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| Number | Title | Issue Date |
| 8138192 | Injectable meclizine formulations and methods Methods of treating or preventing a vertigo, nausea, or vomiting condition comprising injecting a subject with a pharmaceutically acceptable formulation consisting essentially of an effective amount of meclizine or a pharmaceutically acceptable salt thereof, a chemi... | 03/20/2012 |
| 8076342 | Malonate salt of 4-((1R,3S)-6-chloro-3-phenylindan-1-yl)-1,2,2-trimethylpiperazine and uses of same 4-((1R,3S)-6-Chloro-3-phenylindan-1-yl)-1,2,2-trimethylpiperazine hydrogen malonate salt and pharmaceutical comprising and uses of the same, including for the treatment of schizophrenia and other psychotic disorders are described. ... | 12/13/2011 |
| 8034818 | Therapeutic uses of derivatives of piperidinyl- and piperazinyl-alkyl carbamates Therapeutic uses of a compound corresponding to the general formula (I): in which A=N or CR2; R2=H, F, OH, CN, CF3, C1-6-alkyl, C1-6-alkoxy; n=2 or 3 and m=2 when A=N; ... | 10/11/2011 |
| 8022074 | 4-(phenyl-piperazinyl-methyl)benzamide derivatives and their use for the treatment of pain, anxiety or gastrointestinal disorders The invention relates to at least one compound of general formula I wherein R1 is phenyl, pyridinyl, thienyl, furanyl, imidazolyl, pyrrolyl, triazolyl, thiazolyl, or pyridine N-oxide, where each R1 phe... | 09/20/2011 |
| 7985752 | Phenyl piperazine compounds, pharmaceutical composition including the same and use thereof The present invention relates to novel piperazine derivatives or pharmaceutically acceptable salts thereof, a process for preparing the same, and in particular, a high binding for Serotonin 1A(5-hydroxytryptamine; 5-HT1A) receptor, a pharmaceutical composition for t... | 07/26/2011 |
| 7964605 | Phenyl piperazine compounds, pharmaceutical composition comprising the same, and use thereof The present invention relates to a novel piperazine derivative or pharmaceutically acceptable salt thereof, a process for preparing the same, a pharmaceutical composition for treating central nervous system diseases comprising an effective amount of the piperazine c... | 06/21/2011 |
| 7875617 | 3,4-dihydro-2-naphthamide derivatives as selective dopamine D3 ligands The invention relates to 3,4-dihydro-2-naphthamide derivatives of formula (I), pharmaceutical compositions containing them and their therapeutic applications as partial agonists or antagonists of the dopamine D3 receptor for the treatment of neuropsychological disor... | 01/25/2011 |
| 7829569 | Solvate and crystalline forms of carbamoyl-cyclohexane derivatives The present invention relates to novel solvate and crystalline forms of carbamoyl-cyclohexane derivatives and, more particularly, to novel solvate and crystalline forms of trans-1{4-[2-[4-(2,3-dichlorophenyl)-piperazin-1-yl]-ethyl]-cyclohexyl}-3,3-dimethyl-urea hydr... | 11/09/2010 |
| 7772240 | -1(6-chloro-3-phenylindan-1-yl)-3,3-dimethylpiperazine A compound 4-((1R,3S)-6-Chloro-3-phenylindan-1-yl)-2,2-dimethylpiperazine and salts thereof, pharmaceutical compositions comprising the compound and salts, and medical use thereof, including for treatment of schizophrenia and other psychotic disorders. ... | 08/10/2010 |
| 7767684 | Apoptosis promoters Disclosed are compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which occurs expression one or more than one of an ant... | 08/03/2010 |
| 7767683 | Hydrogen succinate salts of trans-4-((1R, 3S)-6-chloro-3-phenylindan-1-YL)-1,2,2-trimethylpiperazine and the use as a medicament 4-((1R,3S)-6-Chloro-3-phenylindan-1-yl)-1,2,2-trimethylpiperazine hydrogen succinate, pharmaceutical compositions containing the salt and the medical use thereof, including for the treatment of schizophrenia and other psychotic disorders. Also described are methods ... | 08/03/2010 |
| 7705003 | Cyclohexylamides as dopamine D3, D2 and 5-HTAntagonists The present invention relates to new dopamine D3 and D2 and serotonin 5-HT1A receptor subtype preferring ligands of formula (I); wherein A represents alkyl, alkenyl, aryl, heteroaryl, cycloalkyl or a group of formula —NR1 | 04/27/2010 |
