Did You Know...
...that the Slinky toy was the result of a failed attempt by engineer Richard James to produce an antivibration device for ship instruments? His goal was to develop a spring that would instantaneously counterbalance the wave motion that rocks a ship at sea. Instead, he developed the Slinky.
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| Number | Title | Issue Date |
| 8178556 | Pyridopyrazinones derivatives insulin secretion stimulators, methods for obtaining them and use thereof for the treatment of diabetes Described are pyridopyrazinone derivatives of formula (I), wherein X, Y, Z, W, A and R1 are as defined in claim 1, as insulin secretion stimulators. Also described is the preparation and use of these pyridopyrazinone deriva... | 05/15/2012 |
| 8168653 | Mediators of hedgehog signaling pathways, compositions and uses related thereto The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function comprising contacting the cell with a hedgehog antagonist of formula (I) in... | 05/01/2012 |
| 8158648 | Heteroaryl 11-beta hydroxysteroid dehydrogenase type I inhibitors Novel compounds are provided which are 11-beta-hydroxysteroid dehydrogenase type I inhibitors. 11-beta-hydroxysteroid dehydrogenase type I inhibitors are useful in treating, preventing, or slowing the progression of diseases requiring 11-beta-hydroxysteroid dehydrog... | 04/17/2012 |
| 8148396 | Triazolopyridine 11-beta hydroxysteroid dehydrogenase type I inhibitors Novel compounds are provided which are 11-beta-hydroxysteroid dehydrogenase type I inhibitors. 11-beta-hydroxysteroid dehydrogenase type I inhibitors are useful in treating, preventing, or slowing the progression of diseases requiring 11-beta-hydroxysteroid dehydrog... | 04/03/2012 |
| 8124617 | Imidazopyridine compounds Compounds, pharmaceutical compositions, kits and methods are provided for use with glucokinase that comprise a compound selected from the group consisting of formula (I) wherein the variables are as defined herein. ... | 02/28/2012 |
| 8119658 | Triazolopyridine 11-beta hydroxysteroid dehydrogenase type I inhibitors Novel compounds are provided which are 11-beta-hydroxysteroid dehydrogenase type I inhibitors. 11-beta-hydroxysteroid dehydrogenase type I inhibitors are useful in treating, preventing, or slowing the progression of diseases requiring 11-beta-hydroxysteroid dehydrog... | 02/21/2012 |
| 8106070 | Substituted imidazoles as bombesin receptor subtype-3 modulators Certain novel substituted imidazoles are ligands of the human bombesin receptor and, in particular, are selective ligands of the human bombesin receptor subtype-3 (BRS-3). They are therefore useful for the treatment, control, or prevention of diseases and disorders ... | 01/31/2012 |
| 8101633 | Preparation and utility of substituted imidazopyridine compounds with hypnotic effects The present disclosure is directed to modulators of GABAA receptors and pharmaceutically acceptable salts and prodrugs thereof, the chemical synthesis thereof, and the medical use of such compounds for the treatment and/or management of sleep disorders an... | 01/24/2012 |
| 8088792 | Triazolopyridinone derivatives for use as stearoyl CoA desaturase inhibitors The present invention discloses triazolopyridinone derivatives for use as inhibitors of stearoyl-CoA desaturase having the structure of Formula I: The compounds are useful in treating and/or preventing various human disease... | 01/03/2012 |
| 8076356 | Triazolopyridinylsulfanyl derivatives as P38 map kinase inhibitors A compound of formula (I), or a pharmaceutical acceptable salt and/or solvate (including hydrate) thereof; and the use of a compound of formula (I) in the treatment of a TNF-mediated disease, disorder, or condition, or a p3... | 12/13/2011 |
| 8063065 | Azaindazole compounds as CCR1 receptor antagonists Disclosed are compounds of the formula (I), useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. | 11/22/2011 |
| 8063063 | Immunopotentiating compounds The invention provides novel compositions comprising Imidazopyridine compounds. Also provided are methods of administering the compositions in an effective amount to enhance the immune response of a subject. Further provided are novel compositions and methods of adm... | 11/22/2011 |
