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| Number | Title | Issue Date |
| 8034817 | Treatment of bacterial diseases of the respiratory organs The invention relates to inhalable quinolonecarboxylic acid derivative compositions for local control of diseases of the respiratory organs, in particular of lung diseases. ... | 10/11/2011 |
| 7902198 | Crystalline aripiprazole solvates Alcoholates of aripiprazole are useful as pharmaceuticals and/or as intermediates in making aripiprazole Form A or Form B. ... | 03/08/2011 |
| 7691862 | Method and composition for treating periodontal disease The present invention is directed to a pharmaceutical composition comprising a therapeutically effective amount of misoprostol and an effective amount of an antibiotic. A suitable antibiotic is selected from the group consisting of doxycycline, gentamicin, tobramici... | 04/06/2010 |
| 7435737 | Inhibitors of macrophage migration inhibitory factor and methods for identifying the same Inhibitors of MIF are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with MIF activity. The inhibitors of MIF have the following structures: | 10/14/2008 |
| 7429580 | Compositions of an anticonvulsant and an antipsychotic drug and methods of using the same for affecting weight loss Disclosed are compositions for affecting weight loss comprising a first compound and a second compound, where the first compound is a psychotherapeutic agent and the second compound is a anticonvulsant. Also disclosed are methods of affecting weight loss, increasing... | 09/30/2008 |
| 7381402 | Stable pharmaceutical solution formulations for pressurized metered dose inhalers Aerosol solution formulations for use in an aerosol inhaler which comprise 8-hydroxy-5-[(1R)-1-hydroxy-2-[[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino]-ethyl]-2(1H)-quinolinone or a salt thereof, in particular the hydrochloride salt (TA 2005), as an active ingredie... | 06/03/2008 |
| 7320985 | Method for stabilizing arylcarboxylic acid, stabilizer thereof and aqueous solution containing stabilized arylcarboxylic acid A method for stabilizing an arylcarboxylic acid, which comprises adding a heterocyclic base to the arylcarboxylic acid or a pharmacologically acceptable salt thereof, a stabilizer thereof and an aqueous solution containing a stabilized arylcarboxylic acid. According... | 01/22/2008 |
| 7273870 | Stabilized difloxacin injectable solution An antibacterial formulation suitable for injection into animals containing approximately 2-10% w/v difloxacin HCl, L-arginine base, propylene glycol, ethanol and/or benzyl alcohol, and water. The formulation is a solution having a pH of form 9 to 10. The formulatio... | 09/25/2007 |
| 7265107 | Rifamycin C-11 oxime cyclo derivatives effective against drug-resistant microbes The current invention relates to a series of rifamycin derivatives having antimicrobial activities, including activities against drug-resistant microorganisms, specifically, the 3,4-cyclo-rifamycin derivatives having an oxime group at the C-11 position. ... | 09/04/2007 |
| 7256187 | Rifamycin C-11 oxime derivatives effective against drug-resistant microbes The invention relates to rifamycin derivatives having antimicrobial activities, including activities against drug-resistant microorganisms, specifically, the rifamycin derivatives having an oxime group at the C-11 position. ... | 08/14/2007 |
| 7247641 | Compounds, derivatives, compositions, preparation and uses This invention relates to compounds, pharmaceutical compositions, and methods of using the disclosed compounds for inhibiting PARP. ... | 07/24/2007 |
| 7247634 | Rifamycin derivatives effective against drug-resistant microbes Rifamycin derivatives having antimicrobial activities, including activities against drug-resistant microorganisms are claimed in this invention. The inventive rifamycin derivatives are uniquely designed in that they have a rifamycin moiety covalently linked to a lin... | 07/24/2007 |
| 7241746 | Method and composition for treating periodontal disease The present invention is directed to a pharmaceutical composition comprising a therapeutically effective amount of misoprostol and an effective amount of an antibiotic. A suitable antibiotic is selected from the group consisting of doxycycline, gentamicin, tobramici... | 07/10/2007 |