| 7659277 | Ubiquitin ligase inhibitors and methods related thereto The application discloses compounds that inhibit ubiquitin ligase activity. The application further discloses antiviral compounds, anticancer compounds, and compounds useful for the treatment of neurological disorders. ... | 02/09/2010 |
| 7648991 | Crystalline base of -1-(()-6-chloro-3-phenylindan-1-yl)-3,3-dimethylpiperazine Crystalline base of compound trans-1-((1R,3S)-6-chloro-3-phenylindan-1-yl)-3,3-dimethylpiperazine, processes for the preparation of purified free base or salts of this compound, pharmaceutical compositions comprising the base and medical use thereof, including for t... | 01/19/2010 |
| 7645760 | 1-(4-Benzyl-piperazin-1-yl)-3-phenyl-propenone derivatives A compound of formula (I), or a pharmaceutically acceptable salt or ester thereof, wherein the symbols have meaning as defined, which are antagonists of CCR-1 and which find use pharmaceutically for treatment of diseases and conditions in which CCR-1 is implicated, ... | 01/12/2010 |
| 7642262 | Arylipiperdinopropanol and arylipiperazinopropanol derivatives and pharmaceuticals containing the same A compound having the formula (I) or its salt, hydrate, hydrate salt or solvate: wherein R1 to R4 independently represent H, halogen, OH, alkoxy, optionally substituted alkyl, aryl, or aralkyl group, R... | 01/05/2010 |
| 7632838 | 11-beta HSD1 inhibitors This invention relates to inhibiting 11βHSD1. ... | 12/15/2009 |
| 7563795 | Phenyl-piperazine derivatives as modulators of muscarinic receptors The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases. ... | 07/21/2009 |
| 7557109 | Treatment for attention-deficit hyperactivity disorder A method for treating Attention Deficit/Hyperactivity Disorder (ADHD) in humans and the symptoms associated therewith, inattentiveness, and hyperactivity with impulsivity, using eltoprazine and related compounds is provided. ... | 07/07/2009 |
| 7517885 | Substituted [4-(4-phenyl-piperazin-1-yl)-cyclohexyl]-urea compounds The present invention relates to substituted [4-(4-phenyl-piperazin-1-yl)-cyclohexyl]-urea compounds of Formula (I) and pharmaceutically acceptable forms thereof, as α1a/α1d adrenoreceptor modulators... | 04/14/2009 |
| 7488731 | Arylpiperazinyl compounds The invention relates to 5-HT receptor agonists or antagonists. Novel arylpiperazinyl sulfonamide compounds represented by Formula I, and synthesis and uses thereof for treating diseases including those mediated directly or indirectly by 5-HT receptors, are disclose... | 02/10/2009 |
| 7488730 | -(1,2,3,4-tetrahydronaphthalen-1-yl)-4-phenyl-1-piperazinealkylamide derivatives, and therapeutic use thereof as 5-HTreceptor ligands A series of N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinealkylamides was prepared and their affinity for serotonin 5-HT7, 5-HT1A, and 5-HT2A receptors was measured using in vitro binding assays. In relation to 5-HT7 ... | 02/10/2009 |
| 7473692 | Sulfonamide derivatives as D3-receptor ligands The present invention relates to new D3 dopamine receptor subtype selectice ligands of formula (I) to pharmacological compositions containing the same and to their use in therapy and/or prevention of psychoses (e.g. schizophrenia, schizo-affective disorde... | 01/06/2009 |
| 7452891 | MCH antagonists and their use in the treatment of obesity The present invention discloses compounds which, are novel antagonists for melanin-concentrating hormone (MCH), as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such MCH antagonist... | 11/18/2008 |
| 7442692 | Indanyl-piperazine compounds A compound selected from those of formula (I): wherein: R3 represents a hydrogen atom, and R1 and R2 together with the carbon atoms carrying them form a be... | 10/28/2008 |
| 7439245 | Compounds Disclosed is a method for use of phenyl sulfone compounds of formula (I) in the treatment of anxiety. ... | 10/21/2008 |
