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| Number | Title | Issue Date |
| 8143245 | Use of 10-[(3R)-1-azabicyclo[2.2.2]oct-3-ylmethyl]-10-phenothiazine for the preparation of a drug having a selective inhibition of muscarinic M, M, and Mreceptors This invention relates to the use of 10-[(3R)-1-azabicyclo[2.2.2]oct-3-ylmethyl]-10H-phenothiazine as well as its pharmaceutically acceptable salts for the preparation of a drug having the particularity of treating or preventing urinary incontinence, by local and/or... | 03/27/2012 |
| 7732440 | Phenothiazin derivatives, method for the production thereof and use thereof as pharmaceuticals The invention relates to compounds of the formula I, wherein R1, R2, R3, R4, R5, R6, R7, A and B are as defined herein, the pharmaceutical compositions and the uses as pharmaceuticals. ... | 06/08/2010 |
| 7659266 | Amidine derivatives and their applications as a medicament The invention concerns amidine derivatives of general formula (I) exhibiting an inhibitory activity of calpains and/or a trapping activity of reactive forms of oxygen. ... | 02/09/2010 |
| 7652005 | Tricyclic δ-opioid modulators The invention is directed to delta opioid receptor modulators. More specifically, the invention relates to tricyclic δ-opioid modulators. Pharmaceutical and veterinary compositions and methods of treating mild to severe pain and various diseases using compounds of ... | 01/26/2010 |
| 7544681 | Conjugated psychotropic drugs and uses thereof Novel chemical conjugates of psychotropic drugs and organic acids, uses thereof in the treatment of psychotic and/or proliferative disorders and diseases and as chemosensitizing agents, and their syntheses are disclosed. The organic acids are selected to reduce side... | 06/09/2009 |
| 7414128 | Crystalline R-guanidines, Arginine or (L)-Arginine (2S)-2-Ethoxy-3-{4-[2-(10H -phenoxazin-10-yl)ethoxy]phenyl}propanoate The present invention relates to crystalline R-guanidines of (2S)-2-Ethoxy-3-{4-[2-(10H-phenoxazin-10-yl)ethoxy]phenyl}propanoate, its preparations and its use as therapeutic agents. More specifically the present invention relates to crystalline Arginine (2S)-2-Etho... | 08/19/2008 |
| 7407953 | Wound healing A phenothiazinium compound, compositions and medicaments for use in promoting wound healing and a method for promoting wound healing or cosmetic use by applying or administering a phenothiazinium compound of Formula (1) to ... | 08/05/2008 |
| 7384933 | Derivatives of 2-hydroxytetrahydrofuran and their use as medicaments A hydroxytetrahydrofuran of formula wherein A is with the substituents as defined in the specification, having a calpain inhibiting activity and/or an activity which traps the rea... | 06/10/2008 |
| 7355042 | Treatment of CNS disorders using CNS target modulators The invention is directed to compositions and methods useful for treating Central Nervous System (CNS) disorders. Furthermore, the invention provides compositions and methods of treating sleep disorders. More specifically, the invention is directed to the compositio... | 04/08/2008 |
| 7334538 | Topical medicants for aquatic animals A topical medicant for fishes, amphibians, reptiles, and aquatic macroinvertebrates applied in a site-specific manner for the localized treatment of skin wounds, lesions and diseases. The medicant comprises a hydrophilic carrier with an antimicrobial therapeutant fo... | 02/26/2008 |
| 7157102 | Multi-layered microcapsules and method of preparing same A multi-layered microcapsule containing one or more active ingredients and process for preparing the same is disclosed. The multi-layered microcapsule comprises an inner solid microparticle core, typically composed of a biodegradable polymer, and having one or more ... | 01/02/2007 |
| 7148216 | Combinations of drugs for the treatment of neoplastic disorders The invention features a method for treating a patient having a cancer or other neoplasm by administering to the patient two compounds simultaneously or within 14 days of each other in amounts sufficient to treat the patient. ... | 12/12/2006 |
| 7119089 | Phenothiazine kinesin inhibitors Phenothiazine derivatives of formula (I) are disclosed. The compounds are inhibitors of the mitotic kinesin KSP and are useful in the treatment of cellular proliferative diseases, such as cancer, hyperplasias, restenosis, cardiac hypertrophy, immune disorders and in... | 10/10/2006 |
