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3M employee and church chorister Art Fry needed something to temporarily mark pages in his hymnal. He was in luck because his colleague, Spencer Silver, accidentally developed a glue that was too weak for other purposes. After initially discouraging consumer response, Post-it Notes became a hit in 1979.
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| Number | Title | Issue Date |
| 8129401 | Heterocyclic compounds useful for the treatment of inflammatory and allergic disorders: process for their preparation and pharmaceutical compositions containing them The present invention relates to novel Phosphodiesterase type 4 (PDE4) inhibitors of the formula (1) and analogs, tautomers, enantiomers, diasteromers, regioisomers, stereoisomers, polymorphs, pharmaceutically acceptable salts, appropriate N-oxides, pharmaceutically... | 03/06/2012 |
| 8088789 | Macrocyclic lactone compounds and methods for their use A method of treating an ophthalmic condition or disease by administering a compound disclosed herein is provided. The compound can be administered systemically or locally and in a variety of ways, such as via a temporary device, an implant, an injection or an eye dr... | 01/03/2012 |
| 8058287 | Chemokine receptor antagonists and methods of use therefor Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: | 11/15/2011 |
| 8053444 | Sirolimus formulation The present invention relates to a stable pharmaceutical composition that includes sirolimus. The pharmaceutical composition includes sirolimus in the amorphous form, a fatty acid ester, such as glyceryl behenate, and a pharmaceutically acceptable polymer wherein th... | 11/08/2011 |
| 8030326 | Crystalline forms of rapamycin analogs Provided is a rapamycin analog composition including a crystalline form of a rapamycin analog. The crystal can be a hydrate. dehydrate, solvate, or desolvate. The rampamycin analog can have a structure of Formula 1, which is optionally a prodrug, salt, derivative, o... | 10/04/2011 |
| 8030325 | Biosynthetic gene cluster for the production of a complex polyketide A polyketide synthase complex composed of polyketide synthase with 15 total modules, a non-ribosomal peptide synthetase with 1 module, and a cytochrome P450 hydroxylase is described. Also provided are novel Streptomyces species and methods of modified Stre... | 10/04/2011 |
| 8022082 | Method for the administration of an anticholinergic by inhalation An inhalation kit comprising: (a) an inhaler displaying a flow resistance of about 0.01 to 0.1 √{square root over (kPa)} min/L; and (b) an inhalable powder comprising tiotropium in admixture with a physiologically acceptable excipient with an average particle size... | 09/20/2011 |
| 8008318 | 39-desmethoxy derivatives of rapamycin The present invention relates to 39-desmethoxyrapamycin derivatives and their uses thereof. The present invention provides for the use of these compounds in the treatment of cancer and/or B-cell malignancies, the induction or maintenance of immunosuppression, the tr... | 08/30/2011 |
| 7994188 | Compounds for treating inflammatory diseases The invention relates to the use of (1α.2β,4β.5α.7β)-7-[(hydroxydi-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane salts for preparing a pharmaceutical composition for the prevention and treatment of diseases associated wit... | 08/09/2011 |
| 7977350 | CCR1 antagonists and methods of use therefor The invention provides compounds having the formula: wherein R1 is halogen. The invention also provides compositions comprising the compounds, and methods of treating diseases or disorders that comprise administe... | 07/12/2011 |
| 7960405 | Compounds and methods for treatment and prevention of diseases A prodrug compound of a rapamycin analog and methods for inhibiting, treating, and preventing mammalian diseases. ... | 06/14/2011 |
| 7943634 | Substituted benzo[4,5]furo[3,2-c]pyridine derivatives as PDE 4 inhibitors The present invention relates to novel Phosphodiesterase type 4 (PDE4) inhibitors of the formula (1) and analogs, tautomers, enantiomers, diasteromers, regioisomers, stereoisomers, polymorphs, pharmaceutically acceptable salts, appropriate N-oxides, pharmaceutically... | 05/17/2011 |
| 7932265 | Solution formulations of sirolimus and its analogs for CAD treatment Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of bioc... | 04/26/2011 |
| 7923455 | Medicaments for the prevention or treatment of heart failure comprising administration of an anticholinergic The present invention relates to a method for the prevention or the treatment of heart failure comprising administration of a therapeutically effective amount of an anticholinergic 1, medicaments for the prevention or treatment of heart failure comprising one or mor... | 04/12/2011 |
| 7897608 | 39-desmethoxy-39-methyl derivatives of rapamycin The present invention relates to novel 39-desmethoxy-39-methylrapamycin derivatives, methods for their production, and uses thereof. In a further aspect the present invention provides for the use of these 39-desmethoxy-39 -methylrapamycin derivatives in the treatmen... | 03/01/2011 |
| 7893082 | Substituted tetrahydroquinolines Disclosed are compounds of formula (I), wherein W, R, R1, R2, R3, R4, R5, R6, and R7 have the meanings indicated in claim 1. Said compounds can be used for the treatment of tumors, a... | 02/22/2011 |
| 7888369 | Oxazoloisoquinoline derivatives as thrombin receptor antagonists This application provides for oxazolisoquinoline derivatives of the formula or a pharmaceutically acceptable salt of said compound wherein: B is —CH═CH—; ... | 02/15/2011 |
| 7879871 | Crystalline forms of tiotropium bromide The invention relates to a new crystalline forms of tiotropium bromide, processes for preparing them and their use for preparing a pharmaceutical composition for the treatment of respiratory complaints, particularly for the treatment of COPD (chronic obstructive pul... | 02/01/2011 |
