Quotables
"Rail travel at high speeds is not possible because passengers, unable to breathe, would die of asphyxia."
Dionysius Lardner, Professor of Natural Philosophy and Astronomy at University College, London ; 1830
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 8188107 | Analgesic combination of oxycodone and N-[3-(formylamino)-4-oxo-6-phenoxy-4H-1-benzopyran-7-yl] methanesulfonamide Disclosed is a pharmaceutical composition, comprising two analgesic compounds and/or pharmaceutically acceptable salts thereof consisting of N-[3 -(formylamino)-4-oxo-6-phenoxy-4H-1-benzopyran-7-yl] methanesulfonamide and/or at least one a pharmaceutically acceptabl... | 05/29/2012 |
| 8188108 | Pharmaceutical composition A pharmaceutical composition comprising an analgesic or analgesic combination and a stool softener is disclosed. The analgesic is selected from morphine, meperidine, fentanyl, hydromorphone, oxymorphone, oxycodone, hydrocodone, methadone, propoxyphene, pentazocine, ... | 05/29/2012 |
| 8183256 | Remedy or preventive for integration dysfunction syndrome A method of treating schizophrenia, which method can treat especially positive symptoms of schizophrenia and does not cause impaired information processing related to cognitive deficiencies or the like which is a symptom of schizophrenia. The method of treating schi... | 05/22/2012 |
| 8173666 | Oligomer-opioid agonist conjugates The invention provides compounds that are chemically modified by covalent attachment of a water-soluble oligomer. A compound of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from those of th... | 05/08/2012 |
| 8143267 | Analgesic combination of oxycodone and nimesulide Disclosed is a pharmaceutical composition, comprising two analgesic compounds and/or pharmaceutically acceptable salts thereof consisting of nimesulide and/or at least one pharmaceutically acceptable salt thereof and oxycodone and/or at least one pharmaceutically ac... | 03/27/2012 |
| 8143268 | Bicyclic pyrimidinones and uses thereof The present invention provides a compound of Formula I or a pharmaceutically acceptable derivative, salt or prodrug thereof. Further provided is a method of treatment or prophylaxis of a viral infection in a subject comprising administering to said subject an effect... | 03/27/2012 |
| 8101630 | Extended release opioid abuse deterrent compositions and methods of making same This invention relates to an abuse deterrent dosage form of opioid analgesics, wherein an analgesically effective amount of opioid analgesic is combined with a polymer to form a matrix. ... | 01/24/2012 |
| 8088787 | Methods related to the treatment of neurodegenerative and inflammatory conditions The invention includes methods of neuroprotection, inducing release of neurotrophic factors, inhibiting the over-activation of innate immune cells, attenuating the toxin-induced death and/or damage of tissues, reducing inflammation, treating an inflammation-related ... | 01/03/2012 |
| 8084460 | 6,7-unsaturated-7-carbamoyl substituted morphinan derivative A novel compound which is useful as an agent for treating and/or preventing emesis, vomiting and/or constipation. A compound represented by the formula (I): wherein R1 and R2 are each independen... | 12/27/2011 |
| 8067431 | Chemically modified small molecules Methods of modifying the rate of systemic absorption of a drug administered to a subject by a pulmonary route, the method comprising covalently conjugating a hydrophilic polymer to a drug, wherein the drug has a half-life of elimination from the lung of less than ab... | 11/29/2011 |
| 8067430 | Anti-HIV activity of the opioid antagonist naloxone A method of treating HIV infection by using the novel anti-HIV activity of the opioid antagonist naloxone. ... | 11/29/2011 |
| 8063059 | Use of compositions containing kappa-opioid receptor antagonists for the treatment of dissociative disorders The invention relates to the use of a composition comprising kappa opioid receptor antagonists for producing a drug for the treatment of dissociative disorders in humans. ... | 11/22/2011 |
| 8058230 | Neurotensin receptor agonists and opioid receptor agonists This document provides methods and materials for treating pain. For example, this document provides methods that involve administering a neurotensin receptor (NTR) agonist and an opioid receptor agonist to a mammal (e.g., a human). Compositions containing an NTR ago... | 11/15/2011 |
