Quotables
"The horse is here to stay, the automobile is only a novelty - fad."
President of Michigan Savings Bank ; 1903
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 8168640 | Cosmetic use of 1-aroyl-N-(2-oxo-3-piperidinyl)-2-piperazine carbomamides and related compounds Cosmetic compositions comprising 1-aroyl-N-(2-oxo-3-piperidinyl)-2-piperazine carboxamides and methods of using such compositions to impart anti-aging benefits to the skin are disclosed. The 1-aroyl-N-(2-oxo-3-piperidinyl)-2-piperazine carboxamides are believed to h... | 05/01/2012 |
| 8133894 | N-benzyl-4-methyleneamino-3-hydroxy-2-pyridones Compounds of Formula (I) are effective in the treatment of a microbial infection. ... | 03/13/2012 |
| 7994175 | Cosmetic use of 1-aroyl-N-(2-oxo-3-piperidinyl)-2-piperazine carboxamides and related compounds Cosmetic compositions comprising 1-aroyl-N-(2-oxo-3-piperidinyl)-2-piperazine carboxamides and methods of using such compositions to impart anti-aging benefits to the skin are disclosed. The 1-aroyl-N-(2-oxo-3-piperidinyl)-2-piperazine carboxamides are believed to h... | 08/09/2011 |
| 7989455 | Compounds, compositions and methods Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure. ... | 08/02/2011 |
| 7939532 | Heterocyclyl pyridyl sulfonamide derivatives, their manufacture and use as pharmaceutical agents Objects of the present invention are the compounds of formula I, their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above compounds, medicaments containing them and their manufacture, as well as the us... | 05/10/2011 |
| 7915261 | Pyridyl non-aromatic nitrogen-containing heterocyclic-1-carboxylate compound A novel pyridyl non-aromatic nitrogen-containing heterocyclic-1-carboxylate compound or its pharmaceutically acceptable salt has a potent FAAH-inhibitory activity. Further, the pyridyl non-aromatic nitrogen-containing heterocyclic-1-carboxylate compound of the prese... | 03/29/2011 |
| 7754724 | N-substituted piperazines Novel N-alkyl substituted piperazines have been discovered, which are useful as insecticides or fungicides. Such compounds are of Formula (I) wherein X, Y, R1 and R2 are as defined herein. ... | 07/13/2010 |
| 7700599 | Gpr38 Receptor Agonists The invention relates to compounds of formula (I) processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of conditions or disorders which are mediated via the GPR38 recep... | 04/20/2010 |
| 7482348 | Piperazinyl substituted cyclohexane-1,4-diamines The present invention relates to piperazine substituted cyclohexane-1,4-diamine compounds of Formula (I) and pharmaceutically acceptable forms thereof, as α1a/α1d adrenoreceptor modulators for the tr... | 01/27/2009 |
| 7423039 | (4-phenylpiperazin-1-yl)acylpiperidine derivatives, preparation thereof and application of same in therapeutics The invention relates to substituted (4-phenylpiperazin-1-yl)acylpiperidine derivatives of formula (I) in the form of a base or an addition salt with an acid, and also in the form of a hydrate or solvate, and their preparat... | 09/09/2008 |
| 7410970 | Substituted 1,4,-di-piperidin-4-yl-piperazine derivatives and their use as neurokinin antagonists The invention concerns substituted 1,4-di-piperidin-4-yl-piperazine derivatives having neurokinin antagonistic activity, in particular NK1 antagonistic activity, their preparation, compositions comprising them and their use as a medicine, in particular fo... | 08/12/2008 |
| 7378420 | Urea derivatives as calcium channel blockers Derivatives of urea that contain piperazine rings and additional substitution with aromatic groups are effective in ameliorating conditions associated with unwanted calcium ion channel activity. ... | 05/27/2008 |
| 7314879 | Melanocortin receptor agonists The present invention relates to melanocortin receptor agonist of the formula (I): which is useful in the treatment for obesity, diabetes, and male and/or female sexual dysfunction ... | 01/01/2008 |
