Class 514/252.06 - Polycyclo ring system having the additional five-membered hetero ring as one of the cyclos

Subclass of Class 514 - Drug, bio-affecting and body treating compositions
Definition: Subject matter wherein the additional nitrogen containing
No. of patents: 176
Last issue date: 10/04/2011

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Number	Title	Issue Date
8030309	Viral polymerase inhibitors An enantiomer, diastereoisomer or tautomer of a compound, represented by formula I: wherein A, B, R1, R2, R3, R4, R5, R6, R7, R8, R	10/04/2011
7947683	3-(1,2,4-triazol-3-ylalkyl) azabicyclo (3.1.0) hexane derivatives as modulators of dopamine D3 receptors The present invention relates to novel compounds of formula (I) or pharmaceutically acceptable salt thereof: processes for their preparation, intermediates used in these processes, pharmaceutical compositions containing the...	05/24/2011
7879859	Diagnosis and treatment of type 2 diabetes and other disorders The present application features the use of the somatostatin subtype 3 receptor (SST3) as a target for affecting insulin secretion and for diagnosing diabetes related disorders. Glucose stimulated insulin secretion was found to be stimulated by knocking down express...	02/01/2011
7834016	Inhibitors of the interaction between MDM2 and p53 The present invention provides compounds of formula (I), their use as an inhibitor of a p53-MDM2 interaction as well as pharmaceutical compositions comprising said compounds of formula (I) wherein n, m, p, s, t, R1	11/16/2010
7820670	6-aminoimidazo[1,2-b]pyridazine analogs as rho kinase inhibitors for the treatment of rho kinase-mediated diseases and conditions Methods for using 6-aminoimidazo[1,2-b]pyridazine analogs are disclosed herein to treat rho kinase-mediated diseases or rho kinase-mediated conditions, including controlling intraocular pressure and treating glaucoma, are disclosed. Ophthalmic pharmaceutical composi...	10/26/2010
7470689	4-benzimidazol-2-ylpyridazin-3-one derivatives Disclosed are compounds of the general formula (I), where the definition of the substituents A, B, D, E, R1 and R2 are detailed in the description, and the physiologically tolerated salts thereof, a process for the preparation of these compound...	12/30/2008
7407950	-(heteroaryl)-1-indole-2-carboxamide derivatives and their use as vanilloid TRPV1 receptor ligands The invention concerns compounds of general formula (I), wherein n, X1, X2, X3, X4, Z1, Z2, Z3, Z4, Z5 and W are as defined herein.	08/05/2008
7405215	Indole acetic acids exhibiting CRTH2 receptor antagonism and uses thereof The invention relates to indole acetic acid compounds which function as antagonists of the CRTH2 receptor. The invention also relates to the use of these compounds to inhibit the binding of prostaglandin D2 and its metabolites or certain thromboxane metab...	07/29/2008
7399765	Substituted diazabicycloalkane derivatives Compounds of formula (I) Z-Ar1—Ar2 (I) wherein Z is a diazabicyclic amine, Ar1 is a 5- or 6-membered aromatic ring, and Ar2 is selected from the group consisting of an unsubstituted or substitute...	07/15/2008
7361657	Respiratory syncytial virus replication inhibitors This invention concerns the use of compounds of formula (I) wherein −a1=a2−a3=a4—is a radical of formula —CH═CH—CH═CH—, —N═CH—CH═CH—, —CH═N—CH═CH—, —CH═CH—N═CH—, —CH═CH—C...	04/22/2008
7309701	Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them The present invention relates to novel pyridazinone derivatives of the general formula (I) wherein A is A1 or A2; ...	12/18/2007
7285551	Fused-ring compounds and use thereof as drugs The present invention provides a fused ring compound of the following formula [I] wherein each symbol is as defined in the specification, a pharmaceutically acceptable salt thereof, and a therapeutic agent for he...	10/23/2007
7282498	Substituted fused pyrroleoximes and fused pyrazoleoximes Disclosed are compounds of the formula and the pharmaceutically acceptable salts thereof wherein R, Ar, A, n, R1 and R2 are defined herein. These compounds are highly selective agonists, ant...	10/16/2007
