Did You Know...
...that after Walter Hunt patented the safety pin in 1849, he sold the rights to it for $400?
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 8114876 | Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase This invention comprises the novel compounds of formula (I) wherein R1, R2, R3 and X have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compo... | 02/14/2012 |
| 8114875 | Substituted N-heterocyclic compounds and their use as dopamine Dreceptor ligands The invention relates to substituted N-heterocyclic compounds of general formula (I.A) and to the tautomers of the compounds the physiologically acceptable salts of the compounds and the physiologically acceptable salts of ... | 02/14/2012 |
| 8101616 | Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase This invention comprises the novel compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9 and X have defined me... | 01/24/2012 |
| 8101615 | 1,4-diaryl-dihydropyrimidin-2-ones and their use as human neutrophil elastase inhibitors The invention relates to novel heterocyclic derivatives of the general formula (I), processes for their preparation, and their use in medicaments, especially for the treatment of chronic obstructive pulmonary diseases, acute coronary syndrome, acute myocardial infar... | 01/24/2012 |
| 8058276 | Heterobicyclic carboxamides as inhibitors for kinases The invention relates to novel organic compounds of formula (I) and their use in the treatment of the animal or human body, to pharmaceutical compositions comprising a compound of formula (I) and to the use of a compound of formula (I) for the preparation of pharmac... | 11/15/2011 |
| 8044055 | 2-phenyl-6-aminocarbonyl-pyrimidine derivatives and their use as P2Y12 receptor The invention relates to 2-phenyl-6-aminocarbonyl-pyrimidine derivatives and their use as P2Y12 receptor antagonists in the treatment and/or prevention and/or treatment of peripheral vascular, of visceral-, hepatic- and renal-vascular, of cardiovascular a... | 10/25/2011 |
| 8044054 | Stereoisomerically enriched 3-aminocarbonyl bicycloheptene pyrimidinediamine compounds and their uses The present invention provides stereoisomers and stereoisomeric mixtures of 3-aminocarbonyl-bicycloheptene-2,4-pyrimidinediamine compounds having antiproliferative activity, compositions comprising the compounds and methods of using the compounds to inhibit cellular... | 10/25/2011 |
| 7960386 | Pyridin-2-one compounds and their use as modulators of the dopamine D3 receptor The invention relates to pyridin-2-one compounds of general formula (I) in which A represents a 4- to 6-membered hydrocarbon chain that can have 1 or 2 methyl groups as substituents, wherein 1 or 2 carbon atoms... | 06/14/2011 |
| 7910590 | Cyclic amine bace-1 inhibitors having a heterocyclic substituent Disclosed are novel compounds of the formula or a pharmaceutically acceptable salt or solvate thereof, wherein R1 is | 03/22/2011 |
| 7897605 | Pyrimidine compounds The present invention relates to substituted pyrimidines of formula I, their preparation, pharmaceutical compositions containing them and their use as inhibitors of cyclin-dependent kinases (CDKs) and hence their use in the treatment of proliferative disorders and/o... | 03/01/2011 |
| 7888360 | Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase This invention comprises the novel compounds of formula (I) wherein R1, R2, R3, X, Y and Z have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation,... | 02/15/2011 |
| 7884105 | Squaric acid derivatives as inhibitors of histone deacetylase This invention comprises the novel compounds of formula (I) wherein R1, R2 and X have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions contain... | 02/08/2011 |
| 7825121 | Piperazine derivatives useful as CCR5 antagonists The use of CCR5 antagonists of the formula or a pharmaceutically acceptable salt thereof, wherein R is optionally substituted phenyl, pyridyl, thiophenyl or naphthyl; R | 11/02/2010 |
| 7799788 | Method of treating chronic myelogenous leukemia cells Here, the inventors disclose the treatment of imatinib mesylate resistant chronic myelogenous leukemia cells with a cotreatment of vorinostat (SAHA, suberoylanilide hydroxamic acid) and dasatinib, a dual Abl/Src kinase (TK) inhibitor. Combined treatment of cultured ... | 09/21/2010 |
| 7767679 | Sulfonylamino-derivatives as novel inhibitors of histone deacetylase This invention comprises the novel compounds of formula (I) wherein n, m, t, R1, R2, R3, R4, R5, L, Q, X, Y, Z and have defi... | 08/03/2010 |
| 7767680 | Ion channel modulators and methods of use In general, the invention relates to novel 4-phenylpyrimidine compounds useful as ion channel modulators. It has now been found that compounds of this invention, and pharmaceutically acceptable compositions thereof, are useful as inhibitors of voltage-gated sodium c... | 08/03/2010 |
| 7763619 | Compounds with 5-HTactivity useful for treating disorders of the outer retina Compositions and methods for treating disorders of the outer retina with compounds with 5-HT1A agonist activity are disclosed. ... | 07/27/2010 |
| 7759350 | Pyrimidine carboxamides The present invention relates to novel compounds of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their hydrates, their solvates, their pharmaceutically acceptable salts and compositions, th... | 07/20/2010 |
