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| Number | Title | Issue Date |
| 8097584 | Stabilized formulations of insulin that comprise ethylenediamine The present invention relates to a pharmaceutical formulation comprising insulin, an insulin analogue or an insulin derivate and ethylenediamine or salts thereof and an antimicrobial preservative agent. ... | 01/17/2012 |
| 7989417 | Linkers for radiopharmaceutical compounds A new and improved method for extending the half life of pharmaceutical compounds for use in diagnostic imaging or therapy uses a novel linker to attach a diagnostic or therapeutic moiety to a targeting peptide or another diagnostic or therapeutic moiety. The result... | 08/02/2011 |
| 7964558 | Therapeutic applications for C-peptide The present invention relates to administration of C-peptide in a once daily dose for use in the treatment of diabetes and diabetic complications. ... | 06/21/2011 |
| 7829532 | Method of treating a nerve-related vision disorder in a non-diabetic subject This invention provides reagents and methods for delivering insulin, insulinomimetic agents, and the like to a vertebrate eye via subconjunctival routes, sub-Tenon's routes, or intravitreal routes for treatment of nerve-related vision disorders such as diabetic reti... | 11/09/2010 |
| 7825084 | Methods and compositions for increasing the anaerobic working capacity in tissues Provided are compositions comprising beta-alanylhistidine peptides and beta-alanines, and methods for administering these peptides and amino acids. In one aspect, the compositions and methods cause an increase in the blood plasma concentrations of beta-alanine and/o... | 11/02/2010 |
| 7820618 | Energy status of an individual by enhanced usage of an endogenous fuel source The present invention relates to a method of improving the energy status of an individual by enhancing the usage of lactate. Improved lactate usage is accomplished through a composition comprising lactate precursors, adrenergic receptor agonists and insulinotropic a... | 10/26/2010 |
| 7803763 | Method of purifying preproinsulin The invention relates to a method for the chromatographic purification of preproinsulins, in which higher molecular weight substances are removed from an aqueous solution of preproinsulin by a first chromatography on an anion exchanger in flow-through mode and a sub... | 09/28/2010 |
| 7790677 | Insulin production methods and pro-insulin constructs Novel pro-insulin having specific amino acid and/or nucleic acid modifications suitable for improved methods of insulin production are provided. Novel and highly efficient processes for preparing the pro-insulin preparations and preparations containing them are also... | 09/07/2010 |
| 7781400 | Pharmaceutical compositions comprising dextran with a molecular weight of 1.0-100 KDA and processes for their preparation A solid or semisolid implant obtainable by providing a liquid composition comprising an aqueous solution of dextran with molecular weight of 1.0-100 kDa and introducing the liquid composition into the body of a mammal, whereby the implant is formed in situ in the bo... | 08/24/2010 |
| 7776820 | Methods for decreasing risk of complications of prematurity using IGF-I and its analogs In one aspect of the present invention there is provided a method for determining the risk of developing a complication of preterm birth in a patient born before 40 weeks of gestation or weighing 10% less than the average for the patient's gestational age. The metho... | 08/17/2010 |
| 7763582 | Localized insulin delivery for bone healing A method of promoting bone healing in a non-diabetic patient in need thereof by locally administering a therapeutically effective amount of insulin to the patient. A drug delivery device, which includes insulin and a pharmaceutically acceptable carrier, wherein the ... | 07/27/2010 |
| 7723295 | Peptides and compounds that bind to a receptor Peptide compounds that bind to and activate the thrombopoietin receptor (c-mpl or TPO-R) or otherwise act as a TPO agonist are disclosed. ... | 05/25/2010 |
| 7718609 | Rapid acting and long acting insulin combination formulations A combined rapid acting-long acting insulin formulation has been developed in which the pH of the rapid acting insulin is adjusted so that the long acting glargine remains soluble when they are mixed together. In the preferred embodiment, this injectable basal bolus... | 05/18/2010 |
