Did You Know...
...that two musicians were responsible for the invention of color print film? Fascinated by photography, Leopold Godowsky and Leopold Mannes worked together to produce an easy-to-use, practical color film. They worked full time as music teachers and gave concerts while experimenting during their off hours in Mannes' kitchen. Their success earned them full-time, well-paying jobs at Kodak and their efforts resulted in Kodachrome film, which was introduced in 1935.
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| Number | Title | Issue Date |
| 8188086 | Specific salt, anhydrous and crystalline form of a dihydropteridione derivative The present invention relates to a specific salt of a dihydropteridione derivative, namely the trihydrochloride salt of the compound N-[trans-4-[4-(cyclopropylmethyl)-1-piperazinyl]cyclohexyl]-4-[[(7R)-7-ethyl-5,6,7,8-tetrahydro-5-methyl-8-(1-methylethyl)-6-oxo-2-pt... | 05/29/2012 |
| 8133892 | Compounds that are useful for improving pharmacokinetics Novel compounds of formula 1 or a pharmaceutically acceptable salt thereof inhibit cytochrome P450 monooxygenase. ... | 03/13/2012 |
| 8039471 | Aza spiro alkane derivatives as inhibitors of metalloproteases The present invention provides a compound of Formula I or Formula II: enantiomer, diastereomer, prodrug, solvate, metabolite, or pharmaceutically acceptable salt thereof, wherein constituent variables are provided herein. T... | 10/18/2011 |
| 8008303 | Biphenyl derivatives and their use in treating hepatitis C Use of a compound which is a biphenyl derivative of formula (I), or a pharmaceutically acceptable salt thereof, for the treatment of Hepatitis C wherein the variables are described herein. ... | 08/30/2011 |
| 8008304 | Substituted propiolic acid amides and their use for producing drugs The present invention relates to substituted propiolic acid amides, methods for the production thereof, medicaments containing these compounds and the use thereof for producing medicaments. ... | 08/30/2011 |
| 8008302 | N-hydroxyamide derivatives and use thereof The present invention is related to N-hydroxyamide derivatives of Formula (I) and use thereof, in particular for the treatment and/or prophylaxis of autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, cancer, respiratory... | 08/30/2011 |
| 7998961 | Hydantoin derivatives useful as antibacterial agents This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate, ester or isomer thereof, which is useful for the treatment of diseases or conditions mediated by LpxC. ... | 08/16/2011 |
| 7973041 | Substituted cyclic hydroxamates as inhibitors of matrix metalloproteinases The present invention provides compounds of the formula: its enantiomers, diastereomers, racemic mixtures thereof, prodrugs, crystalline forms, non-crystalline forms, amorphous forms thereof, solvates thereof, metabolites t... | 07/05/2011 |
| 7960385 | Guanidine-containing compounds useful as muscarinic receptor antagonists The invention provides compounds of formula I: or a pharmaceutically acceptable salt thereof, wherein R1-3, R5-7, a, X, Y, Y′, Y″, and Z are as defined in the specification. These compounds are mus... | 06/14/2011 |
| 7951806 | Plasminogen activator inhibitor-1 inhibitor The present invention relates to an inhibitor of plasminogen activator inhibitor-1. The present invention further relates to a pharmaceutical composition that has an inhibitory action on PAI-1 activity and is useful in the prevention and treatment of various disease... | 05/31/2011 |
| 7935703 | Piperazines and piperidines as Mglur5 potentiators Compounds of Formula I or pharmaceutically acceptable salts or solvates thereof: wherein Ar1, Ar2, A, X, Y, m, n and R1, R2, R3, R4 and R5 are as ... | 05/03/2011 |
| 7910589 | Low hygroscopic aripiprazole drug substance and processes for the preparation thereof The present invention provides low hygroscopic forms of aripiprazole and processes for the preparation thereof which will not convert to a hydrate or lose their original solubility even when a medicinal preparation containing the anhydrous aripiprazole crystals is s... | 03/22/2011 |
