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| Number | Title | Issue Date |
| 8163748 | s-Triazine compounds, pharmaceutical compositions and method of using the same Novel s-triazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of condi... | 04/24/2012 |
| 8063046 | Benzamide derivative Compounds having high angiogenesis inhibiting activity useful as agents for effective treatment and prevention of diseases involving pathologic angiogenesis, e.g. cancer and cancer metastasis, are of formula (II), where A | 11/22/2011 |
| 8012973 | Compounds for the treatment of auricular fibrillation Adenosine A2A receptor antagonists are useful for the preparation of medicaments against atrial fibrillation in mammals, including humans. It has been found that the adenosine A2A receptor is present in human atrial cardiomyocytes and participa... | 09/06/2011 |
| 8003645 | Preventives or remedies for Alzheimer's disease, or amyloid protein fibril-formation inhibitors, which include a nitrogen-containing heteroaryl compound The present invention relates to preventives or remedies for Alzheimer's disease, or to amyloid protein fibril-formation inhibitors, which include as an active ingredient a compound of general formula (I) below or a pharmacologically permitted salt thereof; and also... | 08/23/2011 |
| 7858626 | Pyrimidineamines as angiogenesis modulators Pyrimidine derivatives, which are useful as VEGFR2 inhibitors are described herein. The described invention also includes methods of making such pyrimidine derivatives as well as methods of using the same in the treatment of hyperproliferative diseases. ... | 12/28/2010 |
| 7767676 | Dihydro-1,3,5-triazine amine derivatives and their therapeutic uses The invention relates to the compounds of general formula (I): in which R1, R2, R3, R4, R5 and R6 are as defined in Claim 1. These compounds can be used in the treatment of pathological conditions associated... | 08/03/2010 |
| 7723335 | Triazine compounds and their use in forming multidimensional libraries for affinity chromatography A compound of the formula (I) wherein each Z is the same or different and is formula (a) or —Y wherein each X is the same or different and is a multivalent aminyl group or diaminyl-terminated spacer; each Y is the same or different aminyl group; and M is a support... | 05/25/2010 |
| 7718655 | Trisubstituted triazine compounds, and methods for making and using the compounds, which have antitubulin activity Trisubstituted triazines can be synthesized from cyanuric chloride. These compounds are useful anti-tubulin agents for treating cancer and proliferative diseases. ... | 05/18/2010 |
| 7683061 | Triazine dimers for the treatment of autoimmune diseases Compounds containing two mono- or disubstituted triazine rings covalently linked by an organic linker, but not linked directly to each other, may be used to treat autoimmune diseases. Autoimmune diseases which are amenable to treatment with compounds of this inventi... | 03/23/2010 |
| 7622469 | 2,4-diamino-1,3,5-triazine derivatives The present invention relates to an antibacterial agent, which comprises, as an active ingredient, a compound represented by the following general formula (1): or a pharmaceutically acceptable salt thereof. ... | 11/24/2009 |
| 7608620 | LPAAT-β inhibitors and uses thereof The invention relates to triazines and the use thereof to inhibit lysophosphatidic acid acyltransferase β (LPAAT-β) activity. The invention further relates to methods of treating cancer using said triazines. The invention also relates to methods for screening for ... | 10/27/2009 |
| 7566712 | Biaryl piperazinyl-pyridine analogues Biaryl piperazinyl-pyridine analogues are provided, of the Formula: wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are ... | 07/28/2009 |
| 7485641 | Substituted 3-amino-pyrrolidino-4-lactams The invention provides compounds of formula (1), and the pharmaceutically acceptable salt thereof, wherein R1, n and R2 are as described herein; compositions thereof; and uses thereof. ... | 02/03/2009 |
| 7462617 | Substituted acylpiperazine derivatives The invention relates to compounds of formula wherein the substituents are as defined in the specification and to pharmaceutically acceptable acid addition salts thereof. The invention further relates to methods for... | 12/09/2008 |
| 7452883 | Dihydro-1,3,5-triazine amine derivatives and their therapeutic uses The invention concerns compounds of general formula (I) wherein: R1, R2, R3, R4, R5 and R6 are as defined in Claim 1. The compounds are useful in the treatment of pathologies related to the insulin-resistance syndrome. ... | 11/18/2008 |
| 7425451 | Triazine derivatives as universal peptide isotope tag reagents (U-PIT) Compounds, compositions, methods for sequencing proteins and peptides, and methods for identifying proteins and peptides in a mixture, are disclosed. Compounds of formula A-B-C wherein A is a nucleophilic reactive group, B is a detectable moiety capable of being iso... | 09/16/2008 |
| 7375222 | 2,4,6-Triamino-1,3,5-triazine derivative This invention relates to an anti-dementia agent which uses a BEC 1 potassium channel inhibitor as the active ingredient. It was proved that the BEC 1 potassium channel inhibitor has an action to improve learning disorder and is useful as a preventive or ther... | 05/20/2008 |
| 7371398 | Bovine teat cleaning process using dry powder reagents Animals have been domesticated and kept as a source of milk for tens of thousands of years. When humans keep animals for their ability to produce milk, the animals are usually kept in confined spaces. As a result of this confinement the animals are exposed to high l... | 05/13/2008 |
