Did You Know...
...that while attempting to develop a super strong glue, 3M employee Spencer Silver accidentally developed a glue that was so weak it would barely hold two pieces of paper together? However, his colleague Art Fry needed the glue. Fry sang with his church choir and marked the pages of his hymnal with small scraps of paper that often fell out. He used Silver's glue to hold the papers in place. Today we call this invention Post-it Notes.
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| Number | Title | Issue Date |
| 8183239 | Substituted piperazines and piperidines as modulators of the neuropeptide Y2 receptor The invention provides novel non-peptidic NPY Y2 receptor inhibitors useful in treating or preventing: anxiolytic disorders or depression; injured mammalian nerve tissue; conditions responsive to treatment through administration of a neurotrophic factor; neurologica... | 05/22/2012 |
| 8183240 | Heteroaryls and uses thereof This invention provides compounds of formula I: wherein R1, R2, CY, Y1, Y2, X1, X2, and X3 are as described in the specif... | 05/22/2012 |
| 8178530 | Imidazolopyrazine compounds useful for the treatment of degenerative and inflammatory diseases Novel imidazo[1,2-a]pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a vari... | 05/15/2012 |
| 8178529 | Imidazole substituted pyrimidines Imidazole substituted pyrimidines and pharmaceutically acceptable salts thereof; pharmaceutical formulations containing such pyrimidines; the use of such compounds in therapy; the use of such compounds for the treatment of conditions associated with glycogen synthas... | 05/15/2012 |
| 8178531 | Antiviral agents The present invention relates to antiviral compounds of formula (I), compositions containing these compounds, processes for their preparation, intermediates in their synthesis, and their use as therapeutics for prevention o... | 05/15/2012 |
| 8163745 | HIV inhibiting 5-(hydroxymethylene and aminomethylene) substituted pyrimidines This invention concerns 5-(hydroxymethylene and aminomethylene)pyrimidine derivatives having HIV (Human Immunodeficiency Virus) replication inhibiting properties, to the preparation thereof and to pharmaceutical compositions comprising these compounds. ... | 04/24/2012 |
| 8163746 | Azolecarboxamide derivative Provided is an agent for treating or preventing urinary frequency, urinary urgency and urinary, incontinence which are associated with overactive bladder, a lower urinary tract disease such as interstitial cystitis and chronic prostatitis accompanied by lower urinar... | 04/24/2012 |
| 8153630 | Kinase inhibitors Disclosed are protein kinase inhibitors of Formula Ia and Ib, compositions comprising such inhibitors, and methods of use, thereof. More particularly, these compounds and compositions are inhibitors of Aurora-A (Aurora-2) and Aurora-B (Aurora-1) protein kinase. Also... | 04/10/2012 |
| 8138183 | Morpholino pyrimidine derivatives used in diseases linked to mTOR kinase and/or PI3K A compound of formula (I) or a pharmaceutically acceptable salt thereof, processes for their preparation, pharmaceutical compositions containing them and their use in therapy, for example in the treatment of proliferative disease such as cancer and particularly in d... | 03/20/2012 |
| 8129377 | 6-(pyridinyl)-4-pyrimidone derivates as tau protein kinase 1 inhibitors A compound represented by the formula (I), an optically active isomer thereof, or a pharmaceutical acceptable salt thereof: wherein R1 represents a C1-C12 alkyl; R2 represents a h... | 03/06/2012 |
| 8114872 | Triazolyl aminopyrimidine compounds The present invention provides triazolyl aminopyrimidine compounds useful in the treatment of cancer. ... | 02/14/2012 |
| 8093246 | O-linked pyrimidin-4-amine-based compounds, compositions comprising them, and methods of their use to treat cancer O-linked pyrimidin-4-amine-based compounds, pharmaceutical compositions comprising them, and methods of their use are described. Particular compounds of the invention are of formula I: ... | 01/10/2012 |
| 8093244 | Heteroaryl urea derivatives useful for inhibiting CHK1 Substituted urea compounds useful in the treatment of diseases and conditions related to DNA damage or lesions in DNA replication are disclosed. Methods of making the compounds, and their use as therapeutic agents, for example, in treating cancer and other diseases ... | 01/10/2012 |
| 8093245 | 4-amino-1H-pyrimidin-2-one based compounds, compositions comprising them and methods of their use 4-Amino-1H-pyrimidin-2-one-based compounds, compositions comprising them, and methods of their use for the treatment, prevention and management of various diseases and disorders are disclosed. Particular compounds are of formula I: | 01/10/2012 |
| 8088769 | Cyanopyrimidinones The invention relates to novel cyanopyrimidinones, process for their preparation, and the use thereof for producing medicaments for improving perception, concentration, learning and/or memory. ... | 01/03/2012 |
| 8048881 | Pyrimidine derivatives and their use as P2Y12 receptor antagonists The invention relates to 4-aminocarbonyl-pyrimidine derivatives and their use as P2Y12 receptor antagonists in the treatment and/or prevention and/or treatment of peripheral vascular, of visceral-, hepatic- and renal-vascular, of cardiovascular and of cer... | 11/01/2011 |
| 8017608 | 5-Phenylthiazole derivatives and their use as p13 kinase inhibitors Compounds of formula I in free or salt form, wherein R1, R2, R3, R4 and R5 have the meanings as indicated in the specification, are useful for treating diseases mediate... | 09/13/2011 |
| 8003643 | Inhibitors of Akt activity The present invention is directed to compounds which contain substituted pyridazines and pyrimidines moieties which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the comp... | 08/23/2011 |
