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| Number | Title | Issue Date |
| 8188073 | Benzoxazines and related nitrogen-containing heterobicyclic compounds useful as mineralocorticoid receptor modulating agents The present invention relates to a compound, useful as a mineralocorticoid receptor-modulating agent, of the following formula [I]: wherein Ring A is a benzene ring optionally having a substituent(s) other than R1 | 05/29/2012 |
| 8158620 | Fused aminodihydrothiazine derivatives A compound represented by the general formula: or a pharmaceutically acceptable salt thereof or a solvate thereof, wherein Ring A is a C6-14 aryl group or the like, L is —NReCO— or the like (wherei... | 04/17/2012 |
| 8129369 | Antifungal compounds containing benzothiazinone, benzoxazinone or benzoxazolinone and process thereof The present invention discloses novel compounds of the Formula (1), comprising benzothiazinone, benzoxazinone or benzoxazolinone moieties having antifungal activity, method for preparing these compounds and the use of these compounds as antifungal agents in preventi... | 03/06/2012 |
| 8124602 | Compounds for the treatment of multi-drug resistant bacterial infections The present invention relates to compounds of Formula V(A): that demonstrate antibacterial activity, processes for their preparation, pharmaceutical compositions containing them as the active ingredient, to their use as med... | 02/28/2012 |
| 8114867 | Oxazolidinone antibiotic derivatives The invention relates to antibacterial compounds of formula I wherein R1 is hydrogen, halogen, hydroxy, alkoxy or cyano; Y1 and Y2 each represent CH, one or two of U, V, W and X represent(s)... | 02/14/2012 |
| 8106043 | Benzoxazines, benzothiazines, and related compounds having NOS inhibitory activity The present invention features benzothiazines that inhibit nitric oxide synthase (NOS), particularly those that selectively inhibit neuronal nitric oxide synthase (nNOS) in preference to other NOS isoforms, and that have the formula: ... | 01/31/2012 |
| 8097614 | Transmucosal administration of meloxicam compositions for treating and preventing disorders in non-human domesticated animals The invention includes compositions for transmucosal administration to an animal comprising at least one active agent and a pharmaceutically acceptable carrier. A preferred active agent is selected from the group consisting of meloxicam, carprofen, enrofloxacin, cle... | 01/17/2012 |
| 8093241 | Acid amide derivatives, process for their production and pesticides containing them The present invention relates to an acid amid derivative of the formula (I) or a salt thereof: wherein A is phenyl which may be substituted by X, benzyl which may be substituted by X, naphthyl which may be substituted by X,... | 01/10/2012 |
| 8076327 | Condensed imidazole derivatives as aldosterone synthase inhibitors The application relates to novel heterocyclic compounds of the general formula (I) and salts, preferable pharmaceutically acceptable salts, thereof, in which R, R1, R2, R3, Q, m and n have the meanings explained in detail in the desc... | 12/13/2011 |
| 8044044 | 4-(1-amino-ethyl)-cyclohexylamine derivatives The invention relates to compounds of formula (I) wherein R0 represents H or OH; R1 represents alkoxy; U and W represent N, V represents CH and R2 represents H or F, or U and V represent CH, W represents N and R2 represent... | 10/25/2011 |
| 8012961 | Tricyclic antibiotics The invention relates to antibacterial compounds of formula (I) wherein U represents CH or N; W represents CH or N; R1 represents alkoxy, halogen or CN; ring A represents a pyrr... | 09/06/2011 |
| 7879843 | Benzothiazin-3-one compound and intermediate therefor A medicine which contains as an active ingredient a benzothiazin-3-one-compound represented by the formula (1): (wherein n is 3 or 4; R represents ethyl or hydrogen; and R1 represents hologeno, alkoxy, haloalkyl,... | 02/01/2011 |
| 7863268 | Benzothiazinone derivatives and their use as antibacterial agents Disclosed are benzothiazin derivatives of formula (I), preparation methods therefore, and treatment methods employing such compounds as antibacterial agents in treating infectious diseases of mammals caused by bacteria, especially diseases like tuberculosis and lepr... | 01/04/2011 |
| 7807668 | Anti-inflammatory compounds Compounds of formula (I) or formula (II) have anti-inflammatory activity and comprise a new class of NSAIDs. The compounds are useful for treating inflammatory diseases or disorders. The invention also provides pharmaceutical compositions containing these compounds,... | 10/05/2010 |
| 7759340 | Antibacterial agents Naphthyridine and quinoline derivatives useful in the treatment of bacterial infections in mammals, particularly humans, are disclosed herein. ... | 07/20/2010 |
| 7759339 | Hydroxysteroid dehydrogenase inhibitors Compounds, pharmaceutical compositions, kits and methods are provided for use with hydroxysteroid dehydrogenases that comprise a compound selected from the group consisting of: wherein the variables are as defined herein. | 07/20/2010 |
| 7709472 | Antibacterial agents Naphthyridine and related derivatives useful in the treatment of bacterial infections in mammals, particularly humans, are disclosed herein. ... | 05/04/2010 |
| 7691850 | Antibacterial agents Compounds of formula (I) and derivatives thereof: compositions containing them, their preparation and their use as antibacterials. ... | 04/06/2010 |
| 7659265 | Thioamide derivatives as progesterone receptor modulators Thioamide compounds, and specifically, thioamide pyrrole compounds, and preparation thereof are provided. These thioamide compounds can be used as progesterone receptor modulators, in contraception, and in the treatment of progesterone-related maladies. ... | 02/09/2010 |
