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| Number | Title | Issue Date |
| 8178527 | Tetra-substituted NDGA derivatives via ether bonds and carbamate bonds and their synthesis and pharmaceutical use Disclosed are nordihydroguaiaretic acid derivative compounds including various end groups bonded by a carbon atom or heteroatom though a side chain bonded to the respective hydroxy residue O groups by an ether bond or a carbamate bond, pharmaceutical compositions, m... | 05/15/2012 |
| 7531536 | Pyrazole compounds useful as protein kinase inhibitors This invention describes novel pyrazole compounds of formula IIIa: wherein R1 is T-Ring D, wherein Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyc... | 05/12/2009 |
| 7410965 | Delayed release pharmaceutical composition containing 1-dimethyl-amino-3-(3-methoxyphenyl)-2-methyl-pentan-3-ol A delayed release pharmaceutical formulation containing 1-dimethylamino-3-(3-methoxyphenyl)-2-methylpentan-3-ol or a pharmaceutically acceptable salt thereof in a matrix; said matrix containing from 1 to 80 wt. % of at least one pharmaceutically acceptable, matrix-f... | 08/12/2008 |
| 7365067 | Indanol derivative The present invention provides a compound having the following general formula (I) which is useful as a neurokinin receptor antagonist: (wherein, R1, R2: optionally s... | 04/29/2008 |
| 7358247 | Mycophenolate mofetil impurity Provided is an impurity of mycophenolate mofetil, processes for its preparation and its use as a reference. ... | 04/15/2008 |
| 7329765 | Benzothiophene compounds having antiinfective activity Benzothiophene compounds such as are DNA binding compounds exhibiting antibacterial activity. ... | 02/12/2008 |
| 7300587 | Oxidation of heavy metal ions A water-insoluble polymeric oxidizing medium is contemplated that has a plurality of polymerized N-pyridinium vinylbenzyl triiodide or tribromide moieties whose pyridinium rings bear two substituents, R1 and R2, that are independently a hydrido... | 11/27/2007 |
| 7265088 | Method and compositions for altering mucus secretion Methods and compounds for increasing or decreasing mucus secretion in subjects, and particularly mucus secretion in the airways, are described. Methods of screening compounds for the ability to increase or decrease mucus secretion are also described. ... | 09/04/2007 |
| 7186671 | Particulate alumina and process for removing metal ions from water A water-insoluble polymeric oxidizing medium is contemplated that has a plurality of polymerized N-pyridinium vinylbenzyl triiodide or tribromide moieties whose pyridinium rings bear two substituents, R1 and R2, that are independently a hydrido... | 03/06/2007 |
| 7186714 | Imidazo[1,2-α]pyridine derivatives for the prophylaxis and treatment of herpes viral infections The present invention provides compounds of formula (I) wherein all variables are as defined herein, pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents ... | 03/06/2007 |
| 6995151 | Isophthalic acid derivatives as matrix metalloproteinase inhibitors Selective MMP-13 inhibitors are isophthalic acid derivatives of the formula wherein: R1, R2, and R3 independently are hydrogen, halo, hydroxy, C1 | 02/07/2006 |
| 6921739 | Anti-microbial and oxidative co-polymer A water-insoluble polymeric oxidizing medium is contemplated that has a plurality of polymerized N-pyridinium vinylbenzyl triiodide or tribromide moieties whose pyridinium rings bear two substituents, R1 and R2, that are independently a hydrido... | 07/26/2005 |
| RE38761 | Styryl compounds which inhibit EGF receptor protein tyrosine kinase A method of inhibiting cell proliferation in a patient suffering from such disorder comprising administering to said patient an effective amount of a composition comprising, in admixture with a pharmaceutically acceptable carrier, a compound, or a pharmaceutically a... | 07/19/2005 |
