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"What, sir, would you make a ship sail against the wind and currents by lighting a bonfire under her deck? I pray you, excuse me, I have not the time to listen to such nonsense."
Napoleon Bonaparte ; When told of the Robert Fulton steamboat
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| Number | Title | Issue Date |
| RE40000 | Method of treatment for decreasing mortality resulting from congestive heart failure A method of treatment using a compound of Formula I: wherein: R1 is hydrogen, lower alkanoyl of up to 6 carbon atoms or aroyl selected from benzoyl and naphthoyl; R | 01/08/2008 |
| 7214711 | Method of treating migraine headache without aura The present invention relates to methods and compositions for treating selected conditions of the central and peripheral nervous systems employing non-synaptic mechanisms. More specifically, one aspect of the present invention relates to methods and materials for tr... | 05/08/2007 |
| RE39300 | Inhibiting the development of tolerance to and/or dependence on an addictive substance Nontoxic substances that block the N-methyl-D-aspartate (NMDA) receptor, e.g., a morphinan such as dextromethorphan or dextrorphan, or that block a major intracellular consequence of NMDA-receptor activation, e.g., a ganglioside such as GM1 or GT1b | 09/19/2006 |
| 7067149 | Fast disintegrating tablet The invention concerns an improved multiparticulate tablet disintegrating in the mouth in contact with saliva in less than 40 seconds. The invention is characterized in that it is based on particles of coated active principle, said particles having intrinsic compres... | 06/27/2006 |
| 7030162 | Treatment of migraine headache The invention is directed to pharmaceutical compositions useful in the treatment of migraine. The compositions contain metoclopramide and one or more NSAIDs in unit dosage form. By selecting NSAIDs that are non-acidic or segregating the metoclopramide and NSAID, the... | 04/18/2006 |
| 6951860 | Calcium channel blockers The invention involves the identification of a family of compounds which block calcium channels. The compounds can be formulated in pharmaceutical carriers and administered to subjects. The compounds are useful for treating disorders associated with calcium channel ... | 10/04/2005 |
| 6878703 | Pharmaceutical composition A pharmaceutical composition comprises an angiotensin II receptor antagonist selected from among compounds having the following formula (I), a pharmacologically acceptable salt thereof, a pharmacologically acceptable ester thereof and a pharmacologically acceptable ... | 04/12/2005 |
| 6858228 | Solid oral dosage forms of valsartan The present invention is concerned with solid oral dosage forms of comprising a) an active agent selected from valsartan and optionally HCTZ, and b) Pharmaceutically acceptable additives suitable for the preparatio... | 02/22/2005 |
| 6485745 | Solid oral dosage forms of valsartan The present invention is concerned with solid oral dosage forms of comprising a) an active agent selected from valsartan and optionally HCTZ , and b) Pharmaceutically acceptable additives suitable for the preparation of solid oral dosage forms by compression m... | 11/26/2002 |
| 6436437 | Covalent polar lipid conjugates with neurologically active compounds for targeting This invention herein describes a method of facilitating the entry of drugs into cells and tissues at physiologically protected sites at pharmicokinetically useful levels and also a method of targeting drugs to specific organelles within the cell. This po... | 08/20/2002 |
| 6403579 | Pharmaceutical compositions containing carvedilol and hydrochlorothiazide A pharmaceutical combination preparation for the treatment of cardiac and cardiovascular disorders, such as hypertension, angina pectoris, cardiac insufficiency and illnesses associated therewith, contains the active substances carvedilol, or a pharmaceut... | 06/11/2002 |
| 6342247 | Pharmaceutical compositions containing irbesartan Pharmaceutical compositions containing irbesartan, alone or in combination with a diuretic, providing tablets with a high relative amount of active agent and excellent wetting and disintegration properties.... | 01/29/2002 |
| 6313112 | Methods of protecting neuronal function The present invention is generally directed to potassium adenosine triphosphate ("KATP ") channel opening compositions. The present invention also relates to the use of KATP channel openers in therapeutic applications. The KATP | 11/06/2001 |
