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| Number | Title | Issue Date |
| 8097629 | Dihydropyridinone derivatives The invention relates to novel dihydropyridinone derivatives, processes for their preparation, and their use in medicaments, especially for the treatment of chronic obstructive pulmonary diseases, acute coronary syndrome, acute myocardial infarction and heart failur... | 01/17/2012 |
| 8008305 | TAAR1 ligands The invention relates to a compound of formula wherein R1, R2, X, L, W, n, and o are defined herein and to pharmaceutically suitable acid addition sa... | 08/30/2011 |
| 7816362 | Serotonergic agents Novel piperazine derivatives are provided having the formula wherein R1 is cyano, nitro, trifluoromethyl or halogen, or pharmaceutically acceptable acid addition salts thereof, which are useful as 5-HT1A | 10/19/2010 |
| 7713978 | Compounds The present invention relates to compounds of formula (I) processes for their preparation, pharmaceutical compositions containing the same and to their use in the treatment of gastrointestinal and other disorders. ... | 05/11/2010 |
| 7446106 | Pyridylfurans and pyrroles as Raf kinase inhibitors Compounds and their use as pharmaceuticals particularly as Raf kinase inhibitors for the treatment of neurotraumatic diseases, cancer, chronic neurodegeneration, pain, migraine and cardiac hypertrophy. ... | 11/04/2008 |
| 7435736 | Substituted 1-piperidin-4-yl-4-azetidin-3-yl-piperazine derivatives and their use as neurokinin antagonists The invention concerns substituted 1-piperidin-4-yl-4-azetidin-3-yl-piperazine having neurokinin antagonistic activity, in particular NK1 and NK1/NK3-antagonistic activity, their preparation, compositions comprising them and their us... | 10/14/2008 |
| 7432264 | Antimicrobial biaryl compounds Provided are antibacterial biaryl compounds having micromolar MIC activity against Gram-negative and Gram-positive pathogens, including a methicillin-resistant S. aureus strain. ... | 10/07/2008 |
| 7425558 | Serotonergic agents for treating sexual dysfunction Methods and compositions are provided for treating sexual dysfunction, e.g., sexual dysfunction associated with drug treatment, using 5-HT1A receptor antagonists. ... | 09/16/2008 |
| 7423039 | (4-phenylpiperazin-1-yl)acylpiperidine derivatives, preparation thereof and application of same in therapeutics The invention relates to substituted (4-phenylpiperazin-1-yl)acylpiperidine derivatives of formula (I) in the form of a base or an addition salt with an acid, and also in the form of a hydrate or solvate, and their preparat... | 09/09/2008 |
| 7419980 | Fused-aryl and heteroaryl derivatives and methods of their use The present invention is directed to fused-aryl and heteroaryl derivatives, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms... | 09/02/2008 |
| 7384944 | Piperazine derivatives useful as CCR5 antagonists The use of CCR5 antagonists of the formula or a pharmaceutically acceptable salt thereof, wherein R is optionally substituted phenyl, pyridyl, thiophenyl or naphthyl; R | 06/10/2008 |
| 7345042 | MCH antagonists for the treatment of obesity The present invention discloses methods of using antagonists for melanin-concentrating hormone (MCH), to treat obesity, metabolic disorders, eating disorders such as hyperphagia, and diabetes, as well as novel compounds which are antagonists for melanin-concentratin... | 03/18/2008 |
| 7307081 | Piperidine derivatives useful as CCR5 antagonists The present invention provides a compound of the formula or a pharmaceutically acceptable salt or solvate thereof, wherein the various moieties are as defined in the specification. The present invention also provides pharma... | 12/11/2007 |
| 7288545 | Piperazinedione compounds This invention relates to a method for treating an angiogenesis-related disease. The method includes administering to a subject in need thereof an effective amount of a piperazinedione compound having the formula: | 10/30/2007 |
| 7247631 | Pegylated interferon alfa-CCR5 antagonist combination HIV therapy Methods for treating treatment-naive as well as treatment-experienced adult and pediatric patients having HIV-1 infections as well as patients co-infected with HIV-1 and HCV involving administering a therapeutically effective amount of pegylated interferon-alfa, e.g... | 07/24/2007 |
| 7241764 | 4(phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain or gastrointestinal disorders Compounds of general formula:[Chemical formula should be inserted here. Please see paper copy] wherein R1, R2, and R3 are as defined in the specification, as well as salts, enantiomers thereof and pharmaceutical compositions includin... | 07/10/2007 |
| 7229997 | Compounds and their use Compounds of the general formula (I): wherein R1, R2, R3 and R4 are as described in the specification. F... | 06/12/2007 |
| 7214679 | Piperidine/piperazine-type inhibitors of p38 kinase Compounds of the formula: wherein the substituents are as defined herein are useful for treating conditions mediated by p38 kinase. ... | 05/08/2007 |
| 7196080 | Phenylpyridinecarbonylpiperazinederivative The present invention relates to a compound which is represented by the following general formula and has type 4 phosphodiesterase inhibitory action, and uses and an intermediate compound thereof. (wherein ... | 03/27/2007 |
| 7196106 | Cyanothiophene derivatives, compositions containing such compounds and methods of use The present invention addresses substituted cyanothiophene derivatives of the formula I: as well as compositions containing such compounds and methods of treatment. The compounds in the present invention are gluc... | 03/27/2007 |
