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| Number | Title | Issue Date |
| 8153637 | Phenyl-alkyl piperazines having TNF-modulating activity, preparation method, and therapeutic use thereof The present invention relates to phenyl-alkyl piperazines of formula (I): in which A, R1, R2 and R3 are as defined herein, having TNF-modulating activity. The invention also relates to the preparation thereof, pharmaceutica... | 04/10/2012 |
| 8153636 | Pyridyl derivatives and their use as therapeutic agents Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): ... | 04/10/2012 |
| 8138190 | Diaza heterocyclic amide compounds and their uses Diaza heterocyclic amide derivatives according to Formula (I) have therapeutic utility, particularly in the treatment of diabetes, obesity and related conditions and disorders: where R5, R6, R7 | 03/20/2012 |
| 8129390 | Carboxamide, sulfonamide and amine compounds and methods for using the same Disclosed are carboxamide, sulfonamide and amine compounds, as well as pharmaceutical compositions and methods of use. One embodiment is a compound having the structure in which R1, R2, R4, ... | 03/06/2012 |
| 8106055 | Substituted amide compounds Substituted amide compounds corresponding to formula I: processes for preparing them, pharmaceutical compositions containing these compounds, and the use of substituted amide derivatives for the preparation of medicaments f... | 01/31/2012 |
| 8101617 | Disubstituted ureas and uses thereof in treating heart failure Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure. ... | 01/24/2012 |
| 8039473 | Solid forms of [4-(3-fluoro-5-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl-[5-methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-phenyl]-methanone The present invention relates to four distinct crystalline forms and to an amorphous form of [4-(3-Fluoro-5-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-[5-methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-phenyl]-methanone, and to their use in the preparatio... | 10/18/2011 |
| 8034815 | Compounds and method for treatment of cancer The present invention is directed to a compound of Formula I: and/or a pharmaceutically-acceptable salt, hydrate, solvate, tautomer, optical isomer, or combination thereof, a composition comprising the thiosemicarbazone, a ... | 10/11/2011 |
| 8034816 | Hydrates and polymorphs of 4-[[(7)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy--(1-methyl-4-piperidinyl)-benzamide, process for their manufacture and their use as medicament Disclosed are hydrates and polymorphs of 4-[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-benzamide, processes for preparing them and their use as pharmaceutical compositions. ... | 10/11/2011 |
| 8030310 | Therapeutic agents useful for treating pain Compounds of formulae: where X is S or O and Ar2, R1, R2, R3, R8, n, m, t, and v are disclosed herein, or a pharmaceutically acceptable salt thereof (a “3-substituted... | 10/04/2011 |
| 8026242 | Cyclopropyl amines as modulators of the histamine Hreceptor Certain cyclopropyl amines are histamine H3 modulators useful in the treatment of histamine H3 receptor mediated diseases. ... | 09/27/2011 |
| 7964602 | Biaryl compounds useful as agonists of the Gpr38 receptor The present invention relates to novel biaryl derivatives such as compounds of formula (I), which have activity as agonists of the GPR38 receptor and the use of such compounds or pharmaceutical compositions thereof in the treatment of gastrointestinal disorders.... | 06/21/2011 |
| 7919494 | Pyridyl non-aromatic nitrogen-containing heterocyclic-1-carboxylate compound A novel pyridyl non-aromatic nitrogen-containing heterocyclic-1-carboxylate compound and its pharmaceutically acceptable salt has a potent FAAH-inhibitory activity. Further, the pyridyl non-aromatic nitrogen-containing heterocyclic-1-carboxylate compound of the pres... | 04/05/2011 |
| 7858628 | Use of fused nicotinamides to promote neurogenesis The present invention provides a group of compounds found to increase the number of neurons derived from stem cells for use as a therapeutic agent in neurological conditions or diseases. In one embodiment of the present invention, the compounds are used to detect th... | 12/28/2010 |
| 7842695 | Substituted pyrazole compounds Compounds of formula (I) and salts thereof, in which the following definitions apply: X is N or CH; R1 is H, A, Hal, (CH2)nHet, (CH2)nAr, C3-7-cycloalkyl, CF3, NO2, CN, C(NH)(OH)... | 11/30/2010 |
| 7799789 | Heterocyclic substituted pyridine or phenyl compounds with CXCR3 antagonist activity The present application discloses a compound, or enantiomers, stereoisomers, rotamers, tautomers, racemates or prodrug of said compound, or pharmaceutically acceptable salts, solvates or esters of said compound, or of said prodrug, said compound having the general s... | 09/21/2010 |
| 7795263 | Pharmaceutical combination for and method of anesthetizing and immobilizing non-domesticated mammals Non-domesticated mammalian animals are anesthetized and immobilized by injecting an effective amount of an anesthetizing and immobilizing drug comprising pharmaceutically active ingredients of butorphanol tartrate, azaperone tartrate and medetomidine hydrochloride (... | 09/14/2010 |
| 7776861 | Therapeutic agents useful for treating pain A compound of formula: where Ar1, Ar2, X, R3, and m are as disclosed herein or a pharmaceutically acceptable salt thereof (a “Cycloheteroalkenyl Compound”); compositions comprising an ef... | 08/17/2010 |
| 7776862 | Pyridyl and phenyl substituted piperazine-piperidines with CXCR3 antagonist activity The present application discloses a compound, or enantiomers, stereoisomers, rotamers, tautomers, racemates or prodrug of said compound, or pharmaceutically acceptable salts, solvates or esters of said compound, or of said prodrug, said compound having the general s... | 08/17/2010 |