| 8063064 | Non-nucleoside reverse transcriptase inhibitors The present invention provides for compounds useful for treating an HIV infection, or preventing an HIV infection, or treating AIDS or ARC. The compounds of the invention are of formula I wherein A is A2 and R1, R2, R3, R4a | 11/22/2011 |
| 8058290 | 7-substituted aza-indazoles, compositions containing same, production method and use thereof The disclosure relates to compounds of formula (I): which modulate the activity of proteins, particularly kinases, and to compositions containing the same, and to the use thereof as medicaments, in particular as anticancer ... | 11/15/2011 |
| 8030328 | Imidazolone phenylalanine derivatives Disclosed are compounds of the formula: and the pharmaceutically acceptable salts thereof wherein the variables A, n, R5, R21-R24 and Q are defined herein. These compounds bind VLA-4. Certai... | 10/04/2011 |
| 8022085 | Pyrazolo-pyridinone and pyrazolo-pyrazinone compounds as P38 modulators and methods of use thereof The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation and related conditions. The compounds have a general Formula I wh... | 09/20/2011 |
| 8008322 | Substituted pyrazolopyridines, compositions containing them, method for the production thereof, and their use The disclosure relates to substituted pyrazolo-pyridines, compositions containing them, methods for the production thereof, and to their use as medicaments, in particular, as anticancer agents. ... | 08/30/2011 |
| 8003663 | Pyrazolo[3,4-b]pyridine compounds, and their use as PDE4 inhibitors The invention provides N-{[1,6-diethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo [3,4-b]pyridin-5-yl]methyl}-4-({8-[(2-hydroxyethyl) (methyl)amino]octanoyl}amino)benzamide, whose formula is or a salt thereof, such as th... | 08/23/2011 |
| 7998975 | Nitrogenous fused-ring derivatives, medicinal compositions containing the derivatives, and use thereof as drugs The present invention provides nitrogen-containing fused-ring derivatives represented by the following general formula, or pharmaceutically acceptable salts thereof, or prodrugs thereof, which exhibit an excellent inhibitory activity in human SGLT and are useful as ... | 08/16/2011 |
| 7998976 | Certain chemical entities, compositions and methods Provided are certain chemical entities, and methods of use to modulate skeletal myosin, skeletal actin, skeletal tropomyosin, skeletal troponin C, skeletal troponin I, skeletal troponin T, and skeletal muscle, including fragments and isoforms thereof, as well as the... | 08/16/2011 |
| 7989469 | Certain chemical entities, compositions, and methods Provided are certain chemical entities, and methods of use to modulate skeletal myosin, skeletal actin, skeletal tropomyosin, skeletal troponin C, skeletal troponin I, skeletal troponin T, and skeletal muscle, including fragments and isoforms thereof, as well as the... | 08/02/2011 |
| 7977353 | Heterocyclic aromatic compounds useful as growth hormone secretagogues Novel heterocyclic aromatic compounds are provided that are useful in stimulating endogenous production or release of growth hormone, said compounds having the general structure of formula I wherein R1, R1 | 07/12/2011 |
| 7960407 | Crystal forms of an imidazole derivative The invention relates to the essentially pure Λ/-[({2-[4-(2-Ethyl-4,6-dimethyl-1H-imidazo[4,5-c]pyridin-1-yl)phenyl]ethyl}amino)carbonyl]-4-methylbenzenesulfonamide Polymorph Forms A and B and to processes for the preparation of, compositions containing and to the ... | 06/14/2011 |
| 7951818 | Imidazolopyridine compounds useful for the treatment of degenerative and inflammatory diseases Novel imidazolopyridine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of ... | 05/31/2011 |
| 7951819 | Imidazo[4, 5-B]pyridin-2-one and oxazolo[4, 5-B] pyridin-2-one compounds and analogs thereof as cancer therapeutic compounds The present invention pertains to certain imidazo[4,5-b]pyridin-2-one and oxazolo[4,5 b]pyridin-2-one compounds and analogs thereof, which, inter alia, inhibit RAF (e.g., B RAF) activity, inhibit cell proliferation, treat cancer, etc. The present invention also pert... | 05/31/2011 |
| 7947709 | Non-nucleoside reverse transcriptase inhibitors Compounds of formula I, wherein R1, R2, R3, X and Ar, are as defined herein or pharmaceutically acceptable salts thereof, inhibit HIV-1 reverse transcriptase and afford a method for prevention and treatment of HIV-1 infections and th... | 05/24/2011 |
