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| Number | Title | Issue Date |
| 8168629 | Analgesic combination of tramadol and meloxicam Disclosed is a pharmaceutical composition, comprising a combination of a dose of meloxicam or a pharmaceutically acceptable salt thereof and a dose of tramadol or a pharmaceutically acceptable salt thereof, the combination in an amount sufficient to provide an analg... | 05/01/2012 |
| 8129370 | Use of oxicam compounds The invention relates to the use of lornoxicam or analogues thereof which inhibit cyclo-oxygenase 1 and cyclo-oxygenase 2 (COX 1 and COX 2), cannot penetrate the blood-brain barrier under physiological conditions, and reduce the prostaglandin E2-induced induction of... | 03/06/2012 |
| 8124603 | In vivo studies of crystalline forms of meloxicam The invention is directed to novel crystalline forms of meloxicam. These novel crystalline forms of meloxicam have improved bioavailability, an enhanced rate of dissolution and shorter time to Cmax in blood, as compared to pure meloxicam. ... | 02/28/2012 |
| 8097616 | Process for preparation of high-purity meloxicam and meloxicam potassium salt The invention provides a process for the preparation of high purity meloxicam of the Formula (II). The meloxicam raw product is reacted with the solution of potassium hydroxide or potassium carbonate, whereby high purity meloxicam potassium sait monohydrate is produ... | 01/17/2012 |
| 7846924 | Cyanopyrroles This invention provides a progesterone receptor antagonist of formula 1 having the structure wherein, T is O, S, or absent; R1, and R2 are each, independently, hydrogen, alkyl, substituted alkyl; or R | 12/07/2010 |
| 7820653 | Photosensing soluble organic semiconductor material A photosensing soluble organic semiconductor material is disclosed, which includes a Diels-Alder adduct which is a polycyclic aromatic compound with a dienophile. The polycyclic aromatic compound is pentacene. And the dienophile is represented by the formula of O═... | 10/26/2010 |
| 7781429 | Vehicle for topical delivery of anti-inflammatory compounds A vehicle for topical delivery which contains a liquid eutectic mixture of hydrophobic compounds. ... | 08/24/2010 |
| 7767665 | 1,3-benzothiazinone derivatives and use thereof This invention provides a compound represented by the formula (I): wherein R1 is a hydrogen atom, a halogen atom, hydroxy, nitro, optionally halogenated alkyl, alkoxy optionally having substituents, acyl or amino... | 08/03/2010 |
| 7659267 | 1,3-Benzothiazinone derivatives, process for producing the same use thereof As prophylactic and/or therapeutic agents for cardiovascular diseases, bone or joint diseases, infectious diseases, inflammatory diseases, kidney diseases, etc. having safe and excellent effects of cell death inhibition, MIF binding, etc., there are provided compoun... | 02/09/2010 |
| 7534787 | Method of treating diseases and conditions associated with an altered level of amyloid beta peptides and new enolcarboxamide compounds A method of treating or preventing of a disease or condition associated with an increased level of isoforms of amyloid β peptides (Aβ) and/or with a changed ratio of levels of Aβ isoforms and/or with the formation of plaques containing amyloid β peptide (Aβ) is... | 05/19/2009 |
| 7442695 | Depeptidized inhibitors of hepatitis C virus NS3 protease The present invention discloses novel depeptidized compounds which have HCV protease inhibitory activity as well as pharmaceutical compositions comprising such compounds and methods of using them to treat disorders associated with the HCV protease. ... | 10/28/2008 |
| 7399759 | 1, 3-benzothiazinone derivatives and use thereof This invention provides a compound represented by the formula (I): wherein R1 is a hydrogen atom, a halogen atom, hydroxy, nitro, optionally halogenated alkyl, alkoxy optionally having substituents, acyl or amino... | 07/15/2008 |
| 7375220 | Method of treating diseases and conditions associated with an altered level of amyloid β peptides and new enolcarboxamide compounds A method of treating or preventing of a disease or condition associated with an increased level of isoforms of amyloid β peptides (Aβ) and/or with a changed ratio of levels of Aβ isoforms and/or with the formation of plaques containing amyloid β peptide (Aβ) is... | 05/20/2008 |
