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3M employee and church chorister Art Fry needed something to temporarily mark pages in his hymnal. He was in luck because his colleague, Spencer Silver, accidentally developed a glue that was too weak for other purposes. After initially discouraging consumer response, Post-it Notes became a hit in 1979.
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| Number | Title | Issue Date |
| 8163741 | Use of aryl-substituted polycyclic amines as medicaments The invention relates to therapeutic use of aryl-substituted polycyclic amines of the formula I, especially bicyclic amines, and to the physiologically tolerated salts and physiologically functional derivatives thereof; whe... | 04/24/2012 |
| 8148370 | Polysubstituted derivatives of 2-aryl-6-phenyl-imidazo[1,2-a]pyridines, and preparation and therapeutic use thereof Compounds of formula (I): wherein R1, R2, R3, R4 and X are as defined in the disclosure, or an acid addition salt thereof, and the therapeutic use and process of synthesis thereof... | 04/03/2012 |
| 8148369 | Fused pyrazine compounds useful for the treatment of degenerative and inflammatory diseases Novel fused pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of c... | 04/03/2012 |
| 8129374 | Method of using imidazolothiazole compounds for the treatment of disease Compounds, compositions and methods are provided for modulating the activity of receptor kinases and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder mediated by receptor kinases. ... | 03/06/2012 |
| 8106047 | Triazolophthalazines The compounds of formula (I) in which R1, R2 and R3 have the meanings as given in the description are novel effective PDE2 inhibitors. ... | 01/31/2012 |
| 8088765 | Polysubstituted derivatives of 6-heteroarylimidazo[1,2-a]pyridines, and preparation and therapeutic use thereof Compounds of formula (I): wherein R1, R2, R3, R4, Het and X are as defined in the disclosure, or an acid addition salt thereof, and the therapeutic use and process of synthesis th... | 01/03/2012 |
| 8017604 | Imidazopyridines The invention is concerned with novel imidazopyridine derivatives of formula (I) wherein R1, R2, R3, R4, R5 and A are as defined in the description and in the claims, a... | 09/13/2011 |
| 7943611 | Imidazo[1,2-A]pyridin-3-yl-acetic acid hydrazides, processes, for their preparation and pharmaceutical uses thereof The invention provides novel imidazo[1,2-a]pyridin-3-yl-acetic acid hydrazides of formula (I) wherein R1, R2 and R3 have different meanings, and pharmaceutically acceptable salts, polymorphs, hydrates, tautomers, solvates and stereoi... | 05/17/2011 |
| 7897600 | Amino pyrazole compound The present invention provides amino pyrazole compounds useful in the treatment of chronic myeloproliferative disorders and various cancers, e.g., glioblastoma, breast cancer, multiple myeloma, prostate cancer, and leukemias. ... | 03/01/2011 |
| 7893058 | Imidazolopyrazine compounds useful for the treatment of degenerative and inflammatory diseases Novel imidazo[1,2-a]pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of... | 02/22/2011 |
| 7868001 | Cytokine inhibitors A compound of Formula I: Each variable is defined in the specification. This invention relates to a method of decreasing a level of a cytokine (e.g., TNFα or interlukine such as IL-1β) in a subject with a compound of Form... | 01/11/2011 |
| 7829556 | Sirtuin modulating compounds Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, dis... | 11/09/2010 |
| 7820657 | Imidazolothiazole compounds for the treatment of disease Compounds, compositions and methods are provided for modulating the activity of receptor kinases and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder mediated by receptor kinases. ... | 10/26/2010 |
| 7795255 | Rigidified compounds for modulating heparanase activity Disclosed are novel rigidified compounds having a rhodanine-like residue and at least one aryl or heteroaryl residue linked to the rhodanine-like residue, whereby a core structure of these compounds, as defined in the specification, is characterized as having one or... | 09/14/2010 |
| 7781430 | Benzoxazole carboxamides for treating CINV and IBS-D Compounds of formulae I and II: are disclosed as 5-HT3 inhibitors. Those compounds that exhibit central activity are useful in treating CINV; those that inhibit peripheral receptors are useful to treat IBS-D. | 08/24/2010 |
| 7763613 | Substituted N-arylsulfonylheterocyclic amines as gamma-secretase inhibitors Disclosed are novel gamma secretase inhibitors of the formula: Also disclosed are methods for inhibiting gamma secretase, for treating one or more neurodegenerative diseases, for inhibiting the deposition of beta amyloid prot... | 07/27/2010 |
| 7750000 | Substituted imidazo[1,2b]pyridazines as kinase inhibitors, their preparation and use as medicaments The invention relates to novel inhibitors of kinases, and pharmaceutical compositions comprising them. The inhibitors are substituted imidazo[1,2b]pyridazines. ... | 07/06/2010 |
| 7713969 | Compositions and methods for treatment of cancer The present invention relates to pyrroloquinolinyl-pyrrole-2,5-dione compounds and pyrroloquinolinyl-pyrrolidine-2,5-dione compounds, and methods of preparation of these compounds. The present invention also relates to pharmaceutical compositions comprising pyrroloq... | 05/11/2010 |
| 7700593 | Imidazo- and triazolo-pyridine compounds and methods of use thereof The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation and related conditions. The compounds have a general Formula I wh... | 04/20/2010 |
