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| Number | Title | Issue Date |
| 8093262 | Use of huperzine for disorders Methods and compositions containing huperzine are used to prevent and alleviate neuropathic pain. The invention is also directed to methods and compositions for using huperzine for the prevention and/or treatment of neuropathic pain and orthostatic hypotension. ... | 01/10/2012 |
| 8026252 | Large substituent, non-phenolic opioids and methods of use thereof 8-Substituted-2,6-methano-3-benzazocines of general structure are useful as analgesics, anti-diarrheal agents, anticonvulsants, antitussives and anti-addiction medications. ... | 09/27/2011 |
| 8026251 | Huperzine A and its derivatives as analgesic agents The present invention relates to a method for treating or alleviating migraines, by administering to a patient in need thereof compound (I), or salts thereof, or pharmaceutical preparations thereof comprising mixtures of compound (I) or salts thereof with pharmaceut... | 09/27/2011 |
| 7557119 | Large substituent, non-phenolic opioids 8-Substituted-2,6-methano-3-benzazocines of general structure are useful as analgesics, anti-diarrheal agents, anticonvulsants, antitussives and anti-addiction medications. One embodiment is the subgenus of biphenylethyl co... | 07/07/2009 |
| 7348431 | Tyrosine kinase inhibitors The present invention relates to compounds that are capable of inhibiting, modulating and/or regulating signal transduction of both receptor-type and non-receptor type tyrosine kinases. The compounds of the instant invention possess a core structure that comprises a... | 03/25/2008 |
| 7258850 | Methods and compositions for treating erectile dysfunction Methods are provided for increasing libido and/or treating erectile dysfunction in a man. The methods include the administration of a formulation testosterone alone, another fast-acting drug to treat erectile dysfunction or a combination of the testosterone and the ... | 08/21/2007 |
| 7253283 | Tricyclic modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof Novel non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity including obesity, diabetes, inflammatory and immune diseases, and have the structure of formula ... | 08/07/2007 |
| 7247642 | Antibacterial optically pure benzoquinolizine carboxylic acids, processes, compositions and methods of treatment The present invention relates to optically pure S-(−)-benzoquinolizine carboxylic acids, their derivatives, salts, pseudopolymorphs, polymorphs and hydrates thereof, substantially free of their R-(+)-isomers, to processes for preparation of the optically pure S-(â... | 07/24/2007 |
| 7205300 | Aryl fused azapolycyclic compounds This invention is directed to compounds of the formula (I): and their pharmaceutically acceptable salts, wherein R1, R2, and R3 are as defined herein; intermediates for the synthe... | 04/17/2007 |
| 7144882 | Aryl fused azapolycyclic compounds This invention is directed to compounds of the formula (I): and their pharmaceutically acceptable salts, wherein R1, R2, and R3 are as defined herein; intermediates for the synthe... | 12/05/2006 |
| 7132541 | Crystalline fluoroquinolone arginine salt form The invention relates to the new arginine salt forms of RS-(±)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid, S-(−)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-1H,5H-benzo[i,j]qui... | 11/07/2006 |
| 7041674 | Carbamic acid esters with anticholinergic activity A compound of formula 1 wherein X−, A, R1, R2, R3, and R4 may have the meanings given in the claims and in the specification, processes for preparing them, their... | 05/09/2006 |
| 6982271 | Tropane analogs The present invention provides compounds, specifically novel tropane analogs, capable of acting as inhibitors of reuptake of monoamines. In preferred embodiments, these compositions are selective inhibitors of serotonin and/or norepinephrine reuptake. Also provided ... | 01/03/2006 |
| 6964969 | Composition and method for treating impaired or deteriorating neurological function A nutritional supplement composition for normalizing impaired or deteriorating neurological function in humans is composed of: at least one agent which promotes synthesis of ATP and/or creatine phosphate in the body, at least one antioxidant for scavenging free radi... | 11/15/2005 |
| 6951861 | Chemical compounds The invention relates to piperazine derivatives, to processes for their preparation, to pharmaceutical compositions containing them, and to their medical use. The novel compounds are antagonists of tachykinins, including substance P and other neurokinins. ... | 10/04/2005 |
| 6951868 | Azabicyclic-phenyl-fused-heterocyclic compounds for treatment of disease The invention provides compounds of Formula I: wherein Azabicyclo is any of: These compounds may be in the form of pharmaceutical salts or compositions, and racemic mixtu... | 10/04/2005 |
| 6939867 | β3 agonists and uses thereof Sulfamide compounds having formula (I) are described as well as their use in the treatment of diseases dependent on the signaling pathways associated with β-adrenergic receptors, such as obesity, diabetes, hypertension, gastrointestinal hypo- or hyper-motility and ... | 09/06/2005 |
| 6887884 | Aryl fused azapolycyclic compounds Compounds of the formula and their pharmaceutically acceptable salts, wherein R1, R2, and R3 are defined as in the specification, intermediates in the synthesis of such compounds, pharm... | 05/03/2005 |
| 6878700 | Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds The present invention relates to novel cinnamide compounds that are useful for treating inflammatory and immunune diseases, to pharmaceutical compositions containing these compounds, and to methods of inhibiting inflammation or suppressing immune response in a mamma... | 04/12/2005 |
| 6867203 | Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds The present invention relates to novel cinnamide compounds that are useful for treating inflammatory and immune diseases and cerebral vasospasm, to pharmaceutical compositions containing these compounds, and to methods of inhibiting inflammation or suppressing immun... | 03/15/2005 |
