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| Number | Title | Issue Date |
| 7846923 | Compounds and compositions as protein kinase inhbitors The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or d... | 12/07/2010 |
| 7820652 | Regimen for the administration of rifamycin-class antibiotics The invention features an ascending dose regimen for the administration of rifamycin-class antibiotics. The dosing regimen can be used to treat bacterial infections and diseases related to infection. ... | 10/26/2010 |
| 7772227 | Tricyclic 1-[(indol-3-yl)carbonyl]piperazine derivatives as cannabinoid CB1 receptor agonists The invention relates to tricyclic 1-[(indol-3-yl)carbonyl]piperazine derivative having the general Formula (I) wherein X is CH2, O or S; R represents 1-3 substituents independently selected from H, (C1-4)alkyl, (C1-4)alkyloxy and ha... | 08/10/2010 |
| 7547692 | Rifamycin analogs and uses thereof The present invention features rifamycin analogs and methods of using these compounds to treat a variety of microbial infections. ... | 06/16/2009 |
| 7514427 | 1,5,6,-substituted-2-oxo-3-cyano-1,6a-diaza-tetrahydro-fluoranthenes as anti-inflective agents HIV inhibitory compounds of formula: salts and stereoisomers thereof, wherein R1 and R2 are hydrogen or optionally substituted C1-10alkyl; | 04/07/2009 |
| 7488726 | Rifamycin analogs and uses thereof The present invention features rifamycin analogs that can be used as therapeutics for treating or preventing a variety of microbial infections. In one form, the analogs are acetylated at the 25-position, as is rifamycin. In another form, the analogs are deacetylated... | 02/10/2009 |
| 7342011 | Rifamycin analogs and uses thereof The present invention features rifamycin analogs that can be used as therapeutics for treating or preventing a variety of microbial infections. In one form, the analogs are acetylated at the 25-position, as is rifamycin. In another form, the analogs are deacetylated... | 03/11/2008 |
| 7319155 | 7,7-disubstituted (5H,9H)-6,8-dioxabenzocycloheptene compounds useful in the synthesis of non-steroidal analogues of vitamin D Novel 7,7-disubstituted (5H,9H)-6,8-dioxabenzocycloheptene compounds having the structural formula (I): are useful intermediates in the synthesis of non-steroidal derivatives of vitamin D. ... | 01/15/2008 |
| 7282221 | Antiviral product, use and formulation thereof An antiviral product is comprised of at least three dosages forms, each of which has a different release profile, with the Cmax for the antiviral product being reached in less than about twelve hours. In one embodiment, there is an immediate release dosag... | 10/16/2007 |
| 7273871 | Phenyl-5,6,6A,7,8,9-hexahydro-4H-1,4,9-triaza-phenalene derivatives as CRF antagonists The present invention relates to tricyclic pyridines compounds of formula (I) including stereoisomers, prodrugs and pharmaceutically acceptable salts or solvates thereof: ... | 09/25/2007 |
| 7271165 | Rifamycin analogs and uses thereof The present invention features rifamycin analogs that can be used as therapeutics for treating or preventing a variety of microbial infections. In one form, the analogs are acetylated at the 25-position, as is rifamycin. In another form, the analogs are deacetylated... | 09/18/2007 |
| 7268149 | Cyclothiocarbamate derivatives as progesterone receptor modulators and methods of treating skin disorders The present invention provides methods of treating skin disorders includes delivering to a mammal a composition containing a compound of formula I, or tautomers thereof, in a regimen, wherein formula I is: and wh... | 09/11/2007 |
| 7262190 | Benzothiazine and benzothiadiazine compounds The invention relates to compounds of formula (I): wherein: R1 represents hydrogen, alkyl or cycloalkyl, R2 represents hydrogen, halogen or hydroxy, A ... | 08/28/2007 |
| 7235550 | Polycyclic azaindole compounds The invention relates to compounds of formula (I): wherein: G1 represents an alkylene chain as defined in the description, A represents | 06/26/2007 |
| RE39679 | Substituted heterocycle fused gamma-carbolines The present invention is directed to certain novel compounds represented by structural Formula (I) or pharmaceutically acceptable salt forms thereof, wherein R1, R5, R6a, R6b, R7 | 06/05/2007 |
| 7220738 | Rifamycin analogs and uses thereof The present invention features rifamycin analogs that can be used as therapeutics for treating or preventing a variety of microbial infections. In one form, the analogs are acetylated at the 25-position, as is rifamycin. In another form, the analogs are deacetylated... | 05/22/2007 |
| 7214690 | Tricyclic quinolinone and tricyclic quinoline androgen receptor modulator compounds and methods Novel non-steroidal tricyclic quinolinone and tricyclic quinoline compounds and compositions that are agonists, partial agonists and/or antagonists for androgen receptors (AR), their preparation and their uses are described. ... | 05/08/2007 |
| 7163948 | Heterocyclic substituted 1,4-dihydri-4ox9-1,8-naphthyridine analogs The present invention relates to 1,4-dihydro-4-oxo-1,8-napthpyridine analogs of the formula and pharmaceutically acceptable salts, esters, and prodrugs thereof, wherein A, X, W and Y are ... | 01/16/2007 |
| 7141566 | Benzoxazine and benzothiazine derivatives and the use thereof in medicaments The invention relates to compounds of formula (I), the tautomeric and isomeric forms and salts thereof, in addition to a method for production and use thereof in medicaments. ... | 11/28/2006 |
| 7141565 | Substituted quinobenzoxazine analogs The present invention relates to quinobenzoxazines analogs having the general formula: and pharmaceutically acceptable salts, esters and prodrugs thereof; wherein A, U, V, W, X and Z are substituents. | 11/28/2006 |
