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| Number | Title | Issue Date |
| 7459450 | Neuropeptide receptor modulators The present invention discloses compounds, which are novel receptor antagonists for NPY Y1 as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such NPY Y1 receptor antagonists as well... | 12/02/2008 |
| 7384938 | Aqueous formulations of parasiticides for skin applications The present invention relates to water-containing formulations for the dermal control of parasitic insects on animals, having the following composition a) agonists or antagonists of the nicotinic acetylcholine receptors of insects ... | 06/10/2008 |
| 7375102 | Tetrahydroquinazolin-4(3H)-one-related and tetrahydropyrido[2,3-]pyrimidin-4(3H)-one-related compounds, compositions and methods for their use Compounds are provided having the formula: wherein variables A1, A2, A3, A4, R1, R2, R3, R4, Q and L are as described herein. The subje... | 05/20/2008 |
| 7332512 | Halogenated nitrobutadienes for controlling animal pests The present invention relates to novel halonitrobutadienes, to processes for their preparation and to their use for controlling animal pests. ... | 02/19/2008 |
| 7309711 | Fungicidal agent combinations The invention relates to novel fungicidallly active compound combinations of 2′-cyano-3,4-dichloroisothiazole-5-carboxanilide of the formula and the active compounds listed in the disclosure. ... | 12/18/2007 |
| 7223754 | Thiazolidinone, oxazolidinone, and imidazolone derivatives for treating lower urinary tract and related disorders The invention relates to methods of using Cav2.2 subunit calcium channel modulators, particularly thiazolidinone, oxazolidinone, and imidazolone derivatives, to treat lower urinary tract and related disorders. ... | 05/29/2007 |
| 7214701 | Active substance combinations having insecticidal and acaricdal properties The invention relates to insecticidal mixtures for protecting plants against attack by pests comprising (a) compounds of the formula (I) ... | 05/08/2007 |
| 7205309 | Quinazoline derivatives Compounds of formula I as well as pharmaceutically acceptable salts and esters thereof, wherein R1, R2, R3 and A have the significance given in the specification are provided. The... | 04/17/2007 |
| 7166590 | Amino acid derivatives A compound of the formula (I): [wherein R1 is (substituted) alkyl, alkoxy, phenyl, hetero ring etc.; A is bond, CO, SO2; R2 is H, (substituted) alkyl etc.; D is alkylene etc.; E is COO,... | 01/23/2007 |
| 7166609 | Pyrimidine-4,6-dicarboxylic acid diamides for selectively inhibiting collagenases Pyrimidine-4,6-dicarboxylic acid diamides of the formula I are suitable for selectively inhibiting collagenase (MMP 13). The pyrimidine-4,6-dicarboxylic acid diamides can therefore be used for treating degenerati... | 01/23/2007 |
| 7148221 | Vanilloid receptor ligands and their use in treatments Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular an... | 12/12/2006 |
| 7128928 | Ophthalmic formulation with novel gum composition There is provided a pharmaceutical composition suitable for topical administration to an eye, the composition comprising (a) a pharmacologically effective concentration of an active agent and (b) a combination of at least two ophthalmically compatible polymers compr... | 10/31/2006 |
| 7112588 | Use of proteasome inhibitors to treat dry eye disorders Proteasome inhibitors are useful for treating dry eye disorders and other disorders requiring the wetting of the eye. ... | 09/26/2006 |
| 7101904 | Cyclopentane heptan(ENE)OIC acid, 2-heteroarylalkenyl derivatives as therapeutic agents A compound or a pharmaceutically acceptable salt or a prodrug thereof, wherein A, B, R1, R2, D, and E are defined herein. Use of the diseases for the treatment of diseases, and compositions ... | 09/05/2006 |
| 7087626 | Pyrrole derivatives as pharmaceutical agents Novel pyrrazole derivative compounds and their use as pharmaceutical agents, in particular their use as TGF-beta signal transduction inhibitors. The disclosed invention relates to compounds of the structure (I) wherein (I) is a four, five, or six membered saturated ... | 08/08/2006 |
| 7084151 | 5-(1',1'-cycloalkyl/alkenyl)methylidene 1,2-dihydro--chromeno[3,4-ƒ]quinolines as selective progesterone receptor modulator compounds The present invention is directed to compounds, pharmaceutical compositions, and methods for modulating processes mediated by Progesterone Receptor. Also provided are methods of making such compounds and pharmaceutical compositions. ... | 08/01/2006 |
| RE39130 | Heterocyclic compounds Novel heterocyclic compounds of the formula wherein, R1 represents a hydrogen atom or an alkyl group, A represents an ethylene group which may be substituted by alkyl or a trimethylene group which may be substituted by... | 06/13/2006 |
| 7060728 | 11,12-oxidoarachidonic acid derivatives and methods of their use in treating dry eye disorders 11,12-Oxidoarachidonic acid derivatives and methods of their use for treating dry eye are disclosed. ... | 06/13/2006 |
| 7053213 | Therapeutic heterocycles Pharmaceutical compositions containing novel therapeutic heterocycles for use in diseases in which an NK2 receptor is implicated, processes for preparing and methods for using the same. ... | 05/30/2006 |
| 7022705 | Isoxazoline derivatives useful as antimicrobials Compounds of the formula (I), or a pharmaceutically-acceptable salt, or an in-vivo-hydrolysable ester thereof, wherein, for example, HET is an N-linked 5-membered, fully or partially u... | 04/04/2006 |
| 7001903 | Synergistic insecticidal mixtures The invention relates to insecticidal mixtures of spinosyns and agonists or antagonists of nicotinic acetylcholine receptors for protecting plants against attack by pests. ... | 02/21/2006 |
