Class 514/230.8 - Chalcogen bonded directly to ring carbon of 1,4-oxazine ring

Subclass of Class 514 - Drug, bio-affecting and body treating compositions
Definition: Subject matter in which the six-membered hetero ring has
No. of patents: 163
Last issue date: 03/06/2012

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Number	Title	Issue Date
8129373	Carbonyl compounds Novel compounds of the formula (I), in which D, E, G, W, X, Y, T, R1 and R2 are as defined in Patent Claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and f...	03/06/2012
8101601	Aminoacyl prodrug derivatives and medicaments for the treatment of thromboembolitic disorders The present application relates to prodrug derivatives of 5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxo-morpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and ...	01/24/2012
8039467	Compounds for the treatment of inflammatory disorders This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, TNF-α...	10/18/2011
7879848	Dipeptidyl Peptidase-IV inhibiting compounds, method of preparing the same, and pharmaceutical compositions containing the same as an active agent Novel compounds exhibiting good inhibitory activity versus Dipeptidyl Peptidase-IV(DPP-IV) include those of the following formula (1) or pharmaceutically acceptable salt thereof: wherein A is a substituted or unsubstituted ...	02/01/2011
7659268	Modulators of ATP-binding cassette transporters Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The ...	02/09/2010
7635694	Cyclobutenedione-containing compounds as inhibitors of hepatitis C virus NS3 serine protease The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of us...	12/22/2009
7531535	Lactam-containing compounds and derivatives thereof as factor Xa inhibitors The present application describes lactam-containing compounds and derivatives thereof of Formula I: or pharmaceutically acceptable salt forms thereof, wherein ring P, if present is a 5-7 membered carbocycle or heterocycle a...	05/12/2009
7482341	Pyridines Compounds of formula as well as pharmaceutically acceptable salts and esters thereof, wherein R1 to R6 have the significance given in claim 1 can be used in the form of pharmaceutical compositio...	01/27/2009
7427618	Ethynyl derivatives as factor Xa inhibitors Novel compounds of the formula (I), in which R1, R2, R3, X and Y have the meaning indicated in Patent claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic di...	09/23/2008
7417144	Factor Xa inhibitors The invention is concerned with novel heteroaryl fused cyclic amines of formula (I) wherein A, X1 to X3, Y1 to Y3, Z, R1, R2, m and n are as defined in the d...	08/26/2008
7351707	Spiroazacyclic compounds as monoamine receptor modulators The present invention relates to optionally substituted 1-oxa-4,9-diaza-spiro[5.5]undecan-3-one compounds as monoamine receptor modulators; compositions comprising the same; methods of inhibiting an activity of a monoamine receptor with said compounds; methods of tr...	04/01/2008
7314883	Anti-migraine treatments The present invention relates to methods of treating neurogenic vasodilation, neurogenic inflammaton, migraine and other headaches, thermal injury, circulatory shock, flushing associated with menopause, airway inflammatory diseases, such as asthma and chronic obstru...	01/01/2008
7288539	Spiroazacyclic compounds as monoamine receptor modulators The present invention relates to optionally substituted 1-oxa-4,9-diaza-spiro[5.5]undecan-3-one compounds as monoamine receptor modulators; compositions comprising the same; methods of inhibiting an activity of a monoamine receptor with said compounds; methods of tr...	10/30/2007
7265109	Thiazole derivatives Compounds of formula I as well as pharmaceutically acceptable salts and esters thereof, wherein the substituents have the significance given in the specification, and the compounds are neuropeptide Y(NPY) antagon...	09/04/2007
7253211	(R)-chiral halogenated substituted fused heterocyclic amino compounds useful for inhibiting cholesterol ester transfer protein activity The invention relates to substituted aryl and heteroaryl (R)-Chiral Halogenated 1-Substitutedamino-(n+1)-Alkanol compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for ...	08/07/2007
7220862	Calcitonin gene related peptide receptor antagonists The present invention relates to compounds of Formula (I) as antagonists of calcitonin gene-related peptide receptors (“CGRP-receptor”), pharmaceutical compositions comprising them, methods for identifying th...	05/22/2007
7214701	Active substance combinations having insecticidal and acaricdal properties The invention relates to insecticidal mixtures for protecting plants against attack by pests comprising (a) compounds of the formula (I) ...	05/08/2007
7205408	Quinolines and nitrogenated derivative thereof substituted in 4-position by a piperidine-containing moiety and their use as antibacterial agents Piperidine derivatives and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly in man. ...	04/17/2007
7192957	Compounds as inhibitors of hepatitis C virus NS3 serine protease The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of us...	03/20/2007
7186844	Method for producing cyclic carbamate ester A method for producing a cyclic carbamate ester produces the cyclic carbamate ester by reacting an organic compound having at least two halogen atoms per molecule, an amine having at least two hydrogen atoms on a nitrogen atom, and carbon dioxide. ...	03/06/2007
7173057	Ketoamides with cyclic P4'S as inhibitors of NS3 protease of hepatitis C virus The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of us...	02/06/2007
