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| Number | Title | Issue Date |
| 8183257 | Muscarinic acetylcholine receptor antagonists Muscarinic Acetylcholine Receptor Antagonists and methods of using them are provided. ... | 05/22/2012 |
| RE43390 | Pleuromutilin derivatives as antimicrobials The present invention relates to pleuromutilin derivatives, to processes for their preparation, to pharmaceutical compositions containing them and to their use in medical therapy, particularly antibacterial therapy. ... | 05/15/2012 |
| 8173671 | Topical ophthalmic or otic solution formulations containing moxifloxacin hydrochloride and dexamethasone phosphate Topical ophthalmic and otic solution compositions of moxifloxacin and dexamethasone phosphate are disclosed. ... | 05/08/2012 |
| 8168654 | Quinuclidine derivatives binding to mucarinic M3 receptors Compounds of formula I in salt or zwitterionic form wherein, wherein R1, R2, R3, and R4 have the meanings as indicated in the specification, are useful for treating conditions tha... | 05/01/2012 |
| 8158649 | 3-substituted-2(arylalkyl)-1-azabicycloalkanes and methods of use thereof The present invention relates to 3-substituted-2-(arylalkyl)-1-azabicycloalkanes, methods of preparing the compounds and methods of treatment using the compounds. The compounds exhibit activity at nicotinic acetylcholine receptors (nAChRs), particularly the α7 nACh... | 04/17/2012 |
| 8143272 | 3-substituted-2(arylalkyl)-1-azabicycloalkanes and methods of use thereof The present invention relates to 3-substituted-2-(arylalkyl)-1-azabicycloalkanes, methods of preparing the compounds and methods of treatment using the compounds. The compounds exhibit activity at nicotinic acetylcholine receptors (nAChRs), particularly the α7 nACh... | 03/27/2012 |
| 8138204 | Stereoisomeric compounds and methods for the treatment of gastrointestinal and central nervous system disorders The subject invention provides stereoisomeric compounds of formula (X): wherein the variables are as defined herein, and compositions for the safe and effective treatment of various gastrointestinal... | 03/20/2012 |
| 8129405 | Quinuclidine derivatives and medicinal compositions containing the same The invention provides 3(R)-(2-hydroxy-2,2-dithien-2-ylacetoxy)-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane bromide in powder inhalant form, and methods of using it for treatment of respiratory disorders. ... | 03/06/2012 |
| 8124620 | 3-Substituted-2(arylalkyl)-1-azabicycloalkanes and methods of use thereof The present invention relates to pharmaceutical compositions incorporating compounds capable of affecting nicotinic acetylcholinergic receptors (nAChRs), for example, as modulators of specific nicotinic receptor subtypes (specifically, the α7 nAChR subty... | 02/28/2012 |
| 8124618 | 3-substituted-2(arylalkyl)-1-azabicycloalkanes and methods of use thereof The present invention relates to pharmaceutical compositions incorporating compounds capable of affecting nicotinic acetylcholinergic receptors (nAChRs), for example, as modulators of specific nicotinic receptor subtypes (specifically, the α7 nAChR subtype). The pr... | 02/28/2012 |
| 8124619 | 3-substituted-2(arylalkyl)-1-azabicycloalkanes and methods of use thereof The present invention relates to pharmaceutical compositions incorporating compounds capable of affecting nicotinic acetylcholinergic receptors (nAChRs), for example, as modulators of specific nicotinic receptor subtypes (specifically, the α7 nAChR subty... | 02/28/2012 |
| 8119659 | (2S,3R)-N-(2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)benzofuran-2-carboxamide, novel salt forms, and methods of use thereof The present invention relates to (2S,3R)-N-(2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)benzofuran-2-carboxamide, novel salt forms thereof, methods for its preparation, novel intermediates, and methods for treating a wide variety of conditions and disorders,... | 02/21/2012 |
| 8114891 | 4-substituted quinuclidine derivatives, methods of production, pharmaceutical uses thereof The present invention relates to compounds and formulations capable of affecting nicotinic acetylcholine receptors (nAChRs), for example, as modulators of specific nicotinic receptor subtypes (specifically, the alpha7 nAChR subtype). The present invention also relat... | 02/14/2012 |