| 6899864 | Morpholino imaging and therapy The present invention provides a kit and a method for targeting of a diagnostic or therapeutic agent to a target site in a mammal having a pathological condition. The kit comprises, in separate containers, (a) a first conjugate comprising a targeting moiety and a Mo... | 05/31/2005 |
| 6770641 | Fused heteroaryl derivatives The present invention provides a pharmaceutical composition which is useful as a phosphatidylinositol 3 kinase (PI3K) inhibitor and an antitumor agent, and it provides a novel bicyclic or tricyclic fused heteroaryl derivative or a salt thereof which possesses an exc... | 08/03/2004 |
| 6743788 | Carbamate and oxamide compounds Disclosed are novel aromatic compounds of the formula(I) described herein, wherein G, E, W, Ar, X, Y and Z are disclosed herein. The compounds are useful for treating cytokine mediated diseases or conditions such as chronic inflammatory diseases. Also disclosed are ... | 06/01/2004 |
| 6723719 | Pyrazolopyrimidinones which inhibit type 5 cyclic guanosine 3′,5′—monophosphate phosphodiesterase (cGMP PDE5) for the treatment of sexual dysfunction Compounds of formulae (IA) and (IB) or pharmaceutically or veterinarily acceptable salts thereof, or pharmaceutically or veterinarily acceptable solvates of either entity, wherein R1 is C1 to C3 alkyl substituted with C3 t... | 04/20/2004 |
| 6617323 | Amino-substituted compounds useful as inhibitors of IMPDH enzyme The present invention discloses compounds useful in treating or preventing IMPDH-associated disorders, such as transplant rejection and autoimmune diseases, having the formula (I), ##STR1## wherein X is --C(O)--, --C(S)--, or --S(O)2 --; A is a... | 09/09/2003 |
| 6605635 | N-substituted benzyl or phenyl aromatic sulfamides compounds and the use thereof N-(3,5-bis-disubstituted aminomethyl-4-hydroxy)benzyl aromatic sulfonamides and N-(3,5-bis-disubstituted aminomethyl-4-hydroxy)phenyl aromatic sulfonamides compounds in accordance with the animal test, are active in the prevention and the treatment of car... | 08/12/2003 |
| 6455520 | Benzamide derivatives and their use as cytokine inhibitors The invention concerns amide derivatives of formula (I) ##STR1## wherein R3 is (1-6C)alkyl or halogeno; m is 0-3, p is 0-2 and q is 0-4; each of R1 and R2 is a group such as hydroxy, halogeno, trifluoromethyl and cyano; R | 09/24/2002 |
| 6451791 | Amidoaromatic ring sulfonamide hydroxamic acid compounds An amidoaromatic ring sulfonamide hydroxamic acid compound that inter alia inhibits matrix metalloprotease activity is disclosed, as are a treatment process that comprises administering a contemplated amidoaromatic ring sulfonamide hydroxamic acid compoun... | 09/17/2002 |
| 6248737 | 1-phenyl-3-dimethylaminopropane compounds with a pharmacological effects 1-phenyl-3 -dimethylaminopropane compounds corresponding to the formula I ##STR1## a method of preparing them, and the use of these substances as analgesic active ingredients in pharmaceutical compositions.... | 06/19/2001 |
| 6242446 | Method for treating attention deficit disorder Tachykinin receptor antagonists that are useful for treating or preventing attention deficit disorder, optionally associated with hyperactivity in a patient, are desclosed.... | 06/05/2001 |
| 6211175 | Cardiac diseases improving method This invention relates to cardiac diseases improving agents substantially free from antagonistic action to type 1 receptor of angiotensin II which participates to hypotensive action. Particularly, this invention relates to cardiac diseases improving agent... | 04/03/2001 |
| 6133262 | Antithrombotic agents This application relates to novel compounds of formula I (and their pharmaceutically acceptable salts), as defined herein, processes and intermediates for their preparation, pharmaceutical formulations comprising the novel compounds of formula I, and the ... | 10/17/2000 |
| 6096788 | Antimalaria and antibabesiosis agents and pharmaceutical compositions containing such agents The invention concerns pharmaceutical compositions with antimalaria and antibabesiosis activity, the active substances of these compositions and their use for formulating antimalaria drugs.... | 08/01/2000 |