| 7655648 | Antibacterial agents Naphthalene, quinoline, quinoxaline and naphthyridine derivatives useful in the treatment of bacterial infections in mammals, particularly humans, are disclosed herein. ... | 02/02/2010 |
| 7648980 | Antibacterial agents Naphthyridine and related derivatives useful in the treatment of bacterial infections in mammals, particularly humans, are disclosed herein. ... | 01/19/2010 |
| 7638512 | Phenylaminopropanol derivatives and methods of their use The present invention is directed to phenylaminopropanol derivatives of formula I: or a pharmaceutically acceptable salt thereof, compositions containing these derivatives, and methods of their use for the prevention and tr... | 12/29/2009 |
| 7618959 | Antibacterial agents Quinoline and naphthyridine derivatives useful in the treatment of bacterial infections in mammals, particularly humans. ... | 11/17/2009 |
| 7598240 | Benzothiazin-3-one compound and intermediate therefor A medicine which contains as an active ingredient a benzothiazin-3-one-compound represented by the formula (1): (wherein n is 3 or 4; R represents ethyl or hydrogen; and R1 represents hologeno, alkoxy, haloalkyl,... | 10/06/2009 |
| 7592334 | Antibacterial agents Naphthyridine and related derivatives useful in the treatment of bacterial infections, particularly humans, are disclosed herein. ... | 09/22/2009 |
| 7579342 | Pteridine compounds for the treatment of psoriasis The invention provides pteridine compounds of formula (I), processes and intermediates used in their preparation, pharmaceutical compositions containing them and their use in therapy. Formula (I) in which A is a group of formula (a) or (b). ... | 08/25/2009 |
| 7579343 | Pyrrolo-thiazines and processes for the preparation and use thereof 1H-Pyrrolo-1,4-thiazines and a process for the preparation thereof are described. These compounds are useful as enzyme inhibitors in cells, particularly for medical uses. ... | 08/25/2009 |
| 7576078 | Tetrahydroquinoline analogues as muscarinic agonists The present invention relates to tetrahydroquinoline compounds as muscarinic receptor agonists; compositions comprising the same; methods of inhibiting an activity of a muscarinic receptor with said compounds; methods of treating a disease condition associated with ... | 08/18/2009 |
| 7560456 | Pesticidal pyridinecarboxamide derivatives The invention relates to 3-pyridylcarboxamide derivatives of formula (I): wherein the various symbols are as defined in the description, compositions thereof, methods for controlling pests by applying same, and processes fo... | 07/14/2009 |
| 7531534 | Heterocyclic antiviral compounds Compounds having the formula Ia or Ib wherein R1, R2, R3 and R4 are as defined herein are Hepatitis C virus NS5b polymerase inhibitors. Also disclosed are compositions and methods for treating an HCV infection and inhibiti... | 05/12/2009 |
| 7511035 | Antibacterial agents Naphthyridine and quinoline derivatives useful in the treatment of bacterial infections in mammals, particularly humans, are disclosed herein. ... | 03/31/2009 |
| 7498326 | Compounds Piperidine derivatives and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly in man. The piperidine derivatives include compounds of formula (I): ... | 03/03/2009 |
| 7479489 | Heterocyclic antiviral compounds Compounds having the formula I wherein A, m and R1 are herein defined are Hepatitis C virus polymerase inhibitors. Also disclosed are compositions and methods for treating diseases mediated by HCV and for inhibiting hepatitis replication. Also disclosed a... | 01/20/2009 |
| 7384937 | Fused heterocyclic compounds and use thereof Fused heterocylic compounds of the following Formula wherein R1, R2, R5, Z, J1 and J2 are described herein, and analogs thereof are provided which are useful in treatin... | 06/10/2008 |
| 7354915 | 6-amino-1,4-dihydro-benzo[][1,3]oxazin-2-ones and analogs useful as progesterone receptor modulators Compounds having the structure of formula I are provided. In formula I, R1 is H, OH, substituted or unsubstituted C1 to C3 alkyl, C1 to C3 perfluoroalkyl, or COR6; R6 is H, substituted or u... | 04/08/2008 |
| 7342009 | Cyclic sulfonamides for inhibition of gamma-secretase Compounds of formula I: inhibit the processing of APP by gamma-secretase, and hence are useful in the treatment or prevention of Alzheimer's disease. ... | 03/11/2008 |
| 7342010 | 2-thiaquinolizidines and process for the preparation thereof A process for producing 2-thiaquiolizidines which are glycosidase and glycosyltransferase inhibitors is described. The compounds are of the formula: where x is 0 to 3. ... | 03/11/2008 |
| 7329741 | Polynucleotides that hybridize to DP-75 and their use The present invention is a novel nucleic acid sequence which hybridizes to SEQ ID NO:6 or fragments thereof under stringent conditions, or fragments thereof. The invention also includes diagnostic assays, expression vectors, control sequences, antisense molecules, r... | 02/12/2008 |
| 7326712 | Substituted tricyclic compounds as protein kinase inhibitors Protein kinase inhibitors are disclosed having utility in the treatment of protein kinase-mediated diseases and conditions, such as cancer. The compounds of this invention have the following structure: including ... | 02/05/2008 |
| 7312211 | Pryanone compounds useful as reversible inhibitors of cysteine proteases Disclosed are cathepsin S, K, F, L and B reversible inhibitory compounds of the formulas (Ia) and (Ib) where R2, R3, R4, R6, R8 and Y are defined herein. The compounds are useful for treating autoimmune and othe... | 12/25/2007 |