| 7238694 | Rifamycin imino derivatives effective against drug-resistant microbes The present invention relates to rifamycin 3-iminomethylenyl (—CH═N—) derivatives having antimicrobial activities, including activities against drug-resistant microorganisms. The claimed rifamycin derivative has a rifamycin moiety covalently linked to a linker... | 07/03/2007 |
| 7202248 | Inhibitors of macrophage migration inhibitory factor and methods for identifying the same Inhibitors of MIF are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with MIF activity. The inhibitors of MIF have the following structures: | 04/10/2007 |
| 7192961 | Inhibitors of macrophage migration inhibitory factor and methods for identifying the same Inhibitors of MIF are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with MIF activity. The inhibitors of MIF have the following structures: | 03/20/2007 |
| 7176313 | Anti acid-fast bacterial agent containing pyridonecarboxylic acids as active ingredient An anti acid-fast bacterial agent containing, as an active ingredient, a pyridonecarboxylic acid derivative represented by the following general formula (1), a salt thereof, or a hydrate thereof, which shows excellent antibacterial activity against Mycobacterium ... | 02/13/2007 |
| 7176206 | Antibiotics The invention provides compounds of the general formula: wherein X is selected from the group consisting of oxygen, sulfur and nitrogen-containing groups selected from azine, ox... | 02/13/2007 |
| 7166301 | Immediate release medicinal compositions for oral use The present invention relates to an immediate release oral pharmaceutical composition which comprises as an active ingredient calcium salt of a benzylsuccinic acid derivative represented by the formula: or its hy... | 01/23/2007 |
| 7105519 | Inhibitors of macrophage migration inhibitory factor and methods for identifying the same Inhibitors of MIF are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with MIF activity. The inhibitors of MIF have the following structures: ... | 09/12/2006 |
| 7098219 | Inhibitors of cellular efflux pumps of microbes Compounds are described which are efflux pump inhibitors of cellular efflux pumps of microbes. Also described are methods of preparing such compounds, methods of using such efflux pump inhibitor compounds and pharmaceutical compositions which include such compounds.... | 08/29/2006 |
| 7084141 | Inhibitors of macrophase migration inhibitory factor and methods for identifying the same Inhibitors of MIF are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with MIF activity. The inhibitors of MIF have the following structures: | 08/01/2006 |
| 7049271 | Phenyl-substituted 2-enamino-ketonitriles The present invention relates to novel phenyl-substituted 2-enamino-ketonitriles of the formula (I): in which Ar, X, Z, Y and K are each as defined in the description, to a plurality of pro... | 05/23/2006 |
| 6995156 | Platelet adenosine diphosphate receptor antagonists Compounds of the following formula (I): where a, b, R1, R2, R3, R4 and R6 are described herein, are useful as inhibitors of platelet adenosine diphosphate. Pharmace... | 02/07/2006 |
| 6949241 | Use of lacrophyl preparation in eye drops containing therapeutically active compounds The invention refers to the use of a lacrophyl preparation containing lysozyme, tris(hydroxymethyl)aminomethane, if desired other lacrophyl components, preferably ascorbic acid and/or citric acid and/or ethylenediamine-tetraacetic acid, in the rest distilled water f... | 09/27/2005 |
| 6908745 | Gamma sterilizable culture medium for the identification of yeasts and fungi Gamma sterilizable culture medium for the selectively identification of yeasts and fungi with an addition of ciprofloxacin and, if necessary streptomycin or other antibiotics. ... | 06/21/2005 |
| 6890526 | Methods and reagents for the treatment of multiple sclerosis The invention features methods and reagents for the diagnosis, monitoring, and treatment of multiple sclerosis. The invention is based in part on the discovery that Chlamydia is present in patients with multiple sclerosis, and that anti-chlamydial agents impr... | 05/10/2005 |
