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| Number | Title | Issue Date |
| 8188075 | Triazole compounds that modulate HSP90 activity The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of treating or inhibiting angiogenesis in a subject in need thereof and methods for blocking, occludi... | 05/29/2012 |
| 8188076 | Compositions, synthesis, and methods of utilizing arylpiperazine derivatives The present invention provides arylpiperazine derivatives having Formula I which can be advantageously used for treating schizophrenia and related psychoses such as acute manic, bipolar disorder, autistic disorder and depression. | 05/29/2012 |
| 8178526 | Compounds and compositions as ITPKb inhibitors The invention provides a novel class of compounds of formula (I), pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or dysregulated B cell activities, particul... | 05/15/2012 |
| 8173645 | Glucokinase activators Compounds are provided for use with glucokinase that comprise the formula: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compoun... | 05/08/2012 |
| 8173646 | FAB I inhibitors Compounds of the Formula (I) are disclosed which are Fab I inhibitors and are useful in the treatment of bacterial infections. ... | 05/08/2012 |
| 8168632 | Bicyclic amide derivatives for the treatment of respiratory disorders This invention relates to compounds, pharmaceutical compositions and methods for use in the prevention and treatment of disorders of respiration such as overdose of an alcohol, an opiate, an opioid, a barbiturate, an anesthetic, or a nerve toxin. In a particular asp... | 05/01/2012 |
| 8163739 | 2-arylthiazole-4-carboxamide derivatives, their preparation and use as pharmaceuticals The present invention relates to 2-arylthiazole-4-carboxamide derivatives of the formula (I), the use thereof as medicament for the treatment of various disorders, and processes for the preparation thereof ... | 04/24/2012 |
| 8163740 | 6-substituted benzoxazines The present invention is concerned with 6-substituted benzoxazine derivatives of formula (I) wherein X, Y, R1 and R2 are as described herein, their manufacture, and pharmaceutical compositions containi... | 04/24/2012 |
| 8148368 | 7-nitro-2-(3-nitro phenyl)-4H-3,1-benzoxazin-4-one or derivatives thereof for treating or preventing antiviral infections Surprising antiviral activity of 7-Nitro-2-(3-nitro phenyl)-4H-3,1-benzoxazin-4-one (Compound 1) was reported in the treatment or prevention of viral infections, particularly in combination with other antiviral agents such as interferon and/or ribavarin. ... | 04/03/2012 |
| 8148367 | Renin inhibitors Disclosed are compounds, pharmaceutical compositions, kits, articles of manufacture, methods of using, and methods of preparing compounds having the formula: wherein the variables are as defined herein. The disclosed compou... | 04/03/2012 |
| 8138181 | Imidazo[1,2-a]pyridine compounds as receptor tyrosine kinase inhibitors Compounds of Formula I: in which A, B, R1, R1a, R2, R3, R4, R5 R6, R7 and R8 have the meanings given in the specification, are receptor tyrosine inhibitors useful in t... | 03/20/2012 |
| 8129372 | Compounds having NPY Y5 receptor antagonistic activity This invention provides a compound of the formula (I): a pharmaceutically acceptable salt or solvate thereof, wherein R1 is substituted or unsubstituted alkyl or the like, R2 | 03/06/2012 |
| 8129371 | Thienopyrimidine and pyrazolopyrimidine compounds and their use as mTOR kinase and PI3 kinase inhibitors The invention relates to thienopyrimidine and pyrazolopyrimidine compounds of the Formulas (Ia) and (IIa), or a pharmaceutically acceptable salt thereof, wherein the constituent variables are as defined herein compositions ... | 03/06/2012 |
| 8119632 | Bicyclic amide derivatives for enhancing glutamatergic synaptic responses This invention relates to compounds, pharmaceutical compositions and methods for use in the prevention and treatment of cerebral insufficiency, including enhancement of receptor functioning in synapses in brain networks responsible for basic and higher order behavio... | 02/21/2012 |
| 8114869 | Polymorph form II of tanaproget Tanaproget polymorph Form II, processes for preparing tanaproget polymorph Form II, pharmaceutical compositions including tanaproget polymorph Form II, micronized tanaproget polymorph Form II, and processes for converting Form II to tanaproget Form I are provided. A... | 02/14/2012 |
| 8110570 | Modulators of acetyl-coenzyme A carboxylase and methods of use thereof The present invention provides compounds of formula I: along with methods of use of these compounds as pharmaceuticals, particularly in the treatment of obesity, metabolic syndrome, atherosclerosis, cardiovascular disease, ... | 02/07/2012 |
| 8110569 | Enantiomerically pure S-etifoxine, pharmaceutical compositions thereof and methods of their use Enantiomerically pure S-etifoxine and pharmaceutically acceptable salts, solvates, hydrates or prodrugs thereof are provided. Also provided are pharmaceutical compositions comprising the compounds and methods of treating disorders associated with central nervous sys... | 02/07/2012 |
| 8106044 | 8-{4-[3-(5-fluoro-1H-indol-3-yl)-propyl]-piperazin-1-yl}-2-methyl-4H-benzo[1,4]oxazin-3-one mesylate with high affinity for the dopamine Dreceptor and the serotonin reuptake site The invention relates to the novel mesylate of a phenylpiperazine derivative of the formula (I). This salt has a favorable properties as compared with the free base of this compound. ... | 01/31/2012 |
| 8097618 | Pyridine derivatives and their use in the treatment of psychotic disorders A method of treatment of anxiety disorders which comprises administering to a host in need thereof an effective amount of a compound of formula (I): ... | 01/17/2012 |