| 7687497 | C10-substituted camptothecin analogs The novel C10-modified camptothecin analogs, and pharmaceutically-acceptable salts thereof, of the present invention: (i) possess potent antitumor activity (i.e., in nanomolar or subnanomolar concentrations) for inhibiting the growth of human and animal tumor cells ... | 03/30/2010 |
| 7687496 | C7-substituted camptothecin analogs The novel C7-modified camptothecin analogs, and pharmaceutically-acceptable salts thereof, of the present invention: (i) possess potent antitumor activity (i.e., in nanomolar or subnanomolar concentrations) for inhibiting the growth of human and animal tumor cells i... | 03/30/2010 |
| 7671050 | Triazolophthalazines The compounds of formula (I) in which R1, R2 and R3 have the meanings as given in the description are novel effective PDE2 inhibitors. ... | 03/02/2010 |
| 7612067 | Imidazopyridazine compounds The present invention relates to novel substituted imidazo[1,2-b]pyridazine compounds of Formula (I): pharmaceutical compositions thereof, and the use such compounds as corticotropin releasing factor 1 (CRF1) receptor antagonists in the treatment of psychiatric diso... | 11/03/2009 |
| 7563788 | Substituted Imidazo[1,2-a]pyridines as Antibacterial Agents Compounds of formula I and methods for their preparation are disclosed. Further disclosed are methods of making biologically active compounds of formula I as well as pharmaceutically acceptable compositions comprising compounds of formula I. Compounds of formula I a... | 07/21/2009 |
| 7501411 | Triazolopyrazine compounds useful for the treatment of degenerative and inflammatory diseases Novel [1.2.4]triazolo[1,5-a]pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment o... | 03/10/2009 |
| 7498327 | Indolylalkylamine metabolites as 5-hydroxytryptamine-6 ligands The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of disorders relating to or affected by the 5-HT6 receptor. ... | 03/03/2009 |
| 7419977 | Imidazoquinoline derivatives as adenosine A3 receptor ligands This invention is directed to a compound of formula (I), wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X, Z, m... | 09/02/2008 |
| 7402579 | Quinobenzoxazine analogs and compositions The present invention relates to quinobenzoxazines analogs having the general formula: and pharmaceutically acceptable salts, esters and prodrugs thereof; wherein A, U, W, X, Z, B, ... | 07/22/2008 |
| 7354918 | Derivatives of 14.15-dihydro 20.21-dinoreburnamenin-14-ol and applications thereof The invention relates to novel derivatives of 14,15-dihydro 20,21-dinoreburnamenin-14-ol, having formula (I) in which R represents a radical —AR′ wherein A represents a heteroatom and R′ represents a group selected fr... | 04/08/2008 |
| 7348425 | Inhibitors of HCV replication Indole compounds of Formula I are described. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV. Different forms and compositions comprising the compounds are also described as well as methods of preparing ... | 03/25/2008 |
| 7342012 | Inhibitors of αβmediated cell adhesion The present invention relates to a compound of the following formula: or a pharmaceutically acceptable salt thereof. Also disclosed are compositions containing the compound and methods of preparing and using the compounds. ... | 03/11/2008 |
| 7329663 | Substituted-triazolopyrimidines as anticancer agents The invention provides a method of treating or inhibiting the growth of cancerous tumor cells and associated diseases in a mammal in need thereof which comprises administering to said mammal an effective amount of a substituted triazolopyrimidine derivative or a pha... | 02/12/2008 |
| 7323462 | Morpholine dopamine agonists Compounds of formula (I), (Ia) and (Ib) useful as a medicament. ... | 01/29/2008 |
| 7314871 | 2-phenyl substituted imidazotriazinones as phosphodiesterase inhibitors, for treatment of hypertension The application claims a method for treating hypertension by administering an effective amount of a compound of the formula (I) wherein the variable groups are as defined in the specification and claims. These 2-... | 01/01/2008 |
| 7279473 | Pyrazolopyridazine derivatives Fused pyradazine derivatives which are usefule as CDK inhibitors are described herein. The described invention alos includes methods of making such fused pyradazine derivatives as wells as methods of using the same in the treatment of hyperproliferative diseases. | 10/09/2007 |
| 7276491 | Anticoagulant and fibrinolytic therapy using p38 MAP kinase inhibitors Disclosed are methods for a treating a disease or condition relating to blood coagulation and fibrinolysis using p38 MAP kinase inhibitors. ... | 10/02/2007 |
| 7268136 | Compositions useful as inhibitors of protein kinases The present invention provides a compound of formula (I): or a pharmaceutically acceptable salt thereof. These compounds are inhibitors of protein kinases, particularly inhibitors of PIM-... | 09/11/2007 |
| 7268141 | Xanthine phosphodiesterase V inhibitors A xanthine phosphodiesterase V inhibitor having the formula (I), with the variables defined herein, which is especially useful for treating male (erectile) and female sexual dysfunction and other physiological disorders: | 09/11/2007 |
| 7267827 | Therapeutic compositions for intranasal administration which include KETOROLAC An analgesic/anti-inflammatory pharmaceutical dosage form which comprises an effective amount of an active ingredient selected from the group consisting of racemic 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid, optically active forms thereof and pharmaceuti... | 09/11/2007 |
| 7262199 | Tyrosine kinase inhibitors The present invention relates to compounds which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to treat tyrosine kinase-dependent diseases and conditions, such as angiogen... | 08/28/2007 |
