Class 514/254.03 - The additional five-membered hetero ring consists of two ring carbons, two ring nitrogens, and one ring chalcogen (e.g., oxadiazolyl, thiadiazolyl, etc.)

Subclass of Class 514 - Drug, bio-affecting and body treating compositions
Definition: Subject matter wherein the additional five-membered hetero
No. of patents: 154
Last issue date: 04/05/2011

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Number	Title	Issue Date
7919496	Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-CoA desaturase enzymes Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where x, y, G, J, K, L, M, W, V, R2, R3, ...	04/05/2011
7820674	Aminomethyl beta-secretase inhibitors for the treatment of alzheimer's disease The present invention is directed to aminomethyl compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed ...	10/26/2010
7799792	Metabotropic glutamate receptor oxadiazole ligands and their use as potentiators 841 Compounds of Formula I: wherein R1, R2, R3, R4 and Q are as described in the specification, pharmaceutically-acceptable salts, methods of making, pharmace...	09/21/2010
7601722	Aryl sulfamide derivatives and methods of their use The present invention is directed to aryl sulfamide derivatives of formula I: or a pharmaceutically acceptable salt, stereoisomer or tautomer thereof, which are monoamine reuptake inhibitors, compositions containing these d...	10/13/2009
7601721	Substituted heterocyclic compounds Disclosed are novel piperazine and piperazine derivatives, useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, diabetes, intermittent claudication, Prinzmetal's (variant) angina, stabl...	10/13/2009
7432264	Antimicrobial biaryl compounds Provided are antibacterial biaryl compounds having micromolar MIC activity against Gram-negative and Gram-positive pathogens, including a methicillin-resistant S. aureus strain. ...	10/07/2008
7427620	Azole derivative useful as antifungal agents with reduced interaction with metabolic cytochromes The present invention relates to novel compounds, of the general formula (I), the N-oxide forms thereof, the salts thereof with pharmaceutically acceptable acids and the stereochemical isomers thereof, which are useful as antifungal agents; to pharmaceutical composi...	09/23/2008
7414048	4,5-dihydro-isoxazole derivatives and their pharmaceutical use The present invention is concerned with the compounds of formula wherein m, n and p are each independently 0 or 1 and q is 0, 1, 2, 3, 4 or 5; -A1=A2-A3=A4- is a pyridinylidene, p...	08/19/2008
7405217	N-aroyl piperazine derivatives as orexin receptor antagonists This invention relates to N-aroyl cyclic amino derivatives and their use as pharmaceuticals. ...	07/29/2008
7342017	1,2,5-Thiadiazol-3-yl-piperazine therapeutic agents useful for treating pain, depression and anxiety A compound of formula: (wherein X, R1, R3, R4, and R5 are disclosed herein) or a pharmaceutically acceptable salt thereof (a “Thiadiazolylpiperazine Compound”), pharmaceutical...	03/11/2008
7300939	Substituted 1-propiolylpiperazine compounds, their preparation and use Substituted 1-propiolylpiperazine compounds corresponding to formula I in which X denotes N or C—R2, and n is an integer from 0 to 8, a method for producing such substituted 1-propiolylpiperazine com...	11/27/2007
7300936	α-(N-sulfonamido)acetamide derivatives as β-amyloid inhibitors There is provided a series of novel α-(N-sulfonamido)acetamide compounds of the Formula (I) wherein R, R1, R2 and R3 are defined herein, which are inhibitors of β-amyloid peptid...	11/27/2007
7271168	Piperazine derivatives having SST1 antagonistic activity The invention provides compounds of formula (1) wherein X, R1 and R2 are as defined in the specification, their, preparation and to their use in treating, e.g., depression, anxiety an...	09/18/2007
7241759	Benzo[1,2,5]thiadiazole compounds Certain amidophenyl-sulfanylamino-benzo[1,2,5]thiadiazole compounds are CCK2 modulators useful in the treatment of CCK2 mediated diseases. ...	07/10/2007
7220744	Monocyclic substituted phenyl methanones The present invention relates to compounds of formula I wherein R1, R2, X1, and X2 are as defined in the specification an...	05/22/2007
7220745	Heterocyclic compounds useful to treat HCV The present invention relates to substituted diphenyl heterocycle compounds and pharmaceutical compositions thereof that inhibit replication of HCV virus. The present invention also relates to the use of the compounds and/or compositions to inhibit HCV replication a...	05/22/2007
7189726	Benzofuran derivatives as inhibitors of p38-α kinase The invention is directed to methods to inhibit p38-α kinase using compounds which contain an aromatic residue coupled to an benzofuran moiety through a piperidine. ...	03/13/2007
7166608	-aroyl piperazine derivatives as orexin receptor antagonists This invention relates to N-aroyl piperazine derivatives of formula (I), wherein: Y represents NR2; m represents 1, 2 or 3; p represents 0 or 1; X is O, S, C═O, SO2, or CH═CH—; Ar1 is aryl, or a mono or bicyclic heteroaryl grou...	01/23/2007
7160886	Acylated piperazine derivatives as melanocortin-4 receptor agonists Certain novel N-acylated piperazine derivatives are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention of disease...	01/09/2007
7157464	Substituted piperazines Compounds are provided that act as potent antagonists of the CCR1 receptor, and which have been further confirmed in animal testing for inflammation, one of the hallmark disease states for CCR1. The compounds are generally aryl piperazine derivatives and are useful ...	01/02/2007