| 7135468 | Antibacterial compounds Bacterial protein synthesis-inhibiting compounds having formula (I) and salts, prodrugs, salts of prodrugs, and metabolites thereof, processes for making the compounds and intermediates in the processes, composit... | 11/14/2006 |
| 7128928 | Ophthalmic formulation with novel gum composition There is provided a pharmaceutical composition suitable for topical administration to an eye, the composition comprising (a) a pharmacologically effective concentration of an active agent and (b) a combination of at least two ophthalmically compatible polymers compr... | 10/31/2006 |
| 7115744 | Method for producing 8-methoxy-quinolinecarboxylic acids The present invention relates to a novel process for preparing 8-methoxy-3-quinolonecarboxylic acids which are antibiotics having potent antibacterial action. ... | 10/03/2006 |
| RE39300 | Inhibiting the development of tolerance to and/or dependence on an addictive substance Nontoxic substances that block the N-methyl-D-aspartate (NMDA) receptor, e.g., a morphinan such as dextromethorphan or dextrorphan, or that block a major intracellular consequence of NMDA-receptor activation, e.g., a ganglioside such as GM1 or GT1b | 09/19/2006 |
| 7071211 | Small organic molecules that increase the activity of gelatinase a in ocular cells Small organic molecules capable of effecting a “pharmacological trabeculocanalotomy” in an eye by means of reducing juxtacanalicular meshwork as a barrier to outflow of aqueous. The small organic molecules increase Gelatinase A activity in ocular cells by increa... | 07/04/2006 |
| 7067519 | 7,8,9,10-tetrahydro-6-azepino, 6,7,8,9-tetrahydro-pyrido and 2,3-dihydro-2-pyrrolo[2,1-]-quinazolinone derivatives The invention relates to novel 7,8,9,10-tetrahydro-6H-azepino, 6,7,8,9-tetrahydro-pyrido and 2,3-dihydro-2H-pyrrolo[2,1-b]-quinazolinone derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns re... | 06/27/2006 |
| 7026484 | Tricyclic androgen receptor modulator compounds and methods This invention relates to non-steroidal tricyclic compounds that are modulators of androgen receptors and to methods for making and using such compounds. ... | 04/11/2006 |
| 7018395 | Photodynamic treatment of targeted cells The present invention is drawn to methods for photodynamic therapy (PDT) of a target cell, target tissue or target composition in a mammalian subject, using a therapeutically effective amount of a targeted substance, which is either a targeted photosensitizing agent... | 03/28/2006 |
| 7018999 | Methods for the treatment and prevention of pain Novel methods for the treatment and/or prevention of pain are presented. The methods may comprise administering to a subject in need thereof an effective amount of a stress-activated protein kinase inhibitor. Preferred compounds for use in the methods include fused ... | 03/28/2006 |
| 6964973 | Bicyclic androgen and progesterone receptor modulator compounds and methods The present invention is directed to compounds, pharmaceutical compositions, and methods for modulating processes mediated by AR and PR. More particularly, the invention relates to nonsteroidal compounds and compositions that are high affinity, high specificity agon... | 11/15/2005 |
| 6930190 | Process for the preparation of heterocyclic pentalene derivatives A process for preparing heterocyclic pentalene derivative having formula (I): wherein w is a sulfur atom (S), an oxygen atom (O) or a NR or PR group, wherein R is an hydrocarbon group; R1, R2, R3, and R4, equal to or diffe... | 08/16/2005 |
| 6916484 | Aqueous pharmaceutical composition containing moxifloxacin or salts thereof The invention relates to an aqueous pharmaceutical composition containing moxifloxacin and less than 10 ppb iron. ... | 07/12/2005 |
| 6800623 | Method of treating schizophrenia A method for treating schizophrenia which comprises administering a compound of general formula (I) ... | 10/05/2004 |
| 6720316 | Therapeutic 5-HT ligand compounds The present invention provides compounds of Formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8 and Z have any of the values defined ... | 04/13/2004 |
| 6713471 | Substituted heterocycle fused gamma-carbolines The present invention is directed to certain novel compounds represented by structural Formula (I) or pharmaceutically acceptable salt forms thereof, wherein R1, R5, R6a, R6b, ... | 03/30/2004 |
| 6713468 | Methods of using thiazolobenzoheterocycles Methods of using compounds of formula (I): their racemates, enantiomers, diastereoisomers and inorganic acid salts and organic acid salts thereof. ... | 03/30/2004 |
| 6703401 | Compounds, their preparation and use The present invention relates to compounds of the general formula (I) ##STR1## The compounds are useful in the treatment and/or prevention of conditions mediated by clear receptors, in particular the Peroxisome Proliferator-Activated Receptors (PPAR).... | 03/09/2004 |
| 6638934 | Substituted pyrazinoquinoxaline derivatives as serotonin receptor agonist and antagonists ligands The present invention is directed to novel compounds represented by structural Formulas (I) and (I-a): ##STR1## or a pharmaceutically acceptable salt thereof, wherein R1, R4a, R4b, R5, R6, R7 | 10/28/2003 |
| 6624159 | Heterocycle carboxamides as antiviral agents The present invention provides a compound of formula I ##STR1## which is useful as antiviral agents, in particular, as agents against viruses of the herpes family.... | 09/23/2003 |
| 6608048 | Tricyclic protein kinase inhibitors This invention provides compounds of Formula (I), ##STR1## where A", Z, X and n are defined herein, or a pharmaceutically acceptable salt thereof which are useful as antineoplastic agents and in the treatment of polycystic kidney disease.... | 08/19/2003 |