7125865	Therapeutic compounds for treating dyslipidemic conditions The present invention relates to novel LXR ligands of Formula I and the pharmaceutically acceptable salts, esters and tautomers thereof, which are useful in the treatment of dyslipidemic conditions, particularly depressed levels of HDL cholesterol.	10/24/2006
7122536	(R)-chiral halogenated substituted fused heterocyclic amino compounds useful for inhibiting cholesterol ester transfer protein activity The invention relates to substituted aryl and heteroaryl (R)-Chiral Halogenated 1-Substitutedamino-(n+1)-Alkanol compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for ...	10/17/2006
7056929	Benzo[b]pyrano[3,2-h]acridin-7-one compounds A method for treating a living body afflicted with a cancer selected from lung and ovarian carcinoma, comprising the step of administering to the living animal body an amount of a compound selected from those of formula (I):	06/06/2006
7034017	Substituted oxazolidinones and their use in the field of blood coagulation This invention relates to compounds of formula (I) wherein R1 represents optionally substituted phenyl, R2 represents optionally substituted and the r...	04/25/2006
7034015	Aminobenzoephenones The invention relates to a novel class of aminobenzophenones derivatives, to pharmaceutical preparations comprising said compounds, to dosage units of such preparations, to methods of treating patients comprising administering said compounds, and to the use of said ...	04/25/2006
6972288	4-amino-quinazoline and quinoline derivatives having an inhibitory effect on signal transduction mediated by tyrosine kinases The present invention relates to bicyclic heterocycles of general formula wherein Ra to Rd, A to G and X are defined as in claim 1, the tautomers, the steroisome...	12/06/2005
6950034	Method and apparatus for performing diagnostics on a downhole communication system A method for performing diagnostics on a wired drill pipe telemetry system of a downhole drilling system is provided. The method includes passing a signal through a plurality of drill pipe in the wired drill pipe (WDP) telemetry system, receiving the signal from the...	09/27/2005
6943160	Morpholine derivatives as antagonists of orexin receptors This invention relates to morpholine derivatives of formula (I) and their use as antagonists of orexin receptors. ...	09/13/2005
6936726	Flavanol and cysteamine conjugates The present invention refers to new products generated by the conjugation of flavanols with molecules that contain the thiol group. New molecules are obtained from polyphenolic plant extracts rich in oligomeric and polymeric procyanidines and prodelfinidins. In this...	08/30/2005
6924313	Substituted tertiary-heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity The invention relates to substituted tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid trans: protein-I) and compounds, compositions and methods for treating atherosclerosis and other coronary artery d...	08/02/2005
6903094	Amide derivatives and nociceptin antagonists The present invention relates to a compound of the formula [1′] wherein R2 is lower alkyl optionally substituted by hydroxy, amino and the like, ring B is phenyl, thienyl and the lik...	06/07/2005
6881735	Sulfur substituted sulfonylaminocarboxylic acid N-arylamides, their preparation, their use and pharmaceutical preparations comprising them The present invention relates to compounds of the formula I wherein A1, A2, R1, R2, R3, X and n are as defined in the claims, which are valuable pharmaceutically a...	04/19/2005
6864276	Active substance combinations having insecticidal and acaricidal properties The invention relates to insecticidal mixtures for protecting plants against attack by pests comprising (a) compounds of the formula (I) in which W, X, Y, Z, A, B, D and G ...	03/08/2005
6841551	Brain, spinal, and nerve injury treatment A treatment for brain, spinal and nerve injury comprising use of a substance P receptor antagonist optionally in combination with a magnesium compound. There is also provided a formulation for use in this treatment comprising a substance P receptor antagonist and a ...	01/11/2005
6812226	P2X7 receptor antagonists for use in the treatment of inflammatory, immune or cardiovascular disease The invention provides piperidine compounds of general formula (I) in which A, B, X, Y, Z, R, R1 and R2 are as defined in the specification, their use as medicaments, compositions containing them and processes for their for their preparation. ...	11/02/2004
6743790	Factor VIIa inhibitory (thio)urea derivatives, their preparation and their use The present invention relates to compounds of the formula I, in which R1, R2, R3, R4, R5, R6, A, X, m and n have the meanings indicated in the claims. The...	06/01/2004
6727244	Mammalian metabolites of a tachykinin receptor antagonist This invention is concerned with mammalian metabolites of the compound 2-(R)-(1-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4-fluoro)-phenyl-4-(3-(5-oxo-1H,4H-1,2,4-triazolo)methylmorpholine which is a tachykinin receptor antagonist that is useful in the prev...	04/27/2004
6660734	Oxazinones having antibacterial activity The invention relates to novel oxazinones designed to bind to the penicillin receptor, methods of synthesizing the compounds, and the use of the compounds as antibacterial agents. The compounds have the general formula (I) ##STR1## Preferably the com...	12/09/2003
6656936	Carnitine analogues as topical, microbicidal spermicides Acylcarnitine analogues having alkyl side chains of 10 to 30 carbon atoms display excellent spermicidal and anti-HIV activity, a well as being potent inhibitors of the growth of Candida albicans....	12/02/2003

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Class 514/230.8 - Chalcogen bonded directly to ring carbon of 1,4-oxazine ring