7265115	Diazabicyclic CNS active agents Compounds of formula I: or pharmaceutically acceptable salts thereof, are useful for controlling synaptic transmission in mammals. ...	09/04/2007
7262195	Compounds useful as motilin agonists and method Compounds are provided which are useful in treating disorders of gastrointestinal motility and which have the structure or a pharmaceutically acceptable salt thereof, a prodrug ester thereof, and all stereoisomer...	08/28/2007
7238687	Nonpeptide substituted spirobenzoazepines as vasopressin antagonists The invention is directed to nonpeptide substituted benzodiazepines of Formula I, wherein A, X, n, R1, R2, R3, R4, R5, a and b are as described in the specif...	07/03/2007
7173034	Respiratory syncytial virus replication inhibitors This invention concerns the use of compounds of formula (I) wherein -a1=a2-a3=a4- is a radical of for CH═CH—, —N═CH—CH═CH—, —CH═N—CH═CH—, —CH═CH—N═CH—, —CH═CH—CH═N— wherein each ...	02/06/2007
7166612	Methods for reducing platelet activation platelet aggregaton or thrombosis The invention provides methods and compositions for reducing platelet activation, platelet aggregation and thrombosis. The invention further provides compositions and methods for treating or preventing diseases or disorders in which the pathology of the disease or d...	01/23/2007
7148249	Indolinones substituted by heterocycles, the preparation thereof and their use as medicaments The present invention relates to heterocyclically substituted indolinones of general formula wherein R1 to R5 and X are defined as in claim 1, the tautomers, the diastereomers, ...	12/12/2006
7081458	Melanin concentrating hormone receptor ligands: substituted 1-benzyl-4-aryl piperazine analogues Melanin concentrating hormone receptor ligands (especially 1-benzyl-4-aryl-piperazines, 1-benzyl-4-aryl-piperidines and related compounds), capable of modulating MCH receptor activity, are provided. Such ligands may be used to modulate MCH binding to MCH receptors i...	07/25/2006
7074793	Cyclic substituted fused pyrrolocarbazoles and isoindolones The present invention is directed to cyclic substituted fused pyrrolocarbazoles and isoindolones. The invention also is directed to methods for making and using the cyclic substituted fused pyrrolocarbazoles and isoindolones. ...	07/11/2006
6974815	Hexahydro-benzimidazolone compounds useful as anti-inflammatory agents The present invention is directed to compounds having the formula (I): useful in treating inflammatory and immune diseases, in which K is O or S; Q is —C(═O)— or optionally substituted C1-4alkylene; Ar...	12/13/2005
6924287	Respiratory syncytial virus replication inhibitors This invention concerns the use of compounds of formula (I) wherein -a1=a2-a3=a4- is a radical of formula —CH═CH—CH═CH—, —N═CH—CH═CH—, —CH═N—CH═CH�...	08/02/2005
6903112	Heterocyclylindazole and -azaindazole compounds as 5-hydroxytryptamine-6 ligands The present invention provides a compound of formula I and the use thereof in the therapeutic treatment of disorders related to or affected by the 5-HT6 receptor. ...	06/07/2005
6897229	Synergistic combination comprising roflumilast and a PDE-3 inhibitor The PDE4 inhibitor N-(3,5-dichloropyrid-4-yl)-3-cyclopropylmethoxy-4-difluoromethoxy benzamide, a pharmacologically tolerable salt or N-oxide thereof, in combination with a PDE3 inhibitor is disclosed for use in inhibiting bronchospasms and tre...	05/24/2005
6867206	6-carboxyphenyldihydropyridazinone derivatives and use thereof The present invention relates to 6-carboxyphenyldihydropyridazinone derivatives having the formula wherein R1, R2, R3, A, D, G, and E are as defined in the specification and claims, a p...	03/15/2005
6861430	β-carboline derivatives and its pharmaceutical use against depression and anxiety The invention provides compounds of formula (I) wherein R1 to R5 are as defined in the description, and their preparation. The compounds of formula (I) are useful as pharmaceuticals. ...	03/01/2005
