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| Number | Title | Issue Date |
| 8173659 | Substituted pyrazolo[4,3-C]pyridine derivatives active as kinase inhibitors Substituted pyrazolo[4,3-c]pyridine derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention... | 05/08/2012 |
| 8163756 | Enzyme modulators and treatments Novel compounds and methods of using those compounds for the treatment of inflammatory conditions, hyperproliferative diseases, cancer, and diseases characterized by hyper-vascularization are provided. In a preferred embodiment, modulation of the activation state of... | 04/24/2012 |
| 8143257 | Substituted phenols as active agents inhibiting VEGF production The present invention relates to methods, compounds, and compositions for inhibiting angiogenesis. More particularly, the present invention relates to methods, compounds, and compositions for inhibiting VEGF production. ... | 03/27/2012 |
| 8133893 | Trazodone and trazodone hydrochloride in purified form A process of production of trazodone or trazodone hydrochloride that comprises the steps of: (a) preparing an organic phase comprising trazodone in at least one organic solvent; (b) preparing an aqueous phase comprising at least one basic compound; (c) mixing said a... | 03/13/2012 |
| 8030311 | Phenylacetamides suitable as protein kinase inhibitors The invention relates to compounds of the formula (I) wherein the moieties R1, R2, R3, R9, R10 and Q and X, Y and Z are as defined in the specification, and salts thereof, as well as their use, methods of use for them and method of their synthesis, and the like. The... | 10/04/2011 |
| 7994173 | 2-piperazin-1-yl-3H-imidazo[4,5-b]pyridine derivatives The present invention is concerned with novel compounds of formula (I) having fundic relaxating activity. The invention further relates to methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use as a medicine of... | 08/09/2011 |
| 7977338 | Phenylacetamides being FLT3 inhibitors Compounds of formula wherein the residues R1, R2, R3, R9, R10 and Q and X, Y and Z are as defined in the specification, salts thereof; their use, methods of their use, processes for their production, pharmaceutical composit... | 07/12/2011 |
| 7960388 | 3-(imidazolyl)-pyrazolo[3,4-b]pyridines Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are 3-imidazoyl-pyrazolo[3,4-b]pyridine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR... | 06/14/2011 |
| 7947686 | Substituted pyrazolo[4,3-c]pyridine derivatives active as kinase inhibitors Substituted pyrazolo[4,3-c]pyridine derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention... | 05/24/2011 |
| 7868007 | Triazolopyridine carboxamide derivatives, preparation thereof and therapeutic use thereof The invention relates to the triazolopyridine carboxamide derivatives of general formula (I): Wherein X, A, R1 and R2 are as defined herein. The invention further relates to preparation methods and the... | 01/11/2011 |
| 7829568 | Substituted 5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-ylamine compounds and their use for producing drugs Substituted 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridin-2-ylamine compounds corresponding to formula I, methods for the preparation thereof, pharmaceutical compositions containing said compounds, the use of said compounds for preparing pharmaceutical compositions and r... | 11/09/2010 |
| 7825123 | Isoxazolo[4,5]pyridin-3-yl-piperazin derivatives useful as modulators of dopamine D3 receptors The present invention provides compounds of formula I, having affinity and selectivity for the dopamine D3 receptors, their manufacture, pharmaceutical compositions containing them and their use for the therapeutic and/or prophylactic treatment of cognitive disorder... | 11/02/2010 |
| 7816360 | MTP inhibiting aryl piperidines or piperazines substituted with 5-membered heterocycles The present invention is concerned with novel aryl piperidine or piperazine compounds substituted with certain 5-membered heterocycles having apoB secretion/MTP inhibiting activity and concomitant lipid lowering activity. The invention further relates to methods for... | 10/19/2010 |
| 7795264 | Substituted arylpyrazolopyridines and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same The invention relates to substituted arylpyrazolopyridines according to the general formula (I): in which A, B, D, E, Ra, R1, R2, R3, R4, R5 and q are as def... | 09/14/2010 |
| 7776863 | Methods of treating HIV infection The invention encompasses pharmaceutical compositions and methods for using Compound 1 in combination with other agents for treating patients with AIDS or HIV infection. ... | 08/17/2010 |
| 7772239 | Benzoimidazolone-carboxamide compounds as 5-HT4 receptor agonists The invention provides novel benzoimidazolone-carboxamide 5-HT4 receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT4 | 08/10/2010 |
| 7759351 | Oxazolidinone compounds, and compositions and methods related thereto The invention provides new oxazolidinone compounds of formula (I) wherein A is certain heterocycles optionally substituted; R1, R2, R3 and R4 are independently selected from —H and halogen; X is selected from O, S, NR | 07/20/2010 |
| 7709488 | Imidazopyridine-derivatives as inducible no-synthase inhibitors The compounds of formula (I) in which R1, R2, R3, R4, R5 and A have the meanings as given in the description are novel effective iNOS inhibitors. ... | 05/04/2010 |
