Today In History
Six-year-old Robert W. Patch granted a patent for a "toy truck".
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 8163771 | 11 β-HSD1 modulators A compound according to Formula I: or a pharmaceutically acceptable salt thereof, wherein R1, R2, R11, L1 and X are as defined in the specification, pharmaceutical compositions th... | 04/24/2012 |
| 8153653 | Amido-tropane derivatives The present invention relates to a compound of formula I wherein R1, R2 and R3 are each independently hydrogen, lower alkyl, lower alkoxy, cycloalkyl, lower alkyl substituted by... | 04/10/2012 |
| 8110586 | 8-aza-bicyclo[3.2.1]octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors This invention relates to novel 8-aza-bicyclo[3.2.1]octane derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions c... | 02/07/2012 |
| 8084462 | 3-substituted-2(arylalkyl)-1-azabicycloalkanes and methods of use thereof The present invention relates to the pharmaceutical compositions incorporating compounds capable of affecting nicotinic acetylcholinergic receptors (nAChRs), for example, as modulators of specific nicotinic receptor subtypes (specifically, the α7 nAChR subtype). Th... | 12/27/2011 |
| 8003664 | Indazole-carboxamide compounds The invention provides novel indazole-carboxamide 5-HT4 receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT4 recep... | 08/23/2011 |
| 7989470 | 3,8-substituted 8-aza-bicyclo[3.2.1]octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors This invention relates to novel 8-aza-bicyclo[3.2.1]octane derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical composit... | 08/02/2011 |
| 7947710 | Disubstituted alkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists The invention provides novel 8-azabicyclo[3.2.1]octane compounds of formula (I): where the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are antagonists at the mu opioid rec... | 05/24/2011 |
| 7910603 | 3-monosubstituted tropane derivatives as nociceptin receptor ligands Compounds of the formula or a pharmaceutically acceptable salt thereof, wherein R1 is aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl... | 03/22/2011 |
| 7906531 | M3 muscarinic acetylcholine receptor antagonists Muscarinic Acetylcholine receptor antagonists and methods of using them are provided. ... | 03/15/2011 |
| 7902221 | Amidoalkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists The invention provides novel 8-azabicyclo[3.2.1]octane compounds of formula (I): wherein R1, R2, R3, and a are defined in the specification, or a pharmaceutically-acceptable salt thereof, th... | 03/08/2011 |
| 7902220 | 8-azabicyclo[3.2.1]octyl-2-hydroxybenzamide compounds as mu opioid receptor antagonists The invention provides 8-azabicyclo[3.2.1]octyl-2-hydroxybenzamide compounds of formula (I): wherein R2, R7, and m are defined in the specification, or a pharmaceutically -acceptable salt thereof, that... | 03/08/2011 |
| 7902222 | Biaryl substituted azabicyclic alkane derivatives The invention relates to biaryl substituted azabicyclic alkane derivatives, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions. ... | 03/08/2011 |
| 7875629 | Quinolinone compounds as 5-HTreceptor agonists The invention provides novel quinolinone-carboxamide 5-HT4 receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT4 re... | 01/25/2011 |
| 7786136 | Indazole-carboxamide compounds The invention provides novel indazole-carboxamide 5-HT4 receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT4 recep... | 08/31/2010 |
| 7781456 | Enantiomers of 3-heteroaryl-8H-8-azabicyclo(3.2.1)oct-2-ene and their use as monoamine neurotransmitter re-uptake inhibitors This invention relates to novel enantiomers useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of ... | 08/24/2010 |
| 7781455 | Compounds Heterocyclic amides useful as inhibitors of dipeptylpeptidase-IV (DPP-IV) enzyme, process for the preparation thereof and intermediates therefore. ... | 08/24/2010 |
| 7767691 | Muscarinic acetylcholine receptor antagonists containing an azoniabiocyclo[2.2.1] heptane ring system Muscarinic Acetylcholine receptor antagonists and methods of using them are provided. ... | 08/03/2010 |
| 7763637 | Quinolinone-carboxamide compounds as 5-HT, receptor agonists The invention provides novel quinolinone-carboxamide 5-HT4 receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT4 re... | 07/27/2010 |
| 7728004 | Crystalline form of a quinolinone-carboxamide compound The invention provides a crystalline hydrochloride salt of 1-isopropyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid {(1S,3R,5R)-8-[(R)-2-hydroxy-3-(methanesulfonyl-methyl-amino)propyl]-8-azabicyclo[3.2.1]oct-3-yl}amide or a solvate thereof. The invention also provid... | 06/01/2010 |
| 7700619 | 2-methoxymethyl-3-(3,4-dichlorophenyl)-8-azabicyclo[3.2.1]octane tartrate salts This invention relates to novel (1R,2R,3S,5S)-2-methoxymethyl-3-(3,4-dichlorophenyl)-8-azabicyclo[3.2.1]octane tartrate salts, such as L-tartrate monohydrates and anhydrates, wherein the salts are useful as monoamine neurotransmitter re-uptake inhibitors. Additional... | 04/20/2010 |