| 7723339 | Combination comprising a signal transduction inhibitor and an epothilone derivative The present invention relates to a combination comprising N-{5-[4-(4-methyl-piperazino-methyl) -benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2-pyrimidine-amine and an epothiione derivative; pharmaceutical composition comprising said combination; method of treatment c... | 05/25/2010 |
| 7709487 | Sulfonyl-derivatives as novel inhibitors of histone deacetylase This invention comprises the novel compounds of formula (I) wherein n, m, t, R1, R2, R3, R4, L, Q, X, Y, Z and have defined meanings, h... | 05/04/2010 |
| 7652013 | Inhibitors of stearoyl-CoA desaturase Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositi... | 01/26/2010 |
| 7625903 | Anthranilamide inhibitors of Aurora kinase The present invention relates to a compound represented by the following formula: or a pharmaceutically acceptable salt thereof; where R1, R2, R3, R4, r and s are as ... | 12/01/2009 |
| 7615553 | Inhibitors of histone deacetylase This invention comprises the novel compounds of formula (I) wherein n, R1, R2, R3, R4, Q, X, Y, Z and have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions contain... | 11/10/2009 |
| 7598250 | Cyclic amine BACE-1 inhibitors having a heterocyclic substituent Disclosed are novel compounds of the formula or a pharmaceutically acceptable salt or solvate thereof, wherein R1 is | 10/06/2009 |
| 7582634 | 7-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor The present invention relates to Gonadotropin Releasing Hormone (GnRH, also known as Luteinizing Hormone Releasing Hormone) receptor antagonists. ... | 09/01/2009 |
| 7566717 | Substituted heterocyclic compounds Disclosed are novel heterocyclic compounds having the structure which are useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent cl... | 07/28/2009 |
| 7547702 | 4-amino-quinazolines Quinazolines of the formula (I) in which R, R1, R2, R3, R4 and Y have the meaning indicated in Patent claim 1, and their salts or solvates as glycoprotein 1bIX antagonists. ... | 06/16/2009 |
| 7538113 | 4-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor The present invention relates to Gonadotropin Releasing Hormone (GnRH, also known as Luteinizing Hormone Releasing Hormone) receptor antagonists. ... | 05/26/2009 |
| 7534796 | Imidazo[4,5-b]pyridine antagonists of gonadotropin releasing hormone receptor The present invention relates to Gonadotropin Releasing Hormone (GnRH, also known as Luteinizing Hormone Releasing Hormone) receptor antagonists. ... | 05/19/2009 |
| 7511044 | Vanilloid receptor ligands and their use in treatments Pyrimidine ethers and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis... | 03/31/2009 |
| 7501417 | Aminocarbonyl-derivatives as novel inhibitors of histone deacetylase This invention comprises the novel compounds of formula (I) wherein n, R1, R2, R3, R4, L, Q, X, Y, Z and have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions cont... | 03/10/2009 |
| 7485644 | N-{'4-substituted piperazine-1-sulfonylmethylalkyl}-n-hydroxyfomamide compounds as metalloproteinase inhibitors The invention provides compounds of formula (I): or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein ring B represents a monocyclic aryl ring having six ring atoms or a monocyclic heteroaryl ring having up to six ring atoms and containing one ... | 02/03/2009 |
| 7459455 | Pyrimidine compounds Pyrimidine derivatives, which are useful as TIE-2 and/or VEGFR-2 inhibitors are described herein. The described invention also includes methods of making such pyrimidine derivatives as well as methods of using the same in the treatment of hyperproliferative diseases... | 12/02/2008 |
| 7442698 | Substituted heterocyclic compounds and methods of use The present invention relates to pyrimidine or pyridine carbamate compounds having the general Formula I: and pharmaceutically acceptable salts or derivatives thereof. Also included are methods of treatment of various disea... | 10/28/2008 |
| 7435734 | N-substituted hydroxypyrimidinone carboxamide inhibitors of HIV integrase N-substituted 5-hydroxypyrimidin-6-one-4-carboxamides of formula: are described as inhibitors of HIV integrase and inhibitors of HIV replication, wherein R1, R2, R3 and R4 are def... | 10/14/2008 |
| 7432260 | Pyrimidine compounds The present invention relates to substituted pyrimidines of formula I, their preparation, pharmaceutical compositions containing them and their use as inhibitors of cyclin-dependent kinases (CDKs) and hence their use in the treatment of proliferative disorders and/o... | 10/07/2008 |
| 7419980 | Fused-aryl and heteroaryl derivatives and methods of their use The present invention is directed to fused-aryl and heteroaryl derivatives, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms... | 09/02/2008 |
| 7414046 | Gyrase inhibitors and uses thereof The present invention relates to compounds of the formula I: or a pharmaceutically acceptable derivative or prodrug thereof. The compounds are useful as inhibitors of bacterial gyrase activity. The present invention also re... | 08/19/2008 |
| 7384944 | Piperazine derivatives useful as CCR5 antagonists The use of CCR5 antagonists of the formula or a pharmaceutically acceptable salt thereof, wherein R is optionally substituted phenyl, pyridyl, thiophenyl or naphthyl; R | 06/10/2008 |
| 7381719 | Diaryl ethers as opioid receptor antagonist A compound of the formula (I) wherein the variables X1 to X10, R1 to R7 including R3′, E, v, y, z, A and B are as described, or a pharmaceutically acceptable salt, solvate, enantiomer, racemate, diastereomer o... | 06/03/2008 |