| 6294197 | Solid oral dosage forms of valsartan The present invention is concerned with solid dosage forms comprising a) valsartan and optionally HCTZ, and b) pharmaceutically acceptable additives suitable for the preparation of solid oral dosage forms by compression methods.... | 09/25/2001 |
| 6245787 | Composition containing amlodipine or a pharmaceutically acceptable salt thereof, and an ACE inhibitor Methods of treating congestive heart failure in a mammal, especially a human, by co-administration of (1) amlodipine, a pharmaceutically acceptable salt of amlodipine; (2) an ACE inhibitor; and optionally (3) a diuretic and/or (4) digoxin.... | 06/12/2001 |
| 6242440 | Synergistic compositions comprising an oxathiazine and a benzothiophene-2-carboxamide-S,S-dioxide This invention relates to synergistic compositions of oxathiazines and benzothiophene-2-carboxamide-S,S-dioxides for use as fungicidal preservatives in the protection of materials, such as protection of wood, wood products, biodegradable materials and coa... | 06/05/2001 |
| 6093731 | Isoquinolines Isoquinolinylguanidine compounds of formula (I): ##STR1## wherein the substituents are as defined herein, and salts thereof, are disclosed as urokinase inhibitors.... | 07/25/2000 |
| 6024977 | Covalent polar lipid conjugates with neurologically active compounds for targeting This invention herein describes a method of facilitating the entry of drugs into cells and tissues at physiologically protected sites at pharmicokinetically useful levels and also a method of targeting drugs to specific organelles within the cell. This po... | 02/15/2000 |
| 5994348 | Pharmaceutical compositions containing irbesartan Pharmaceutical compositions containing irbesartan, alone or in combination with a diuretic, providing tablets with a high relative amount of active agent and excellent wetting and disintegration properties.... | 11/30/1999 |
| 5985897 | Benzothiphene compounds, intermediates, compositions, and methods The invention provides benzothiophene compounds, formulations, and methods of inhibiting bone loss or bone resorption, particularly osteoporosis, and cardiovascular-related pathological conditions, including hyperlipidemia, and estrogen-dependent cancer.... | 11/16/1999 |
| 5856331 | Method for preventing tissue injury from hypoxia There is disclosed a method for preventing tissue injury caused by tissue hypoxia and reoxygenation, comprising administering a compound that inhibits signal transduction by inhibiting cellular accumulation of linoleoyl phosphatidic acid (PA) through an i... | 01/05/1999 |
| 5824677 | Substituted amino alcohol compounds Disclosed are compounds having a straight or branched aliphatic hydrocarbon structure of formula I: ##STR1## In formula I, n is an integer from one to four and m is an integer from four to twenty. Independently, R1 and R2 are hy... | 10/20/1998 |
| 5760069 | Method of treatment for decreasing mortality resulting from congestive heart failure A method of treatment using a compound of Formula I: ##STR1## wherein: R1 is hydrogen, lower alkanoyl of up to 6 carbon atoms or aroyl selected from benzoyl and naphthoyl; R2 is hydrogen, lower alkyl of up to 6 carbon atoms or arylal... | 06/02/1998 |
| 5753651 | Method of modifying angiotensin receptor activity for mediation of pain The present invention relates to a method of modifying Angiotensin II subtype 1 (AT1) receptor activity for the treatment of premenstrual syndrome (PMS) and the symptoms associated therewith, and further relates to a method for the treatment of... | 05/19/1998 |
| 5688809 | 5-heteroarylindole derivatives The present invention relates to compounds of the formula ##STR1## The present invention also relates to intermediates for the preparation of compounds of the formula I, pharmaceutical compositions and method of use.... | 11/18/1997 |
| 5686451 | Combination of an ace inhibitor and a diuretic Pharmaceutical formulations comprising as active ingredients an angiotensin converting enzyme (ACE) inhibitor at a dose level normally found effective as an antihypertensive and a diuretic at a dose level below its minimum effective dose, demonstrate grea... | 11/11/1997 |
| 5654281 | Inhibiting the development of tolerance to and/or dependence on an addictive substance Nontoxic substances that block the N-methyl-D-aspartate (NMDA) receptor, e.g., a morphinan such as dextromethorphan or dextrorphan, or that block a major intracellular consequence of NMDA receptor activation, e.g., a ganglioside such as GM1 or ... | 08/05/1997 |
