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| Number | Title | Issue Date |
| 8163767 | Heterocyclic Janus Kinase 3 inhibitors The invention relates to compound of the formula (I) or its salt, wherein —R1, —R2, —R3, —R4, —R5, -M-, —X— and —Y═ are as defined in the description, their use of as, medicament, the process f... | 04/24/2012 |
| 8163768 | 1,4-dihydropyridine-fused heterocycles, process for preparing the same, use and compositions containing them This invention relates to compounds of formula (I) to processes for the preparation of such compounds, to pharmaceutical compositions comprising such compounds, and to methods of treatment comprising administering of such c... | 04/24/2012 |
| 8143270 | 2-amino 1-in-imidazo ring systems and methods 1H-Imidazo ring systems (e.g., imidazopyridines, imidazoquinolines, imidazonaphthyridines, 6,7,8,9-tetrahydro imidazoquinolines and imidazonaphthyridines) with an amino substituent at the 2-position, pharmaceutical compositions containing these compounds, methods of... | 03/27/2012 |
| 8114888 | Isothiazoloquinolones and related compounds as anti-infective agents The invention provides certain compounds and salts of Formula I and Formula II: which possess antimicrobial activity. The invention also provides novel synthetic intermediates useful in making compounds of Formula I and For... | 02/14/2012 |
| 8088790 | Hydroxy and alkoxy substituted 1-imidazoquinolines and methods 1H-Imidazo[4,5-c]quinolin-4-amines with a hydroxy, alkoxy, hydroxyalkoxy, or alkoxyalkoxy substituent at the 2-position, pharmaceutical compositions containing these compounds, methods of making the compounds, intermediates, and methods of use of these compounds as ... | 01/03/2012 |
| 8008319 | Treatment of colorectal polyps with imidazoquinoline derivatives The invention relates to treating colorectal polyps and precancercerous colorectal changes by topical administration of immunomodulating drugs of the imidazoquinoline family, such as imiquimod (1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine), resiquimod (4-ami... | 08/30/2011 |
| 7998972 | 1H-imidazo[4,5-c]quinoline derivatives in the treatment of protein kinase dependent diseases The invention relates to the use of imidazoquinolines and salts thereof in the treatment of protein kinase dependent diseases and for the manufacture of pharmaceutical preparations for the treatment of said diseases, imidazoquinolines for use in the treatment of pro... | 08/16/2011 |
| 7968563 | Oxime and hydroxylamine substituted imidazo[4,5-c] ring compounds and methods Imidazo[4,5-c] ring compounds, (e.g. imidazo[4,5-c]pyridines, imidazo[4,5-c]quinolines, 6,7,8,9-tetrahydro imidazo[4,5-c]quinolines, imidazo[4,5-c]naphthyridine, and 6,7,8,9-tetrahydro imidazo[4,5-c]naphthyridine compounds) having an oxime or hydroxylamine substitue... | 06/28/2011 |
| 7943635 | Benzylimidazolyl substituted 2-quinoline and quinazoline derivatives for use as farnesyl transferase inhibitors This invention comprises the novel compounds of formula (I) wherein r, t, Y1, Y2, R1, R2, R3, R5, R6 and R7 have defined meanings, havi... | 05/17/2011 |
| 7943636 | 1-substituted pyrazolo (3,4-C) ring compounds as modulators of cytokine biosynthesis for the treatment of viral infections and neoplastic diseases Pyrazolo[3,4-c] ring compounds of Formula (I), e.g., pyrazolo[3,4-c]pyridines, pyrazolo[3,4-c]quinolines, 6,7,8,9-tetrahydro pyrazolo[3,4-c]quinolines, and pyrazolo[3,4-c]naphthyridines, substituted at the 1-position, pharmaceutical compositions containing the compo... | 05/17/2011 |
| 7915281 | Isoxazole, dihydroisoxazole, and oxadiazole substituted imidazo ring compounds and method Imidazo ring compounds, (e.g. imidazo[4,5-c]pyridine, imidazo[4,5-c]quinoline, 6,7,8,9-tetrahydro imidazo[4,5-c]quinoline, and imidazo[4,5-c]naphthyridine compounds) having an isoxazole, dihydroisoxazole, or oxadiazole substituent at the 1-position, pharmaceutical c... | 03/29/2011 |
| 7897609 | Aryl substituted imidazonaphthyridines Imidazonaphthyridine ring systems substituted with an aryl substituent, pharmaceutical compositions containing the compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases in... | 03/01/2011 |
