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| Number | Title | Issue Date |
| 8080553 | Methods and reagents for the treatment of immunoinflammatory disorders The invention features a method for treating a patient diagnosed with, or at risk of developing, an immunoinflammatory disorder by administering to the patient a tetra-substituted pyrimidopyrimidine, either alone or in combination with one or more additional agents.... | 12/20/2011 |
| 8044058 | Merocyanine derivatives Disclosed is the use of merocyanine derivatives of formula Q is hydrogen; C1-C22alkyl; —OH; —OR7; —NR7R8; or —N═R9; ... | 10/25/2011 |
| 7977343 | Adenine derivatives Novel adenine derivatives of the formula (I), in which R1, R2, R3, X and Y have the meanings indicated in Claim 1, are HSP90 inhibitors and can be used for the preparation of a medicament for the treatment of diseases in which... | 07/12/2011 |
| 7977342 | HCV inhibiting bi-cyclic pyrimidines The present invention relates to the use of bi-cyclic pyrimidines as inhibitors of HCV replication as well as their use in pharmaceutical compositions aimed to treat or combat HCV infections. In addition, the present invention relates to processes for preparation of... | 07/12/2011 |
| 7960394 | Quinazoline derivative This invention provides a compound or its pharmaceutically-acceptable salt of formula (I) wherein R1 represents a lower alkyl group et al; R2 and R3 are same and different and represents hyd... | 06/14/2011 |
| 7915265 | Combinations for the treatment of immunoinflammatory disorders The invention features pharmaceutical compositions that include dipyridamole and a corticosteroid. ... | 03/29/2011 |
| 7902203 | Anti-infective agents The present invention provides an HCV polymerase inhibiting compound having the formula (I) and a composition comprising a therapeutically effective amount of said compound. The present invention also provides a method for ... | 03/08/2011 |
| 7879861 | Combi-molecules having EGFR and DNA targeting properties A series of new chemical agents that demonstrate anti-tumor activity are described. The new chemical agents combine two major mechanisms of anti-tumor action. In an embodiment, the agents are capable of both inhibiting EGFR and damaging DNA while also, upon degradat... | 02/01/2011 |
| 7790729 | Inhibitors of VEGF receptor and HGF receptor signaling The invention relates to the inhibition of VEGF receptor signaling and HGF receptor signaling. The invention provides compounds and methods for inhibiting VEGF receptor signaling and HGF receptor signaling. The invention also provides compositions and methods for tr... | 09/07/2010 |
| 7772242 | Merocyanine derivatives Disclosed is the use of the compounds of formula wherein Q is —OH; —OR7; —NH2; —NHR7; —NR7R8; or ... | 08/10/2010 |
| 7759353 | Substituted spiro iminopyrimidinones as aspartyl protease inhibitors, compositions, and methods of treatment Disclosed are certain substituted spiro iminopyrimidinones and other compounds of the formula I or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein U, W, A, R, R1, R2... | 07/20/2010 |
| 7718660 | Inhibitors of folic acid-dependent enzymes The invention relates to compounds of the formula I, or pharmaceutically acceptable salts thereof: wherein: Z=O or S; n=1−3; R3═—CO2R8, —C(O)SR8, —C(O)NHR8, —C(S)OR8, —C(S)SR8... | 05/18/2010 |
| 7691864 | Anti-hypertensive composition and methods of treatment Pharmaceutical compositions for the treatment of hypertension comprising an effective anti-hypertensive amount of at least one compound in association with a pharmaceutically acceptable, substantially non-toxic carrier or excipient, the compound having one of the fo... | 04/06/2010 |
| 7652019 | 5,6-trimethylenepyrimidin-4-one compounds Pyrimidone compounds of formula (I): are inhibitors of the enzyme Lp-PLA2 and are of use in treating atherosclerosis. ... | 01/26/2010 |
| 7638520 | Pyrimidine compounds Pyrimidone compounds of formula (I): are inhibitors of the enzyme Lp-PLA2 and are of use in treating atheroscelerosis. ... | 12/29/2009 |
| 7612077 | Crystalline forms of the anti-cancer compound ZD1839 The invention concerns certain crystalline solvates and hydrates of the compound of the Formula (I) which is known inter alia by way of the code number ZD1839. In particular, the invention concerns a first solvate that occurs in the presence of methanol which is des... | 11/03/2009 |
| 7598252 | Compounds specific to adenosine A, receptors and uses thereof This invention pertains to compounds which specifically inhibit the adenosine A1 receptor and the use of these compounds to treat a disease associated with A1 adenosine receptors in a subject. ... | 10/06/2009 |
| 7569569 | Pyrrolo[2,3-d]pyrimidine compounds A compound of the formula wherein R1, R2 and R3 are as defined above, which are inhibitors of the enzyme protein tyrosine kinases such as Janus Kinase 3 and as such are useful therapy as imm... | 08/04/2009 |
| 7528137 | Compounds, compositions, and methods Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed. ... | 05/05/2009 |
| 7482352 | Chemical derivatives and their application as antitelomerase agents The present invention relates to cancer therapy and to novel anticancer agents having a mechanism of action which is quite specific. It also relates to novel chemical compounds as well as their therapeutic application in humans. ... | 01/27/2009 |