| 7713929 | Rapid acting and long acting insulin combination formulations A combined rapid acting-long acting insulin formulation has been developed in which the pH of the rapid acting insulin is decreased so that the long acting glargine remains soluble when they are mixed together. In the preferred embodiment, this injectable basal bolu... | 05/11/2010 |
| 7713930 | Acidic insulin preparations having improved stability The invention relates to a pharmaceutical formulation comprising a polypeptide selected from the group consisting of insulin, an insulin metabolite, an insulin analog, an insulin derivative and combinations thereof; a surfactant or combinations of two or more surfac... | 05/11/2010 |
| 7700549 | Exendin agonist analogs to treat diabetes Methods for treating conditions or disorders which can be alleviated by reducing food intake are disclosed which comprise administration of an effective amount of an exendin or an exendin agonist, alone or in conjunction with other compounds or compositions that aff... | 04/20/2010 |
| 7696161 | Exendin agonist compounds Novel exendin agonist compounds are provided. These compounds are useful in treating diabetes and conditions which would be benefited by lowering plasma glucose or delaying and/or slowing gastric emptying. ... | 04/13/2010 |
| 7696162 | Zinc-free and low-zinc insulin preparations having improved stability The invention relates to a formulation comprising a polypeptide selected from at least one of insulin, an insulin metabolite, an insulin analog, and an insulin derivative; at least one surfactant; optionally at least one preservative; and optionally at least one of ... | 04/13/2010 |
| 7683029 | Liquid aerosol formulations containing insulin and aerosol generating devices and methods for generating aerosolized insulin Liquid aerosol formulations for generating aerosolized insulin include insulin and at least one high volatility carrier which protects the insulin from thermal degradation during vaporization of the carrier. The carrier can be a mixture of ethanol and water and the ... | 03/23/2010 |
| 7683030 | Methods of treating diabetes with albumin-conjugated exendin peptides Modified exendins and exendin agonists having an exendin or exendin agonist linked to one or more polyethylene glycol polymers, for example, and related formulations and dosages and methods of administration thereof are provided. These modified exendins and exendin ... | 03/23/2010 |
| 7674767 | Nanoparticle compositions of water-soluble drugs for oral administration and preparation methods thereof The present invention relates to an orally administrable composition containing nanoparticles with the particle size of 500 nm or less, comprising 0.1-30 weight % of a complex of a water-soluble drug and a counter-ion substance in which the charged water-soluble dru... | 03/09/2010 |
| 7655619 | Insulin-associated peptides with effects on cerebral health The present invention provides compositions and methods for ameliorating neurological, attention, or memory disorders and improving learning and cognition through the delivery of insulin A-chain and analogs thereof to a subject. Insulin A-chain, peptides comprising ... | 02/02/2010 |
| 7651996 | Pharmaceutical compositions and methods for insulin treatment Compositions and methods for treating a patient with insulin that combines insulin, a permeation enhancer, and a carrier that maintains an acidic pH, are disclosed. ... | 01/26/2010 |
| 7651995 | Absorption enhancers such as e.g. BHT, BHA or propyl gallate The invention provides a pharmaceutical composition comprising a mixture of (a) an active macromolecular principle, and (b) an aromatic alcohol absorption enhancer chosen from butylated hydroxy toluene, butylated hydroxy anisole and analogues and derivatives thereof... | 01/26/2010 |
| 7648960 | Method for delivery of monomeric or dimeric insulin complexed to diketopiperazine microparticles Methods are provided for purifying peptides and proteins by incorporating the peptide or protein into a diketopiperazine or competitive complexing agent to facilitate removal of one or more impurities from the peptide or protein. Formulations and methods also are pr... | 01/19/2010 |
| 7625865 | Insulin highly respirable microparticles The invention describes novel dried powders of peptide therapeutic agent useful for producing highly respirable aerosols and the methods for their manufacture. Insulin is the peptide therapeutic agent in the preferred embodiment. The powders of insulin prepared for ... | 12/01/2009 |
