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"The abolishment of pain in surgery is a chimera. It is absurd to go on seeking it...knife and pain are two words in surgery that must forever be associated in the consciousness of the patient."
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| Number | Title | Issue Date |
| 7365076 | Substituted aryl cycloalkanol derivatives and methods of their use The present invention is directed to substituted aryl cycloalkanoyl derivatives, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor sym... | 04/29/2008 |
| 7365070 | Modulators of melanocortin receptor This invention provides compounds and methods for treating melanocortin receptor associated disorders, such as weight loss disorders including cachexia resulting from cancer and other chronic illnesses. The compounds are represented by formula I: ... | 04/29/2008 |
| 7338953 | Method of treating chronic fatigue syndrome Disclosed herein are methods of treating an individual suffering from, chronic fatigue syndrome. The methods generally include administration of a therapeutic amount of racemic reboxetine, or a pharmaceutically acceptable salt thereof, to the individual. ... | 03/04/2008 |
| 7276503 | Method of treating chronic fatigue syndrome Disclosed herein are methods of treating an individual suffering from, chronic fatigue syndrome. The methods generally include administration of a therapeutic amount of optically pure (S,S) reboxetine, or a pharmaceutically acceptable salt thereof, to the individual... | 10/02/2007 |
| 7241762 | Method of treating peripheral neuropathy Disclosed herein are methods of treating an individual suffering from peripheral neuropathy. The methods generally include administration of a therapeutic amount of racemic reboxetine, or a pharmaceutically acceptable salt thereof, to the individual. ... | 07/10/2007 |
| 7230132 | Aryl N-cyanoguanidines and methods related thereto Compounds, compositions and methods treating arthritic disorders such as osteoarthritis or rheumatoid arthritis, and for treating other diseases associated with altered mitochondrial function, such as cancer, psoriasis, stroke, Alzheimer's Disease and diabetes. The ... | 06/12/2007 |
| 7129238 | Mandelic acid derivatives The invention is concerned with novel mandelic acid derivatives of formula (I) wherein R1 to R10, X and Y are as defined in the description and in the claims, as well as pharmaceutically acc... | 10/31/2006 |
| 6998415 | Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to compounds, compositions and methods for treating disorders mediated by cyclooxygenase-2 or 5-lipoxygenase, such as inflammation. ... | 02/14/2006 |
| 6927218 | Aryl N-cyanoguanidines and methods related thereto Compounds, compositions and methods treating arthritic disorders such as osteoarthritis or rheumatoid arthritis, and for treating other diseases associated with altered mitochondrial function, such as cancer, psoriasis, stroke, Alzheimer's Disease and diabetes. The ... | 08/09/2005 |
| 6849626 | Aza-amino acid derivatives (factor Xa inhibitors 15) The invention relates to semicarbazides of the general formula I where R1, R2, R3, R4 and I have the meaning indicated in claim 1. The compounds of the formul... | 02/01/2005 |
| 6800659 | Compounds for modulating cell proliferation Novel styrylacrylonitrile compounds which are useful in treating a variety of cell proliferative disorders such as cancer are disclosed. The compounds are of the Formula I: ... | 10/05/2004 |
| 6720319 | Compounds useful as reversible inhibitors of cysteine proteases Disclosed are novel cathepsin S, K, F, L and B reversible inhibitory compounds of the formula (Ia) and (Ib) where R2, R3, R4, R5, R6, R7, R8, Het and X are defined herein. The compounds are... | 04/13/2004 |
| 6703389 | Method of treating chronic pain Methods and compositions for treating humans suffering from, or preventing a human from suffering, a physiological or psychiatric disease, disorder, or a condition where inhibiting reuptake of norepinephrine is a benefit are disclosed. The compositions co... | 03/09/2004 |
| 6680317 | IL-8 receptor antagonists This invention relates to novel compounds of Formula (I), and compositions thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).... | 01/20/2004 |
| 6638930 | Morpholine and thiomorpholine tachykinin receptor antagonists Substituted heterocycles of the general structural formula: ##STR1## are tachykinin receptor antagonists useful in the treatment of inflammatory diseases, pain or migraine, asthma and emesis, and calcium channel blockers useful in the treatment of cardiov... | 10/28/2003 |
| 6562821 | Aryl-N-cyanoguanidines and methods related thereto Compounds, compositions and methods treating arthritic disorders such as osteoarthritis or rheumatoid arthritis, and for treating other diseases associated with altered mitochondrial function, such as cancer, psoriasis, stroke, Alzheimer's Disease and dia... | 05/13/2003 |
| 6552025 | Diimino-piperazine derivatives for use as modulators of cell regulation Compositions, methods of use, isolation and biosynthesis of diimino-piperazine derivatives useful for the modification of sphingolipid metabolism and other biological functions are described. The preferred derivative is 2,6-bis-(ω-aminobutyl)-3,5-diimino... | 04/22/2003 |
| 6525036 | Compounds and compositions as protease inhibitors The present invention relates to novel cysteine protease inhibitors of Formula I: ##STR1## the pharmaceutically acceptable salts and N-oxide derivatives thereof, their use as therapeutic agents and methods of making them.... | 02/25/2003 |
| 6436933 | Inhibitors of anthrax lethal factor activity Methods and compositions that act as specific inhibitors of ALF activity for the prophylaxis and treatment of anthrax infections.... | 08/20/2002 |
| 6303652 | BTK inhibitors and methods for their identification and use The invention provides BTK inhibitors, methods for their identification and use, and pharmaceutical compositions comprising BTK inhibitors.... | 10/16/2001 |
