaxants during emergency intubation procedures, routine surgery and post-operative settings are disclosed, wherein q and t are independently from 0 to 4;... | 01/23/2001 |
| 6174901 | Substituted pyridine and pyridazine compounds and methods of use Selected novel substituted pyridine and pyridazine compounds are effective for prophylaxis and treatment of diseases, such as TNF-, IL-1ଲ, IL-6 and/or IL-8 mediated diseases, and other maladies, such as cancer, pain and diabetes. The inventio... | 01/16/2001 |
| 6162809 | Pyridylthio compounds for controlling helicobacter bacteria Pyridinylthiomethyl- and pyrimidinylthiomethyl-pyridines and their pharmacologically-acceptable compositions are useful for controlling Helicobacter bacteria and for treating those afflicted with diseases based on Helicobacter bacteria.... | 12/19/2000 |
| 6156767 | Antagonists of gonadotropin releasing hormone There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both m... | 12/05/2000 |
