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3M employee and church chorister Art Fry needed something to temporarily mark pages in his hymnal. He was in luck because his colleague, Spencer Silver, accidentally developed a glue that was too weak for other purposes. After initially discouraging consumer response, Post-it Notes became a hit in 1979.
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| Number | Title | Issue Date |
| 8188116 | Agents for therapy efficacy monitoring and deep tissue imaging Compounds and methods related to NIR molecular imaging, in-vitro and in-vivo functional imaging, therapy/efficacy monitoring, and cancer and metastatic activity imaging. Compounds and methods demonstrated pertain to the field of peripheral benzodiazepine receptor im... | 05/29/2012 |
| 8188115 | 5-HTreceptor antagonists The invention relates to compounds having pharmacological activity towards the 5-HT7 receptor, and more particularly to some tetrahydroisoquinoline substituted sulfonamide compounds, to processes of preparation of such compounds, to pharmaceutical compositions compr... | 05/29/2012 |
| 8173673 | Biofilm-inhibiting effect and anti-infective activity of -linked aryl isoquinolines and the use thereof Anti-infective and biofilm-inhibiting activities of aryl isoquinoline-derivatives of the general formulae 1 to 3 are described. ... | 05/08/2012 |
| 8168655 | Compositions and methods for treatment of eye disorders The present invention provides compounds and methods for the treatment of LFA-1 mediated diseases. In particular, LFA-1 antagonists are described herein and these antagonists are used in the treatment of LFA-1 mediated diseases. One aspect of the invention provides ... | 05/01/2012 |
| 8153655 | Compositions useful as inhibitors of voltage-gated sodium channels The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of... | 04/10/2012 |
| 8153654 | 6-and 7-amino isoquinoline compounds and methods for making and using the same 6- and 7-amino isoquinoline compounds are provided that influence, inhibit or reduce the action of a kinase. Pharmaceutical compositions including therapeutically effective amounts of the 6- and 7-aminoisoquinoline compounds and pharmaceutically acceptable carriers ... | 04/10/2012 |
| 8148397 | 5-HT7 receptor antagonists The invention relates to compounds having pharmacological activity towards the 5-HT7 receptor, and more particularly to some tetrahydroisoquinoline propyl sulfonamide compounds, to processes of preparation of such compounds, to pharmaceutical compositions comprising... | 04/03/2012 |
| 8097636 | Heterocyclic derivatives as modulators of ion channels The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of v... | 01/17/2012 |
| 8084464 | Tetrahydroisoquinoline derivatives This invention relates to novel tetrahydroisoquinoline derivatives, their derivatives, pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treatin... | 12/27/2011 |
| 8080562 | Crystalline pharmaceutical and methods of preparation and use thereof Novel crystalline polymorphic forms, Forms A, B, C, D, and E of a compound of Formula I, which has been found to be a potent inhibitor of LFA-1, are disclosed. Methods of preparation and uses thereof in the treatment of LFA-1 mediated diseases are also disclosed in ... | 12/20/2011 |
| 8071617 | Modulators of cellular adhesion The present invention provides compounds having formula (I): and pharmaceutically acceptable derivatives thereof, wherein R1-R4, n, p, A, B, D, E, L and AR1 are as described generally and in... | 12/06/2011 |
| 8071616 | Pyridine, quinoline, and isoquinoline N-oxides as kinase inhibitors This invention relates to urea compounds containing a pyridine, quinoline, or isoquinoline functionality which is oxidized at the nitrogen heteroatom and which are useful in the treatment of (i) raf mediated diseases, for example, cancer, (ii) p38 mediated diseases ... | 12/06/2011 |
| 8071615 | Carbonylamino-derivatives as novel inhibitors of histone deacetylase This invention comprises the novel compounds of formula (I) wherein n, m, t, R1, R2, R3, R4, R5, L, Q, X, Y and have defined... | 12/06/2011 |