| 7285553 | Serotonergic 5HTreceptor compounds for treating ocular and CNS disorders Compounds with 5HT7 receptor affinity (some of which are novel) useful for lowering IOP, improving blood flow to the optic nerve head and the retina, providing neuroprotection, and treating retinal diseases are disclosed. The Compounds are also useful for... | 10/23/2007 |
| 7253160 | Depeptidized inhibitors of hepatitis C virus NS3 protease The present invention discloses novel depeptidized compounds which have HCV protease inhibitory activity as well as pharmaceutical compositions comprising such compounds and methods of using them to treat disorders associated with the HCV protease. ... | 08/07/2007 |
| 7253164 | Bicyclic compounds and compositions as PDF inhibitors This invention is directed to novel bicyclic compounds, to the uses of these compounds in various medicinal applications, including treating disorders amenable to treatment by peptidyl deformylase inhibitors such as treatment of bacterial infections, and to pharmace... | 08/07/2007 |
| 7199153 | Pharmaceutical composition comprising paracetamol and niflumic acid A formulation is described comprising paracetamol, niflumic acid or a pharmaceutically acceptable salt or ester thereof and a pharmaceutically acceptable excipient. ... | 04/03/2007 |
| 7199118 | Benzothiazine derivatives, their preparation and use This invention relates to novel benzothiazine derivatives of Formula I useful as modulators of the AMPA sensitive glutamate receptors, pharmaceutical compositions comprising such compounds and their use in therapy. ... | 04/03/2007 |
| 7141566 | Benzoxazine and benzothiazine derivatives and the use thereof in medicaments The invention relates to compounds of formula (I), the tautomeric and isomeric forms and salts thereof, in addition to a method for production and use thereof in medicaments. ... | 11/28/2006 |
| 7138394 | Vehicle for topical delivery of anti-inflammatory compounds A vehicle for topical delivery which contains a liquid eutectic mixture of hydrophobic compounds. ... | 11/21/2006 |
| 7125868 | Thienothiazine compound having anti-inflammatory and analgesic properties and method of making and using the same The present invention is related to a type of thienothiazine compounds having molecular structure of formula (1) and their pharmaceutically acceptable salts or solvates. The present invention is also related to the method of producing the formula (1) compound, an an... | 10/24/2006 |
| 7115130 | Method for installing dynamic, modular, multilock anterior cervical plate system having detachably fastened assembleable and moveable segments An anterior cervical plating system having moveable and modular plate segments that are assembleable to vary the overall length of the plate, moveable to allow and/or cause intersegmental compression of vertebral bodies, and coupled together by a detachable fastener... | 10/03/2006 |
| 7112202 | Method for installing dynamic, modular, single-lock anterior cervical plate system having assembleable and moveable segments An anterior cervical plating system having modular plate segments that are assembleable to vary the overall length of the plate, moveable to allow and/or cause intersegmental compression of vertebral bodies, and coupled together by a detachable fastener. The plating... | 09/26/2006 |
| 7105512 | Ophthalmic aqueous pharmaceutical preparation The present invention provides an ophthalmic aqueous pharmaceutical preparation, which is excellent in anti-inflammatory effect, which is less stimulative and which has high safety and excellent storage stability. The ophthalmic aqueous pharmaceutical preparation co... | 09/12/2006 |
| 7090859 | Ketoprofen compositions and methods of making them A wide variety of pharmaceutically and commercially acceptable dosage forms of ketoprofen are prepared by dissolving ketoprofen in pharmaceutically acceptable solvents. ... | 08/15/2006 |
| 7087588 | Nitric oxide donors capable of reducing toxicity from drugs Use of organic compounds containing the —ONO2 function, or inorganic compound containing the —NO group or compositions comprising said compounds to reduce the toxicity caused by drugs to the gastrointestinal and/or renal apparatus, said compounds bein... | 08/08/2006 |
| 7060704 | Serotonergic 5HTreceptor compounds for treating ocular and CNS disorders Compounds with 5HT7 receptor affinity (some of which are novel) useful for lowering IOP, improving blood flow to the optic nerve head and the retina, providing neuroprotection, and treating retinal diseases are disclosed. The Compounds are also useful for... | 06/13/2006 |