| 7439356 | Substituted indan derivatives The present invention relates to intermediates of the formula useful in the preparation of piperazinyl-substituted indan derivatives, wherein Y is CONR2 wherein R2 is H or C1-C | 10/21/2008 |
| 7427612 | Benzoyl-piperazine derivatives A compound of formula wherein the substituents are as described in the specification for the treatment of psychoses, pain, neurodegenerative disfunction in memory and learning, schizophrenia, dementia and other diseases in ... | 09/23/2008 |
| 7425554 | 1,2-di(cyclic)substituted benzene compounds In one aspect, the present invention provides compounds having formula (1) or (100), a salt thereof or a hydrate of the foregoing, which compounds exhibit excellent cell adhesion inhibitory action or cell infiltration inhibitory action, and are useful as therapeutic... | 09/16/2008 |
| 7410971 | 1,2-di(cyclic)substituted benzene compounds A compound represented by the following general formula (1) or (100), a salt thereof or a hydrate of the foregoing has excellent cell adhesion inhibitory action or cell infiltration inhibitory action, and is useful as a therapeutic or prophylactic agent for various ... | 08/12/2008 |
| 7390812 | N, N'-disubstituted piperazine compounds and their use as analgesics N,N′-disubstituted piperazine compounds, processes for the production thereof, and pharmaceutical preparations containing these compounds. The use of N,N′-disubstituted piperazine compounds for the production of pharmaceutical preparations and in related methods... | 06/24/2008 |
| 7381728 | Piperazine derivatives useful for the treatment of gastrointestinal disorders The invention provides compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein Ra, Rb, Rc, Rd, Re, Rf and Y are as defined in the specification. The compounds are partial or ful... | 06/03/2008 |
| 7345041 | Chemical compounds The invention relates to methods for the treatment of a sleep disorder comprising administering a compound of formula (I): wherein all variables are as defined herein. ... | 03/18/2008 |
| 7319097 | Compounds The present invention relates to substituted bis-arylsulfonamide and arylsulfonamide compounds of the general formula (I) or the formula (II), which compounds are potentially useful for the prophylaxis and treatment of medical conditions relating to obesity, type II... | 01/15/2008 |
| 7319099 | Benzoyl-piperazine derivatives The invention relates to compounds of formula wherein the substituents are described herein. The compounds may be used in the treatment of illnesses based on the glycine uptake inhibitor, such as psychoses, pain,... | 01/15/2008 |
| RE39921 | Chemical compounds The invention relates to piperazine derivatives, to processes for their preparation, to pharmaceutical compositions containing them, and to their medical use. The novel compounds are antagonists of tachykinins, including substance P and other neurokinins. ... | 11/13/2007 |
| 7291621 | Substituted biaryl amides C5a receptor modulators Substituted biaryl amides of Formula I are provided. Such compounds are ligands that may be used to modulate C5a receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological C5... | 11/06/2007 |
| 7285553 | Serotonergic 5HTreceptor compounds for treating ocular and CNS disorders Compounds with 5HT7 receptor affinity (some of which are novel) useful for lowering IOP, improving blood flow to the optic nerve head and the retina, providing neuroprotection, and treating retinal diseases are disclosed. The Compounds are also useful for... | 10/23/2007 |
| 7279481 | Quinoline and quinazoline derivatives having affinity for 5HT1-type receptors Compounds of formula (I) and pharmaceutically acceptable salts thereof are provided: wherein R1, m, X, R2, n, W, p, Y, Z, R3, R4, R5 and q have the meanings ... | 10/09/2007 |
| 7262188 | Phenyl sulfone derivatives and their use in the treatment of CNS disorders This invention relates to novel phenyl sulfone compounds having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of CNS and other disorders. ... | 08/28/2007 |
