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| Number | Title | Issue Date |
| 8088775 | Pharmaceutical composition for treating hair loss Disclosed is the use of 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-acetic acid or its pharmaceutically acceptable salt for the reduction of hair loss; for hair regrowth, hair toning and hair growth; and for the treatment of female hirsutism. ... | 01/03/2012 |
| 8017613 | Beta-3 receptor ligands and their use in therapy The present invention relates to new compounds, ligands of the beta-3 adrenergic receptor, their preparation and their use in therapy or as research tools for said receptor; the invention also relates to a process for the preparation of the compounds of the inventio... | 09/13/2011 |
| 8017612 | Piperazine compound and use thereof as a HCV polymerase inhibitor The present invention relates to a compound represented by the following formula [I] wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof, or a solvate thereof and an anti-HC... | 09/13/2011 |
| 7989454 | Leukotriene B4 inhibitors Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositi... | 08/02/2011 |
| 7985751 | Piperazine derivatives Compounds of general formula (I) in which R1 and R0 have any of the meanings given in the specification have affinity for sigma receptors and are useful in the treatment of disorders of the central ner... | 07/26/2011 |
| 7981895 | Carbamic acid compounds comprising a piperazine linkage as HDAC inhibitors This invention pertains to certain carbamic acid compounds which inhibit HDAC (histone deacetylase) activity of the following formula: The present invention also pertains to pharmaceutical compositions comprising such compo... | 07/19/2011 |
| 7968549 | Diarylmethylpiperazines as therapeutic agents for viral myocarditis To provide a therapeutic agent for viral myocarditis and viral myocarditis-related viral diseases by treating the occurrence of cell damage in various organs regardless of the type of virus. A therapeutic agent for viral myocarditis and viral myocarditis-related vir... | 06/28/2011 |
| 7968548 | Melanocortin receptor-specific piperazine compounds with diamine groups Melanocortin receptor-specific compounds with diamine groups of the general formula and pharmaceutically acceptable salts thereof, where W is a diamine heteroatom unit with at least one cationic center, hydrogen bond donor ... | 06/28/2011 |
| 7964601 | Melanocortin receptor-specific compounds A melanocortin receptor-specific compound of the general formula of structure I: where X, R1, R2a, R2b, R3, R4a, R4b, R5a and R5b are a... | 06/21/2011 |
| 7956057 | Imidazole compounds Imidazole compounds, compositions, and methods of using them in leukocyte recruitment inhibition, in modulating H4 receptor expression, and in treating conditions such as inflammation, H4 receptor-mediated conditions, and related conditions. | 06/07/2011 |
| 7943621 | Salts of piperazine compounds as D/Dantagonists The present invention relates to novel monohydrochloride, dihydrochloride, monohydrobromide, maleate and methanesulphonate salts of trans 4-{2-[4-(2,3-dichlorophenyl)-piperazine-1-yl]-ethyl}-N,N-dimethylcarbamoyl-cyclohexylamine and/or their hydrates and/or solvates... | 05/17/2011 |
| 7943620 | Anti-anginal compounds This invention relates to novel compounds that partially inhibit fatty acid oxidation and pharmaceutically acceptable salts thereof. More specifically, this invention relates to novel compounds that are derivatives of ranolazine. This invention also provides composi... | 05/17/2011 |
| 7868006 | Heterocyclic substituted piperazines with CXCR3 antagonist activity The present application discloses a compound, or enantiomers, stereoisomers, rotamers, tautomers, racemates or prodrug of said compound, or pharmaceutically acceptable salts, solvates or esters of said compound, or of said prodrug, said compound having the general s... | 01/11/2011 |
| 7863276 | Salts of modulators of PPAR and methods of treating metabolic disorders Salt forms of potent modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed. ... | 01/04/2011 |
| 7851474 | Dipiperazinyl ketones and related analogues Dipiperazinyl ketones and related analogues are provided, as are methods for their preparation and use. Such compounds may generally be used to modulate ligand binding to histamine H3 receptors in vivo or in vitro, and are particularly useful in the treatment of a v... | 12/14/2010 |
| 7834017 | Diamine-containing, tetra-substituted piperazine compounds having identical 1- and 4-substituents There is provided compounds having the formula of structure I: wherein the groups —C(R8)(CH2)vCH(R9)(CH2)y-Q and —C(R8)(CH2)v | 11/16/2010 |
| 7834018 | Aminopyridine derivatives having aurora a selective inhibitory action The present invention relates to a compound represented by the general formula (I): wherein m1 and m2 are 1, 2, or 3; n1 and n2 are 0 or 1; i is an integer of any of 1 to m1 | 11/16/2010 |
| 7829565 | Indole derivatives as serotonin reuptake inhibitors Compounds of the formula (I), the use thereof for the preparation of a medicament for the treatment of diseases associated with the serotonin receptor and/or serotonin reuptake, in particular for the preparation of a medicament as anxiolytic, antidepressant, neurole... | 11/09/2010 |
| 7825120 | Certain substituted ((piperazin-1-ylmethyl)benzyl)ureas Certain substituted ((piperazin-1-ylmethyl)benzyl)urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and may be useful in the treatment of systolic heart failure including congestive heart failure. ... | 11/02/2010 |