| 7288545 | Piperazinedione compounds This invention relates to a method for treating an angiogenesis-related disease. The method includes administering to a subject in need thereof an effective amount of a piperazinedione compound having the formula: | 10/30/2007 |
| 7279470 | Compounds and uses thereof for decreasing activity of hormone-sensitive lipase Use of compounds to inhibit hormone-sensitive lipase, pharmaceutical compositions comprising the compounds, methods of treatment employing these compounds and compositions, and novel compounds. The present compounds are inhibitors of hormone-sensitive lipase and may... | 10/09/2007 |
| 7271168 | Piperazine derivatives having SST1 antagonistic activity The invention provides compounds of formula (1) wherein X, R1 and R2 are as defined in the specification, their, preparation and to their use in treating, e.g., depression, anxiety an... | 09/18/2007 |
| 7230017 | Dihydropyridinone derivatives The invention relates to novel dihydropyridinone derivatives, processes for their preparation, and their use in medicaments, especially for the treatment of chronic obstructive pulmonary diseases, acute coronary syndrome, acute myocardial infarction and heart failur... | 06/12/2007 |
| 7226925 | Compounds, their use and preparation The invention relates to compounds of the general Formula (I): The compounds may be prepared by per se conventional methods and can be used for treating a human or animal subject suffering from a serotonin-related ... | 06/05/2007 |
| 7223757 | Tyrosine kinase inhibitors The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase enzymes thereby making them useful as anti-cancer agent... | 05/29/2007 |
| 7119203 | Piperidinyl- and piperazinyl-sulfonylmethyl hydroxamic acids and their use as protease inhibitors This invention is directed generally to proteinase (also known as “protease”) inhibitors, and, more particularly, to piperidinyl- and piperazinyl-sulfonylmethyl hydroxamic acids that, inter alia, inhibit matrix metalloproteinase (also known as “matrix metallop... | 10/10/2006 |
| 7101885 | Piperazinyl-aryloxy and piperazinyl-heteroaryloxy-n-aryl lactams The present invention relates to compounds of formula I wherein Ar, Y and G are as defined in the specification, a is 1 to 4, Z and W are carbon or nitrogen and n is 1, 2 or 3; and to pharmaceutical compositions ... | 09/05/2006 |
| 7034042 | N-(4-aryloxypiperidin-1-ylalkyl) cinnamic amides as CCR33 receptor antagonists Compounds of formula (I) in free or salt form, where Ar1 is phenyl substituted by one or more substituents selected from halogen, cyano, nitro, and C1–C8-alkyl optionally substituted by cyano or halogen, Ar2 is phenyl op... | 04/25/2006 |
| 7009051 | 4-(2-pyridyl) piperazines having 5HT7 receptor agonist activity The present invention relates to compounds of the formula I wherein R1, R2, R3, X and Y are defined as in the specification. Those compounds are 5HT7 partial agonists and are useful in t... | 03/07/2006 |
| 6974817 | Sulfonic acid derivatives A compound of the formula or the pharmaceutically acceptable salt thereof; wherein X, Y, a, b, c, d, R1, R2, R3 and R5 are as defined above useful to treat inflammation and o... | 12/13/2005 |
| 6953801 | Melanin concentrating hormone receptor ligands: substituted 1-benzyl-4-aryl piperazine analogues Melanin concentrating hormone receptor ligands (especially 1-benzyl-4-aryl-piperazines, 1-benzyl-4-aryl-piperidines and related compounds), capable of modulating MCH receptor activity, are provided. Such ligands may be used to modulate MCH binding to MCH receptors i... | 10/11/2005 |
| 6949552 | Remedial agent for anxiety neurosis or depression and piperazine derivative There are provided a therapeutic preparation for anxiety neurosis or depression which comprises a MC4 receptor antagonist as an effective ingredient; and a piperazine derivative represented by Formula [1]: [... | 09/27/2005 |
| 6936610 | Heterocyclic derivatives The invention relates to heterocyclic derivatives of formula (I) A—B—X1—T1(R2)—L1—T2(R3)—X2—Q (I) or pharmaceutically-acceptable salts thereof, which ... | 08/30/2005 |
