Class 514/298 - Phenanthridines (including hydrogenated)

Subclass of Class 514 - Drug, bio-affecting and body treating compositions
Definition: Subject matter wherein the tricyclo ring system has the
No. of patents: 81
Last issue date: 03/06/2012

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Number	Title	Issue Date
8129402	Screening molecules with anti-prion activity: kits, methods and screened molecules The invention concerns screening molecules with anti-prion activity. More particularly, it concerns kits for screening molecules with anti-prion activity characterized in that they comprise in combination a [PSI+], phenotype yeast, an antibiogram and an agent for pu...	03/06/2012
8071612	6-alkenyl and 6-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(ADP-ribose) polymerase inhibitors The present invention provides compounds of formula (I) and compounds of formula (VII-a) as well as pharmaceutical compositions comprising said compounds and their use as PARP inhibitors wherein n, R1, R2	12/06/2011
8034827	Phenanthridine derivatives as bradykinin antagonists The present invention relates to new phenanthridine derivatives of formula (I), wherein the variables are as defined in the specification, to processes for producing the same, to pharmacological compositions containing the same and to their use in therapy or prevent...	10/11/2011
7718668	Salts of 6-heterocycle substituted hexahydrophenanthridine derivatives The invention relates to salts of 6-heteroaryl substituted hexahydrophenanthridine PDE4-inhibiting compounds, which can be used in the pharmaceutical industry for the production of pharmaceutical compositions for use, e.g., in treatment of airway disorders. ...	05/18/2010
7632844	2-hydroxy-6-phenylphenanthridines as PDE-4 inhibitors The compounds of formula I in which R1, R2, R3, R31, R4, R5, R6 and R7 have the meanings as indicated in the description, are novel effective PDE4 inhibitors. ...	12/15/2009
7585872	Guanidinyl-substituted hydroxy-6-phenylphenanthridines as effective phosphodiesterase (PDE) 4 inhibitors The compounds of a certain formula (1), in which R1, R2, R3, R31, R4, R5, R6 and R7 have the meanings as given in the description, are novel effective PDE4 inhibitors. ...	09/08/2009
7378427	Processes for preparing 6-alkyl-5-arylsulfonyl-dihydrophenanthridines Synthetic methods are provided for production of compounds of the formula: where R1, R2, R3, R4, R5, R6, R7, R8, R9, R1...	05/27/2008
7358245	Treatment of gastroesophageal reflux disease The administration of cannabinoid receptor agonists for inhibition of transient lower esophageal sphincter relaxations, gastroesophageal reflux disease and regurgitation is disclosed. ...	04/15/2008
7329676	2-hydroxy-6-phenylphenanthridines as PDE-4 inhibitors The compounds of formula I in which R1, R2, R3, R31, R4, R5, R6 and R7 have the meanings as indicated in the description, are novel effective PDE4 inhibitors. ...	02/12/2008
7320805	CB2 receptors blocks accumulation of human hepatic myofibroblasts: a novel artifibrogenic pathway in the liver Methods and compositions for treating diseases mediated by CB2 receptors are disclosed, including fibrosis associated with liver injury. ...	01/22/2008
7304073	Method of treating myocardial ischemia-reperfusion injury using NF-kB inhibitors The present invention concerns a method of treatment or prevention of myocardial ischemia-reperfusion injury by diagnosing that a person is in need of treatment or prevention of myocardial ischemia-reperfusion injury and administering a therapeutically effective amo...	12/04/2007
7291596	Pharmaceutical composition for thrombin peptide derivatives Disclosed are pharmaceutical compositions comprising a thrombin peptide derivatives and a chelating agent and/or a pharmaceutically acceptable thiol-containing compound. The pharmaceutical compositions optionally further comprise an antioxidant. Also, disclosed are ...	11/06/2007
7214685	Prodrugs for a selective cancer therapy The chemotherapy of malignant tumours is greatly restricted by the generally slight differentiation of the available cytostatic agents between normal and malignant tissue. In order to achieve an improvement of the selectivity in cancer therapy, novel prodrugs have b...	05/08/2007