| 7816358 | Pharmaceutical formulations comprising N,N′-disubstituted piperazine compounds Pharmaceutical formulations comprising N,N′disubstituted piperazine compounds and related methods of treatment using these formulations. ... | 10/19/2010 |
| 7816359 | N-phenyl-2-pyrimidine-amine derivatives The present invention relates to novel amides and a process for preparing these amides. ... | 10/19/2010 |
| 7807679 | Piperazine derivatives and their use in controlling pests The use of a compound of formula (I) wherein Y is a single bond, C═O, C═S or S(O)m where m is 0, 1 or 2; the ring is a 6-membered aromatic or is a 5 or 6 membered heteroaromatic ring; Ra, R1, R2, R4 and R8 a... | 10/05/2010 |
| 7807678 | Peptidomimetics of biologically active metallopeptides The invention relates to a method of deriving a peptidomimetic of a biologically active metallopeptide, wherein the peptidomimetic includes at least one non-peptide ring structure defining a template space superimposable on a corresponding defined template space of ... | 10/05/2010 |
| 7795262 | Piperazinyl oxoalkyl tetrahydroisoquinolines and related analogues Piperazinyl oxoalkyl tetrahydroisoquinolines and related analogues of the Formula: are provided, in which variables are as described herein. Such compounds may be used to modulate ligand binding to histamine H3 receptors in... | 09/14/2010 |
| 7786121 | Derivatives of hydroxamic acid as metalloproteinase inhibitors A compound of formula (I), or an enantiomer or diastereoisomer thereof, or a salt, hydrate or solvate thereof: for the treatment or prophylaxis of arthritis in mammals. ... | 08/31/2010 |
| 7786122 | α-(N-sulfonamido)acetamide derivatives as β-amyloid inhibitors There is provided a series of novel α-(N-sulfonamido)acetamide compounds of the Formula (I) wherein R, R1, R2 and R3 are defined herein, which are inhibitors of β-amyloid peptide (β-AP) p... | 08/31/2010 |
| 7776860 | Process for the preparation of 3-amino-8-(1-piperazinyl)-2H-1-benzopyran-2-one and salts and solvates thereof The invention relates to a novel process for the preparation of 3-amino-8-(1-piperazinyl)-2H-1-benzopyran-2-one, a broad spectrum 5-HT receptor binding ligand having potent 5-HT1A-agonistic as well as 5-HT1D-antagonistic activity. The invention... | 08/17/2010 |
| 7772237 | Thio-substituted tricyclic and bicyclic aromatic methanesulfinyl derivatives The present invention is related to chemical compositions, processes for the preparation thereof and uses of the composition. Particularly, the present invention relates to compositions of compounds of Formula (A): ... | 08/10/2010 |
| 7767678 | Crystalline forms of 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile and methods of preparing the same This invention is directed to a crystalline 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile monohydrate having an x-ray diffraction pattern wherein 2θ angles (°) of significant peaks are at about: 9.1... | 08/03/2010 |
| 7763618 | Pyridyl derivatives and their use as therapeutic agents Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): wherein W, V, x, y, R1, R2, R3... | 07/27/2010 |
| 7727990 | Melanocortin receptor-specific piperazine and keto-piperazine compounds Melanocortin receptor-specific compounds of the general formula and pharmaceutically acceptable salts thereof, where X, W, J, Q, L1, L2, L3, R1a, R1b, R2a, a... | 06/01/2010 |
| 7723338 | Crystalline forms of 1-benzoyl-4-[2-[4,7-dimethoxy-1-[(phosphonooxy)methyl]-1-pyrrolo[2,3-C]pyridin-3-yl]-1,2-dioxoethyl]-piperazine The instant disclosure provides crystalline forms of 1-benzoyl-4-[2-[4,7-dimethoxy-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-c]pyridin-3-yl]-1,2-dioxoethyl]-piperazine, salts and solvates thereof. The present disclosure also generally relates to pharmaceutical composi... | 05/25/2010 |
| 7718657 | Certain indanyl urea modulators of the cardiac sarcomere Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure. ... | 05/18/2010 |
| 7718656 | Prostaglandin derivatives Nitroderivatives of prostaglandin amides having improved pharmacological activity and enhanced tolerability are described. They can be employed for the treatment of glaucoma and ocular hypertension. ... | 05/18/2010 |
| 7709485 | IL-8 receptor antagonists This invention relates to novel compounds of Formula (I) to (VII), and compositions thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8). ... | 05/04/2010 |
| 7709484 | Substituted melanocortin receptor-specific piperazine compounds A substituted piperazine compound having the structure I: or the structure IX: or an enantomeric, stereoisomeric or diastereomeric form of the foregoing, and pharmaceutically acce... | 05/04/2010 |
| 7700597 | Substituted piperazines as CB1 antagonists Compounds of Formula (I): or pharmaceutically acceptable salts, solvates, or esters thereof, are useful in treating diseases or conditions mediated by CB1 receptors, such as metabolic syndrome and obesity, neuroinf... | 04/20/2010 |
| 7662821 | Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents The invention relates to tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents. ... | 02/16/2010 |
| 7645758 | Heterocyclic compounds Certain thienopyrrolyl and furanopyrrolyl compounds are disclosed as useful to treat or prevent disorders and conditions mediated by the histamine H4 receptor, including allergic rhinitis. ... | 01/12/2010 |
| 7642260 | Apoptosis promoters Disclosed are compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which occurs expression one or more than one of an ant... | 01/05/2010 |