| 8093242 | Crystalline forms of a pyridine derivative The invention relates to 4-methylbenzenesulfonate salt of the compound of formula (I) in a crystalline form or a solvate thereof, pharmaceutical formulations containing them, their use in therapy and processes for preparing... | 01/10/2012 |
| 8084450 | Organic compounds 3,4-substituted piperidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on activity of renin; the use of a compound of that class for the p... | 12/27/2011 |
| 8071592 | Derivatives and analogs of N-ethylquinolones and N-ethylazaquinolones Bicyclic nitrogen containing compounds and their use as antibacterials. ... | 12/06/2011 |
| 8048878 | Two cyclic cinnamide compound The present invention relates to a novel two cyclic cinnamide compound and a pharmaceutical agent comprising the compound as an active ingredient. The two cyclic cinnamide compound represented by the general formula (I): wh... | 11/01/2011 |
| 8044046 | Medicaments for the treatment of chronic obstructive pulmonary disease A pharmaceutical composition comprising a compound of formula 1 wherein: n is 1 or 2; R1 is hydrogen, C1-C4-alkyl, halogen, OH, or —O—C1-C4 | 10/25/2011 |
| 8044047 | 5-substituted benzoxazines The present invention is concerned with 5-substituted benzoxazine derivatives of formula (I) wherein X, R1 and R2 are as described herein, as well as their manufacture, pharmaceutical compositions cont... | 10/25/2011 |
| 8034809 | Enantiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments Enantiomerically pure compounds of general formula 1 wherein the groups R1, R2, R3, R4, and X− may have the meanings given in the claims and in the specification, pro... | 10/11/2011 |
| 8026235 | Pyridyl benzoxazine derivatives, pharmaceutical composition comprising the same, and use thereof Discloses is a benzoxazine benzimidazole derivative, represented by Chemical Formula 1, functioning as an antagonist to the vanilloid receptor-1, a pharmaceutical composition comprising the same, and the use thereof. The benzoxazine benzimidazole derivative can be u... | 09/27/2011 |
| 8022069 | Substituted piperidines as renin inhibitors The present invention relates to compounds of the general formula (I) and the salts thereof, preferably the pharmaceutically acceptable salts thereof; in which R has the meaning explained in the description, a process for their preparation and the use of these compo... | 09/20/2011 |
| 8022068 | Substituted piperidines as renin inhibitors The present invention relates to compounds of the general formula (I) and the salts thereof, preferably the pharmaceutically acceptable salts thereof; in which R has the meaning explained in the description, a process for their preparation and the use of these compo... | 09/20/2011 |
| 8017601 | Bis-aryl kinase inhibitors and method Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophyl... | 09/13/2011 |
| 8017602 | N-(2-(2-(5-hydroxy-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-8-yl)ethylamino)ethyl)-3-(phenethoxy)propanamide derivatives, processes for their preparation, pharmaceutical compositions containing them and their use in therapy The present invention provides a compound of formula (I) wherein W, R1, R2 and R3 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing... | 09/13/2011 |
| 8017603 | Pyrimido [4,5-B]-oxazines for use as DGAT inhibitors Compounds of formula (I) or salts thereof, wherein A, and R1 to R5 are as defined in the specification, are DGAT-1 inhibitors and are thereby useful in the treatment of, for example, obesity. Processes to make compounds of formula (I) are also ... | 09/13/2011 |
| 8012963 | 3,4-dihydro-2H-benzo[1,4]oxazine and thiazine derivatives as CETP inhibitors The invention is directed to compounds of Formula (I) described herein useful as CETP inhibitors, compositions containing them, and methods of using them. ... | 09/06/2011 |
| 8008292 | Condensed benzamide compounds and inhibitors of vanilloid receptor subtype 1 (VR1) activity To provide a compound having an excellent inhibitory effect on vanilloid receptor subtype 1 (VR1) activity which is effective in treating diseases to which the vanilloid receptor subtype 1 (VR1) activity is involved, such as pain, acute pain, chronic pain, neuropath... | 08/30/2011 |
| 8008293 | Bicyclic oxomorpholine derivative The present invention relates to a compound represented by formula (I): wherein R1 represents a C1-3 alkyl group, R2 represents a hydrogen atom or a C1-3 alkyl group, Ar represents a phenyl group or th... | 08/30/2011 |
| 8003640 | Organic compounds The present invention relates to compounds of the general formula (I) and the salts thereof, preferably the pharmaceutically acceptable salts thereof; in which in which R1 has the meaning explained in the description, a process for their preparation and t... | 08/23/2011 |
| 7998956 | Benzoxazines and related nitrogen-containing heterobicyclic compounds useful as mineralocorticoid receptor modulating agents The present invention relates to a compound, useful as a mineralocorticoid receptor-modulating agent, of the following formula [I]: wherein Ring A is a benzene ring optionally having a substituent(s) other than R1 | 08/16/2011 |
| 7989449 | 4,5-dihydro-oxazol-2-yl amine derivatives The present invention relates to a compounds of formula I wherein R1, R1′, R2, R3, R4, X, Ar, and m are as defined in the specification and claims and pharmaceuticall... | 08/02/2011 |
| 7989448 | Prodrugs of 2,4-pyrimidinediamine compounds and their uses The present disclosure provides compounds of the following formula, and methods of using the compounds to inhibit cellular degranulation and to treat diseases associated therewith. ... | 08/02/2011 |
| 7985748 | ALPHA2C adrenoreceptor agonists In its many embodiments, the present invention relates to a novel class of phenylmorpholine and phenylthiomorpholine compounds useful as α2C adrenergic receptor agonists, pharmaceutical compositions containing the compounds, and methods of treatment, prevention, in... | 07/26/2011 |