| 7691878 | Heteroarylalkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists The invention provides heteroarylene substituted 8-azabicyclo[3.2.1]octane compounds of formula (I): wherein R1, R2, A, and m are defined in the specification, or a pharmaceutically-acceptable salt the... | 04/06/2010 |
| 7645771 | CCR5 antagonists as therapeutic agents The present invention relates to compounds of formula (I) or a pharmaceutically acceptable derivatives thereof, useful in the treatment of prophylazis of CCR5-related diseases and disorders, for example, in the inhibition of HIV replication, the prevention or treatm... | 01/12/2010 |
| 7638532 | 3-aryloxy-8-aza-bicyclo[3.2.1]oct-6-ene derivatives and their use as monoamine neurotransmitter re-uptake inhibitors This invention relates to novel 8-aza-bicyclo[3.2.1]oct-6-ene derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical composition... | 12/29/2009 |
| 7605170 | 8-azabicyclo[3.2.1]octane derivatives The present invention relates to a 8-azabicyclo[3.2.1] octane derivative of Formula I, wherein each of the substituents is given the definition as set forth in the specification and claims, or a pharmaceutically acceptable ... | 10/20/2009 |
| 7592355 | Quinolinone-carboxamide compounds as 5-HT, receptor agonists The invention provides novel quinolinone-carboxamide 5-HT4 receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT4 re... | 09/22/2009 |
| 7589103 | Tricyclic-bridged piperidinylidene derivatives as 8-opioid modulators Disclosed are compounds, compositions and methods for treating various diseases and conditions, including pain. Such compounds are represented by Formula I as follows: wherein A, Z, Y, R1-R5 are define... | 09/15/2009 |
| 7589104 | Tricyclic-bridged piperidinyline derivatives as §-opioid modulators Disclosed are compounds, compositions and methods for treating various diseases and conditions, including pain. Such compounds are represented by Formula I as follows: wherein A, G, Y, R3, R4, and R | 09/15/2009 |
| 7585877 | Aminophenyl derivatives as selective androgen receptor modulators Disclosed herein is a novel class of aminophenyl compounds having the structure: wherein R1 is cyano or nitro and ring A is a bi- or tricyclic bridged heterocycle and to their use as modulators of androgen recept... | 09/08/2009 |
| 7579361 | Muscarinic acetylcholine receptor antagonists Muscarinic Acetylcholine Receptor Antagonists and methods of using them are provided. ... | 08/25/2009 |
| 7576097 | Tropane derivatives useful in therapy The present invention provides compounds of the formula: wherein R1 is C3-6 cycloalkyl optionally substituted by one or more fluorine atoms, or C1-6 alkyl optionally substituted by one or... | 08/18/2009 |
| 7576096 | Muscarinic acetylcholine receptor antagonists Muscarinic Acetylcholine Receptor Antagonists and methods of using them are provided. ... | 08/18/2009 |
| 7569582 | Aminotropane derivatives, preparation thereof and therapeutic use thereof The present invention relates to compounds of formula (I) as defined herein that are melanocortin receptor agonists, to the preparation thereof and to the therapeutic use thereof in the treatment and in the prevention of obesity, diabetes and sexual dysfunctions tha... | 08/04/2009 |
| 7569581 | Anticholinergics which may be used as medicaments as well as processes for preparing them The present invention relates to new anticholinergics of general formula 1 wherein A, X−, and the groups R1, R2, R3, R4, R5, R6 and R7 | 08/04/2009 |
| 7563803 | Mmuscarinic acetylcholine receptor antagonists Muscarinic Acetylcholine receptor antagonists and methods of using them are provided. ... | 07/21/2009 |
| 7553850 | Tricyclic-bridged piperidinylidene derivatives as δ-opioid modulators Disclosed are compounds, compositions and methods for treating various diseases and conditions, including pain. Such compounds are represented by Formula I as follows: wherein A, G, Y, R3, R4, and R | 06/30/2009 |
| 7541368 | Pyrazoles as inhibitors of tumor necrosis factor The present invention provides compounds of Formula (I) and ester prodrugs, pharmaceutically acceptable salts or solvates of such compounds; or ester prodrugs of such salts or solvates; pharmaceutical compositions comprisin... | 06/02/2009 |
| 7507747 | Muscarinic acetylcholine receptor antagonists Muscarinic Acetylcholine Receptor Antagonists and methods of using them are provided. ... | 03/24/2009 |
| 7488737 | Indoles, 1H-indazoles, 1,2-benzisoxazoles, 1,2-benzoisothiazoles, and preparation and uses thereof The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nACh receptors), activation of nACh receptors, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptor... | 02/10/2009 |
| 7485650 | High affinity ligands for nociceptin receptor ORL-1 The compound of the formula or a pharmaceutically acceptable salt or solvate thereof, pharmaceutical compositions therefore, and the use of said compounds as nociceptin receptor inhibitors useful in the treatment of anxiety... | 02/03/2009 |
| 7459464 | Triple monoamine reuptake inhibitors for the treatment of chronic pain The present invention relates to the use of triple monoamine reuptake inhibitors for the treatment of chronic pain. ... | 12/02/2008 |