| 6075026 | Certain substituted 1-aryl-3-piperazin-1'-yl propanones Disclosed are compounds of formula I: or the pharmaceutically acceptable salts thereof wherein X is a carbonyl, sulfonyl, methylene, or methylene substituted with optionally substituted phenyl; Z is nitrogen or CH; Ar1 and Ar2 independent... | 06/13/2000 |
| 5948778 | Difluoro statone antiviral analogs This invention relates to novel statone antiviral analogs, to the processes and intermediates useful for their preparation and to their use as antiviral agents.... | 09/07/1999 |
| 5914351 | Anti-viral aromatic hydrazones Compounds of the formula ##STR1## wherein Q is a hydrazone derivative; R1 is hydrogen, halogen, alkyl or alkoxy; R2 is hydrogen, halogen, alkyl, alkoxy, alkenoxy, alkynyloxy, halomethyl, trifluoromethoxy, alkylthio, nitro or cyano; a... | 06/22/1999 |
| 5869484 | Phenylcarbamate derivatives suitable to the use as anticholinesterase substances Phenylcarbamate derivatives suitable to the use as anticholinesterase substances having the general formula (I) ##STR1## wherein the meaning of R1 -R7 and X substituentes together with n will be defined in the text.... | 02/09/1999 |
| 5869067 | Bi-aromatic compounds and pharmaceutical and cosmetic compositions The present invention relates to new aromatic compounds, to their preparation and to their use in human and veterinary medicine and in cosmetic compositions.... | 02/09/1999 |
| 5849738 | 1,2,4-benzotriazine oxides as radiosensitizers and selective cytotoxic agents A method of using 1,2,4-benzotriazine oxides, some of which are novel compounds, as radiosensitizers and selective cytotoxic agents is disclosed. These compounds are shown to specifically radiosensitize hypoxic tumor cells. Some are additionally disclosed... | 12/15/1998 |
| 5753239 | Bi-aromatic compounds and pharmaceutical and cosmetic compositions Bi-aromatic compounds are provided along with methods for their preparation and use.... | 05/19/1998 |
| 5719149 | Morpholine derivatives and their use as therapeutic agents The present invention relates to compounds of formula (I) wherein: R1, R2, R3, R4 and R5 are selected from a variety of suitable aromatic substituents; R6 is hydrogen, C1-6 alkyl, ... | 02/17/1998 |
| 5693674 | Method of using triaryl-ethylene derivatives in the treatment and prevention of osteoporosis The present invention relates to a method of using triaryl-ethylene derivatives in the treatment or prevention bone tissue loss or osteoporosis.... | 12/02/1997 |
| 5693619 | Method of using renin inhibiting N-(2-amino-2-oxoethyl) butanediamide derivatives Disclosed herein is a method of using compounds of the formula: A-N(R1)C(O)CH2 CHR2 C(O)-B wherein A is R3 R4 NC(O)CH2 when, for example, R3 is hydrogen or alkyl and R4 is hydro... | 12/02/1997 |
| 5691384 | Method of using triaryl-ethylene derivatives in the treatment and prevention of osteoporosis The present invention relates to a method of using triaryl-ethylene derivatives in the treatment or prevention bone tissue loss or osteoporosis.... | 11/25/1997 |
| 5684004 | Triaryl-ethylene derivatives The present invention relates to novel triaryl-ethylene derivatives that are useful as anti-neoplastic agents, antiatherosclerotic agents, and hypocholesterolemic agents.... | 11/04/1997 |
| 5624925 | 1,2,4-benzotriazine oxides as radiosensitizers and selective cytotoxic agents A method of using 1,2,4-benzotriazine oxides, some of which are novel compounds, as radiosentitizers and selective cytotoxic agents is disclosed. These compounds are shown to specifically radiosensitize hypoxic tumor cells. Some are additionally disclosed... | 04/29/1997 |
| 5616584 | 1,2,4-benzotriazine oxides as radiosensitizers and selective cytotoxic agents A method of using 1,2,4-benzotriazine oxides, some of which are novel compounds, as radiosensitizers and selective cytotoxic agents is disclosed. These compounds are shown to specifically radiosensitize hypoxic tumor cells. Some are additionally disclosed... | 04/01/1997 |