7094801	Chalcone derivatives and their use to treat diseases The invention relates to compounds, pharmaceutical compositions and methods of using compounds of the general formula or its pharmaceutically acceptable salt or ester, wherein the substituents are defined in the ...	08/22/2006
7087106	Materials and methods for inhibiting fouling of surfaces exposed to aquatic environments The subject invention provides materials and methods for inhibiting the biofouling of surfaces exposed to aquatic environments. In one embodiment, the subject invention provides additives for marine paints and surface treatments. The subject invention further provid...	08/08/2006
7074782	Carbamate caspase inhibitors and uses thereof This invention provides caspase inhibitors of formula I: wherein Z is oxygen or sulfur; R1is hydrogen, —CHN2, R, CH2OR, CH2SR, or —CH2Y; Y is an electron...	07/11/2006
7060729	Composition and method for treating skin The present invention relates to a composition and method for treating individuals afflicted with rosacea by combining a dicarboxylic acid, at least an antimicrobial agent, and a pharmaceutically acceptable carrier therefor into a topically applicable composition.	06/13/2006
7037919	Tetrahydroquinoline derivatives Tetrahydroquinoline derivatives of general formula (I) or salts thereof, having a specific and strong binding affinity for AR and exhibiting AR agonism or antagonism; and pharmaceutical compositions containing the derivatives or the salts.	05/02/2006
6958347	Aminophenanthridinone and aminophenanthridine as NPY-5 antagonists The present invention provides NPY-5 receptor antagonists having a Formula (I) Methods and pharmaceutical compositions useful for treating diseases, conditions and/or disorders modulated by the above NPY-5 receptor ant...	10/25/2005
6943266	Bicyclic cannabinoid agonists for the cannabinoid receptor Novel polycyclic cannabinoid analogs are presented which have preferentially high affinities for the cannabinoid CB2 receptor sites. The improved receptor affinity makes these analogs therapeutically useful as medications in individuals and animals for treatment of ...	09/13/2005
6894061	Substituted dihydrophenanthridinesulfonamides This invention provides a compound of formulae (I) or (II) having the structure or a pharmaceutically acceptable salt thereof which are useful for the treatment of the inflammatory component of diseases and are particu...	05/17/2005
6884802	6-heteroarylphenanthridines Compounds of formula 1, in which Het is an unsubstituted or R6- and/or R7-substituted pyrrolyl, furanyl, thiophenyl, pyrazolyl, imidazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, thiadiazolyl, pyrimidinyl, pyrazinyl or pyradazinyl radical, or an unsubstitute...	04/26/2005
6770668	Pharmaceutically active compounds and methods of use The present invention relates to pharmaceutically acceptable compounds, including certain substituted indolinyl and derivatives thereof, 1,2,3,4-tetrahydroquinolinyl and derivatives thereof, 1,2,3,4-tetrahydroisoquinolinyl, benz[cd]indolinyl and 5,6-dihydrophenanthr...	08/03/2004
6743817	Substituted fused pyrroleimines and pyrazoleimines Disclosed are compounds of the formula and the pharmaceutically acceptable salts thereof wherein R, Ar, A, n, R1 and R2 are defined herein. These compounds are highly selective agonists, antagonists...	06/01/2004
6723733	Sulfonamide and carbamide derivatives of 6(5H)phenanthridinones and their uses This invention relates to compounds, pharmaceutical compositions, and methods of using the disclosed compounds for inhibiting PARP. ...	04/20/2004
6706729	Thiolesters and uses thereof This invention pertains to the discovery of a novel family of thiolesters and uses thereof. Also provided for are viricidal compounds and pharmaceutical formulations comprising these novel thiolesters. The invention also provides thiolester-inactivated viruses and t...	03/16/2004
