Did You Know...
...that the Slinky toy was the result of a failed attempt by engineer Richard James to produce an antivibration device for ship instruments? His goal was to develop a spring that would instantaneously counterbalance the wave motion that rocks a ship at sea. Instead, he developed the Slinky.
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| Number | Title | Issue Date |
| 7732450 | Antifungal ketoconazole composition for topical use A pharmaceutical composition suitable for topical application comprising ketoconazole in a solution which comprises: (i) 13 to 50 wt % water; (ii) 45 to 85 wt % of an alcohol having a boiling point of less than 100° C.; and (iii) 2 to 30 wt % of a non-volatile, wat... | 06/08/2010 |
| 7446107 | Crystalline forms of conazoles and methods of making and using the same The invention provides novel soluble conazole crystalline forms (e.g. itraconazole, posaconazole and saperconazole) that include salts, co-crystals and related solvates useful as pharmaceuticals. The invention also provides pharmaceutical compositions comprising, an... | 11/04/2008 |
| 7427620 | Azole derivative useful as antifungal agents with reduced interaction with metabolic cytochromes The present invention relates to novel compounds, of the general formula (I), the N-oxide forms thereof, the salts thereof with pharmaceutically acceptable acids and the stereochemical isomers thereof, which are useful as antifungal agents; to pharmaceutical composi... | 09/23/2008 |
| 7417046 | Substituted pyrazoles Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S. ... | 08/26/2008 |
| 7393850 | Substituted pyrazoles Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S. ... | 07/01/2008 |
| RE40387 | Pharmaceutical compositions, dosage forms and methods for oral administration of epothilones The invention relates to methods of increasing the bioavailability of orally administered epothilones. Epothilones administered by the methods of the invention are sufficiently bioavailable to have a pharmacological effect. The invention further relates to pharmaceu... | 06/17/2008 |
| 7335660 | Isochroman compounds for treatment of CNS disorders This invention relates to compounds of formula (I) where R1 to R12, —W—V—, —X—Y—, p and n have the values defined in claim 1, their preparation and use as pharmaceuticals for the tre... | 02/26/2008 |
| 7311928 | Topical compositions containing tea tree oil for treatment of viral lesions A composition and method for treatment of viral-induced skin lesions, such as warts, are described. The composition is comprised of tea tree oil and/or derivatives from tea tree oil and one or more minerals, such as iodide and/or selenium. The composition is used to... | 12/25/2007 |
| 7309703 | Substituted pyrazoles Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S are described. ... | 12/18/2007 |
| 7193084 | Polymorphic form of itraconazole The present invention provides a polymorphic form of itraconazole. ... | 03/20/2007 |
| 7189415 | Rapidly disintegrable pharmaceutical composition The present invention relates to a pharmaceutical composition useful for rapid disintegration, which comprises a sparingly soluble medicament held on a gel-forming water-soluble polymer as a solid dispersion, wherein it contains a salt substance that comprises an al... | 03/13/2007 |
| 7179475 | Anhydrous topical skin preparations The present invention provides anhydrous compositions for topical delivery of a medicament comprising (A) a penetration enhancer/solvent selected from the group consisting of alcohol, propylene glycol, or a combination thereof; (B) a humectant/solvent selected from ... | 02/20/2007 |
| 7163689 | Intravenous valproate for acute treatment of migraine headache The present invention features a novel therapy for effecting acute treatment of migraine headache. The therapy involves intravenous administration of valproate and is equal to and in some respects superior to previously-known therapies for abortive treatment of prol... | 01/16/2007 |
| 7157464 | Substituted piperazines Compounds are provided that act as potent antagonists of the CCR1 receptor, and which have been further confirmed in animal testing for inflammation, one of the hallmark disease states for CCR1. The compounds are generally aryl piperazine derivatives and are useful ... | 01/02/2007 |