| 7662823 | Pharmaceutical formulations of substituted azaindoleoxoacetic piperazine derivatives This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with azaindoleoxoacetyl piperazine derivatives. These compounds possess unique antiviral activi... | 02/16/2010 |
| 7629344 | 3-(imidazolyl)-pyrazolo[3,4-b]pyridines Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are 3-imidazoyl-pyrazolo[3,4-b]pyridine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR... | 12/08/2009 |
| 7615555 | Piperidine derivatives as modulators of chemokine receptor CCR5 Compounds of formula (I): compositions comprising them, processes for preparing them and their use in medical therapy (for example modulating CCR5 receptor activity in a warm blooded animal). ... | 11/10/2009 |
| 7582637 | Pyrrolo-pyridine kinase modulators The present invention provides novel pyrrolo-pyridine kinase modulators and methods of using the novel pyrrolo-pyridine kinase modulators to treat diseases mediated by kinase activity. ... | 09/01/2009 |
| 7582636 | Piperazinylimidazopyridine and piperazinyltriazolopyridine antagonists of Gonadotropin Releasing Hormone receptor The present invention relates to Gonadotropin Releasing Hormone (GnRH, also known as Luteinizing Hormone Releasing Hormone) receptor antagonists. ... | 09/01/2009 |
| 7544685 | 2,3-dihydroindole compounds The invention relates to compounds of the formula I wherein the variables are as defined in the claims. The compounds are useful in the treatment of a disease where a D4 receptor and/or a 5-HT2A receptor is impli... | 06/09/2009 |
| 7507736 | Indol-2-yl-piperazin-1-yl-methanone derivatives The present invention relates to compounds of formula I wherein A and R1 to R4 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for ... | 03/24/2009 |
| 7504399 | Piperazine enamines as antiviral agents This disclosure provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the disclosure is concerned with indole and azaindole piperazine enamine derivatives that possess unique antiviral activi... | 03/17/2009 |
| 7501419 | 4-Squarylpiperazine derivatives as antiviral agents This disclosure provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the disclosure is concerned with 4-squarylpiperazine derivatives that possess unique antiviral activity. More particularl... | 03/10/2009 |
| 7501420 | Composition and antiviral of substituted azaindoleoxoacetic piperazine derivatives This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with azaindoleoxoacetyl piperazine derivatives. These compounds possess unique antiviral activi... | 03/10/2009 |
| 7468370 | [1,7]naphthyridines as PDE4 inhibitors Compounds of formula I in free or salt form, wherein R1, R2 and R3 have the meanings as indicated in the specification, are useful for treating conditions mediated by of phosphodiesterase ty... | 12/23/2008 |
| 7396830 | Piperazine amidines as antiviral agents This disclosure provides compounds of Formula I as described herein having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the disclosure is concerned with indole and a... | 07/08/2008 |
| 7390799 | Apoptosis promoters Compounds which inhibit the activity of anti-apoptotic family protein members, compositions containing the compounds and methods of treating diseases during which occur expression one or more than one of an anti-apoptotic family protein member are disclosed. ... | 06/24/2008 |
| 7390811 | Respiratory syncytial virus replication inhibitors This invention concerns the use of compounds of formula (I) wherein -a1=a2-a3=a4- is a radical of formula —CH═CH—CH═CH—, —N═CH—CH═CH—, —CH═N—CH═CH—, —CH═CH—N═CH—, —CH═CH—CH═N... | 06/24/2008 |
| 7365200 | Thienopyridinone derivatives as macrophage migration inhibitory factor inhibitors Inhibitors of macrophage migration inhibitory factor having a thienopyridinone backbone are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with macrophage migration inhibitory fac... | 04/29/2008 |
| 7361760 | Substituted naphthyridine derivatives as inhibitors of macrophage migration inhibitory factor and their use in the treatment of human diseases Inhibitors of MIF having a naphthyridine backbone are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with MIF activity. The inhibitors of MIF have the following structures: | 04/22/2008 |
| 7358253 | Indolylmaleimide derivatives Provided are compounds of formula (I) which are useful in the treatment and/or prevention of diseases or disorders mediated by T lymphocytes and/or PKC, e.g. acute or chronic rejection of organ or tissue allo- or xenografts... | 04/15/2008 |
| 7358249 | Heterocyclic compounds having inhibitory activity against HIV integrase A heterocyclic compound of the formula (I): wherein B1 is —C(R2)═ or —N═; R1′ is H, etc.; one of R1 and R2 is -Z1-Z2-Z3-R | 04/15/2008 |
| 7354924 | Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives This invention provides Compounds I having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with azaindoleoxoacetyl piperazine derivatives. These compounds possess unique antiviral acti... | 04/08/2008 |
| 7351704 | Indazole-carboxamide compounds as 5-HTreceptor agonists The invention provides novel indazole-carboxamide 5-HT4 receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT4 recep... | 04/01/2008 |
| 7351708 | Pyrrolo [2,3-b] pyridine derivatives The present invention relates to compounds of formula I wherein R1 to R4 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the tr... | 04/01/2008 |
| 7348323 | Pyrrolo [2,3-c] pyridine derivatives The present invention relates to compounds of formula I wherein R1 to R4 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the tr... | 03/25/2008 |