| 7897604 | Inhibitors of polyisoprenylated methylated protein methyl esterase Inhibitors of the enzyme prenylated methylated protein methyl esterase (PMPMEase), the last step in the prenylation process for many eukaryotic proteins, having the general structure R1-X-A-B(R2)-Y or R1-X-A(R2)-B-Y, where... | 03/01/2011 |
| 7863277 | Topical antipsychotic composition A transdermal composition that contains an antipsychotic is provided for the treatment of neuropsychiatric disorders. Also, provided are methods for preparing a topical antipsychotic composition. Methods for treating neuropsychiatric disorders, including schizophren... | 01/04/2011 |
| 7855209 | Allosteric modulators of the Aadenosine receptor The present invention provides compounds of formula (I) wherein R1, R2, R3, R4 and Q have a meaning as defined herein in the specification. The compounds of formula (I) are allost... | 12/21/2010 |
| 7772238 | Benzothiophene hydroxamic acid derivatives The present invention relates to a novel class of hydroxamic acid derivatives. The hydroxamic acid compounds can be used to treat cancer. The hydroxamic acid compounds can also inhibit histone deacetylase and are suitable for use in selectively inducing terminal dif... | 08/10/2010 |
| 7754722 | Piperazine derivatives and methods of use The invention provides 2-carboxamide piperazine compounds of formula I, R3.IN\′N˜′R2I(0)z-oR4I wherein R′, R2, R3 and R4 are as defined in the claims and methods of treatment and pharmaceutical... | 07/13/2010 |
| 7750012 | Biaryl nitrogen-heterocycle inhibitors of LTA4H for treating inflammation The present invention relates to a chemical genus of biaryl nitrogen-attached heterocycles that are inhibitors of LTA4H (leukotriene A4 hydrolase). The compounds have the general formula They are useful for the treatment an... | 07/06/2010 |
| 7732449 | Inhibitors of cathepsin S The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides m... | 06/08/2010 |
| 7709486 | CXCR4 antagonists The present invention is drawn to novel antiviral compounds, pharmaceutical compositions and their use. More specifically this invention is drawn to derivatives of monocyclic polyamines which have activity in standard tests against HIV- or FIV-infected cells as well... | 05/04/2010 |
| 7687504 | Pyrrolidine compounds A compound of the following formula: wherein R1 R2, R3, R4, R5, R6, W, X, Y, Z, m, n, and p are as defined herein. This invention also covers methods for inh... | 03/30/2010 |
| 7678797 | 1-phenyl-3-piperazine-pyrazoles and pesticidal compositions of matter thereof The invention relates to 5-diazacycloalkylpyrazole derivatives of the formula (I) or salts thereof a process for their preparation, to compositions thereof and to their use for the control of pests, including arthropods and helminths ... | 03/16/2010 |
| 7655658 | Thieno [2,3-D]pyrimidine-2,4-dione melanocortin-specific compounds A thienopyrimidine compound of the formula: wherein R1, R2, R3, and R4 are as defined herein, and methods of use of such compounds for the treatment of melanocortin receptor-assoc... | 02/02/2010 |
| 7652012 | 2-(R)-(4-fluoro-2-methyl-phenyl)-4-(S)-((8aS)-6-oxo-hexahydro-pyrrolo[1,2-]-pyrazin-2-yl)-piperidine-1-carboxylic acid [1-(R)-3,5-bis-trifluoromethyl-phenyl)-ethyl]-methylamide maleate and pharmaceutical compositions thereof The present invention relates to piperidine derivatives of formula (I) specifically 2-(R)-(4-Fluoro-2-methyl-phenyl)-4-(S)-((8aS)-6-oxo-hexahydro-pyrrolo[1,2-a]-pyrazin-2-yl)-piperidine-1-carboxylic acid [1-(R)-(3,5-bis-tri... | 01/26/2010 |
| 7612075 | Substituted oxoazaheterocyclyl compounds This invention is directed to oxoazaheterocycyl compounds which inhibit Factor Xa, to oxoazaheterocycyl compounds which inhibit both Factor Xa and Factor IIa, to pharmaceutical compositions comprising these compounds, to intermediates useful for preparing these comp... | 11/03/2009 |