| 6828311 | Formulation for the parenteral application of a sodium channel blocker The invention relates to a new formulation containing Bill 890 or one of the pharmaceutically acceptable salts thereof for parenteral administration. ... | 12/07/2004 |
| 6784186 | Therapeutic compounds This invention relates to novel structural analogues and derivatives of compounds with general analgesic or related pharmacological activity. In particular the invention relates to derivatives of opioid compounds, particularly morphine and related compounds, in whic... | 08/31/2004 |
| 6750224 | Antibacterial optically pure benzoquinolizine carboxylic acids, processes, compositions and methods of treatment The present invention relates to optically pure S-(−)-benzoquinolizine carboxylic acids, their derivatives, salts, pseudopolymorphs, polymorphs and hydrates thereof, substantially free of their R-(+)-isomers, to processes for preparation of the optically pure S-(â... | 06/15/2004 |
| 6683089 | N-allyoxyethyl-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocine-10-ols The present invention relates to 1,2,3,4,5,6-hexahydro-2,6-methano-3 -benzazocin-10-ols of general formula 1 ##STR1## wherein the groups R1, R2, R3, R4, R5, R6, R7, R8... | 01/27/2004 |
| 6605610 | Aryl fused azapolycyclic compounds Compounds of the formula ##STR1## and their pharmaceutically acceptable salts, wherein R1, R2, and R3 are as defined herein; intermediates for the synthesis of such compounds, pharmaceutical compositions containing such co... | 08/12/2003 |
| 6486169 | Botanical drug for treatment and prevention of alzhimer's disease The present invention related to safe botanical drug for treatment and prevention of Alzheimer's disease. Specifically, this invention proves a safe botanical drug, Huperzine (HUE) and Clausenamide (CLE) and their preparation. HUE has the following pharma... | 11/26/2002 |
| 6455538 | 1,2,3,4,5,6-Hexahydro-2,6-methano-3-benzazocin-10-ols Compounds of general formula I ##STR1## wherein X is a single bond, --O--, C-C4 -alkylene, or an alkylene bridge having 1 to 8 carbon atoms which may be branched or unbranched and optionally have one or two oxygen atom(s) anywhere in the bridge... | 09/24/2002 |
| 6451806 | Methods and compositions involving opioids and antagonists thereof Novel methods and compositions comprising opioids and opioid antagonists. In preferred embodiments, the methods and compositions comprise opioids and peripheral mu opioid antagonist compounds. The methods and compositions are particularly suitable for tre... | 09/17/2002 |
| 6410550 | Aryl fused azapolycyclic compounds Compounds of the formula ##STR1## and their pharmaceutically acceptable salts, wherein R1, R2, and R3 are defined as in the specification, intermediates in the synthesis of such compounds. pharmaceutical compositions conta... | 06/25/2002 |
| 6387921 | Substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines and their use as pharmaceutical compositions Substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines of general formula 1: ##STR1## wherein: R1 and R2, which are identical or different, are each hydrogen, C1 -C6 -alkyl, C1 --C6 -... | 05/14/2002 |
| 6369052 | Combination of huperzine and nicotinic compounds as a neuroprotective agent The present invention provides compositions and methods for treating, preventing, or reversing neuronal dysfunction including cognitive decline, such as cognitive decline associated with aging and minimal cognitive impairment; severe neurodegenerative dis... | 04/09/2002 |
| 6355652 | Substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines and their use as pharmaceutical compositions Substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines of general formula 1: ##STR1## wherein: R1 and R2, which may be identical or different, are each hydrogen, C1 -C6 -alkyl, C1 -C6... | 03/12/2002 |
| 6255302 | 1,4-piperazine derivatives Compounds of the formula ##STR1## are useful for the treatment of disorder of the central nervous system including anxiety, depression, panic, alcohol and drug addiction, sexual dysfunction, sleep disorders, cognitive disorders, Alzheimer's disease and ... | 07/03/2001 |
| 6251916 | Muscarinic agonists and antagonists The present invention provides novel compounds and pharmaceutical compositions thereof useful in the treatment of pain. The compounds of the present invention are azaadamantanes, azanoradamantanes and azahomoadamantanes.... | 06/26/2001 |
| 6245777 | N-(5-phenyl-tetrahydrofuranyl)methyl- and N-(6-phenyl-tetrahydropyranyl)methyl-substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-10-ols The present invention relates to N-(5-phenyl-tetrahydrofuranyl)methyl- and N-(6-phenyl-tetrahydropyranyl)methyl-substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-10-ols of general formula 1, processes for preparing such compounds, pharmaceutical ... | 06/12/2001 |
| 6218376 | Uracil compounds as P2-purinoreceptor 7-transmembrane G-protein coupled receptor antagonists Compounds of formula I or salts thereof ##STR1## where for example Y is a group of the formula (i) ##STR2## and R1 is a group of formula (ii) ##STR3## are provided along with compositions containing them and processes for their preparation... | 04/17/2001 |
| 6191139 | Medical use for tachykinin antagonists The present invention relates to the use of NK1 antagonists, in the treatment of depression. Also described are novel NK1 antagonists of formula (I), processes for their preparation, pharmaceutical compositions containing them and th... | 02/20/2001 |
| 6159986 | Compounds and therapy for resisting memory loss in humans Therapies and compounds for the inhibition of memory loss. In one embodiment, a combination of Huperzine A and hypericin is employed.... | 12/12/2000 |
| 6124312 | Heterocyclic compounds The present invention provides heterocyclic 2-aza-bicyclo[2.2.1]heptane compounds which are useful for modulating a muscarinic ptor.... | 09/26/2000 |
| 6121269 | Reduction of hair growth Mammalian hair growth is reduced by applying to the skin an inhibitor of protein-tyrosine kinase.... | 09/19/2000 |