| 8044067 | Isoquinolines as IGF-1R inhibitors Compounds of the formula (I): were synthesized. In at least one embodiment, they were found to down-regulate or inhibit the expression or function of the IGF-1 receptor. ... | 10/25/2011 |
| 7998977 | Inhibitors of AKT (protein kinase B) 4-[5-(2-Amino-ethanesulfonyl)-isoquinolin-7-yl]-phenol or a pharmaceutically acceptable salt thereof or a hydrate of the compound or the salt thereof as Akt inhibitors that are antineoplastic and/or antiviral agents as well as compositions comprising these compounds... | 08/16/2011 |
| 7951820 | Triazole compounds useful as protein kinase inhibitors This invention describes novel triazole compounds of formula IX: wherein Z1 is nitrogen or CR9 and Z2 is nitrogen or CH, provided that at least one of Z1 and Z2 is nitr... | 05/31/2011 |
| 7928121 | 5-HT7 receptor antagonists The invention relates to compounds having pharmacological activity towards the 5-HT7 receptor, and more particularly to some tetrahydroisoquinoline substituted sulfonamide compounds, to processes of preparation of such compounds, to pharmaceutical compositions compr... | 04/19/2011 |
| 7928122 | Modulators of cellular adhesion The present invention provides compounds having formula (I); and pharmaceutically acceptable derivatives thereof, wherein R1-R4, n, p, A, B, D, E, L and AR1 are as d... | 04/19/2011 |
| 7928120 | Cyanoisoquinoline compounds and methods of use thereof The present invention relates to cyanoisoquinoline compounds suitable for use in treating hypoxia inducible factor-mediated and/or erythropoietin-associated conditions. The cyanoisoquinoline compounds of the invention have the following structure: ... | 04/19/2011 |
| 7919504 | Thiadiazole modulators of PKB The invention relates to thiazole compounds of Formula I and Formula II and compositions thereof useful for treating diseases mediated by protein kinase B (PKB) where the variables have the definitions provided herein. The ... | 04/05/2011 |
| 7915288 | 1-aryl-4-substituted isoquinolines 1-aryl-4-substituted isoquinoline or 1-aryl-3,4-disubstituted isoquinoline analogues of Formula I and Formula II, as follows: wherein R1, R2, R3, R8, R9, A and Ar are d... | 03/29/2011 |
| 7897618 | N-aroyl cyclic amine derivatives as orexin receptor antagonists Disclosed are N-aroyl cyclic amine derivatives having the formula: where the variables are as define herein, and their use as pharmaceuticals, specifically as orexin receptor antagonists. ... | 03/01/2011 |
| 7868019 | Dermatitis treating agent The present invention is to provide a topical dermatitis treating agent which comprises a pyridine compound represented by the following formula [I]: wherein R1 and R2 each rep... | 01/11/2011 |
| 7820692 | Tetrahydro isoquinoline derivatives, preparation methods and medicinal uses thereof A kind of tetrahydro isoquinoline derivatives (I), their preparation methods, medicine compositions and medicinal uses thereof, especially their uses as κ-opioid receptor excitant in pain relieving, which belongs to the medicine chemistry. The substituents R1 | 10/26/2010 |
| 7807692 | Antidiabetic oxazolidinediones and thiazolidinediones Phenoxyphenyl and phenoxybenzyl oxazolidine-2,4-diones and thiazolidine-2,4-diones are agonists or partial agonists of PPAR gamma and are useful in the treatment and control of hyperglycemia that is symptomatic of type II diabetes, as well as dyslipidemia, hyperlipi... | 10/05/2010 |
| 7795277 | 7-(2-(4-(3-trifuloromethyl-phenyl)-1,2,3,6-tetrahydropyrid-1-yl)ethyl)isoquinoline besylate salt, preparation and therapeutic use thereof The present invention relates to the besylate salt of 7-(2-(4-(3-(trifluoromethyl)phenyl)-1,2,3,6-tetrahydropyrid-1-yl)ethyl)isoquinoline, to its preparation and to its use in therapeutics. The salt may be represented by the formula (II) below. | 09/14/2010 |