| 7973039 | Sulfonyl amino cyclic derivatives and use thereof The present invention is related to derivatives of Formula (I) and use thereof in particular for the treatment and/or prophylaxis of autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, cancer, respiratory diseases and fi... | 07/05/2011 |
| 7964597 | Piperazinyl-sulfonamide derivatives useful in the treatment of GPR38 receptor mediated diseases Disclosed are motilin agonists, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders. ... | 06/21/2011 |
| 7956053 | Inhibitors of tyrosine kinases The invention relates to compounds of formula wherein the substituents R1, R2 and R4 have the meaning as set forth and explained in the description of the invention, to processes for the preparation of these compounds, p... | 06/07/2011 |
| 7935698 | Heteroaryl-hydrazone compounds This invention relates to compounds having a formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, hydrate, prodrug or polymorph thereof wherein X is —C(Rg)═N-A. The invention also relates t... | 05/03/2011 |
| 7919492 | Compounds Compounds of formula (I) wherein R1 is 2-indanyl, R2 is 1-methylpropyl, R3 is a group selected from 2,6-dimethyl-3-pyridyl or 4,6-dimethyl-3-pyridyl, R4 represents methyl and R | 04/05/2011 |
| 7915256 | Triazolopyrazine compounds useful for the treatment of degenerative and inflammatory diseases Novel [1.2.4]triazolo[1,5-a]pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of ... | 03/29/2011 |
| 7910585 | Pyrimidine derivatives Novel pyrimidine derivatives of formula I to processes for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them. ... | 03/22/2011 |
| 7906511 | Cyclic compound having pyrimidinylalkylthio group The present invention has its object to study synthesis of novel cyclic compounds having a pyrimidinylalkylthio group and to find pharmacological actions of the compounds. According to the present invention, a compound represented by the formula (1) or a salt thereo... | 03/15/2011 |
| 7902192 | Inhibitors of P38 and methods of using the same In general, the present invention relates to compounds capable of inhibiting p38, methods for inhibiting p38 in vivo or in vitro, and methods for treating conditions associated with p38 activity or cytokine activity. ... | 03/08/2011 |
| 7893064 | Hydrazone derivatives as kinase inhibitors The present invention is directed to novel bicyclic pyrimidine compounds of Formula (I) or a form or composition thereof as inhibitors of ATP-protein kinase interactions, wherein substituents on each side of the iminomethyl... | 02/22/2011 |
| 7893063 | 2,4,6-trisubstituted pyrimidines as phosphotidylinositol (PI) 3-kinase inhibitors and their use in the treatment of cancer The invention concerns pyrimidine derivatives of Formula (I) wherein each of Qa, G1, G2, q, R3, r, R4, X1 and Qb have any of the meanings defined in the description; processes for their pre... | 02/22/2011 |
| 7879853 | 4,6-disubstituted pyrimidines and their use as protein kinase inhibitors The invention relates to novel pyrimidine derivatives of Formula (1) which are efficacious inhibitors of protein kinases, in particular of one or more isoforms of the protein kinase B/Akt. ... | 02/01/2011 |
| 7875610 | Pyrimidinyl-piperazines useful as D/Dreceptor ligands The present invention relates to new dopamine D3 and D2 ligands of formula (I): wherein R1, R2 and Q are as described herein, and/or geometric isomers and/or stereoisomers and/or diastereomers and/or s... | 01/25/2011 |
| 7872005 | 2-substituted heteroaryl compounds This invention relates to compounds of formula (I): or pharmaceutically acceptable salts, solvate, clathrates hydrates or polymorphs thereof, their compositions and methods of use and methods of making thereof. The compound... | 01/18/2011 |
| 7855205 | Pyrimidinyl substituted fused-pyrrolyl compounds useful in treating kinase disorders The present invention provides pyrimidinyl substituted fused-pyrrolyl compounds of Formula (I) and pharmaceutical compositions comprising the compounds and methods of synthesis and use thereof. The compounds are kinase inhi... | 12/21/2010 |
| 7851471 | Compounds I The present application relates to new compounds of formula (I), to pharmaceutical compositions comprising the compounds, to processes for their preparation, and to the use of the compounds as leptin receptor modulator mime... | 12/14/2010 |
| 7842693 | Substituted piperazines Compounds are provided that act as potent antagonists of the CCR1 receptor, and which have been further confirmed in animal testing for inflammation, one of the hallmark disease states for CCR1. The compounds are generally aryl piperazine derivatives and are useful ... | 11/30/2010 |
| 7838524 | Substituted pyrazolyl urea derivatives useful in the treatment of cancer The present invention relates to compounds of formula (I), pharmaceutical compositions which contain them and methods for treating cancer using compounds of formula (I). ... | 11/23/2010 |
| 7838525 | Trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto The present invention relates to certain trisubstituted aryl and heteroaryl derivatives of Formula (I) that are modulators of metabolism. Accordingly, compounds of the present invention are useful in the prophylaxis or trea... | 11/23/2010 |
| 7834011 | Heterocyclylalkyl derivatives as novel inhibitors of histone deacetylase This invention comprises the novel compounds of formula (I) wherein R1, T, X, Y, A, n, m and p have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions cont... | 11/16/2010 |
| 7829560 | 1,4-disubstituted naphthalenes as inhibitors of P38 MAP kinase 1,4 disubstituted napthylenes, of formula (I), are disclosed. These compounds may be useful in treating cell-proliferative diseases. ... | 11/09/2010 |
| 7825116 | N2, N4-bis-aryl-5-fluoro-2,4-pyrimidinediamines The present invention provides methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds, as well as methods of treating, preventing or ameliorating symptoms associated with such diseases. Specific examples of autoimmune diseases tha... | 11/02/2010 |