| 7041320 | High drug loaded injectable microparticle compositions and methods of treating opioid drug dependence Methods and compositions to induce opioid drug independence in opioid drug dependent individuals comprising administering opioid agonists and/or antagonists encapsulated in biodegradable polymer microspheres in a dosage formulation. ... | 05/09/2006 |
| 7008934 | Composition and method for reducing adverse interactions between phenothiazine derivatives and plasma using cyclodextrins Compositions and methods are provided for reducing adverse reactions as a result of parenteral administration of certain phenothiazine derivatives such as promethazine hydrochloride. The active compound may be admixed with an effective amount of one or more cyclodex... | 03/07/2006 |
| 6995186 | Olopatadine formulations for topical administration Topical formulations of olopatadine for treatment of allergic or inflammatory disorders of the eye and nose are disclosed. The aqueous formulations contain approximately 0.17-0.62% (w/v) of olopatadine and an amount of polyvinylpyrrolidone or polystyrene sulfonic ac... | 02/07/2006 |
| 6991806 | Pharmaceutical compositions comprising ibuprofen and domperidone A stable pharmaceutical composition comprising a mixture of (i) an ibuprofen medicament; (ii) a domperidone medicament and (iii) a carrier material characterized in that the carrier material is substantially free of providone and comprises at least one diluent combi... | 01/31/2006 |
| 6992191 | Hydrogenation of precursors to thiazolidinedione antihyperglycemics Provided is a method of hydrogenating the exocyclic double bond of a thiazolidinedione precursor in a method of making a thiazolidinedione antihyperglycemic, for example pioglitazone, including work-up steps to afford pure thiazolidinedione antihyperglycemic. ... | 01/31/2006 |
| 6992092 | Anti-diabetic agents The present invention provides compounds of formula (I) the stereoisomers and prodrugs thereof, and the pharmaceutically acceptable salts of the compounds, stereoisomers, and prodrugs; wherein R1, R2 | 01/31/2006 |
| 6992082 | Phenothiazine kinesin inhibitors Phenothiazine derivatives of formula (I) are disclosed. The compounds are inhibitors of the mitotic kinesin KSP and are useful in the treatment of cellular proliferative diseases, such as cancer, hyperplasias, restenosis, cardiac hypertrophy, immune disorders and in... | 01/31/2006 |
| 6919351 | Aza-and polyaza-naphthalenyl-carboxamides useful as HIV integrase inhibitors Aza- and polyaza-naphthalenyl carboxamide derivatives including certain quinoline carboxamide and naphthyridine carboxamide derivatives are described as inhibitors of HIV integrase and inhibitors of HIV replication. These compounds are useful in the prevention or tr... | 07/19/2005 |
| 6846816 | Combinations of drugs for the treatment of neoplastic disorders The invention features a method for treating a patient having a cancer or other neoplasm by administering to the patient two compounds simultaneously or within 14 days of each other in amounts sufficient to treat the patient. ... | 01/25/2005 |
| 6800618 | Chemosensitizing agents against chloroquine resistant plasmodium falciparum and methods of making and using thereof A compound having the structural formula or a pharmaceutically acceptable salt or prodrug thereof, wherein X is a substituted or unsubstituted alkyl or a heteroatom; n is 4, 5 or 6; Y is a substituted or unsubstituted al... | 10/05/2004 |
| 6703401 | Compounds, their preparation and use The present invention relates to compounds of the general formula (I) ##STR1## The compounds are useful in the treatment and/or prevention of conditions mediated by clear receptors, in particular the Peroxisome Proliferator-Activated Receptors (PPAR).... | 03/09/2004 |
| 6583138 | Heterocyclic-ring condensed benzothiazine compound The invention provides a novel heterocyclic ring condensed benzothiazine compound which is effective for prevention or remedy of disease, in which histamine, leukotriene and the like participate. The heterocyclic ring condensed benzothiazine compound of t... | 06/24/2003 |
| 6544986 | Pyridones and their use as modulators of serine hydrolase enzymes This invention relates to a compound of formula I: ##STR1## or a pharmaceutically acceptable salt thereof; in which preferably R3, R4 and R6 are each hydrogen; X is C.dbd.O or CH2 ; and R7 and R8 are... | 04/08/2003 |