| 7592345 | Piperazine and [1,4]diazepan derivatives as NK antagonists The present invention relates to a compound of formula I wherein R1, R2, R3, R4, R9, R10, m and n are as defined herein, or to a ph... | 09/22/2009 |
| 7585865 | Protein kinase C zeta inhibition to treat vascular permeability Methods of treating or preventing a disease or disorder in a subject are provided by the present invention which include administering a composition including a therapeutically effective amount of a protein kinase C (PKC) zeta inhibitor. A disease or disorder treate... | 09/08/2009 |
| 7582633 | Azacycloalkane derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase Azacycloalkane derivatives of structural formula I are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment o... | 09/01/2009 |
| 7576086 | Aralkyl-alcohol peiperazine derivatives and their uses as antidepressant Aryl alkanol piperazine derivatives of the formula and pharmaceutical compositions comprising the same. Also disclosed are methods for treating depression using the pharmaceutical composition. Compounds of the invention hav... | 08/18/2009 |
| 7569568 | Cytokine inhibitors Disclosed are compounds of formula (I) Where Ar1, X, R3, R4, R5 and R6 are defined herein. The compounds of the invention inhibit production of cytokines involved in infl... | 08/04/2009 |
| 7507735 | Compounds, compositions and methods Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure. ... | 03/24/2009 |
| 7491724 | Substituted cyclic hydroxamates as inhibitors of matrix metalloproteinases The present invention provides compounds of the formula I: its enantiomers, diastereomers, racemic mixtures thereof, prodrugs, crystalline forms, non-crystalline forms, amorphous forms thereof, solvates thereof, metabolites... | 02/17/2009 |
| 7488729 | Polymorphic forms of ziprasidone and its hydrochloride salt and process for preparation thereof The present invention is related to crystalline forms of ziprasidone and its hydrochloride salt and an amorphous form of ziprasidone hydrochloride and the process for the preparation thereof. The crystalline forms and amorphous form of the invention are suitable for... | 02/10/2009 |
| 7476675 | Quinolinone derivatives and uses thereof The invention provides compounds of the formula: and pharmaceutically acceptable salts or prodrugs thereof, wherein m, p, q, r, A, E, X, Y, R1, R4, R5, R6, R7, R8 | 01/13/2009 |
| 7468369 | Sulfonyl pyrrolidines, method for producing the same and their use as drugs The invention relates to substituted sulfonylpyrrolidines of the formula I and to the physiologically tolerated salts thereof, as well as to their use as medicaments. ... | 12/23/2008 |
| 7442692 | Indanyl-piperazine compounds A compound selected from those of formula (I): wherein: R3 represents a hydrogen atom, and R1 and R2 together with the carbon atoms carrying them form a be... | 10/28/2008 |
| 7439242 | PPARγ modulators Modulators of PPARγ activity are provided which are useful in pharmaceutical compositions and methods for the treatment of conditions such as type II diabetes and obesity. ... | 10/21/2008 |
| 7432264 | Antimicrobial biaryl compounds Provided are antibacterial biaryl compounds having micromolar MIC activity against Gram-negative and Gram-positive pathogens, including a methicillin-resistant S. aureus strain. ... | 10/07/2008 |
| 7425557 | Inhibitors of glycogen synthase kinase 3 New pyridine-based compounds of Formula I, compositions, and methods of inhibiting the activity of glycogen synthase kinase (GSK3) in vitro and of treatment of GSK3-mediated disorders in vivo are provided. The methods, compounds, and compositions of the invention ma... | 09/16/2008 |
| 7419980 | Fused-aryl and heteroaryl derivatives and methods of their use The present invention is directed to fused-aryl and heteroaryl derivatives, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms... | 09/02/2008 |