| 8058286 | Method for therapy of diarrhea-predominant irritable bowel disorders A method for therapy of diarrhea-predominant irritable bowel disorders comprising as an effective ingredient a morphinan derivative having a nitrogen-containing cyclic group or a pharmaceutically acceptable acid addition salt thereof is disclosed. The method for the... | 11/15/2011 |
| 8034825 | Chemically modified small molecules The invention provides small molecule drugs that are chemically modified by covalent attachment of a water-soluble oligomer obtained from a monodisperse or bimodal water-soluble oligomer composition. A conjugate of the invention, when administered by any of a number... | 10/11/2011 |
| 8017622 | Opioid and opioid-like compounds and uses thereof The present invention relates to opioid and opioid-like compounds, and pharmaceutical formulations thereof, and use thereof for prevention and treatment of disorders such as septic shock and organ damage. ... | 09/13/2011 |
| 8012990 | Methods of converting a patient's treatment regimen from intravenous administration of an opioid to oral co-administration of morphine and oxycodone using a dosing algorithm to provide analgesia A method of converting a treatment for pain comprising intravenous administration of opioids, to a treatment for pain comprising oral administration of a first dose of an immediate release morphine-oxycodone combination in patients in need of analgesia. The method m... | 09/06/2011 |
| 7973048 | Pharmaceutical composition A pharmaceutical composition comprising an analgesic or analgesic combination and a stool softener is disclosed. The analgesic is selected from morphine, meperidine, fentanyl, hydromorphone, oxymorphone, oxycodone, hydrocodone, methadone, propoxyphene, pentazocine, ... | 07/05/2011 |
| 7943631 | Method of treating drug addiction using dextro-morphine The present invention relates a method of treating drug addiction in an individual by administering to the addicted individual a therapeutically effective amount of dextro-morphine capable of activating an opioid receptor. It is disclosed here that dextro-morphine i... | 05/17/2011 |
| 7939543 | Method of reducing α, β unsaturated ketones in opioid compositions The present invention is directed to a process for reducing the level of α, β-unsaturated ketone in an opioid analgesic composition by hydrogenation the opioid analgesic composition with diimide or a diimide progenitor. ... | 05/10/2011 |
| 7923453 | Methods of converting a patient's treatment regimen from intravenous administration of an opioid to oral co-administration of morphine and oxycodone using a dosing algorithm to provide analgesia A method of converting a treatment for pain comprising intravenous administration of opioids, to a treatment for pain comprising oral administration of a first dose of an immediate release morphine-oxycodone combination in patients in need of analgesia. The method m... | 04/12/2011 |
| 7919499 | Naltrexone long acting formulations and methods of use The inventions described herein arose from unexpected discoveries made during clinical trials with a long acting formulation of naltrexone. As such, the invention includes a method for treating an individual in need of naltrexone comprising the step of parenterally ... | 04/05/2011 |
| 7910599 | Method for treating eating disorders by selective extinction with transdermal naloxone A method for treating eating disorders by repeatedly administering naloxone in a dosage sufficient to block the effects of opiate agonists to a subject suffering from an eating disorder caused by one or more related problem responses; while the amount of naloxone in... | 03/22/2011 |
| 7902207 | Process for production of amines A process for producing an amine which is characterized by reacting an imine with a nucleophilic compound (except a trialkylsilyl vinyl ether) in the presence of a phosphoric acid derivative represented by the formula (1): ... | 03/08/2011 |
| 7879870 | Treatment of inflammatory and ulcerative diseases of the bowel with opioid antagonists Methods for the treatment of inflammatory and ulcerative diseases of the bowel (e.g., Crohn's disease and ulcerative colitis) with a therapeutically effective dose less than 50 mg. of opioid antagonists (e.g., naltrexone, nalmefene or naloxone) are disclosed. An emb... | 02/01/2011 |