| 8084463 | Quinuclidine derivatives and their use as muscarinic M3 receptor antagonists Compounds of Formula (I); in salt or zwitterionic form wherein R1, R2, R3 and R4 have the meanings as indicated in the specification, are useful for treating conditions that are mediated by the muscarinic M3 receptor, espe... | 12/27/2011 |
| 8048893 | Pyrazolyl derivatives, preparation process and intermediates of this process as medicinal products and pharmaceutical compositions containing them The present invention relates to the novel derivatives of formula (I) in which A is, if it is present, a (C1-C6) alkyl, a (C3-C6) alkenyl, a (C3-C6) alkynyl, a (C3-C7) cycloalkyl or a (C5-C7) cycloalkenyl, R1 is an NR6R7, (... | 11/01/2011 |
| 8039483 | Quinuclidine carbonate salts and medicinal composition thereof Quinuclidine carbonate derivatives act as muscarinic receptor antagonists and are effective for the prevention and/or treatment of a broncho-obstructive or inflammatory diseases. ... | 10/18/2011 |
| 8039482 | Composition of solifenacin or salt thereof for use in solid formulation A solid pharmaceutical preparation of solifenacin or a salt thereof, the preparation being stable and inhibited from decomposing with time when supplied to clinical fields. In a pharmaceutical preparation containing solifenacin or a salt thereof, the compound in an ... | 10/18/2011 |
| 8030329 | N-biarylamides The invention relates to N-biarylamides useful for the prophylaxis and/or treatment of impairments of perception, concentration, learning and/or memory, and to processes for preparing them, and pharmaceutical compositions containing them. ... | 10/04/2011 |
| 7981906 | (2S,3R)-N-(2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl-benzofuran-2-carboxamide, novel salt forms, and methods of use thereof The present invention relates to (2S,3R)—N-(2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)benzofuran-2-carboxamide, novel salt forms thereof, methods for its preparation, novel intermediates, and methods for treating a wide variety of conditions and disorder... | 07/19/2011 |
| 7897617 | Quinuclidine derivatives and medicinal compositions containing the same The invention provides 3-(2-hydroxy-2,2-dithien-2-ylacetoxy)-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2] octane in salt form, pharmaceutical compositions comprising it, and methods of using it for treatment of respiratory disorders, in association with steroids. ... | 03/01/2011 |
| 7893087 | Quinuclidine derivatives and medicinal compositions containing the same A compound of formula (I) is provided, wherein B, A, R1, R2, R3, R4, R5 and R6 are as defined herein and X− represents a pharmaceutically acceptable anion of a mono or polyvalent acid. Pr... | 02/22/2011 |
| 7888370 | Topical ophthalmic or otic solution formulations containing moxifloxacin hydrochloride and dexamethasone phosphate Topical ophthalmic and otic solution compositions of moxifloxacin and dexamethasone phosphate are disclosed. ... | 02/15/2011 |
| 7879874 | Quinuclidine derivatives and medicinal compositions containing the same A compound of formula (I) is provided, wherein B, A, R1, R2, R3, R4, R5 and R6 are as defined herein and X− represents a pharmaceutically acceptable anion of a mono or polyvalent acid. Pr... | 02/01/2011 |
| 7875630 | Process salts compositions and use The present invention provides a novel process for preparing pleuromutilin derivatives, novel salts of mutilin 14-(exo-8-methyl-8-azabicyclo[3.2.1]oct-3-ylsulfanyl)-acetate or solvates thereof, novel pharmaceutical compositions or formulations for topical administra... | 01/25/2011 |
| 7863291 | Quinuclidine compounds as alpha-7 nicotinic acetylcholine receptor ligands The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands for the nicotinic α7 receptor and may be useful for the treatment of various disorders of the central nervou... | 01/04/2011 |
| 7838534 | Quinuclidine derivatives as M3 antagonists Quinuclidine derivative of the general formula (I) in the form of single enantiomers or mixtures thereof are useful in the manufacture of a medicament for the prevention and therapy of respiratory diseases such as asthma, chronic obstructive pulmonary disease (COPD)... | 11/23/2010 |
