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| Number | Title | Issue Date |
| 8076334 | Prodrugs of thyroid hormone analogs Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical composition... | 12/13/2011 |
| 8048882 | Pharmaceutical compositions with increased activity The invention relates to novel pharmaceutical combinations with improved sodium channel blocking effect. Further, the invention relates to the use of said pharmaceutical combinations in chronic pain, in disturbances of the motor system, in epilepsy, as well as in ot... | 11/01/2011 |
| 7943614 | Carboxamide compound and use of the same A carboxamide compound represented by the formula (I): [wherein Q represents a nitrogen-containing 6-membered aromatic heterocyclic group optionally fused with a benzene ring, two or more ring constitutional atoms of the he... | 05/17/2011 |
| 7888356 | Antibiotics containing borinic acid complexes and methods of use The structure and preparation of antibiotics incorporating borinic acid complexes are disclosed, especially hydroxyquinoline, imidazole and picolinic acid derivatives, along with compositions of these antibiotics and methods of using the antibiotics and compositions... | 02/15/2011 |
| 7713971 | 1,2,4-triazine derivatives, preparation and use thereof in human therapy The invention relates to 3,5-dioxo-(2H,4H)-1,2,4-triazine compounds of formula I in which the variables are defined herein, as well as additive salts with pharmaceutically acceptable bases and the various enantiomers of com... | 05/11/2010 |
| 7713970 | Substituted cyclic urea derivatives Certain novel phenyl substituted cyclic urea derivatives have unexpected insecticidal activity. These compounds are represented by formula I: where A, B a, D, b, E, G, c, d, J, X and R through R10, inclusively, are fully described herein. In addition, com... | 05/11/2010 |
| 7687500 | Substituted oxetanes, method of making, and method of use thereof Oxetane-containing nucleosides, particularly non-reducing psiconucleoside oxetanes are described herein. Therapeutic application of these oxetane compounds toward the treatment of nucleoside analog related disorders such as disorders involving cellular proliferation... | 03/30/2010 |
| 7671053 | Benzamide inhibitors of the P2Xreceptor The present invention provides benzamide inhibitors of the P2X7 receptor of the formula: wherein R1-R3 are as defined herein. The compounds of the invention are useful in the treatment of IL... | 03/02/2010 |
| 7625897 | Non-nucleoside reverse transcriptase inhibitors The present invention provides compounds of formula I where R1 to R4 are as defined herein which are useful for treating or preventing an human immunodeficiency virus (HIV) infection, or treating AIDS or ARC. The invention further provides for ... | 12/01/2009 |
| 7585861 | HIV inhibiting 1,2,4-triazines The present invention relates to HIV replication inhibitors of formula (I) as defined in the specification their use as a medicine, their processes for preparation and pharmaceutical compositions comprising them. ... | 09/08/2009 |
| 7550463 | Carbamoylpyridone derivatives having inhibitory activity against HIV integrase An object of the present invention provides a novel compound having the anti-viral activity, particularly, the HIV integrase inhibitory activity, and a drug containing the same, particularly, an anti-HIV drug. There is provided a compound represented by the f... | 06/23/2009 |
| 7517881 | Triazine derivatives, their preparation and therapeutic application thereof The invention relates to triazine derivatives of general formula (I): Wherein R1, R2 and R3 are as defined herein. The invention also relates to a method for preparing these triazine derivat... | 04/14/2009 |
| 7494996 | Substituted 4,5-dihydro-1,2,4-triazin-6-ones, 1,2,4-triazin-6-ones and their use as fungicides and insecticides This invention relates to dihydrotriazinones, triazinones and related compounds, compositions comprising such compounds and an agronomically acceptable carrier, and the use thereof as broad spectrum fungicides and insecticides. This invention also teaches methods of... | 02/24/2009 |
| 7494997 | Amide derivative The present invention provides an amide derivative represented by the following general formula (1): wherein R1 represents a saturated cyclic amino group, R2 represents alkyl, halogen or haloalkyl, R | 02/24/2009 |
| 7485639 | 4-(benzylidene-amino)-3-(methylsulfanyl)-4h-(1,2,4)triazin-5-one derivatives having a PDE-IV inhibiting and TNF-antagonistic effect for the treatment of cardiac diseases and allergies Triazine derivatives of the formula (I) and physiologically acceptable salts and solvates thereof, in which R1, R2, A and R5 are as defined in Claim 1, exhibit phosphodiesterase IV inhibition and can be employed for the treatm... | 02/03/2009 |
| 7452882 | Thyroid hormone analogs Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositi... | 11/18/2008 |
| 7439268 | Compositions containing prodrugs of florfenicol and methods of use The present invention provides compositions and methods for administering florfenicol to mammals. The compositions contain a prodrug of florfenicol in a pharmaceutically acceptable carrier. In one embodiment the prodrug is an esterized form of florfenicol. Examples ... | 10/21/2008 |
| 7432254 | Method for treating glaucoma IC Provided is a method of treating or ameliorating or preventing glaucoma, decreasing intraocular pressure or improving or amemliorting ocular accommodation in an animal, including a human comprising administering an intraocular pressure decreasing or accommodation im... | 10/07/2008 |