| 7875623 | Process for reducing contaminating Michael acceptor levels in oxycodone and other compositions The present invention relates to processes for removal of Michael acceptors from certain compositions wherein the composition is treated with a thiol-containing compound under conditions sufficient to remove Michael acceptors and the resulting thiol-Michael adducts.... | 01/25/2011 |
| 7872013 | Preparation and utility of opioid analgesics The present disclosure is directed to modulators of opiate- and/or NMDA receptors and pharmaceutically acceptable salts and prodrugs thereof, the chemical synthesis thereof, and the use of such compounds for the treatment and/or management of pain, anxiety, neurodeg... | 01/18/2011 |
| 7851482 | Method for making analgesics Improved analgesic oxymorphone hydrochloride contains less than 10 ppm of alpha, beta unsaturated ketones and pharmaceutical preparations comprising such oxymorphone hydrochloride. The oxymorphone hydrochloride is produced by reducing a starting material oxymorphone... | 12/14/2010 |
| 7820689 | Methods and compositions for preventing or treating cardiovascular disease The present invention relates to a method for preventing or treating a cardiovascular disease. ... | 10/26/2010 |
| 7820688 | Topical anesthetic/opioid formulations and uses thereof Many chemical and pharmaceutical compositions are known to produce antinociceptive effects that are helpful in relieving pain and inflammation. Both opioids and local anesthetics serve an important function in providing peripheral pain relief. Topical administration... | 10/26/2010 |
| 7786133 | Chemically modified small molecules The invention provides small molecule drugs that are chemically modified by covalent attachment of a water-soluble oligomer obtained from a monodisperse or bimodal water-soluble oligomer composition. A conjugate of the invention, when administered by any of a number... | 08/31/2010 |
| 7781444 | Pharmaceutical composition for treating fecal incontinence and anal itch Fecal incontinence and anal itch can be treated by administration, more particularly by local application to the anus, of an α adrenergic blocker, nitric oxide synthase inhibitor, prostaglandin F2α, dopamine, morphine, β-blockers, and 5-Hydroxytryptami... | 08/24/2010 |
| 7759358 | Oral bioavailable prodrugs The invention is directed to forming duplex prodrugs that provide significant increase in the transdermal flux of drugs across human skin. The prodrugs are prepared by reacting a drug that can form an ester moiety with phosgene to form a carbonate. The drug can be a... | 07/20/2010 |
| 7718664 | Anti-itching agent A method of inhibiting or reducing occurrence or intensity of pruritus including administering to a patient an effective amount of one or more of the morphinan derivative having a nitrogen-containing cyclic group of the Formula (Ia): ... | 05/18/2010 |
| 7696220 | Methods for the treatment or inhibition of ileus Methods for the treatment of ileus are disclosed wherein the peripheral mu opioid antagonist methylnaltrexone is administered. ... | 04/13/2010 |
| 7691873 | Preparation of pharmaceutical formulations A process for the production of a composition comprising a water-insoluble opioid which comprises the steps of: a) providing a mixture comprising: i) a water-insoluble opioid, ii) a water soluble carrier, and iii) a solvent for each of the opioid and the carrier, an... | 04/06/2010 |
| 7683072 | Oxycodone hydrochloride having less than 25 ppm 14-hydroxycodeinone In certain embodiments the invention is directed to a process for preparing an oxycodone hydrochloride composition having less than 25 ppm of 14-hydroxycodeinone. ... | 03/23/2010 |
| 7674799 | Oxycodone hydrochloride having less than 25 ppm 14-hydroxycodeinone In certain embodiments the invention is directed to a process for preparing an oxycodone hydrochloride composition having less than 25 ppm of 14-hydroxycodeinone. ... | 03/09/2010 |
| 7674800 | Oxycodone hydrochloride having less than 25 PPM 14-hydroxycodeinone In certain embodiments the invention is directed to a process for preparing an oxycodone hydrochloride composition having less than 25 ppm of 14-hydroxycodeinone. ... | 03/09/2010 |
| 7674798 | Oxycodone hydrochloride having less than 25 ppm 14-hydroxycodeinone In certain embodiments the invention is directed to a process for preparing an oxycodone hydrochloride composition having less than 25 ppm of 14-hydroxycodeinone. ... | 03/09/2010 |