| 7928119 | Use of EP4 receptor ligands in the treatment of IL-6 involved diseases Methods of treating IL-6 involved diseases with EP4 receptor ligands, including EP4 receptor antagonists. Assays to determine the effect of test compounds on PGE2-induced whole blood cells activation. ... | 04/19/2011 |
| 7923456 | 5-anilinoimidazo[1,5-a]-pyridines inhibitors of MEK kinase The invention relates to imidazopyridines of formula I with anti-cancer and/or anti-inflammatory activity and more specifically to imidazopyridines which inhibit MEK kinase activity. The invention provides compositions and methods useful for inhibiting abnormal cell... | 04/12/2011 |
| 7915286 | Substituted pyrazolo [3,4-b] pyridines as phosphodiesterase inhibitors The present invention relates to phosphodiesterase (PDE) type IV selective inhibitors. Processes for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds and their use as PDE type IV selective inhibitors are provided... | 03/29/2011 |
| 7915285 | Method for treating drug and behavioral addictions The present invention is directed to the use of ibudilast for treating addictions, including drug and behavioral addictions. In particular, ibudilast is used to diminish the dopamine-mediated reward associated with addictions and to treat withdrawal syndromes after ... | 03/29/2011 |
| 7910602 | Pyrazolopyridine derivatives as inhibitors of β-Adrenergic receptor kinase 1 The invention relates to 6-amido substituted pyrazolopyridine derivatives of the formula (I) useful as inhibitors of beta-adrenergic receptor kinase 1 (βARK-1), compositions containing such compounds and their use for the ... | 03/22/2011 |
| 7897616 | Imidazopyridin-2-one derivatives as inhibitors of lipases and phospholipases The present invention relates to imidazopyridin-2-one derivatives of the formula I with the definitions specified in the description, to their pharmaceutically usable salts and to their use as medicaments. ... | 03/01/2011 |
| 7879873 | Azaindazole compounds as CCR1 receptor antagonists Disclosed are compounds of the formula (I), useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. | 02/01/2011 |
| 7858639 | Bicyclic heterocycles as cannabinoid-1 receptor modulators The present application describes compounds according to Formula I, pharmaceutical compositions comprising at least one compound according to Formula I and optionally one or more additional therapeutic agents and methods of treatment using the compounds according to... | 12/28/2010 |
| 7851484 | Certain chemical entities, compositions, and methods Provided are certain chemical entities, and methods of use to modulate skeletal myosin, skeletal actin, skeletal tropomyosin, skeletal troponin C, skeletal troponin I, skeletal troponin T, and skeletal muscle, including fragments and isoforms thereof, as well as the... | 12/14/2010 |
| 7846944 | Pyrazolo-pyridinone compounds and methods of use thereof The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation and related conditions. The compounds have a general Formula I wh... | 12/07/2010 |
| 7834028 | Pyrazolo-tetrahydro pyridine derivatives as orexin receptor antagonists The invention relates to novel pyrazolo-tetrahydropyridines compounds and their use as orexin receptor antagonists. ... | 11/16/2010 |
| 7816369 | Mediators of hedgehog signaling pathways, compositions and uses related thereto The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function comprising contacting the cell with a hedgehog antagonist, such as a small ... | 10/19/2010 |
| 7807691 | Substituted N-arylpyrrolidines as selective androgen receptor modulators The present invention provides a compound of the Formula (I) or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising an effective amount of a compound of Formula (I) in combination with a suitable carrier, diluent, or excipient; and met... | 10/05/2010 |
| 7799801 | Heterocyclic aromatic compounds useful as growth hormone secretagogues Novel heterocyclic aromatic compounds are provided that are useful in stimulating endogenous production or release of growth hormone, said compounds having the general structure of formula I wherein R1, R1 | 09/21/2010 |