| 6872723 | Stabilized difloxacin injectable solution An antibacterial formulation suitable for injection into animals containing approximately 2-10% w/v difloxacin HCl, L-arginine base, propylene glycol, ethanol and/or benzyl alcohol, and water. The formulation is a solution having a pH of form 9 to 10. The formulatio... | 03/29/2005 |
| 6861424 | Platelet adenosine diphosphate receptor antagonists Compounds of the following formula (I): where a, b, R1, R2, R3, R4 and R6 are described herein, are useful as inhibitors of platelet adenosine diphosphate. Pharmac... | 03/01/2005 |
| 6803369 | Compounds and methods for the treatment of neoplastic disease A method of modulating the activity of a aberrant cell topoisomerase enzyme involving contacting the enzyme with a compound that inhibits enzyme-mediated cleavage of a polynucleotide substrate with which the enzyme is in complex. Pharmaceutical compositions containi... | 10/12/2004 |
| 6770650 | Cyclic amine derivatives-CCR-3 receptor antagonists This invention relates to certain cyclic amine derivatives of Formula (I) that are CCR-3 receptor antagonists, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.... | 08/03/2004 |
| 6699492 | Quinolone carboxylic acid compositions and related methods of treatment The present invention relates to the use of quinolone carboxylic acid formulations in the treatment of ocular and periocular infections. The present invention also relates to sustained release compositions comprising specific quinolone carboxylic acid com... | 03/02/2004 |
| 6613770 | Quinoline derivatives as NK-2 and NK-3 receptor ligands A compound, or a solvate or a salt thereof, of formula (I): ##STR1## wherein R is linear or branched alkyl; R1 represents hydrogen or up to four optional substituents selected from the list consisting of: C1-6 alkyl, C1-6 a... | 09/02/2003 |
| 6605295 | Storage-stable ophthalmic compositions comprising diclofenac and ofloxacin The invention relates to stable ophthalmic preparations including the penetrant antiphlogistic diclofenac or salts thereof and the penetrant antibiotic ofloxacin present in the form of the racemate, an enantiomer, particularly levofloxacin, or the corresp... | 08/12/2003 |
| 6589955 | Pediatric formulation of gatifloxacin There is provided in accordance with the present invention the quinolone antibacterial gatifloxacin adequately taste-masked so that it can be utilized for pediatric formulations. A crystalline co-precipitate of gatifloxacin and one or both of stearic acid... | 07/08/2003 |
| 6534508 | Methods and compositions for treating infection using optically pure (S)-lomefloxacin Methods and compositions are disclosed utilizing the optically pure (S)-isomer of lomefloxacin to treat bacterial infection. In particular, this compound is a potent drug for the treatment of Mycobacteria infection.... | 03/18/2003 |
| 6528517 | Synthesis of quinobenzoxazine analogues with topoisomerase II and quadruplex interactions for use as antineoplastic agents The present invention discloses a novel quinobenzoxazine self-assembly complex on DNA and on the topoisomerase II-DNA complex. The related model is used to design a new series of quinobenzoxazines, pyridobenzophenoxazines, pyrridonaphthophenoxazines, and ... | 03/04/2003 |
| 6503906 | Method for optimizing ciprofloxacin treatment of anthrax-exposed patients according to the patient's characteristics The present invention relates to a method for optimizing ciprofloxacin treatment of anthrax-exposed patients according to the patient's characteristics. More particularly, the invention optimizes the survival outcome of a ciprofloxacin treatment for an an... | 01/07/2003 |
| 6492373 | 6-fluoro-1,4-dihydro-7-[4-(2-hydroxyiminoethyl)-1-piperazinyl]-4-oxoquinoli ne-3-carboxylic acid derivatives, their preparation and pharmaceutical compositions The present invention discloses a novel 6-fluoro-1,4-dihydro-7-[4-(2-hydroxyiminoethyl)-1-piperazinyl]-4-oxoquinol ine-3-carboxylic acid derivatives (formula I), with a process for their preparation, and with pharmaceutical compositions containing them as ... | 12/10/2002 |
| 6492361 | Antibiotic compositions and methods for using same Compositions including a quinolone component in an amount effective as an antibiotic when the composition is placed in a mammalian eye, and a carrier component in an amount effective to act as a carrier for the quinolone component are provided. The presen... | 12/10/2002 |