| 7790742 | Substituted 4-phenyltetrahydroisoquinolines, pharmaceutical compositions thereof, methods for their preparation and therapeutic use The present invention relates to substituted 4-phenyltetrahydroisoquinoline compounds of the structure of formula I and pharmaceutical compositions comprising them wherein the R groups are herein defined. These are excellen... | 09/07/2010 |
| 7790743 | Modulators of cellular adhesion The present invention provides compounds having formula (I): and pharmaceutically acceptable derivatives thereof; wherein R1-R4, n, p, A, B, D, E, L and AR1 are as d... | 09/07/2010 |
| 7786137 | Bicyclic derivatives as modulators of ion channels Bicyclic derivatives having formula (I) and a composition thereof are useful as ion channel antagonists: ... | 08/31/2010 |
| 7745460 | Modulators of cellular adhesion The present invention provides compounds having formula (I): and pharmaceutically acceptable derivatives thereof, wherein R1-R4, n, p, A, B, D, E, L and AR1 are as d... | 06/29/2010 |
| 7718671 | Substituted arylthiourea derivatives useful as inhibitors of viral replication Substituted arylthiourea compounds of Formula I, and the pharmaceutically acceptable salts of such compounds, useful as antiviral agents, are provided herein. Certain substituted arylthioureas disclosed herein are potent an... | 05/18/2010 |
| 7718672 | Substituted tetrahydroisoquinoline compounds, methods of making, and their use Disclosed are novel substituted tetrahydroisoquinoline compounds, pharmaceutical compositions containing the compounds, methods of making the compounds, and methods of using the compounds to destroy a target cell, such as a cancer cell, and to treat or prevent a can... | 05/18/2010 |
| 7705017 | Compounds for treatment of neurodegenerative diseases The present invention relates to a class of small molecule hydroxamic acid compounds capable of inhibiting histone deacetylases (HDACs). The present invention also relates to methods of preparation of hydroxamic acid HDAC inhibitor compounds of the invention, which ... | 04/27/2010 |
| 7700620 | C-linked cyclic antagonists of P2Yreceptor useful in the treatment of thrombotic conditions The present invention provides novel C-linked cyclic compounds and analogues of Formula (I): or a stereoisomer, tautomer, pharmaceutically acceptable salt or solvate form thereof, wherein the variables A, B, D and W are as ... | 04/20/2010 |
| 7691879 | Isoquinoline potassium channel inhibitors The present invention relates to compounds having the structure (I) useful as potassium channel inhibitors to treat cardiac arrhythmias, and the like. ... | 04/06/2010 |
| 7678811 | Pyridine, quinoline, and isoquinoline N-oxides as kinase inhibitors This invention relates to urea compounds containing a pyridine, quinoline, or isoquinoline functionality which is oxidized at the nitrogen heteroatom and which are useful in the treatment of (i) raf mediated diseases, for example, cancer, (ii) p38 mediated diseases ... | 03/16/2010 |
| 7678812 | Aminotetralin-derived urea modulators of vanilloid VR1 receptor This invention is directed to vanilloid receptor VR1 ligands. More particularly, this invention relates to β-aminotetralin-derived ureas that are potent antagonists or agonists of VR1 which are useful for the treatment and prevention of inflammatory and other pain ... | 03/16/2010 |
| 7635703 | Imidazole substituted pyrazole kinase inhibitors The present invention is directed to novel substituted pyrazole compounds of Formula (I) or a form or composition thereof and the use thereof as inhibitors of ATP-protein kinase interactions. ... | 12/22/2009 |
| 7625926 | P-glycoprotein inhibitor, method for preparing the same and pharmaceutical composition comprising the same The bioavailability of an anticancer agent is enhanced when the anticancer agent is administered together with a pharmaceutical composition comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof. ... | 12/01/2009 |
| 7615563 | Compositions useful as inhibitors of voltage-gated sodium channels The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of... | 11/10/2009 |