6696407	Huntington's disease treatment comprising administering aldose reductase inhibitors to increase striatal CNTF The present invention provides methods of modulating neurotrophic factor-associated activity, especially CNTF-associated levels and activity, using aldose reductase inhibitors. These methods are especially useful in individuals suffering from, or at risk ...	02/24/2004
6677350	Beta-fluoroethyl thiourea compounds and use The present invention relates to compounds, compositions and methods for the prevention or treatment of mycobacterium infections. The compounds are naturally occurring and synthetic biflavonoids, flavonoids, chalcones and chalcone like compounds. The comp...	01/13/2004
6670369	Use of phanquinone for the treatment of alzheimer's disease The use of phanquinone for the manufacture of a pharmaceutical composition for the prevention or the treatment of Alzheimer's disease is disclosed. Also methods of treatment or prevention of Alzheimer's disease are disclosed....	12/30/2003
6630483	Phenanthridine-N-oxides N-oxides of the compounds of formula (I) in which R1 is hydroxyl, 1-4C-alkoxy, 3-7C-cycloalkoxy, 3-7C-cycloalkylmethoxy or completely or predominantly fluorine-substituted 1-4C-alkoxy, R2 is hydroxyl, 1-4C-alkoxy, 3-7C-cycloalkoxy, 3-7C-cycloalkylmethoxy ...	10/07/2003
6538005	Phenanthridine-N-oxides with PDE-IV inhibiting activity The N-oxides of the compounds of formula (I), in which R1, R2, R3, R31, R4, R5, R51 and R6 have the meanings indicated in the description, arm novel active bronchial therapeutics. ##STR1##...	03/25/2003
6534519	Phenanthridine-N-oxides with PDE-IV inhibiting activity The N-oxides of the compounds of formula (I), in which R1, R2, R3, R31, R4, R5, R51 and R6 have the meanings indicated in the description, are novel active bronchial therapeutics. ##STR1##...	03/18/2003
6534518	Polysubstituted 6-phenylphenanthridines with PDE-IV inhibiting activity Compounds of formula (I), in which R1, R2, R3, R31, R4, R5, R51 and R6 have the meanings indicated in the description, are novel active bronchial therapeutics. ##STR1##...	03/18/2003
6521637	Methods for inhibiting immunostimulatory DNA associated responses The invention features methods for inhibiting immunostimulatory DNA-associated immune responses, through the administration of specific compounds of the general class of 9-aminoacridines and 4-aminoquiniolines. The invention also features methods of scree...	02/18/2003
6521622	Fungicidal heterocyclic aromatic amides and their compositions, methods of use and preparation Heterocyclic aromatic amides having a hydroxy group adjacent to the amide functionality are useful as antifungal agents, particularly for plants....	02/18/2003
6514988	Condensed-ring thiophene derivatives, their production and use A gonadotropin-releasing hormone antagonistic composition, which comprises an optionally substituted condensed-bicyclic compound consisting of a homo or hetero 5 to 7 membered ring and a homo or hetero 5 to 7 membered ring is effective as a propylactic or...	02/04/2003
6479505	6-arylphenanthridines with PDE-IV inhibiting activity Compounds of formula (I), in which R1, R2, R3, R31, R4, R5, R51 and Ar have the meanings indicated in the description, are novel active bronchial therapeutics. ##STR1##...	11/12/2002
6476025	Phenylphennanthridines with PDE-IV inhibiting activity Compounds of formula (I), in which R1, R2, R3, R31, R4, R5, R51, R6, R13 and R20 have the meaning indicated in the description, are novel active bronchial therapeutics ##STR1##...	11/05/2002
6476048	Substituted phenanthridinones and methods of use thereof This invention provides a novel class of substituted 6(5H)phenanthridinone compounds. Pharmaceutical compositions, and methods of making and using the compounds, or a pharmaceutically acceptable salt, hydrate, prodrug, or mixture thereof are also describe...	11/05/2002
6469047	Tyrosine derivatives The compounds of the invention are inhibitors of alpha4 containing integrin-mediated binding to ligands such as VCAM-1 and MAdCAM....	10/22/2002

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Class 514/298 - Phenanthridines (including hydrogenated)