| 7872014 | Anaplastic lymphoma kinase modulators and methods of use The present invention comprises compounds and pharmaceutical compositions comprising the compounds that are inhibitors of ALK. The invention also comprises methods of using the compounds and compositions to treat diseases mediated by ALK, including diseases such as ... | 01/18/2011 |
| 7851483 | Medicaments comprising steroids and a novel anticholinergic A pharmaceutical composition comprising: (a) a salt of formula 1 wherein: X− is an anion with a single negative charge; and (b) a steroid 2, processe... | 12/14/2010 |
| 7846940 | Solution formulations of sirolimus and its analogs for CAD treatment Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of bioc... | 12/07/2010 |
| 7825129 | Thieno[2,3-c] isoquinolines for use as inhibitors of PARP The present invention relates to compounds for the inhibition of poly(ADP-ribose) polymerase (PARP). In some embodiments, the compounds have the Formula: wherein the constituent variables are as defined herein. The inventio... | 11/02/2010 |
| 7812032 | Crystalline forms of rapamycin analogs A rapamycin analog composition includes a crystalline form of a rapamycin analog. The crystal can be a hydrate, dehydrate, solvate, or desolvate. The rapamycin analog can have a structure of Formula 1, which is optionally a prodrug, salt, derivative, or combination ... | 10/12/2010 |
| 7803808 | Production of polyketides and other natural products The present invention relates to production of polyketides and other natural products and to libraries of compounds and individual novel compounds. Therefore in aspect the present invention provides 17-desmethylrapamycin and analogues thereof, methods for their prod... | 09/28/2010 |
| 7803809 | Substituted pyrano [2,3-b] pyridinamine compounds as beta-secretase modulators and methods of use The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compound... | 09/28/2010 |
| 7781446 | Use of CCI-779 as an antineoplastic agent This invention provides the use of CCI-779 in the treatment of neoplasms. ... | 08/24/2010 |
| 7781447 | O-methylated rapamycin derivatives for alleviation and inhibition of lymphoproliferative disorders The present invention relates to methods of alleviating and inhibiting a lymphoproliferative disorder in a mammal, the method comprising administering one or more rapamycin derivatives (including rapamycin) to the mammal. Further, the invention provides a method for... | 08/24/2010 |
| 7754734 | O-methylated rapamycin derivatives for alleviation and inhibition of lymphoproliferative disorders The present invention relates to methods of alleviating and inhibiting a lymphoproliferative disorder in a mammal, the method comprising administering one or more rapamycin derivatives (including rapamycin) to the mammal. Further, the invention provides a method for... | 07/13/2010 |
| 7745457 | Meridamycin analogues for the treatment of neurodegenerative disorders A compound of the structure is described. This compound and its use for preparing medicines useful in the treatment of neurodegenerative disorders is described. ... | 06/29/2010 |
| 7741338 | Macrolides The invention relates to the stabilization of poly-ene macrolides and to a particular macrolide obtained in crystalline form. ... | 06/22/2010 |
| 7732459 | CCR1 antagonists and methods of use therefor The invention provides compounds having the formula: wherein R1 is halogen. The invention also provides compositions comprising the compounds, and methods of treating diseases or disorders that comprise administe... | 06/08/2010 |
| 7700614 | One pot synthesis of tetrazole derivatives of rapamycin A single-step, one-pot process to obtain zotarolimus and other rapamycin derivatives on large scale is presented, which improves currently available synthesis schemes. In one embodiment, dried rapamycin is dissolved in isopropylacetate (IPAc). The solution is cooled... | 04/20/2010 |
| RE41253 | Antineoplastic combinations This invention provides the use of a combination of CCI-779 and EKB-569 in the treatment of neoplasms. ... | 04/20/2010 |
| 7671068 | N-(alkoxyalkyl) carbamoyl-substituted 6-phenyl-benzonaphthyridine derivatives and their use as PDE ¾ inhibitors Compounds of the formula I in which the substitutents have the definitions provided in the specification, are novel, effective PDE 3/4 inhibitors. ... | 03/02/2010 |
| 7655673 | 39-desmethoxyrapamycin, compositions and methods of use thereof The present invention relates to medical uses of 39-desmethoxyrapamycin. ... | 02/02/2010 |
| 7652030 | Compositions for treatment of common cold New stable compositions comprising the combination of a topically active vasoconstrictor and a topically active anticholinergic drug are disclosed. Preferably, the composition comprises ipratropium or a salt thereof in combination with xylometazoline hydrochloride a... | 01/26/2010 |
| 7648996 | 39-desmethoxy derivatives of rapamycin The present invention relates to novel 39-desmethoxyrapamycin derivatives, methods for their production, and uses thereof. In a further aspect the present invention provides for the use of these 39-desmethoxyrapamycin derivatives in the treatment of cancer and/or B-... | 01/19/2010 |
| RE41084 | Antineoplastic combinations This invention provides the use of a combination of CCI-779 and EKB-569 in the treatment of neoplasms. ... | 01/19/2010 |
| 7645768 | Production of polyketides and other natural products The present invention relates to production of polyketides and other natural products and to libraries of compounds and individual novel compounds. One important area is the isolation and potential use of novel FKBP-ligand analogues and host cells that produce these... | 01/12/2010 |
| 7642268 | Crystalline micronisate, process for the manufacture thereof and use thereof for the preparation of a medicament The invention relates to a crystalline micronisate of (1 α,2β,4β,5α,7β)-7-[(hydroxydi-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane-bromide, processes for preparing it and its use for preparing a pharmaceutical compositio... | 01/05/2010 |