| 6924289 | Benzyl(Idene)-lactam derivatives, their preparation and their use as selective (ANT) agonists of 5-HT1A- and/or 5-HT1D receptors The present invention relates to lactam derivatives of the formula wherein R1, R2, R3, A, X, Z, n and the dashed line are defined herein, and pharmaceutical compositions thereof, to pro... | 08/02/2005 |
| 6897218 | Nitric oxide donors based on metallic centers A metal complex of a piperazineNONOate derivative of the formula: wherein a) R1 and R2 independently represent hydrogen, linear or branched (C1-C4) alkyl, optionally substitu... | 05/24/2005 |
| 6706716 | Compounds specific for the human α1d adrenergic receptor and uses thereof This invention is directed towards a method of inhibiting activation of a human α1d adrenergic receptor which comprises contacting the receptor with a compound so as to inhibit activation of the receptor, wherein the compound binds selectively to a human... | 03/16/2004 |
| 6635649 | Piperazinedione compounds Piperazinedione compounds of the formula: ##STR1## Each of and {character pullout} and {character pullout} independently, is a single bond or a double bond; A is H or CH(Ra Rb) when {character pullout} is a single bond, or C(Ra | 10/21/2003 |
| 6608060 | Inhibitors of p38 The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides... | 08/19/2003 |
| 6559140 | Cyclic and bicyclic diamino histamine-3 receptor antagonists Compounds of formula (I) ##STR1## compounds of formula (II) ##STR2## compounds of formula (III) ##STR3## and compounds of formula (IV) ##STR4## or pharmaceutically acceptable salts thereof are useful as H3 receptor antagonists. Proces... | 05/06/2003 |
| 6462048 | Benzyl(idene)-lactam derivatives, their preparation and their use as selective (ant)agonists of 5-HT1A- and/or 5-HT1D receptors The present invention relates to lactam derivatives of the formula ##STR1## wherein R1, R2, R3, A, X, Z, n and the dashed line are defined herein, and pharmaceutical compositions thereof, to processes and intermediates for... | 10/08/2002 |
| 6455528 | Piperazine compounds and medicinal use thereof The present invention relates to a piperazine compound of the formula ##STR1## wherein R1 and R2 are each hydrogen, halogen, lower alkyl, lower alkoxy, amino, substituted amino, nitro, hydroxy or cyano, R3, R4 a... | 09/24/2002 |
| 6448270 | 4-substituted piperidine analogs and their use as subtype selective NMDA receptor antagonists Novel 4-substituted piperidine analogs, pharmaceutical compositions containing the same and the method of using the 4-substituted piperidine analogs as selectively active antagonists of N-methyl-D-aspartate (NMDA) receptor subtypes for treating conditions... | 09/10/2002 |
| 6448250 | Sulfamato hydroxamic acid metalloprotease inhibitor A sulfamato hydroxamic acid compound that inter alia inhibits matrix metalloprotease activity is disclosed as are a process for preparing the same, intermediate compounds useful in those syntheses, and a treatment process that comprises administering a co... | 09/10/2002 |
| 6432956 | Method for treatment of sleep apneas Certain azapirone compounds and their pharmaceutically acceptable salts are useful in the treatment of sleep apneas.... | 08/13/2002 |
| 6420366 | 1-(4-arylpiperazin-1-yl)-ω-[N-(ω-dicarboximido)]-alkanes useful as uro-selective 댑-adrenoceptor blockers Novel piperzine derivatives substituted on one nitrogen by an aromatic system and on the other nitrogen by (2,5-dioxopyrrolidin)-1-yl) alkanes or (2,6-dioxopiperidin-1-yl) alkanes have been found to exhibit selective adrenergic activi... | 07/16/2002 |
| 6420385 | Substituted pyrimidinone and pyridone compounds and methods of use Selected novel substituted pyrimidinone and pyridone compounds are effective for prophylaxis and treatment of diseases, such as TNF-, IL-1ଲ, IL-6 and/or IL-8 mediated diseases, and other maladies, such as pain and diabetes. The invention enco... | 07/16/2002 |