| 7135465 | Sustained release beadlets containing stavudine Extended dosage forms of stavudine are provided comprising beadlets formed by extrusion-spheronization and coated with a seal coating. The beadlets are also coated with a modified release coating such that a hard gelatin capsule containing such beadlets will provide... | 11/14/2006 |
| 7119203 | Piperidinyl- and piperazinyl-sulfonylmethyl hydroxamic acids and their use as protease inhibitors This invention is directed generally to proteinase (also known as “protease”) inhibitors, and, more particularly, to piperidinyl- and piperazinyl-sulfonylmethyl hydroxamic acids that, inter alia, inhibit matrix metalloproteinase (also known as “matrix metallop... | 10/10/2006 |
| 7104267 | Planarized copper cleaning for reduced defects A process for treating a copper or copper alloy substrate surface with a composition and corrosion inhibitor solution to minimize defect formation and surface corrosion, the method including applying a composition including one or more chelating agents, a pH adjusti... | 09/12/2006 |
| 7101885 | Piperazinyl-aryloxy and piperazinyl-heteroaryloxy-n-aryl lactams The present invention relates to compounds of formula I wherein Ar, Y and G are as defined in the specification, a is 1 to 4, Z and W are carbon or nitrogen and n is 1, 2 or 3; and to pharmaceutical compositions ... | 09/05/2006 |
| 7098213 | CCR5 antagonists useful for treating AIDS Compounds of the formula or a pharmaceutically acceptable salt or isomer thereof, wherein: Q, X and Z are CH or N; R, R4–R7 and R13... | 08/29/2006 |
| 7091219 | Bis-sulfonamide hydroxyethyl-amino retroviral protease inhibitors Bis-sulfonamido hydroxyethylamino compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to retroviral protease inhibiting compounds of the formula: | 08/15/2006 |
| 7071191 | Non-imidazole aryloxypiperidines Substituted non-imidazole aryloxypiperidine compounds, compositions containing them, and methods of making and using them to treat or prevent histamine-mediated conditions. ... | 07/04/2006 |
| 7067518 | Pyridinyl-methyl-ethyl cyclohexanecarboxamides as serotonergic agents A compound having 5-HT1A receptor activity, represented by the chemical formula wherein: Ar is 2-methoxyphenyl, 1H-indol-4-yl or 2,3-dihydro-1,4-benzodioxin-5-yl; R1 | 06/27/2006 |
| 7067517 | Use of compounds for decreasing activity of hormone-sensitive lipase Use of compounds to inhibit hormone-sensitive lipase, pharmaceutical compositions comprising the compounds, methods of treatment employing these compounds and compositions, and novel compounds. The present compounds are inhibitors of hormone-sensitive lipase and may... | 06/27/2006 |
| 7057042 | Fused bicyclic aromatic compounds that are useful in treating sexual dysfunction The present invention relates to the use of compounds of formula (I) for the treatment of sexual dysfunction and to compositions containing compounds of formula (I) for the treatment of sexual dysfunction, wherei... | 06/06/2006 |
| 7026314 | Therapeutic chromone compounds Provided herein is a compound of the formula (I) wherein said compound is useful for the treatment of psychiatric disorders including but not limited to depression, generalized anxiety, eating, disorders, dementia, panic disorder, and sleep disorders. The compounds ... | 04/11/2006 |
| 7026320 | Serotonergic agents Novel piperazine derivatives are provided having the formula wherein R1 is cyano, nitro, trifluoromethyl or halogen, or pharmaceutically acceptable acid addition salts thereof, which are useful as 5-HT1A... | 04/11/2006 |
| 7019008 | Pyrrolidine sulfonamides A compound of Formula (I): wherein: R1 is C1-6 alkyl, benzyl, or (CH2)n—C(O)NH2; wherein the benzyl may be unsubstituted or substituted by one or two... | 03/28/2006 |
| 7012030 | Very low dielectric constant plasma-enhanced CVD films The present invention provides a method for depositing nano-porous low dielectric constant films by reacting an oxidizable silicon containing compound or mixture comprising an oxidizable silicon component and an oxidizable non-silicon component having thermally liab... | 03/14/2006 |
| 7008946 | CCR5 antagonists useful for treating AIDS Compounds of the formula or a pharmaceutically acceptable salt or isomer thereof, wherein: Q, X and Z are CH or N; R, R4–R7 and R13 ... | 03/07/2006 |
| 6992189 | Synthesis of piperidine and piperazine compounds as CCR5 antagonists In its several embodiments, this invention discloses novel processes to prepare the compounds of formula II and formula IV: ... | 01/31/2006 |
| 6958331 | Bradykinin receptor antagonists The invention relates to sulfonyl amine derivatives of formula IA wherein R5A, X1, X2, R9 and R10 are as defined herein, which derivatives are useful as bradykinin... | 10/25/2005 |
| 6924376 | Compounds, compositions and methods Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed. ... | 08/02/2005 |
| 6916817 | Inhibitors of metalloproteinases Arylpiperazines of Formula I useful as metalloproteinase inhibitors, especially as MMP13 inhibitors. ... | 07/12/2005 |
| 6900315 | 2-amino-9H-purin-9-yl compounds and methods for inhibiting/treating HIV infections and AIDS related symptoms The present invention relates to novel compounds, compositions and methods for inhibiting the growth, elaboration and/or replication of HIV in human patients and to the prevention and treatment of human acquired immunodeficiency syndrome (AIDS) and other diseases ca... | 05/31/2005 |