| 7893083 | Method of treating genital herpes The present invention is directed to a method of increasing the time period between outbreaks of genital herpes comprising providing an imidazoquinolinamine formulation, disposing an amount of the imidazoquinolinamine formulation into a first nare of an individual i... | 02/22/2011 |
| 7858637 | Administration of TLR7 ligands and prodrugs thereof for treatment of infection by hepatitis C virus This invention relates to methods for treating or preventing hepatitis C virus infections in mammals using Toll-Like Receptor (TLR)7 ligands and prodrugs thereof. More particularly, this invention relates to methods of orally administering a therapeutically effectiv... | 12/28/2010 |
| 7842701 | Pyrazoloquinolone derivative and use thereof The present invention provides a pyarzoloquinolone derivative having kinase inhibitory activity. The derivative is represented by the formula: wherein R1 is an aryl group which may be substituted, or an aromatic ... | 11/30/2010 |
| 7671069 | Tricyclic, heteroaromatic compounds modulating CXCR4 and/ or CXCR7 The present invention is directed to novel compounds and pharmaceutical compositions that inhibit the binding of the SDF-1 chemokine to the chemokine receptor CXCR4 and/or the binding of the SDF-1 or I-TAC chemokines to the chemokine receptor CCXCKR2 (CXCR7). These ... | 03/02/2010 |
| 7648997 | Hydroxylamine substituted imidazoquinolines Imidazo-containing compounds (e.g., imidazoquinolines, imidazonaphthyridines, imidazopyridines) with a hydrox-ylamine substituent at the 1-position, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunom... | 01/19/2010 |
| 7589101 | Compounds and compositions as protein kinase inhibitors The invention provides a novel class of compounds of formula I, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly ... | 09/15/2009 |
| 7579359 | 1-alkoxy 1H-imidazo ring systems and methods Imidazo-containing compounds (e.g., imidazonaphthyridines, imidazopyridines, imidazoquinolines, and imidazote-trahydroquinolines) with an alkoxy substituent at the 1-position, pharmaceutical compositions containing the compounds and methods of use of these compounds... | 08/25/2009 |
| 7569580 | Heterotricyclic compounds for use as HCV inhibitors The present invention comprises tetrazoloquinoline-compounds that are inhibitors of HCV. Compositions comprising the compounds in combination with a pharmaceutically acceptable carrier are also disclosed, as are methods of using the compounds and compositions to inh... | 08/04/2009 |
| 7544697 | Pyrazolopyridines and analogs thereof Pyrazolopyridin-4-amines, pyrazoloquinolin-4-amines, pyrazolonaphthyridin-4-amines, and 6,7,8,9-tetrahydropyrazoloquinolin-4-amines, pharmaceutical compositions containing the compounds, intermediates, methods of making, and methods of use of these compounds as immu... | 06/09/2009 |
| 7521459 | Method for treating damaged skin The invention relates to a method and composition for treating aged or photo-damaged skin. In one embodiment, the invention includes using a composition comprising about 1% to about 2% of 1-isobutyl-1H-imidazo [4,5,-C] quinolin-4-amine in a topical preparation or cr... | 04/21/2009 |
| 7465742 | Heterocyclic compounds having anti-HBV activity This application relates to novel fused tricyclic thienopyridines of Formulas I and II, which useful for treating Hepatitis B infection and other diseases. This application also relates to pharmaceutical compositions comprising thienopyridines and to the use ... | 12/16/2008 |
| 7456194 | Imidazo-fused oxazolo [4,5-]pyridine and imidazo-fused thiazolo[4,5-]pyridine based tricyclic compounds and pharmaceutical compositions comprising same The present invention provides for pyrazolopurine-based tricyclic compounds having the formula (I), wherein R1, R2, R3, and R6 are as described herein. The present invention furth... | 11/25/2008 |
| 7439253 | Heterocyclic compounds, their preparation and their use as medicaments, in particular as antibacterials and beta-lactamase inhibitors The invention relates to novel heterocyclic compounds of general formula (I), and their salts with a base or an acid: The invention also relates to a method for preparing these compounds, and to their use as medicaments, in p... | 10/21/2008 |