| 5641783 | Substituted amino alcohol compounds Disclosed are compounds having a straight or branched aliphatic hydrocarbon structure of formula I: ##STR1## In formula I, n is an integer from one to four and m is an integer from four to twenty. Independently, R1 and R2 are hy... | 06/24/1997 |
| 5556838 | Inhibiting the development of tolerance to and/or dependence on an addictive substance Nontoxic substances that block the N-methyl-D-aspartate (NMDA) receptor, e.g., a morphinan such as dextromethorphan or dextrorphan, or that block a major intracellular consequence of NMDA-receptor activation, e.g., a ganglioside such as GM1 or ... | 09/17/1996 |
| 5464854 | Method of modifying ovarian hormone-regulated AT1 receptor activity as treatment of incapacitating symptom(s) of P.M.S. The method of treatment moderating, blocking and/or eliminating premenstrual syndrome embodies the intermittent administering of an AT1 antagonist to a female having menstrual cycles characterized predominately by during substantially the luteal phase inc... | 11/07/1995 |
| 5321012 | Inhibiting the development of tolerance to and/or dependence on a narcotic addictive substance Nontoxic substances that block the N-methyl-D-aspartate (NMDA) receptor, e.g., a morphinan such as dextromethorphan or dextrorphan, or that block a major intracellular consequence of NMDA receptor activation, e.g., a ganglioside such as GM1 or ... | 06/14/1994 |
| 5321024 | Antiviral pharmaceutical composition for treating lymphocytes The present invention provides a pharmaceutical composition containing 3,4-dihydro-1-phenyl-1-thio -1,2,4-benzothiadiazine 1-oxide useful for protecting lymphocytes.... | 06/14/1994 |
| 5256647 | Compositions comprising 1-substituted azacycloalkanes This invention provides compositions comprising a physiologically-active agent and a compound having the structural formula ##STR1## wherein X may represent sulfur or two hydrogen atoms; R' is H or a lower alkyl group having 1-4 carbon atoms; m is 2-... | 10/26/1993 |
| 5234922 | Use of sulfonylureas and other potassium channel regulators to treat secretory diarrhea Methods for the treatment of secretory diarrhea comprised of administering to a patient in need thereof, an effective amount of a CFTR chloride channel blocker or a potassium channel opener are disclosed. The CFTR chloride channel blocker is a sulfonylure... | 08/10/1993 |
| 5231083 | Method for the treatment of cardiac and of vascular hypertrophy and hyperplasia The invention relates to a method for the treatment of cardiac and of vascular hypertrophy and hyperplasia by administration of angiotensin converting enzyme inhibitors. Administration of compounds of the formula I ##STR1## in which n is 1 or 2, R, R... | 07/27/1993 |
| 5214041 | Hair revitalizing tonic composition A hair revitalizing tonic composition comprising (i) an amine oxide and (ii) a compound having a calmodulin inhibitory activity and/or a compound having an activity as a calcium antagonist.... | 05/25/1993 |
| 5155105 | Pharmaceutical methods for relief of dysmenorrhea and/or premenstrual syndrome and process A pharmaceutical composition for relieving symptoms of dysmenorrhea and/or premenstrual syndrome comprising a combination of ibuprofen and hydrochlorothiazide.... | 10/13/1992 |
| 5140012 | Method for preventing onset of restenosis after angioplasty employing pravastatin A method is provided for preventing or reducing the risk of restenosis following angioplasty by administering pravastatin alone or in combination with an ACE inhibitor such as captopril or ceranapril, prior to, during and/or after angioplasty.... | 08/18/1992 |
| 5132106 | Halogenated pyrimidine 3-oxide derivatives, their use for the treatment and prevention of hair loss and for stimulating its regrowth The invention relates to compounds of formula: ##STR1## in which: R1 and R2 denote, independently of one another, a hydrogen atom or alternatively a carbamoyl group of formula: ##STR2## with R'3 denoting hydroge... | 07/21/1992 |
| 5098889 | Method for preventing or inhibiting loss of cognitive function employing a combination of an ace inhibitor and a drug that acts at serotonin receptors A method is provided for imhibiting loss of cognitive functon, including memory, which may or may not be associated with Alzheimer's disease, by administering an ACE inhibitor, such as captopril, fosinopril, zofenopril or ceranapril in combination with a ... | 03/24/1992 |