7119203	Piperidinyl- and piperazinyl-sulfonylmethyl hydroxamic acids and their use as protease inhibitors This invention is directed generally to proteinase (also known as “protease”) inhibitors, and, more particularly, to piperidinyl- and piperazinyl-sulfonylmethyl hydroxamic acids that, inter alia, inhibit matrix metalloproteinase (also known as “matrix metallop...	10/10/2006
7115639	Pyrrolidine oxadiazole- and thiadiazole oxime derivatives being oxytocin receptor antagonists The present invention is related to pyrrolidine oxadiazole and thiadiazole derivatives for use as pharmaceutically active compounds, as well as pharmaceutical formulations containing such pyrrolidine oxadiazole derivatives. Said pyrrolidine derivatives are useful in...	10/03/2006
7101898	Amides of aminoalkyl-substituted azetidines, pyrrolidines, piperidines and azepanes Novel amides of aminoalkyl-substituted azetidines, pyrrolidines, piperidines and azepanes, use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds, and a method of treatment employing these compounds and compositio...	09/05/2006
7056924	Substituted heterocyclic compounds Disclosed are novel heterocyclic derivatives, useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent claudication, Prinzmetal's (variant) angina, stable and unstable angina, ...	06/06/2006
7026314	Therapeutic chromone compounds Provided herein is a compound of the formula (I) wherein said compound is useful for the treatment of psychiatric disorders including but not limited to depression, generalized anxiety, eating, disorders, dementia, panic disorder, and sleep disorders. The compounds ...	04/11/2006
7026321	Substituted heterocyclic compounds Disclosed are novel heterocyclic derivatives, useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent claudication, Prinzmetal's (variant) angina, stable and unstable angina, ...	04/11/2006
7001909	Substituted heterocyclic compounds Disclosed are novel heterocyclic derivatives, useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent claudication, Prinzmetal's (variant) angina, stable and unstable angina, ...	02/21/2006
6974818	1,2,5-thiadiazol-3-YL-piperazine therapeutic agents useful for treating pain A compound of formula: (wherein X is O or S and R1, R3, R4, and R5 are disclosed herein) or a pharmaceutically acceptable salt thereof (a “Thiadiazolylpiperazine Compound�...	12/13/2005
6936611	Serine protease inhibitors Compounds of formula (I) in which R2, X, Y, Cy, L and Lp(D)n have the meanings given in the specification, are inhibitors of the serine protease, Factor Xa and are useful in the treatment of cardi...	08/30/2005
6930111	Substituted heterocyclic compounds Disclosed are novel heterocyclic derivatives, useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent claudication, Prinzmetal's (variant) angina, stable and unstable angina, ...	08/16/2005
6861432	Piperazine derivatives that destabilize androgen receptors This invention relates to new piperazine derivatives of general formula I, in which V, W, n, R, R′, i, j, Y and Z have the meaning that is indicated in the description. The compounds according to the inventio...	03/01/2005
6852739	Methods using proton pump inhibitors and nitric oxide donors The present invention describes novel nitrosated and/or nitrosylated proton pump inhibitor compounds, and novel compositions comprising at least one proton pump inhibitor compound that is optionally substituted with at least one NO and/or N02 group, and, ...	02/08/2005
6846825	Antibacterial agents Compounds of formula (II) are antibacterial agents wherein Q represents a radical of the formula: —N(OH)CH(═O) or the formula: —C(═O)NH(OH); R1 represents hydrogen, C1-C6 alkyl or C1-C6 alkyl substituted...	01/25/2005
6838461	N-(indolcarbonyl-)piperazine derivatives Compounds of the formula I in which R1, R2, R4 and R5 have the meanings indicated in claim 1, are potent 5-HT2A antagonists and are suitable for the treatme...	01/04/2005
6833369	Angiogenesis inhibiting 5-substituted-1,2,4,-thiadiazolyl derivatives This invention concerns compounds of formula the N-oxide forms, the pharmaceutically acceptable acid addition salts and stereochemically isomeric forms thereof, wherein X is CH or N; R1 is hydrogen, C1-...	12/21/2004
6818644	Substituted piperazine derivatives, the preparation thereof and their use as medicaments The present invention relates to substituted piperazine derivatives of general formula wherein Ra, Rb, Rc Rf, Rg and m, n and X ...	11/16/2004
6747030	Piperazine derivatives as 5-HT1B antagonists Piperazine derivatives of formula(1), processes for their preparation, pharmaceutical compositions containing them in the treatment of CNS and other disorders and in their use in therapy as 5-HT1B antagonists ...	06/08/2004
6649609	Benzimidazole derivatives and pharmaceutical compositions comprising these compounds The present invention relates to novel 1-phenylbenzimidazole derivatives having particular alkoxycarbonyl substituents in the 5-position of the benz ring and having particular cyclic substituents in the meta-position of the phenyl ring, as well as to phar...	11/18/2003
6642238	Oxazolidinone thioamides with piperazine amide substituents The present invention provides a compound of formula I ##STR1## which have potent activities against gram-positive and gram-negative bacteria....	11/04/2003
6624165	Cyclopentene derivatives useful as antagonists of the motilin receptor The compounds of formula I are useful in treating gastrointestinal disorders associated with antagonizing the motilin receptor. The compounds compete with erythromycin and motilin for the motilin receptor. In addition the compounds are antagonists of the ...	09/23/2003

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Class 514/254.03 - The additional five-membered hetero ring consists of two ring carbons, two ring nitrogens, and one ring chalcogen (e.g., oxadiazolyl, thiadiazolyl, etc.)