| 7776879 | Quinuclidine carbamate derivatives and their use as M3 antagonists A carbamate of formula (I), wherein R1 represents wherein R2 represents a benzyl, phenethyl, furan... | 08/17/2010 |
| 7759361 | Azabicyclooctan-3-one derivatives and use thereof Compounds of Formula (1) process for preparing them, pharmaceutical compositions comprising them. The use of compounds of formula (1) for hyperproliferative diseases, e.g. cancer as well as autoimmune diseases and heart disease. ... | 07/20/2010 |
| 7750023 | Quinuclidine derivatives and medicinal compositions containing the same The invention provides 3-(2-hydroxy-2,2-dithien-2-ylacetoxy)-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane in salt form, pharmaceutical compositions comprising it, and methods of using it for treatment of respiratory disorders, in association with β2 ... | 07/06/2010 |
| 7750022 | Quinuclidine derivatives and their pharmaceutical use This invention relates to novel quinuclidine derivatives and their use as pharmaceuticals. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic sys... | 07/06/2010 |
| 7723356 | Quinuclidine derivatives and their use as muscarinic m3 receptor antagonists Compounds of Formula (I); in salt or zwitterionic form wherein R1, R2, R3 and R4 have the meanings as indicated in the specification, are useful for treating conditions that are mediated by the muscarinic M3 receptor, espe... | 05/25/2010 |
| 7718670 | Quinuclidine amide derivatives New quinuclidine amide derivatives having the chemical structure of general formula (I) and pharmaceutically acceptable salts thereof including quaternary salts of formula (II) ar... | 05/18/2010 |
| 7705016 | Regulation of food intake by modulation of long-chain fatty acyl-CoA levels in the hypothalamus Methods of reducing food intake and glucose production in a mammal, or restoring hepatic autoregulation are provided. The methods involve increasing long-chain fatty acyl-Co-A (LC-CoA) levels in the hypothalamus, or stimulating efferent fibers in the hepatic branch ... | 04/27/2010 |
| 7683075 | Isoquinoline-3-carboxylic acid amides and pharmaceutical uses thereof The present invention relates to novel isoquinoline-3-carboxylic acid amides having α7 nicotinic acetylcholine receptor agonistic activity, their preparation, their use as pharmaceuticals and pharmaceutical compositions containing them. ... | 03/23/2010 |
| 7598267 | Muscarinic acetylcholine receptor antagonists Muscarinic Acetylcholine Receptor Antagonists and methods of using them are provided. ... | 10/06/2009 |
| 7579362 | Aza-bicycloalkyl ethers and their use as alpha7-nAChR agonists The present invention relates to 1-aza-bicycloalkyl derivatives of formula I, wherein X is CH2 or a single bond; Y is a group of formula and wherein R has the meanings ... | 08/25/2009 |
| 7566727 | 2-(1-aza-bicyclo[2.2.2]oct-3-yl)-2,3-dihydro-isoindole-1-one/5,6-dihydro-furo[2,3-c] pyrrol-4-one derivative ligands for alpha 7 nicotinic acetylcholine receptor This invention encompasses nicotinic acetylcholine receptor reactive compounds in accord with formula (I) Wherein: D represents O; E represents CH2, NH, O or S; n is 1 or 2 and stereoisomers, enantiomers, in vivo-hydrolysable precursors and pharmaceutically-acceptab... | 07/28/2009 |
| RE40861 | Compounds having reversible inhibiting activity of carnitine palmitoyl-transferase Compounds of formula (I) wherein the groups are as defined in the description are disclosed. The compounds of formula (I) are endowed with reversible inhibiting activity of carnitine palmitoyl-transferase and are useful i... | 07/21/2009 |
| 7553851 | Amides of acetic and propionic acids The invention relates to novel amides of acetic and propionic acids, methods for production and use thereof for the production of medicaments for the treatment and/or prophylaxis of diseases and for improving perception, concentration, learning ability and memory. | 06/30/2009 |
| 7514450 | Azabicyclic aryl derivatives This invention relates to novel azabicyclic aryl derivatives which are found to be cholinergic ligands at the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disord... | 04/07/2009 |