| 6936606 | Cyanoamido-containing heterocyclic compounds useful as reversible inhibitors of cysteine proteases Disclosed are novel cathepsin S, K, F, L and B reversible inhibitory compounds of the formulas (Ia) and (Ib) where R1, R2, R3, R4, R5, R6, R8, R9 and X are defined herein. The co... | 08/30/2005 |
| 6916806 | Medicinal composition containing 1,3-thiazine derivative A compound of the formula (I) having a binding activity to the cannabinoid type 2 receptor: wherein R1 is optionally substituted heterocyclic group or the like; R2 and R2 each is indepe... | 07/12/2005 |
| 6903119 | Amino acid derivatives and drugs containing the same as the active ingredient The present invention relates to the compounds of the formula (I) and salts thereof (all the symbols are the same meanings as described in the specification). The compounds of the formula (I) possess inhibitory activity ... | 06/07/2005 |
| 6767907 | 4-aryl-1-(indanmethyl dihydrobenzofuranmethyl or dihydrobenzothiophenemethyl) piperidines tetrahydropyridines or piperazines 4-Aryl-1-(indanmethyl, dihydrobenzofuranmethyl or dihydrobenzothiophenemethyl)piperidine, -tetrahydropyridine or -piperazine compounds of general formula (I), wherein one of X and Y is CH2 and the other one is CH2, O or S; Z is N, C, CH or COH;... | 07/27/2004 |
| 6759407 | Acyclic and cyclic guanidine- and acetamidine derivatives, their preparation and their use as pesticides, ESP as parasiticides Novel pesticides of formula (I) wherein the substituents, R, R1, R2, R2′, T, U, X and Y are as defined in claim 1, are described. Also described are compositions suitable for use as par... | 07/06/2004 |
| 6743798 | Substituted pyrazole derivatives condensed with six-membered heterocyclic rings The present invention relates to novel substituted pyrazole derivatives of the general formula (I) in which R1, R2, R3 and A are each as defined, and to processes for their preparation an... | 06/01/2004 |
| 6743817 | Substituted fused pyrroleimines and pyrazoleimines Disclosed are compounds of the formula and the pharmaceutically acceptable salts thereof wherein R, Ar, A, n, R1 and R2 are defined herein. These compounds are highly selective agonists, antagonists... | 06/01/2004 |
| 6699898 | Substituted N,N-disubstituted non-fused heterocyclo amino compounds useful for inhibiting cholesteryl ester transfer protein activity The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating... | 03/02/2004 |
| 6605608 | Amino acid derivatives and drugs containing the same as the active ingredient The present invention relates to the compounds of the formula (I) and salts thereof (all the symbols are the same meanings as described in the specification). ##STR1## The compounds of the formula (I) possess inhibitory activity of N-type calcium cha... | 08/12/2003 |
| 6566362 | Benzo[f]naphthyridine derivatives, their preparation and compositions containing them Benzo[f]naphthyridine derivatives of formula (I): ##STR1## benzo[f]naphthyridine derivatives and benzo[f]naphthyridine esters of formula (IVa): ##STR2## aminoquinoline derivatives of formula (X): ##STR3## processes for preparing such compounds; and c... | 05/20/2003 |
| 6559155 | Pyrimidinone derivatives for the treatment of atherosclerosis Pyrimidones of formula (I) are inhibitors of the enzyme LpPLA2 and thereof use in treating inter alia atherosclerosis, ##STR1## in which: R1 is COOH or a salt thereof, COOR10, CONR11R.sup.12, CN or CH... | 05/06/2003 |
| 6544990 | Substituted quinolinecarboxamides as antiviral agents The present invention discloses disubstiuted 4-oxo-1,4-dihydro-3-quinolinecarboxamide derivatives. The compounds are useful as antiviral agents, in particular, as agents against viruses of the herpes family.... | 04/08/2003 |
| 6525076 | Selective factor Xa inhibitors Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.... | 02/25/2003 |
| 6514988 | Condensed-ring thiophene derivatives, their production and use A gonadotropin-releasing hormone antagonistic composition, which comprises an optionally substituted condensed-bicyclic compound consisting of a homo or hetero 5 to 7 membered ring and a homo or hetero 5 to 7 membered ring is effective as a propylactic or... | 02/04/2003 |
| 6469000 | 1,3-diheterocyclic metalloprotease inhibitors Disclosed are compounds which are inhibitors of metalloproteases having the following structure: ##STR1## where Ar, W, X, Y, Z, R1 and R2 have the meanings described in the specification and optical isomers, diastereomers, and enanti... | 10/22/2002 |
| 6451830 | Use of substituted N,N-disubstituted non-fused heterocyclo amino compounds for inhibiting cholesteryl ester transfer protein activity The invention relates to use of substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for t... | 09/17/2002 |
| 6429206 | Non-systemic control of parasites Use of agonists and antagonists of the nicotinergic acetylcholine receptors of insects for the non-systemic control of parasitic insects, such as fleas, lice and flies, on humans and on animals.... | 08/06/2002 |
| 6395730 | Potassium channel inhibitors Certain thiazolidinone and metathiazanone compounds, as described, are useful as potassium channel inhibitors and are especially useful for the treatment of cardiac arrhythmias and other diseases, conditions and disorders.... | 05/28/2002 |
| 6391327 | Pesticidal composition A pesticidal composition comprising prallethrin and a neonicotinoid compound given in the following formula (1), (2) or (3), as an active ingredient ##STR1## wherein, A represents a 6-chloro-3-pyridyl, 2-chloro-5-thiazolyl, tetrahydrofuran-2-yl, tetr... | 05/21/2002 |