| 7618940 | Fat regulation The present invention provides methods and compounds for regulating fat metabolism and achieving fat homoeostasis in a subject. Methods and compound for regulating body weight, reducing body fat, and inducing weight loss are also provided, as are methods and compoun... | 11/17/2009 |
| 7615533 | TPO peptide compounds for treatment of anemia Peptide compounds that bind to and activate the thrombopoietin receptor (c-mpl or TPO-R) or otherwise act as a TPO agonist are disclosed. ... | 11/10/2009 |
| 7615532 | Insulin derivatives The present invention relates to insulin derivatives which are naturally occurring insulins or analogues thereof which have a side chain attached either to the α-amino group of the N-terminal amino acid residue of the B chain or to the ε-amino group of a Lys resid... | 11/10/2009 |
| 7608583 | Process for the extraction and isolation of insulin from recombinant sources The present invention relates to the extraction and isolation of insulins from recombinant sources, particularly those expressed in and secreted by yeasts. Organic solvents have been used to extract host surface bound forms of insulin polypeptide. In addition, proce... | 10/27/2009 |
| 7605124 | Ejection liquid and ejection method An ejection liquid that allows a solution containing at least one kind of insulins to be stably ejected by an inkjet system using a thermal energy and a method of ejecting the solution containing at least one kind of insulins, using such an ejection liquid. The ejec... | 10/20/2009 |
| 7605123 | Fatty acid formulations for oral delivery of proteins and peptides, and uses thereof Fatty acid compositions for administration of of pharmaceutical agents, such as proteins and peptides, protein and peptide conjugates, and/or cation-polypeptide conjugate complexes. In particular, the invention provides a solid pharmaceutical composition formulated ... | 10/20/2009 |
| 7601688 | Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus The present invention provides compositions and methods for reducing hypoglycemic episodes experienced by a subject in need of treatment for diabetes mellitus, said method comprising orally administering an amount of an insulin polypeptide-oligomer conjugate to the ... | 10/13/2009 |
| 7576056 | Peptides and compounds that bind to a receptor Peptide compounds that bind to and activate the thrombopoietin receptor (c-mpl or TPO-R) or otherwise act as a TPO agonist are disclosed. ... | 08/18/2009 |
| 7569540 | Method for enhanced parenteral nutrition A method for improved administration of nutrient is provide. The method includes co- or separate administration of a source of nutrients, especially carbohydrates, and insulinotropic peptides and derivatives, analogs, fragments and the like. The method provides high... | 08/04/2009 |
| 7544656 | Long acting injectable insulin composition and methods of making and using thereof A method of lowering blood glucose in a mammal includes injecting a therapeutically effective amount of crystallized dextran microparticles and insulin to the mammal to lower blood glucose of the mammal. The composition may be a one phase or a structured multi-phase... | 06/09/2009 |
| 7524813 | Selectively conjugated peptides and methods of making the same Methods for the selective conjugation of peptides which comprises an enzymatic incorporation of a functional group at the C-terminal end of a peptide followed by reaction with a second compound comprising the moiety to be conjugated to the peptide, wherein said seco... | 04/28/2009 |
| 7514403 | Process for the stabilization of proteins in an aqueous solution comprising cysteine in a concentration between 150 and 220mM The present invention relates to a process for the storage of proteins in an aqueous solution. The addition of cysteine delays the temporal decrease in the effective concentration of the protein. The process is suitable for use in the production of heterologous prot... | 04/07/2009 |
| 7504376 | Methods and compositions for increasing the anaerobic working capacity in tissues The invention provides compositions comprising beta-alanylhistidine peptides and beta-alanines, and methods for administering these peptides and amino acids. In one aspect, the compositions and methods cause an increase in the blood plasma concentrations of beta-ala... | 03/17/2009 |
| 7476652 | Acidic insulin preparations having improved stability The invention relates to a pharmaceutical formulation comprising a polypeptide selected from the group consisting of insulin, an insulin metabolite, an insulin analog, an insulin derivative and combinations thereof; a surfactant or combinations of two or more surfac... | 01/13/2009 |
