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| Number | Title | Issue Date |
| 8188085 | Antifungal agents Novel derivatives of enfumafungin are disclosed herein, along with their pharmaceutically acceptable salts, hydrates and prodrugs. Also disclosed are compositions comprising such compounds, methods of preparing such compounds and methods of using such compounds as a... | 05/29/2012 |
| 8183241 | 2-oxo-1-pyrrolidine derivatives The present invention concerns 2-oxo-1-pyrrolidine derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals. ... | 05/22/2012 |
| 8178538 | Pyridazinones The present invention is concerned with novel pyridazinones of formula (I) wherein R1, R2, R3 and R4 are as defined in the description and in the claims, as well as physiologicall... | 05/15/2012 |
| 8153634 | Carbinol derivatives having cyclic linker [Object] To provide a novel LXRβ agonist that is useful as a preventative and/or therapeutic agent for atherosclerosis; arteriosclerosis such as those resulting from diabetes; dyslipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases that ar... | 04/10/2012 |
| 8044053 | Sulfonamide substituted pyrazoline compounds, their preparation and use as CB1 modulators The present invention relates to substituted pyrazoline compounds of general formula (I), methods for their preparation, medicaments comprising these compounds as well as their use for the preparation of a medicament for the treatment of humans and animals. | 10/25/2011 |
| 8017610 | Phenylpyrrole derivative The present invention relates to a compound or a pharmacologically acceptable salt thereof having superior glucokinase activating activity, and is a compound represented by general formula (I), or pharmacologically acceptable salt thereof: | 09/13/2011 |
| 8008301 | Histamine H3 receptor agents, preparation and therapeutic uses The present invention discloses novel compounds of Formula (I) or pharmaceutically acceptable salts thereof, which have histamine—H3 receptor antagonist or inverse agonist activity, as well as methods for preparing such compounds. In another embodiment, the invent... | 08/30/2011 |
| 8003650 | Hydrazide compound and harmful arthropod-controlling agent containing the same Disclosed is a hydrazine compound represented by the formula (1) below, which has an excellent control activity against a harmful arthropod. (1) (In the formula, R1, R5, R6 and R7 represent a hydrogen atom or the like; R | 08/23/2011 |
| 8003649 | Bicyclic derivatives for use in the treatment of androgen receptor associated conditions-155 The invention concerns bicyclic compounds of Formula I wherein the integers X1, X2, X3, Ring A, R4, R5 and m are as defined in the description. The present invention al... | 08/23/2011 |
| 7943619 | Isoxazolo-pyridazine derivatives The invention relates to isoxazolo-pyridazine compounds, in particular those of formula I as described above and to a pharmaceutically acceptable salts thereof, having affinity and selectivity for the GABA A α5 receptor binding site, their manufacture, pharmaceutic... | 05/17/2011 |
| 7875615 | Substituted triazole derivatives as oxytocin antagonists The present invention relates to a class of substituted 1,2,4-triazoles of formula (I) with activity as oxytocin antagonists, uses thereof, processes for the preparation thereof and compositions containing said inhibitors. These inhibitors have utility in a variety ... | 01/25/2011 |
| 7790724 | c-fms kinase inhibitors The invention is directed to compounds of Formula II: wherein A, R1, R2, R3, R4, X, Y and W are set forth in the specification, as well as solvates, hydrates, tautomers or pharmac... | 09/07/2010 |
| 7772235 | mGluR5 modulators The present invention is directed to compounds of formula I: Wherein R1 to R5, X and Z are further defined in the description. The invention also relates to processes for the preparation of the compoun... | 08/10/2010 |
| 7759349 | Control of parasites in animals by the use of imidazo[1,2-b]pyridazine derivatives Novel imidazo[1,2-b]pyridazine compounds useful for controlling parasites in animals and methods of treatment of parasite infestation in animals using the compounds are disclosed. ... | 07/20/2010 |
| 7678796 | MGluR5 modulators I The present invention is directed to novel compounds, to a process for their preparation, their use in therapy and pharmaceutical compositions comprising the novel compounds. ... | 03/16/2010 |
| 7666871 | Oxazole derivatives as histamine H3 receptor agents, preparation and therapeutic uses The present invention discloses novel aryl oxazole compounds of Formula I (I), or pharmaceutically acceptable salts thereof, which have histamine-H3 receptor antagonist or inverse agonist activity, as well as methods for preparing and using such compounds. In anothe... | 02/23/2010 |
| 7511042 | Triazole compounds Disclosed are compounds of formula (I) Where Ar1, X, R3, R4, R5 and R6 are defined herein. The compounds of the invention inhibit production of cytokines and are thus u... | 03/31/2009 |
| 7452885 | Amino-5-(6-membered)heteroarylimidazolone compounds and the use thereof for β-secretase modulation The present invention provides a 2-amino-5-heteroaryl-5-phenylimidazolone compound of formula I The present invention also provides methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyloid deposits and ... | 11/18/2008 |
| 7432254 | Method for treating glaucoma IC Provided is a method of treating or ameliorating or preventing glaucoma, decreasing intraocular pressure or improving or amemliorting ocular accommodation in an animal, including a human comprising administering an intraocular pressure decreasing or accommodation im... | 10/07/2008 |