| 7344727 | Process for cleaning bovine teats Animals have been domesticated and kept as a source of milk for tens of thousands of years, When humans keep animals for their ability to produce milk, the animals are usually kept in confined spaces. As a result of this confinement the animals are exposed to high l... | 03/18/2008 |
| 7335656 | Medical devices employing triazine compounds and compositions thereof The present invention relates to methods, compounds, and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses, and is directed to compounds that inhibit or block glycated protein produced induction of the sig... | 02/26/2008 |
| 7335770 | Triazine compounds and their analogs, compositions, and methods The present invention relates to triazine compounds and their analogs and derivatives, and methods and compositions comprising these compounds. The compounds and compositions of this invention are useful for, among other things, treating pathophysiological condition... | 02/26/2008 |
| 7335672 | Vanilloid receptor ligands and their use in treatments Substituted pyridines and pyrimidines and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inf... | 02/26/2008 |
| 7332490 | Methods and compositions of novel triazine compounds The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced... | 02/19/2008 |
| 7332489 | Methods and compositions of novel triazine compounds The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced... | 02/19/2008 |
| 7332488 | Methods and compositions of novel triazine compounds The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced... | 02/19/2008 |
| 7329658 | Cannabinoid receptor ligands and uses thereof Compounds of Formula (I) that act as cannabinoid receptor ligands and their uses in the treatment of diseases linked to the mediation of the cannabinoid receptors in animals are described herein. ... | 02/12/2008 |
| 7319099 | Benzoyl-piperazine derivatives The invention relates to compounds of formula wherein the substituents are described herein. The compounds may be used in the treatment of illnesses based on the glycine uptake inhibitor, such as psychoses, pain,... | 01/15/2008 |
| 7312356 | Medicament The present invention relates to 3β,28-diacetoxy-18-oxo-19,20,21,29,30-pentanorlupan-22-oic acid methanol solvate, its use in medicine and processes for its preparation. ... | 12/25/2007 |
| 7307079 | 1,3,5-Triazine derivatives as ligands for human adenosine-A3 receptors The invention relates to a group of novel triazine derivatives which are ligands for human adenosine-A3 receptors, as well as to pharmaceutical compositions containing a pharmacologically active amount of at least one of these compounds as an active ingre... | 12/11/2007 |
| 7291616 | Aryl triazines as LPAAT-β inhibitors and uses thereof The invention relates to aryl triazines and uses thereof, including to inhibit lysophosphatidic acid acyltransferase β (LPAAT-β) activity and/or proliferation of cells such as tumor cells. ... | 11/06/2007 |
| 7285550 | Triazolotriazines and pyrazolotriazines and methods of making and using the same The invention is based on the discovery that compounds of formula (I) possess unexpectedly high affinity for the A2a adenosine receptor, and can be useful as antagonists thereof for preventing and/or treating numerous diseases, including Parkinson's disea... | 10/23/2007 |
| 7285159 | Ink jet ink, ink set, ink jet recording method, ink cartridge, recording unit, and ink jet recording apparatus Provided is an ink jet ink comprising at least a coloring material comprising a compound represented by the general formula (I) or a salt thereof; and a compound represented by the general formula (II). Thereby, there can be provided an ink jet ink that provides ima... | 10/23/2007 |
| 7273712 | Methods and compositions for detecting compounds that modulate inflammatory responses The present invention relates to compositions and methods for identification and development of compounds or therapeutic agents that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to methods ... | 09/25/2007 |
| 7265114 | Methods and compositions of novel triazine compounds The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced... | 09/04/2007 |
| 7265125 | Neuropeptide Y antagonists Quinoline and quinazoline derivatives can be used in the form of pharmaceutical preparations as Neuropeptide Y antagonists for the treatment or prevention of arthritis, cardiovascular diseases, diabetes, renal failure, eating disorders and obesity. ... | 09/04/2007 |
| 7256218 | Biguanide and dihydrotriazine derivatives Biguanide and dihydrotriazine derivatives, preferably substituted asymmetrical imidodicarbonimidic diamides derived from hydroxylamines, and compositions containing biguanide and dihydrotriazine derivatives are disclosed. In addition, methods of using the biguanide ... | 08/14/2007 |
| 7253211 | (R)-chiral halogenated substituted fused heterocyclic amino compounds useful for inhibiting cholesterol ester transfer protein activity The invention relates to substituted aryl and heteroaryl (R)-Chiral Halogenated 1-Substitutedamino-(n+1)-Alkanol compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for ... | 08/07/2007 |
| 7244735 | Heterocyclic protein kinase inhibitors and uses thereof Described herein are compounds that are useful as protein kinase inhibitors of formula I: or a pharmaceutically acceptable salt thereof, wherein Ring B, Z1, Z2, U, p, Q, R1, R | 07/17/2007 |
| 7244732 | Prodrugs of heteroaryl compounds The present invention provides hydrophobic prodrugs of bases, nucleosides, and nucleotides as well as methods of using the prodrugs as antiviral and anti-cancer chemotherapeutic agents. ... | 07/17/2007 |
| 7238692 | Medical devices employing triazine compounds and compositions thereof The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced... | 07/03/2007 |