| 7429590 | Antiprotozoal imidazopyridine compounds Compounds described by the Formula (I) or (II): or pharmaceutically acceptable salts, or N-oxides thereof. The compounds are useful for the treatment and prevention of protozoal diseases in mammals and birds. A method for controlling coccidiosis in poultry comprises... | 09/30/2008 |
| 7410968 | Capped pyrazinoylguanidine sodium channel blockers The present invention relates to compounds represented by formula (I): where the structural variables are as defined herein. The compounds are useful for promoting hydration of mucosal surfaces. ... | 08/12/2008 |
| 7407956 | Benzamide inhibitors of the P2Xreceptor The present invention provides benzamide inhibitors of the P2X7 receptor of the formula: wherein R1-R3 are as defined herein. The compounds of the invention are useful in the treatment of IL... | 08/05/2008 |
| 7390806 | Antibiotics containing borinic acid complexes and methods of use The structure and preparation of antibiotics incorporating borinic acid complexes are disclosed, especially hydroxyquinoline, imidazole and picolinic acid derivatives, along with compositions of these antibiotics and methods of using the antibiotics and compositions... | 06/24/2008 |
| 7390807 | Crystal forms of lamotrigine and processes for their preparations The present invention relates to lamotrigine, a useful agent for anti-epilepsia. New crystal forms of lamotrigine containing molecules of the solvent in stoichiometric ratios are disclosed. The present invention also provides processes for preparing the new crystal ... | 06/24/2008 |
| 7371750 | Compounds and compositions as protein kinase inhibitors The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or d... | 05/13/2008 |
| 7361689 | Antibacterial 1-(4-mono- and di-halomethylsulphonylphenyl)-2-acylamino-3-fluoroproponals and preparation thereof Novel florfenicol compounds having the chemical structure: or a pharmaceutically-acceptable salt thereof or a solvate thereof, or prodrug thereof, wherein R1 is CHCl2, CHClF, C... | 04/22/2008 |
| 7354929 | Cannabinoid receptor ligands and uses thereof Compounds of Formula (I) that act as cannabinoid receptor ligands and their uses in the treatment of diseases linked to the mediation of the cannabinoid receptors in animals are described herein ... | 04/08/2008 |
| 7354939 | Pyrrole inhibitors of ERK protein kinase, synthesis thereof and intermediates thereto The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, ... | 04/08/2008 |
| 7348335 | Compositions useful as inhibitors of JAK and other protein kinases The present invention provides a compound of formula I: or a pharmaceutically acceptable salt thereof. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and metho... | 03/25/2008 |
| 7326706 | Pyrazine modulators of cannabinoid receptors The present application describes compounds according to Formula I, wherein A, G1, G2 and R1 are described herein. Additionally, the present application describes pharmaceutical compositions comprising at least one compound according... | 02/05/2008 |
| 7312227 | Compositions useful as inhibitors of JAK and other protein kinases The present invention provides a compound of formula I: or a pharmaceutically acceptable salt thereof. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the inventio... | 12/25/2007 |
| 7309800 | Biphenylcarboxylic amide derivatives as p38 kinase inhibitors Compounds of formula (I): or pharmaceutically acceptable salts or solvates thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors. ... | 12/18/2007 |
| 7309711 | Fungicidal agent combinations The invention relates to novel fungicidallly active compound combinations of 2′-cyano-3,4-dichloroisothiazole-5-carboxanilide of the formula and the active compounds listed in the disclosure. ... | 12/18/2007 |
| 7304063 | Inhibitors of Akt activity The present invention is directed to compounds which contain a heterocyclic triazine moiety which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this inve... | 12/04/2007 |
| 7271167 | Compounds, compositions, and methods 1,2,4-Triazin-5-ones useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed. ... | 09/18/2007 |
| 7271289 | Biphenylcarboxylic amide derivatives as p38 kinase inhibitors Compounds of formula (I): or pharmaceutically acceptable derivatives thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors. ... | 09/18/2007 |
| 7268095 | Transition metal catalysts for (co) polymerizing of olefinic monomers A compound of the formula Ia or Ib; where, in the formula Ia, E1 is O, S, Se, Te, NR, CR2, or PR; E2, E... | 09/11/2007 |
| 7265138 | Vanilloid receptor ligands and their use in treatments Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular an... | 09/04/2007 |
| 7262202 | Inhibitors of cyclin dependent kinases as anti-cancer agent The present invention relates to 2-substituted 4-heteroaryl-pyrimidines, their preparation, pharmaceutical compositions containing them and their use as inhibitors of cyclin-dependent kinases (CDKs) and hence their use in the treatment of proliferative disorders suc... | 08/28/2007 |
| 7262200 | Indazolinone compositions useful as kinase inhibitors The present invention provides compounds of formula I: These compounds, and pharmaceutically acceptable compositions thereof, are useful generally as kinase inhibitors, particularly as inhibitors of PRAK, GSK3, ERK... | 08/28/2007 |
| 7253211 | (R)-chiral halogenated substituted fused heterocyclic amino compounds useful for inhibiting cholesterol ester transfer protein activity The invention relates to substituted aryl and heteroaryl (R)-Chiral Halogenated 1-Substitutedamino-(n+1)-Alkanol compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for ... | 08/07/2007 |