| 7476677 | Substituted thieno- and thiazolo- [2,3-d]pyrimidines and [2,3-c]pyridines as inhibitors of Tie2 A compound of the formula(I); wherein the substituents are as defined in the text for use in the production of an anti-angiogenic effect in a warm blooded animal such as man. The compounds are inhibitors Tie2 receptor tyrosine kinase (TEK). | 01/13/2009 |
| 7470693 | Oxalamide derivatives as kinase inhibitors The invention is directed to compounds having the following Formula I: and methods of using them for the treatment of proliferative diseases. ... | 12/30/2008 |
| 7470694 | 5,6-trimethylenepyrimidin-4-one compounds Pyrimidone compounds of formula (I): are inhibitors of the enzyme Lp-PLA2 and are of use in treating atheroscelerosis. ... | 12/30/2008 |
| 7462620 | Pyrimidinone derivatives and their use in the treatment of atherosclerosis Compounds of formula (I): are inhibitors of the enzyme Lp-PLA2 and are of use in therapy, in particular for treating atherosclerosis. ... | 12/09/2008 |
| 7456185 | Substituted quinazoline compounds useful as p38 kinase inhibitors Compounds having the formula (I), are useful as p38 kinase inhibitors, wherein R4 and R5 are hydrogen, halogen, cyano, haloalkyl, or haloalkoxy, but are not both hydrogen; R6 and R7 | 11/25/2008 |
| 7439246 | Fused heterocyclic kinase inhibitors In general, the instant invention comprises compounds of Formulas I and II including pharmaceutically acceptable salts thereof. The compounds of the invention are useful as protein kinase inhibitors and therefore are useful... | 10/21/2008 |
| 7439248 | Pharmaceutical composition and the process for its preparation The present invention provides a new stable pharmaceutical composition containing 5-[[4-[3-Methyl-4-oxo-3,4-dihydro-2-quinazolinyl]methoxy]phenyl-methyl]thiadiazolidine-2,4-dione as active ingredient. ... | 10/21/2008 |
| 7432273 | Phosphonate analogs of antimetabolites The invention is related to phosphorus substituted antimetabolites, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds. ... | 10/07/2008 |
| 7407962 | Heteroaryl compounds useful as inhibitors or protein kinases The present invention provides compounds that are inhibitors of protein kinase, particularly inhibitors of ERK2, GSK3, PKA, CDK2 protein kinases, mammalian protein kinases involved in proliferative and neurodegenerative disorders. The invention also provides pharmac... | 08/05/2008 |
| 7348326 | Heteroaryl fused aminoalkyl imidazole derivatives: selective modulators of GABAreceptors Disclosed are compounds of the formula: or the pharmaceutically acceptable non-toxic salts thereof wherein the A, B, C, D, X, R1, R2, R3, R4, R5, and R6, are... | 03/25/2008 |
| 7345045 | Pyrido-pyrimidine compounds as medicaments The invention is directed to methods to inhibit TGF-β and/or p38-α kinase using compounds of the formula or the pharmaceutically acceptable salts thereof wherein R3 is a nonin... | 03/18/2008 |
| 7338955 | Medicament for treatment of neuropathies Compounds of formula (I) in which R1=C1-6 alkyl, optionally halosubstituted; R2=H, C1-4 alkyl, optionally halosubstituted or replaced by halogen; R3=C2-4 alkyl, optionally halosubstituted; R4 | 03/04/2008 |
| 7329665 | Quinazolinone derivative An optically active form of the quinazolinone derivatives represented by the general formula (1): [wherein Y represents a phenyl group or C2-C7 alkyl group; E represents —CH═ or nitrogen atom; and R represent... | 02/12/2008 |
| 7297700 | Bicycloheteroaryl compounds as P2X modulators and uses thereof Bicycloheteroaryl compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of cond... | 11/20/2007 |
| 7265123 | Heterocyclic compounds Heteroaromatic compounds are described, methods for their preparation, pharmaceutical compositions containing them, methods of use, and their use in medicines. In particular, the invention relates to quinazoline and pyridopyrimidine derivatives which exhibit protein... | 09/04/2007 |
| 7265221 | Pyrrolo[2,3-d]pyrimidine compounds A compound of the formula wherein R1, R2 and R3 are as defined above, which are inhibitors of the enzyme protein kinases such as Janus Kinase 3 and as such are useful therapy as i... | 09/04/2007 |
| 7253155 | Combinations for the treatment of immunoinflammatory disorders The invention features a method for treating a patient having an immunoinflammatory disorder, by administering to the patient (i) a tetra-substituted pyrimidopyrimidine, and (ii) a corticosteroid simultaneously or within 14 days of each other in amounts sufficient t... | 08/07/2007 |
| 7250420 | Method of treatment of transplant rejection A method of treating or preventing chronic organ transplant rejection comprising administering a compound of the formula wherein R1, R2 and R3 are as defined above. ... | 07/31/2007 |
| 7238698 | Substituted quinazoline compounds useful as p38 kinase inhibitors Compounds having the formula (I), are useful as p38 kinase inhibitors, wherein R4 and R5 are hydrogen, halogen, cyano, haloalkyl, or haloalkoxy, but are not both hydrogen; R6 and ... | 07/03/2007 |
| 7230000 | Methods and compositions utilizing quinazolinones Quinazolinones of formulae 1a, 1b, 1c and 1d are disclosed. They are useful for treating cellular proliferative diseases and disorders associated with KSP kinesin activity ... | 06/12/2007 |