6849629	Pyridazinone aldose reductase inhibitors The present invention relates to novel pyridazinone compounds, pharmaceutical compositions comprising those compounds and to methods of using such compounds and compositions to inhibit aldose reductase, lower sorbitol levels and, thus, lower fructose levels, and/or ...	02/01/2005
6846818	Selective inhibitors of cyclooxygenase-2 The present invention relates to cyclooxygenase-2 (COX-2) selective inhibitors of formula I: pharmaceutical compositions containing them, to their medicinal use, and to their preparations. The compounds of the inventio...	01/25/2005
6762182	Converting cox inhibition compounds that are not COX-2 selective inhibitors to derivatives that are COX-2 selective inhibitors A method of altering specificity of cyclooxygenase-inhibiting compounds that have a COOH moiety by changing the various COOH containing compounds, such as indomethacin, into ester derivatives or into secondary amide derivatives. ...	07/13/2004
6747028	Respiratory syncytial virus replication inhibitors This invention concerns compounds of formula (I) prodrugs, addition salts, or stereochemically isomeric forms thereof for use as, inter alia, respiratory syncytial virus replication inhibitors; their preparation, composi...	06/08/2004
6743817	Substituted fused pyrroleimines and pyrazoleimines Disclosed are compounds of the formula and the pharmaceutically acceptable salts thereof wherein R, Ar, A, n, R1 and R2 are defined herein. These compounds are highly selective agonists, antagonists...	06/01/2004
6693098	Carboxylic acid derivatives as IP antagonists This invention relates to compounds which are generally IP receptor antagonists and which are represented by Formula I: ##STR1## wherein: R1, R2, and R3 are each independently in each occurrence aryl or heteroaryl; ...	02/17/2004
6680316	Pyridazin-3-one derivatives and medicines containing the same Objects of the invention are to provide compounds having excellent activity against interleukin-1ଲ production and also medicines comprising them as effective ingredients. Pyridazin-3-one derivatives represented by the following formula (1): ##STR1##...	01/20/2004
6656941	Aryl substituted tetrahydroindazoles Disclosed are compounds of the formula ##STR1## and the pharmaceutically acceptable salts thereof wherein the variables R1, R2, R3, n, and Ar are defined herein. These compounds are highly selective agonists, antagonists o...	12/02/2003
6649613	Diacylhydrazine derivatives Diacylhydrazine derivatives of general formula (I) ##STR1## wherein X, Y, Z, R1, 2 and R3 are as defined herein, and their physiologically acceptable salts or solvates thereof, are integrin inhibitors and can be used to co...	11/18/2003
6620834	Medicinal compositions for treating colorectal cancer Medicinal compositions for colorectal cancer to be administered to the large intestine by taking advantage of preparations disintegrating in the large intestine, characterized by containing a cyclooxygenase inhibitor and an HMG-CoA reductase inhibitor. Th...	09/16/2003
6610677	Pyrazole compounds useful as protein kinase inhibitors This invention describes novel pyrazole compositions comprising a pharmaceutically acceptable carrier and a compound of formula VIII: ##STR1## wherein Z1 is N or C--R9, Z2 is N or CH, and Z3 is N or C--Rx	08/26/2003
6579879	Pyridazinone aldose reductase inhibitors The present invention relates to novel pyridazinone compounds, pharmaceutical compositions comprising those compounds and to methods of using such compounds and compositions to inhibit aldose reductase, lower sorbitol levels and, thus, lower fructose leve...	06/17/2003
6562817	Tricyclic compound The present invention provides a compound of the formula (I): ##STR1## wherein A ring, B ring and C ring are each independently optionally substituted aromatic carbocycle or optionally substituted 5- or 6-membered heterocycle which may fuse with benzene ring, ...	05/13/2003

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Class 514/252.06 - Polycyclo ring system having the additional five-membered hetero ring as one of the cyclos