| 7122509 | High temperature foamer formulations for downhole injection Disclosed is a process for preparing a foamer composition having an anionic surfactant and a neutralizing amine. The process includes the steps of estimating an extent to which the anionic surfactant will decompose into acidic components under an elevated temperatur... | 10/17/2006 |
| 7109237 | Emulsion containing ascorbic acid and its uses in the cosmetics and dermatological fields A water-in-oil emulsion containing ascorbic acid and, as an emulsifier, a dimethiconecopolyol or an alkyldimethiconecopolyol, where the aqueous phase having a pH ranging from 5.5 to 7.5. This emulsion allows ascorbic acid to be stabilized and can be used, in particu... | 09/19/2006 |
| 7081255 | Antifungal compositions with improved bioavailability The present invention is concerned with novel pharmaceutical compositions of itraconazole which can be administered to a mammal suffering from a fungal infection, whereby a single such dosage form can be administered once daily, and in addition at any time of the da... | 07/25/2006 |
| 7078526 | CIS-itraconazole crystalline forms and related processes, pharmaceutical compositions and methods The invention provides novel soluble conazole crystalline forms (e.g. itraconazole, posaconazole and saperconazole) that include salts, co-crystals and related solvates useful as pharmaceuticals. The invention also provides pharmaceutical compositions comprising, an... | 07/18/2006 |
| 7071328 | Method for the preparation of 21-hydroxy-6,19-oxidoprogesterone (21 oh-6op) The present invention relates to a novel method for preparing 21-hydroxy-6,19-oxidopro-gesterone (21OH-6OP) and/or its 21-acetate, 21-propionate, 21-hemisuccinate, 21-phosphate, 21-oleate derivatives. 21OH-6OP and its ester derivatives are antiglucocorticoids for th... | 07/04/2006 |
| 7026308 | Topical anti-microbial compositions Disclosed are topical compositions for the treatment of microbial infections on the skin or scalp which include a polyvalent metal salt of pyrithione and include a metal ion source. Also disclosed are methods for treating microbial infections of the skin or scalp us... | 04/11/2006 |
| 7009169 | Method for measuring particle size distribution of a population of particles The present invention provides for measuring a particle size distribution of a population of particles using a light scattering particle sizing instrument having a plurality of selectable imaginary component values of the refractive index. The particles each having ... | 03/07/2006 |
| 6958337 | Crystalline antifungal polymorph The crystalline polymorph Form I of (−)-4-[4-[4-[4-[[(2R-cis)-5-(2,4-difluorophenyl)tetrahydro-5-(1H-1,2,4-triazol-1-ylmethyl)furan-3-yl]methoxy]phenyl]-1-piperazinyl]phenyl-2,4-dihydro-2-[(S)-1-ethyl-2(S)-hydroxylpropyl]-3H-1,2,4-triazol-3-one represented by the ... | 10/25/2005 |
| 6861432 | Piperazine derivatives that destabilize androgen receptors This invention relates to new piperazine derivatives of general formula I, in which V, W, n, R, R′, i, j, Y and Z have the meaning that is indicated in the description. The compounds according to the inventio... | 03/01/2005 |
| 6770306 | Drugs for reducing vaginal acidity and treatment of vaginitis, and the use thereof The present invention relates to a pharmaceutical composition for reducing vaginal acidity, treating abnormal enhancement of vaginal acidity, and high acidity vaginitis associated with abnormal enhancement of vaginal acidity, especially for the treatment of fungal v... | 08/03/2004 |
| 6759387 | Compositions and methods for enhancing drug delivery across and into epithelial tissues This invention provides compositions and methods for enhancing delivery of drugs and other agents across epithelial tissues, including the skin, gastrointestinal tract, pulmonary epithelium, and the like. The compositions and methods are also useful for delivery acr... | 07/06/2004 |
| 6713481 | Crystalline antifungal polymorph The crystalline polymorph Form I of (−)-4-[4-[4-[4-[[(2R-cis)-5-(2,4-difluorophenyl)tetrahydro-5-(1H-1,2,4-triazol-1-ylmethyl)furan-3-yl]methoxy]phenyl]-1-piperazinyl]phenyl-2,4-dihydro-2-[(S)-1-ethyl-2(S)-hydroxylpropyl]-3H-1,2,4-triazol-3-one represented by the ... | 03/30/2004 |
| 6680318 | Piperazinomethylbenzamides as delta-opioid receptor agonists The present application is directed to compounds having the general formula: ##STR1## and to the use of these compounds in therapeutic methods.... | 01/20/2004 |
