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| Number | Title | Issue Date |
| 8101606 | Neurofibromin pathway modulators The present invention encompasses methods for treating neurofibromatosis. ... | 01/24/2012 |
| 8067412 | Macrocyclic compounds useful as inhibitors of kinases and HSP90 Disclosed are macrocyclic compounds of formulae I-V, which are analogs of the pochonin resorcylic acid lactones, and processes for the preparation of the compounds. The compounds disclosed are useful as inhibitors of kinases and Heat Shock Protein 90 (HSP 90). Also ... | 11/29/2011 |
| 7915255 | Metabolism-modulating agents and uses therefor The present invention is directed to methods and agents for modulating adipogenesis. More particularly, the present invention relates to molecules that modulate the level or functional activity of inosine-5′ monophosphate dehydrogenase (IMPDH) and to their use in ... | 03/29/2011 |
| 7855200 | Method for treatment of gastric ulcers and ulcers induced by aspirin The present invention relates to methods of using Oroxylum indicum as a rich source for flavanoid compounds having mucoprotective and antigastric ulcer properties, and containing Oroxylin A, Chrysin and Baicalein. ... | 12/21/2010 |
| 7829557 | 2-heterosubstituted 3-aryl-4H-1-benzopyran-4-ones as novel therapeutics in breast cancer The present invention provides 2-heterosubstituted 3-aryl-4H-benzopyran-4-one compounds for the treatment of cancers, namely breast cancer. This invention further provides a method of synthesis of 2-(alkylthio)isoflavones that can be carried out at ambient condition... | 11/09/2010 |
| 7812019 | Chromanylurea compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor and uses thereof Compounds that are antagonists of the VR1 receptor, having formula (I) or a pharmaceutically acceptable salt, prodrug, or salt of a prodrug thereof, wherein A1, A2, A3, A4, R... | 10/12/2010 |
| 7772230 | Chroman compound, processes for its preparation, and its pharmaceutical use The present invention provides a chroman compound of formula (I) and its pharmaceutical salt, methods of its preparation and its pharmaceutical applications. Wherein: X is O or S; n is for 2, 3 or 4; R1 is 6-substituted or 7-substituted halogen, C1-4... | 08/10/2010 |
| 7767671 | 3-Quinolinecarbonitrile protein kinase inhibitors This invention provides a compound of Formula 1 where Ar, X, R1, R2, R3, and R4 are defined herein, or a pharmaceutically acceptable salt thereof useful in the prevention or inhib... | 08/03/2010 |
| 7622465 | Costunolide derivatives Disclosed are methods for inhibiting TNFα expression, IL-1β expression, iNOS expression, and NF-κB activity and methods for treating autoimmune disease, cancer, or atherosclerosis with a compound of the following formula: ... | 11/24/2009 |
| 7605158 | Carbamoyl-type benzofuran derivatives The present invention provides a carbamoyl-type benzofuran derivative of the formula [1]: wherein Ring Z is a group of the formula: etc.; A is a single bond, and the like; Y is a ... | 10/20/2009 |
| 7572791 | Therapeutic morpholino-substituted compounds Morpholino-substituted pyridopyrimidine, quinolone, and benzopyranone derivatives inhibit phosphoinositide (PI) 3-kinase, an enzyme that regulates platelet-adhesion processes. As a consequence, the compounds in question have anti-thrombotic activity, as well as othe... | 08/11/2009 |
| 7449460 | 3-Quinolinecarbonitrile protein kinase inhibitors This invention provides a compound of Formula 1 where Ar, X, R1, R2, R3, and R4 are defined herein, or a pharmaceutically acceptable salt thereof useful in the prevention or inhib... | 11/11/2008 |
| 7371749 | Benzothiazole derivatives The present invention relates to compounds of formulae IA and IB wherein R1 and R2 are each independently lower alkyl or —(CH2)m—O-lower alkyl, or together with t... | 05/13/2008 |
| 7358244 | Azabicycloalkane compounds This invention provides compounds of formula I: wherein R1, R2, R3, R4, R5, R6 and R7 are as defined in the specification, or a pharmaceutically acc... | 04/15/2008 |
| 7338949 | Mycobacterial inhibitors The present invention relates to novel substituted quinoline derivatives according to the general formula (Ia) or the general formula (Ib) salts, quaternary amines, stereochemically isomeric forms, tautomeric forms and N-ox... | 03/04/2008 |
| 7304058 | Carbamic acid esters of benzothiazoles The present invention relates to a compound of formula I wherein R, X and n are defined hereinabove, and to a pharmaceutically acceptable salt thereof. The compound may be used for the treatment of diseases relat... | 12/04/2007 |
| 7297692 | 1,3-dihydro-2-indol-2-one derivatives, process for preparing them and pharmaceutical compositions containing them The invention relates to compounds of formula: as well as the possible salts thereof with mineral or organic acids, and the solvates and/or hydrates thereof, which have affinity for and selectivity towards the V1b | 11/20/2007 |
| 7291619 | Melanocortin receptor agonists The present invention relates to melanocortin receptor agonists of formula (I), which is useful in the treatment of obesity, diabetes and male and/or female sexual dysfunction ... | 11/06/2007 |
| 7285548 | Urea substituted benzothiazoles The present invention relates to compounds of formula I wherein R1 and R2 are described herein, and their pharmaceutically acceptable salts thereof for the... | 10/23/2007 |
| 7282497 | Pyrrolidin-2-one derivatives as inhibitors of factor xa The invention relates to compounds of formula (Ic) processes for their preparation, pharmaceutical compositions containing them and to their use in medicine, particularly use in the amelioration of a clinical con... | 10/16/2007 |