| 7429581 | Pyrazole-derivatives as factor Xa inhibitors The present invention is directed to a compound of formula I, in which R0; R1; R2; R3; R4; Q; V, G and M have the meanings indicated below. The compound of formula I is... | 09/30/2008 |
| 7399765 | Substituted diazabicycloalkane derivatives Compounds of formula (I) Z-Ar1—Ar2 (I) wherein Z is a diazabicyclic amine, Ar1 is a 5- or 6-membered aromatic ring, and Ar2 is selected from the group consisting of an unsubstituted or substitute... | 07/15/2008 |
| 7396831 | Vanilloid receptor ligands and their use in treatments Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascu... | 07/08/2008 |
| 7368573 | Triamide-substituted heterobicyclic compounds This invention relates to MTP/Apo-B secretion inhibitors of Formula (I) wherein R1-R7, X1, m and n are as defined in the specification, as well as pharmaceutical compositions comprising the ... | 05/06/2008 |
| 7361654 | Substituted heteroaryl amide modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof The present invention relates to new class of non-steroidal compounds which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity including obesity, diabetes, inflammatory- and immune-associated disea... | 04/22/2008 |
| 7335753 | Bifunctional heterocyclic compounds and methods of making and using same The invention provides a family of bifunctional heterocyclic compounds useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. The invention also provides methods of making the bifunctional heterocyclic compounds, and methods of using... | 02/26/2008 |
| 7335658 | Pyridazine derivatives and their use as therapeutic agents Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): ... | 02/26/2008 |
| 7323480 | Substituted triazoles as modulators of PPAR and methods of their preparation The present invention is directed to certain novel triazole compounds represented by Formula I and pharmaceutically acceptable salts, solvates, hydrates, and prodrugs thereof. The present invention is also directed to methods of making and using such compounds and p... | 01/29/2008 |
| 7309701 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them The present invention relates to novel pyridazinone derivatives of the general formula (I) wherein A is A1 or A2; ... | 12/18/2007 |
| 7288542 | Non-nucleoside reverse transcriptase inhibitors The present invention relates to a compounds according to formula I, methods for treating diseases mediated by human immunodeficieny virus by administration of a compound according to formula I and pharmaceutical compositions for treating diseases mediated by human ... | 10/30/2007 |
| 7259175 | Peroxisome proliferator activated receptor modulators The present invention is directed to compounds represented by the following structural formula, and pharmaceutically acceptable salts thereof, Formula I: wherein: (a) R5 is selected from the group consisting of (C1-C6) alkyl, (C1-C | 08/21/2007 |
| 7253170 | Pyrazole-amine compounds useful as kinase inhibitors The present invention provides pyrazole derived compounds of formula (I) useful for treating p38 kinase-associated conditions, where W, X, R1, R2, R3, R4, R5... | 08/07/2007 |
| 7253169 | Aza compounds, pharmaceutical compositions and methods of use The present invention relates to N-substituted cyclic aza compounds, pharmaceutical compositions comprising such compounds, and methods of their use for effecting neuronal activities. ... | 08/07/2007 |
| 7241760 | Heteroaryl-substituted imidazole derivatives The present invention relates to imidazole derivatives of the general formula wherein R1, R2, R3 and R4 are described hereinbelow. These compounds can be used in the tr... | 07/10/2007 |
| 7223760 | Substituted triazole compounds Novel substituted triazole compounds and compositions for use in therapy as CSBP/p38 kinase inhibitors. ... | 05/29/2007 |
| 7214678 | Arylsulfanyl and heteroarylsulfanyl derivatives for treating pain According to the invention there is provided a compound the formula I; wherein A, X, B, R1, R2, R3 and R4 are as defined in the specification. | 05/08/2007 |
| 7196106 | Cyanothiophene derivatives, compositions containing such compounds and methods of use The present invention addresses substituted cyanothiophene derivatives of the formula I: as well as compositions containing such compounds and methods of treatment. The compounds in the present invention are gluc... | 03/27/2007 |
| 7186722 | 2-heteroaryl-3,4-dihydro-2h-pyrrole derivatives and the use thereof as pesticides Novel Δ1-pyrrolines of the Formula (I) in which R1, R2, R3 and Het have the meanings given in the description, a plurality of processes for prep... | 03/06/2007 |
| 7179812 | Diazine derivatives The present invention provides compounds of formula (I): their pharmaceutically acceptable salts or esters, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, ph... | 02/20/2007 |
| 7179806 | Δ1-pyrrolines used as pesticides The invention relates to novel Δ1-pyrrolines of the formula (I) in which R1, R2, R3, m, and Q have the meanings given in the disclosure, to a plurality of processes fo... | 02/20/2007 |
| 7173044 | Imidazoline derivatives having CB-antagonistic activity The present invention relates to 1,2,4-tri-substituted imidazoline derivatives, to methods for the preparation of these compounds, to novel intermediates useful for the synthesis of said imidazoline derivatives, to methods for the preparation of these intermediates,... | 02/06/2007 |