| 6673373 | Antifungal formulation and the methods for manufacturing and using the same The present invention provides novel pharmaceutical compositions for azole antimicrobial drugs such as itraconazole, saperconazole, ketoconazole, and fluconazole. The pharmaceutical compositions are in the form of pellets which comprise a core and a drug ... | 01/06/2004 |
| 6670363 | Azole compounds as therapeutic agents for fungal infections The present invention relates to the derivatives of specially substituted azole compounds which have improved antifungal activity as compared to known compounds such as fluconazole and itraconazole and the processes for the preparation thereof. This inven... | 12/30/2003 |
| 6593292 | Compositions and methods for enhancing drug delivery across and into epithelial tissues This invention provides compositions and methods for enhancing delivery of drugs and other agents across epithelial tissues, including the skin, gastrointestinal tract, pulmonary epithelium, and the like. The compositions and methods are also useful for d... | 07/15/2003 |
| 6585963 | Nail compositions and methods of administering same Nail compositions and methods of use thereof are disclosed. Additionally, nail kits comprising a nail composition and pre-treatment compositions are disclosed. Further, supportive devices such as bandages for use in the administering a nail composition ar... | 07/01/2003 |
| 6583136 | Antifungal ethers The present invention concerns compounds of formula ##STR1## the N-oxide forms, the salts, the quaternary amines and stereochemically isomeric forms thereof, wherein D represents a tetrahydrofuran or dioxolane ring substituted with aryl and azolmethyl; --... | 06/24/2003 |
| 6576161 | Polyphosphate ester morpholides, mixtures thereof, and thermoplastic resin compositions containing polyphosphate ester morpholides as flame retardants The present invention relates to polyphosphate ester morpholides, compositions comprising mixtures thereof and thermoplastic resin compositions containing the polyphosphate ester morpholide composition as a flame retardant. The flame retardant composition... | 06/10/2003 |
| 6573266 | Piperazine derivatives and their use as anti-inflammatory agents This invention is directed to acyl piperazine derivatives of the following formula (Id): ##STR1## wherein R1b, R3, R4, R5, R6 and R10 are described herein. These derivatives are useful as a... | 06/03/2003 |
| 6552014 | Methods of inhibiting platelet activation with selective serotonin reuptake inhibitors The present invention pertains to methods for reducing the platelet activation state in an individual comprising administering a selective serotonin reuptake inhibitor (SSRI). The platelet activation state is reduced upon administering a SSRI, as measured... | 04/22/2003 |
| 6551583 | Antibiofouling method and apparatus for optical sensors An antibiofouling material, a method for making said antibiofouling material, a sensor apparatus employing said antibiofouling material, and a method of making said sensor apparatus. The disclosed antibiofouling material includes one or more biocides and ... | 04/22/2003 |
| 6545028 | Chemical compounds having ion channel blocking activity for the treatment of immune dysfunction This invention relates to treatment or alleviation of a disease, condition or disorder selected from inflammatory bowel disease, Chron's disease, colitis ulcerosa, Coeliac disease, dermatitis herpetiformis, dermatomyositis, enteritis allergia, erytherma n... | 04/08/2003 |
| 6511681 | Aqueous solubility pharmaceutical formulations A formulation of a sparingly water-soluble, crystalline pharmaceutically active agent wherein the active agent is converted to and stabilized in its amorphous form as a solid solution of a normally hydrophobic vehicle is described. The amorphous state is ... | 01/28/2003 |
| 6509038 | Antifungal compositions with improved bioavailability The present invention is concerned with novel pharmaceutical compositions of itraconazole which can be administered to a mammal suffering from a fungal infection, whereby a single such dosage form can be administered once daily, and in addition at any tim... | 01/21/2003 |
| 6497905 | Aqueous solubility pharmaceutical formulations A formulation of a sparingly water-soluble, crystalline pharmaceutically active agent wherein the active agent is converted to and stabilized in its amorphous form as a solid solution of a normally hydrophobic vehicle is described. The amorphous state is ... | 12/24/2002 |