| 7414046 | Gyrase inhibitors and uses thereof The present invention relates to compounds of the formula I: or a pharmaceutically acceptable derivative or prodrug thereof. The compounds are useful as inhibitors of bacterial gyrase activity. The present invention also re... | 08/19/2008 |
| 7407963 | Cyclopropane CGRP antagonists, medicaments containing these compounds, and method for the production thereof A compound of general formula (I) wherein R and R1 are as defined herein, or a tautomer, diastereomer, enantiomer, or salt thereof, particularly the physiologically acceptable salts thereof, which have valuable p... | 08/05/2008 |
| 7393860 | Tetrahydropyridoethers The compound (7R,8R,9R)-2,3-Dimethyl-8-hydroxy-7-(2-methoxyethoxy)-9-phenyl-7,8,9,10-tetrahydro-imidazo-[1,2-h] [1,7] naphthyridine inhibits the secretion of gastric acid. ... | 07/01/2008 |
| 7393859 | Amide substituted imidazoquinolines Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain amide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in t... | 07/01/2008 |
| 7390819 | Imidazo[4,5-b]quinoline-derivatives and their use as no-synthase inhibitors The compounds of formula I in which R1, R2, R3 and A have the meanings as given in the description are novel effective INOS inhibitors. ... | 06/24/2008 |
| 7358259 | HCV inhibitors and methods of using them The present invention comprises tetrazoloquinoline-compounds that are inhibitors of HCV. Compositions comprising the compounds in combination with a pharmaceutically acceptable carrier are also disclosed, as are methods of using the compounds and compositions to inh... | 04/15/2008 |
| RE40245 | Gyrase inhibitors and uses thereof The present invention relates to compounds of the formula I: or a pharmaceutically acceptable derivative or prodrug thereof. The compounds are useful as inhibitors of bacterial gyrase activity. The present invention also relates ... | 04/15/2008 |
| 7348324 | Cyclic amine compounds as CCR5 antagonists A compound of formula (I) (wherein R1 is a hydrogen atom, a hydrocarbon group which may be substituted, a non-aromatic heterocyclic group which may be substituted, R2 is a hydrocarbon group which may be substituted, a non-aromatic heterocyclic ... | 03/25/2008 |
| 7341995 | Use of SARP-1 for the treatment and/or prevention of scleroderma The invention relates to the use of SARP-1 for the preparation of a medicament for the treatment and/or prevention of scleroderma, in particular of systemic sclerosis. ... | 03/11/2008 |
| 7338956 | Acylamino-substituted heteroaromatic compounds and their use as pharmaceuticals The present invention relates to acylamino-substituted heteroaromatic compounds of formula I, wherein R1, R2, R3, R4 and R5 and X are as defined herein, to pharmaceutic... | 03/04/2008 |
| 7335772 | 1H-imidazo [4,5-c] quinolin-4-cyano and 1H-imidazo [4,5-c] quinolin-4-carboxamide intermediates The invention relates to a process for the synthesis of 1H-imidazo[4,5-c]quinoline 4-cyano and 1H-imidazo[4,5-c]quinoline 4-carboxamide intermediates useful in preparing 1H-imidazo[4,5-C]quinoline 4-amines, a process for preparing 1H-imidazo[4,5-C]quinoline 4... | 02/26/2008 |
| 7323567 | RSV polymerase inhibitors Compounds or enantiomers of formula (I) or a salt thereof: wherein R1, R2, R3, R4 and R5 are as defined herein, are useful for the manufacture of a medicamen... | 01/29/2008 |
| 7323568 | Process for preparing Imiquimod The present invention provides a process for preparing 4-amino-1-isobutyl-1H-imidazo[4,5-c]quinoline (Imiquimod) of formula (I). The process comprises heating 4-chloro-1-isobutyl-1H-imidazo[4,5-c]quinoline of formula (II) with formamide, and optionally with b... | 01/29/2008 |
| 7314935 | Tricyclic n-acyl compounds The invention relates to compounds of the formula (1) where the substituents and symbols are as defined in the description. The compounds are valuable intermediates for preparing active pharmaceutical ingredients. ... | 01/01/2008 |
| 7307084 | Cyclic benzimidazoles The invention relates to cyclic benzimidazoles of formula 1, in which the substituents and symbols have the meanings indicated in the description. The compounds have gastric secretion inhibiting and excellent gastric and in... | 12/11/2007 |