| 7256188 | 3-aminoalkyl-2-aryl-indole derivatives and their use as GnRH antagonists The present invention relates to compounds of formula I which are antagonists of gonadotropin releasing hormone (GnRH) activity. The invention also relates to pharmaceutical formulations, the use of a compound of the present invention in the manufacture of a medicam... | 08/14/2007 |
| 7247627 | Salts and polymorphs of a pyrrole-substituted indolinone compound The invention relates to non-hygroscopic salts of 5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-morpholin-4-ylpropyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide, such as maleate salts, and to crystalline polymorphs of these salts. The ... | 07/24/2007 |
| 7235675 | Conjugates of mycophenolic acid The present invention provides a method for the measurement of an analyte in biological samples whereby an uncompetitive inhibitor is coupled to a ligand and utilized in a homogeneous assay. The analyte can be a drug or drug derivative, hormone, polypeptide, or olig... | 06/26/2007 |
| 7214701 | Active substance combinations having insecticidal and acaricdal properties The invention relates to insecticidal mixtures for protecting plants against attack by pests comprising (a) compounds of the formula (I) ... | 05/08/2007 |
| 7196082 | Ophthalmic compositions for treating ocular hypertension This invention relates to potent potassium channel blocker compounds of Formula I or a formulation thereof for the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the us... | 03/27/2007 |
| 7189715 | Compositions comprising zopiclone derivatives and methods of making and using the same The invention is directed to racemic and stereomerically pure compounds of Formula 3: and to pharmaceutical compositions comprising them, methods of their use, and methods of their preparation. ... | 03/13/2007 |
| 7189714 | N-type calcium channel antagonists for the treatment of pain Compounds useful for the treatment of pain in accord with the following structural diagram, wherein R1, R2 and R3 are any of a number of groups as defined in the specification and... | 03/13/2007 |
| 7186715 | Piperazine- and piperidine-derivatives as melanocortin receptor agonists The present invention relates to melanocortin receptor agonists of formula I, which is useful in the treatment of obesity, diabetes and male and/or female sexual dysfunction ... | 03/06/2007 |
| 7173136 | 3-Cyano-quinoline derivatives The invention concerns quinoline derivatives of Formula (I) wherein each of Z1, m, R1, n, R3, Z2 and R14 have any of the meanings defined hereinbefore in the description; processes for their preparation, pharmac... | 02/06/2007 |
| 7169777 | Melanocortin receptor agonists The present invention relates to melanocortin receptor agonist of the formula I useful in the treatment of obesity, diabetes, and male and/or female sexual dysfunction ... | 01/30/2007 |
| 7157466 | Quinazoline ditosylate salt compounds Ditosylate salts of 4-quinazolineamines are described as well as methods of using the same in the treatment of disorde4rs characterized by aberrant erbB family PTK activity. ... | 01/02/2007 |
| 7157577 | 5-sulfonamido-substituted indolinone compounds as protein kinase inhibitors The present invention relates to 5-sulfonamido substituted indolinones that modulate the activity of protein kinases (“PKs”). The compounds of this invention are therefore useful in treating disorders related to abnormal PK activity. Pharmaceutical compositions ... | 01/02/2007 |
| 7157463 | Substituted piperidines/piperazines as melanocortin receptor agonists The present invention relates to melanocortin receptor agonists of formula I, which is useful in the treatment of obesity, diabetes and male and/or female sexual dysfunction ... | 01/02/2007 |
| 7148230 | Quinazoline derivatives The invention concerns quinazoline derivatives of Formula I wherein R1 and R2 have any of the meanings defined in the description; processes for their preparation, pharmaceutical composition... | 12/12/2006 |
| 7148252 | Use of benzopyranones for treating or preventing a primary brain cancer or a brain metastasis This invention relates to methods for using benzopyranones, or their pharmaceutically acceptable salts, for treating or preventing a primary brain cancer or a brain metastasis. The benzopyranones have the formula: | 12/12/2006 |
| 7129240 | 1,3-dihydro-2H-indol-2one derivatives, process for preparing them and pharmaceutical compositions containing them The invention relates to compounds of formula: as well as the possible salts thereof with mineral or organic acids, and the solvates and/or hydrates thereof, which have affinity for and selectivity towards the V | 10/31/2006 |
| 7128900 | Light-protection agents The invention relates to a preparation having light-protection properties comprising at least one compound of the formula I where R1 and R2 are selected from H and OR11, where eac... | 10/31/2006 |
| 7122687 | Process for the production of an immunosuppressant In one aspect, the present invention provides a process for producing a sodium salt of an immunosupressant of Formula I ... | 10/17/2006 |
| 7109333 | Heterocyclic compounds A process for the preparation of a compound of formula (I) comprising the steps: (a) reacting a compound of formula (II) ... | 09/19/2006 |
| 7105513 | Acylated, heteroaryl-condensed cycloalkenylamines and their use as pharmaceuticals The present invention relates to acylated, heteroaryl-condensed cycloalkenylamines, to pharmaceutical compositions comprising such compounds, to methods for the stimulation of the expression of endothelial NO synthase, and methods of treatment comprising administeri... | 09/12/2006 |