| 7754723 | Therapeutic agents useful for treating pain Compounds of formulae: where Ar1, Ar2, R3, R4, and m are disclosed herein, or a pharmaceutically acceptable salt thereof (a “Nitro(cyano)vinylpiperazine Compound”); compositio... | 07/13/2010 |
| 7696208 | Therapeutic agents useful for treating pain Compounds of formulae: where X is S or O and Ar2, R1, R2, R3, R8, n, m, and t are disclosed herein, or a pharmaceutically acceptable salt thereof (a “3-substituted Py... | 04/13/2010 |
| 7691861 | Indolymaleimide derivatives A compound of formula I wherein R, Ra, Rb, Rc, Rd and Re are as defined in the specification, processes for their production, their uses, in particular in transplantati... | 04/06/2010 |
| 7683065 | Pyridines useful as modulators of ion channels The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of... | 03/23/2010 |
| 7671055 | Insecticidal 3-(dihaloalkenyl) phenyl derivatives Certain novel 3-(dihaloalkenyl)phenyl derivatives have unexpected insecticidal activity. These compounds are represented by formula (I), where R through R5, a, b, D, E, G and U are fully described herein. In addition, compositions comprising an insecticid... | 03/02/2010 |
| 7648989 | Indolylmaleimide derivatives as PKC inhibitors This invention relates to PKC inhibitors which are able to selectively inhibit e.g. the and optionally 0, isoforms of PKC, and their use in particular in transplantation. ... | 01/19/2010 |
| 7625904 | Methods for the treatment of sleep disorders The invention relates to methods for the treatment of a sleep disorder in a mammal comprising administering to said mammal an effective amount of a compound of formula (I): wherein all variables are as defined herein. ... | 12/01/2009 |
| 7618970 | 3-aminocyclopentanecarboxamides as modulators of chemokine receptors The present invention is directed to compounds of Formula I: which are modulators of chemokine receptors. The compounds of the invention, and compositions thereof, are useful in the treatment of diseases related to chemokin... | 11/17/2009 |
| 7612076 | Piperazinyl-pyridine derivatives The present invention relates to compounds of formula I wherein R1, R2, X, Y, Z and m are as defined in the description and claims, and pharmaceutically acceptable salts thereof as well as to pharmaceu... | 11/03/2009 |
| 7566718 | Amine-linked pyridyl and phenyl substituted piperazine-piperidines with CXCR3 antagonist activity The present application discloses a compound, or enantiomers, stereoisomers, rotamers, tautomers, racemates or prodrug of said compound, or pharmaceutically acceptable salts, solvates or esters of said compound, or of said prodrug, said compound having the general s... | 07/28/2009 |
| 7528135 | Pyridine derivatives as H3 antagonists The present invention relates to compounds of formula I wherein R1, R2 and A are as defined in the description and claims, and pharmaceutically acceptable salts thereof as well as to pharmaceutical com... | 05/05/2009 |
| 7524848 | Diaza heterocyclic amide compounds and their uses Diaza heterocyclic amide derivatives according to Formula (I) have therapeutic utility, particularly in the treatment of diabetes, obesity and related conditions and disorders: where R5, R6, R7 | 04/28/2009 |
| 7491727 | Arylpiperazinyl compounds The invention relates to 5-HT receptor agonists or antagonists. Novel arylpiperazinyl sulfonamide compounds represented by Formula I, and synthesis and uses thereof for treating diseases including those mediated directly or indirectly by 5-HT receptors, are disclose... | 02/17/2009 |
| 7485645 | 17β-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases In its many embodiments, the present invention provides a novel class of compounds as inhibitors of type 3 17β-hydroxysteroid dehydrogenase, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing... | 02/03/2009 |
| 7449466 | Cyclic aminophenyl sulfamate derivative This invention provides cyclicamino-phenyl sulfamate derivatives represented by a formula wherein each of R1 and R2 stands for hydrogen or lower alkyl; each of R3 an... | 11/11/2008 |
| 7449467 | 3-aminocyclopentanecarboxamides as modulators of chemokine receptors The present invention is directed to compounds of Formula I: which are modulators of chemokine receptors. The compounds of the invention, and compositions thereof, are useful in the treatment of diseases related to chemokin... | 11/11/2008 |
| 7442692 | Indanyl-piperazine compounds A compound selected from those of formula (I): wherein: R3 represents a hydrogen atom, and R1 and R2 together with the carbon atoms carrying them form a be... | 10/28/2008 |
| 7439360 | Vanilloid receptor ligands and their use in treatments Therapeutic benzimidazoles and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, ... | 10/21/2008 |
| 7432269 | Arylpiperaszine derivatives, to the process for the production thereof and to the use thereof as therapeutic agents The invention relates to compounds of the general formula (I): to the process for preparing them, and to the use thereof as a therapeutic agent having the property of being selective ligands for the dopamine D3 receptor. Th... | 10/07/2008 |
| 7429599 | Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK This invention generally relates to methods for treating or preventing a condition responsive to JNK inhibition, such as a metabolic condition, comprising administering to a patient in need thereof an effective amount of an Anilinopyrimidine Derivative having the fo... | 09/30/2008 |
| 7427612 | Benzoyl-piperazine derivatives A compound of formula wherein the substituents are as described in the specification for the treatment of psychoses, pain, neurodegenerative disfunction in memory and learning, schizophrenia, dementia and other diseases in ... | 09/23/2008 |