| 7060730 | Rapidly absorbed liquid compositions The present invention provides a method which provides for a faster absorption of pharmaceutically acceptable amines. The method provides a pharmaceutically acceptable amine in combination with a non-steroidal anti-inflammatory drug in a liquid form. A preferred emb... | 06/13/2006 |
| 7030162 | Treatment of migraine headache The invention is directed to pharmaceutical compositions useful in the treatment of migraine. The compositions contain metoclopramide and one or more NSAIDs in unit dosage form. By selecting NSAIDs that are non-acidic or segregating the metoclopramide and NSAID, the... | 04/18/2006 |
| 7026313 | 2-thia-1,6,8-triaza-naphthalene-2,2-dioxides are kinase inhibitors The present invention provides 2-thia-1,6,8-triaza-naphthalene-2,2-dioxide inhibitors of cyclin-dependent kinases, uses thereof and pharmaceutical compositions thereof. These compounds are useful for treating cell proliferative disorders, such as cancer, athe... | 04/11/2006 |
| 6967248 | Crystalline forms of meloxicam and processes for their preparation and interconversion The invention relates to the new crystalline forms II, III and V of meloxicam; to the processes for obtaining the crystalline forms I, II, III and V; and, finally, to the interconversion processes of the forms II, III, IV and V into the form I. | 11/22/2005 |
| 6960579 | Serotonergic 5HTreceptor compounds for treating ocular and CNS disorders Compounds with 5HT7 receptor affinity (some of which are novel) useful for lowering IOP, improving blood flow to the optic nerve head and the retina, providing neuroprotection, and treating retinal diseases are disclosed. The Compounds are also useful for... | 11/01/2005 |
| 6903082 | Methods of treating inflammatory conditions of the gastrointestinal tract using 4-APAA and compositions thereof Compounds are disclosed having the structure of Formula I: where R1, R3, and R4 are independently hydrogen or C1 to C4 alkyl, and R2 is: | 06/07/2005 |
| 6894041 | Oxazolyl-acid amide derivatives useful as inhibitors of PDE4 isozymes This application is directed to compounds useful as inhibitors of PDE4 in the treatment of diseases regulated by the activation and degranulation of eosinophils, especially asthma, chronic bronchitis, and chronic obstructuive pulmonary disease, of the formula: | 05/17/2005 |
| 6869948 | Meloxicam for oral administration The invention relates in its first aspect to a rapidly decomposing tablet for pain therapy containing meloxicam [4-hydroxy-2-methyl-N-(5-methyl-2-thiazolyl)-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide] in the form of a salt with an inorganic or organic base provi... | 03/22/2005 |
| 6869945 | Pyrrolyl-and imidazolyl-acid amide derivatives useful as inhibitors of PDE4 isozymes This application is directed to compounds useful as inhibitors of PDE4 in the treatment of diseases regulated by the activation and degranulation of eosinophils, especially asthma, chronic bronchitis, and chronic obstructuive pulmonary disease, of the formula: | 03/22/2005 |
| 6867236 | Method of preventing of delaying the onset and progression of Alzheimer's disease and related disorders The present invention relates, in general, to a method of preventing or delaying the onset of Alzheimer's disease and related neurodegenerative disorders. The invention also relates to a method of treating Alzheimer's disease and related neurodegenerative disorders ... | 03/15/2005 |
| 6844338 | Piperidyindoles as serotonin receptor ligands A pharmaceutical compound of the formula (I) in which R1 and R2 are each hydrogen or C1-6 alkyl, R3 is —SR10, —SOR10, —SO2R10, —COR10, —CH2OH or ... | 01/18/2005 |
| 6811768 | Use of inhaled NO as anti-inflammatory agent A method for lessening or preventing non-pulmonary ischemia-reperfusion injury or inflammation in a mammal by identifying a mammal which has ischemia-reperfusion or is at risk for developing ischemia-reperfusion in a non-pulmonary tissue; and causing the mammal to i... | 11/02/2004 |
| 6759406 | Quaternary ammonium compounds Compounds of formula corresponding to either formula (Ia) or (Ib): wherein: M represents a molecule that can be used for the treatment or diagnosis of pathologies caused by attack on the cartilage, R1 | 07/06/2004 |