| 6509335 | Benzoxazinoes/benzothiazinones as serine protease inhibitors This invention discloses benzoxazinone and benzothiazinone compounds which display inhibitory effects on serine proteases such as factor Xa, thrombin, and/or factor VIIa. The invention also discloses pharmaceutically acceptable salts of the compounds, pha... | 01/21/2003 |
| 6485750 | Phenothiazine in prill form and method for making the same Phenothiazine and its derivatives products are provided with a minimal level of fines or dust as a result of forming such products in prill form. The prills are generally spherical. Also provided is a method for reducing the level of powder in phenothiazi... | 11/26/2002 |
| 6482822 | N-(iminomethyl)amines derivatives, their preparation, their use as medicines and compositions containing them The invention concerns novel N-(iminomethyl)amine derivatives comprising in their skeleton the aminophenylamine, oxodiphenylamine, carbazole, phenazine, phenoxazine or oxodiphenyl motif, their use as medicines and pharmaceutical compositions containing th... | 11/19/2002 |
| 6468996 | Substituted hetero-polycyclic compounds as PPAR and PPARγ activators The present invention relates to compounds of the general formula (I) ##STR1## The compounds are useful in the treatment and/or prevention of conditions mediated by nuclear receptors, in particular the Peroxisome Proliferator-Activated Receptors (PPAR).... | 10/22/2002 |
| 6440961 | Tricyclic compounds and their use in medicine: process for their preparation and pharmaceutical compositions containing them A compound of formula (1) ##STR1## it derivatives, its analogs, its tautomeric forms, its stereoisomers, its polymorphs, its pharmaceutically acceptable salts, or its pharmaceutically acceptable solvates, processes for its preparation and methods of use ... | 08/27/2002 |
| 6365586 | Compounds, their preparation and use The present invention relates to compounds of the general formula (I) ##STR1## The compounds are useful in the treatment and/or prevention of conditions mediated by nuclear receptors, in particular the Peroxisome Proliferator-Activated Receptors (PPAR).... | 04/02/2002 |
| 6319514 | Analgesic and anti-inflammatory compositions comprising domperidone and methods of using same The present invention provides a method for eliciting an onset hastened analgesic and anti-inflammatory response and combating nausea in acute migraine attacks. This method comprises administering a pharmaceutical composition comprising more than one acti... | 11/20/2001 |
| 6166009 | N-substituted azaheterocyclic carboxylic acids and esters thereof The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them... | 12/26/2000 |
| 6159966 | Azolidinediones useful for the treatment of diabetes, dyslipidemia and hypertension: process for their preparation and pharmaceutical compositions containing them A compound of formula (I) ##STR1## its tautomeric forms, its stereoisomers, its polymorphs, its pharmaceutically acceptable salts or its pharmaceutically acceptable solvates, wherein R3, R4, R5, and R6 are ... | 12/12/2000 |
| 6110913 | N-substituted azaheterocyclic carboxylic acids and esters thereof The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them... | 08/29/2000 |
| 6054453 | Tricyclic compounds and their use in medicine process for their preparation and pharmaceutical compositions containing them Novel ଲ-aryl--oxysubstituted alkylcarboxylic acids of the formula (I) and compositions containing them. ##STR1## The compounds have hypolipidemic, antihyperglycemic uses.... | 04/25/2000 |
| 5861394 | Use of N-substituted phenothiazines The invention relates to the use of N-substituted phenothiazines for the production of medicaments for the treatment of cerebral disorders. The invention likewise relates to novel active compounds which are prepared by reaction of phenothiazine with the a... | 01/19/1999 |
| 5795888 | N-substituted azaheterocyclic carboxlic acids and esters thereof The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them, and to th... | 08/18/1998 |
| 5770596 | Pharmaceutical compositions based on mequitazine The subject of this invention is a ready-for-use collyrium intended for the treatment of ocular allergies, comprising, in aqueous solution, mequitazine and a ଲ- or a γ-cyclodextrin optionally etherified by C1 -C4 alkyl or C | 06/23/1998 |