| 6294575 | BTK inhibitors and methods for their identification and use The invention provides BTK inhibitors, methods for their identification and use, and pharmaceutical compositions comprising BTK inhibitors.... | 09/25/2001 |
| 6160010 | BTK inhibitors and methods for their identification and use The invention provides BTK inhibitors, methods for their identification and use, and pharmaceutical compositions comprising BTK inhibitors.... | 12/12/2000 |
| 6114323 | Methods for inhibiting the advanced glycosylation of proteins The present invention relates to methods for inhibiting protein aging. Accordingly, methods are disclosed for treating an animal to inhibit the formation of advanced glycosylation end products of target proteins with the animal by adminstering a pharmaceu... | 09/05/2000 |
| 5972940 | Arginine analogues having nitric oxide synthase inhibitor activity A compound selected from the group consisting of a compound of the formula wherein A is selected from the group consisting of hydrogen, alkyl of 1 to 6 carbon atoms and --NO2, E is --O-- or a covalent bond, n is an integer from 1 to 12, R1... | 10/26/1999 |
| 5852009 | Compositions, including pharmaceutical compositions, for inhibiting the advanced glycosylation of proteins, and therapeutic methods based thereon The present invention relates to compositions and methods for inhibiting protein aging. Accordingly, a composition is disclosed which comprises an agent or compound capable of inhibiting the formation of advanced glycosylation end products of target prote... | 12/22/1998 |
| 5840725 | Substituted oximes, hydrazones and olefins as neurokinin antagonists Compound represented by the structural formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein: a is 0, 1, 2 or3; b, d and e are independently 0, 1 or 2; R is H, C1-6 alkyl, --OH or C2 -C6 hydroxyalkyl; A is an ... | 11/24/1998 |
| 5612332 | Di- and triaminoguanidines, and methods of use The present invention relates to compounds, compositions and methods for inhibiting nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises a di- or tri-aminoguanidine capable of inhibiting the formation of adva... | 03/18/1997 |
| 5578594 | Sulfonamidocarboxamides Sulfonamidocarboxamides of the formula ##STR1## wherein A, M, Q, X and Y have the significance given in the description, as well as hydrates, solvates and salts thereof, which inhibit thrombin-induced blood platelet aggregation and clotting of fibrin... | 11/26/1996 |
| 5563168 | O-Benzyloxime ethers and crop protection agents containing these compounds O-Benzyloxime ethers of the formula I ##STR1## where 5 X is substituted or unsubstituted CH2, NOalkyl Y is O, S, NR5 R1, R2, R5 are H, alkyl Z1, Z2 are H, halogen, methyl, methoxy, cy... | 10/08/1996 |
| 5543433 | Azine-substituted phenylacetic acid derivatives and fungicides containing these Compounds of the formula I ##STR1## where X is hydrogen, halogen, alkyl, alkoxy, trifluoromethyl, cyano or nitro, Y is an amino, methylamino or dimethylamino group, Z is a group CHCH3, CHOCH3 or NOCH3, R is hydrogen or alk... | 08/06/1996 |
| 5523325 | Amidrazones and their use as pesticides This invention relates to amidrazones, insecticidal amidrazone compositions, and methods of using such compositions.... | 06/04/1996 |
| 5464832 | Substituted 3-thioacryloyl compounds and their use as antimicrobial agents A thioacryloyl compound of the formula ##STR1## wherein Z is selected from the group consisting of OR, R and NR1 R2 ; R is selected from the group consisting of hydrogen; (C1 -C18)alkyl; (C1 -C | 11/07/1995 |
| 5281625 | Fungicidal guanidines Guanidines I ##STR1## (A=C5 -C12 -cycloalkyl which may bear up to three further substituents; benzyl substituted in the para-position; R1, R2, R3 =H, C1 -C4 -alkyl; R4 | 01/25/1994 |
| 5268373 | Guanidine derivatives, compositions and use This invention relates to new heterocyclic derivatives of guanidine and more particularly to such derivatives which have hypoglycemic activity, their methods of use for treating hyperglycemia and novel intermediate compounds for their preparation.... | 12/07/1993 |
| 5126374 | Fungicidal guanidines Guanidines I ##STR1## (A=C5 -C12 -cycloalkyl which may bear up to three further substituents; benzyl substituted in the para-position; R1, R2, R3 =H, C1 -C4 -alkyl; R4 | 06/30/1992 |
| 5082840 | Morpholine compounds and treatment A method for increasing the weight gain and/or improving the feed utilization efficiency and/or increasing the lean body mass and/or decreasing birth mortality rate and increasing post-natal survival rate of livestock comprises the administration to lives... | 01/21/1992 |
| 5006523 | Antiarrhythmic agents: aryl cyanoguanidine potassium channel blockers Novel compounds of the formula ##STR1## and tautomers thereof are disclosed. These compounds possess potassium channel blocking activity and, as such, are useful as antiarrhythmic agents.... | 04/09/1991 |
| 4983604 | Inhibitors of nonenzymatic cross-linking The present invention relates to compositions and methods for inhibiting nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises an agent capable of inhibiting the formation of advanced glycosylation endproducts... | 01/08/1991 |
| 4837236 | Fungicidal morpholine compounds, and their production and use A heterocyclic compound of the formula: ##STR1## wherein A is an oxygen atom or a sulfur atom; B is either one of the groups: --CH2 --CHR1 -- or --CH.dbd.CR1 -- (in which R1 is a hydrogen atom or a methyl g... | 06/06/1989 |
| 4810725 | 1-aryloxy-3-(substituted aminoalkylamino)-2-propanols, pharmaceutical compositions and use 1-Aryloxy-3-(substituted aminoalkylamino)-2-propanols and pharmaceutically acceptable salts thereof have ଲ-adrenergic blocking activity with some cardioselectivity and hence are useful as anti-hypertensive, antianginal, antiarrhythmic and cardioprot... | 03/07/1989 |
