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| Number | Title | Issue Date |
| 8129368 | 5,6-dihydro-1H-pyridin-2-one compounds The invention is directed to 5,6-dihydro-1H-pyridin-2-one compounds of formula: wherein R is C1-C6 alkyl or (Aryl)CH2-,and pharmaceutical compositions containing such compounds that are usef... | 03/06/2012 |
| 8101600 | Method of treating depression Methods for treatment of depression-related mood disorders in mammals, particularly humans are disclosed. The methods of the invention include administration of compounds capable of enhancing glutamate transporter activity in the brain of mammals suffering from depr... | 01/24/2012 |
| 8022066 | 2-(2-hydroxyphenyl) benzothiadiazines useful for treating obesity and diabetes The present invention relates to novel compounds that act as chemical uncouplers. Compounds of the invention are useful, inter alia, in the treatment, including prevention, of obesity, diabetes and a number of diseases or conditions associated therewith. ... | 09/20/2011 |
| 7939524 | 5,6-dihydro-1H-pyridin-2-one compounds The invention is directed to 5,6-dihydro-1H-pyridin-2-one compounds of Formula I wherein X is N, and A is and pharmaceutical compositions containing such compo... | 05/10/2011 |
| 7834009 | 4-hydroxy-5,6-dihydro-1-pyridin-2-one compounds The invention is directed to 4-hydroxy-5,6-dihydro-1H-pyridin-2-one compounds of Formula I and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus: ... | 11/16/2010 |
| 7799777 | Salts of potassium ATP channel openers and uses thereof Provided are immediate or prolonged administration of certain salts of KATP channel openers such as diazoxide to a subject to achieve novel pharmacodynamic, pharmacokinetic, therapeutic, physiological, metabolic and compositional outcomes in the treatment... | 09/21/2010 |
| 7741320 | Cycloalkylated benzothiadiazines, a process for their preparation and pharmaceutical compositions containing them Compounds of formula (I): wherein: RCy represents an unsubstituted or substituted cycloalkyl group or cycloalkylalkyl group, R1, R2, R | 06/22/2010 |
| 7595313 | Nitric oxide donating diuretic compounds, compositions and methods of use The invention describes novel compositions and kits comprising at least one nitric oxide enhancing diuretic compound, or pharmaceutically acceptable salts thereof, and, optionally, at least one nitric oxide enhancing compound and/or at least one therapeutic agent. T... | 09/29/2009 |
| 7582626 | 5,6-dihydro-1-pyridin-2-one compounds The invention is directed to 5,6-dihydro-1H-pyridin-2-one compounds of Formula I and pharmaceutical compositions containing such compounds that are useful in treating hepatitis C virus infections: w... | 09/01/2009 |
| 7572789 | Salts of potassium ATP channel openers and uses thereof Provided are immediate or prolonged administration of certain salts of KATP channel openers such as diazoxide to a subject to achieve novel pharmacodynamic, pharmacokinetic, therapeutic, physiological, metabolic and compositional outcomes in the treatment... | 08/11/2009 |
| 7524841 | 4,4-disubstituted piperidine derivatives having CCR3 antagonism The invention provides low molecular compounds having activity which inhibits binding of CCR3 ligands to CCR3 on target cells, i.e. CCR3 antagonists. The invention also provides 4,4-(disubstituted)piperidine derivatives represented by formula (I) below, pharmaceutic... | 04/28/2009 |
| 7517875 | Piperidine derivatives having CCR3 antagonism The invention provides low molecular compounds having activity which inhibits binding of CCR3 ligands to CCR3 on target cells, i.e. CCR3 antagonists. The invention also provides compounds represented by formula (I) below, pharmaceutically acceptable acid adducts the... | 04/14/2009 |
| 7517876 | Anti-infective agents Compounds having the formula are hepatitis C (HCV) polymerase inhibitors. Also disclosed are compositions and methods for inhibiting hepatitis C (HCV) polymerase, processes for making the compounds, and synthetic intermedia... | 04/14/2009 |
| 7425552 | Pyridazinone compounds The invention is directed to pyridazinone compounds of Formula I and pharmaceutical compositions containing compounds of Formula I wherein R1 and R2 are independently H, alkyl, cycloalkyl, aryl, or het... | 09/16/2008 |
| 7423034 | Benzothiazine and benzothiadiazine compounds Compounds of formula (I): wherein: R1 represents hydrogen, a halogen or alkyl, R1a represents hydrogen or alkyl, R2 represents hydrogen, a halogen or h... | 09/09/2008 |
| 7396829 | Nitric oxide enhancing diuretic compounds, compositions and methods of use The invention describes novel compositions and kits comprising at least one nitric oxide enhancing diuretic compound, or pharmaceutically acceptable salts thereof, and, optionally, at least one nitric oxide enhancing compound and/or at least one therapeutic agent. T... | 07/08/2008 |
| 7378414 | Anti-infective agents Compounds having the formula are hepatitis C (HCV) polymerase inhibitors. Also disclosed are a composition and method for inhibiting hepatitis C (HCV) polymerase, processes for making the compounds, and synthetic intermedia... | 05/27/2008 |
| RE40000 | Method of treatment for decreasing mortality resulting from congestive heart failure A method of treatment using a compound of Formula I: wherein: R1 is hydrogen, lower alkanoyl of up to 6 carbon atoms or aroyl selected from benzoyl and naphthoyl; R | 01/08/2008 |
| 7279497 | Benzopyran derivatives substituted with secondary amines including imidazole, their preparation and pharmaceutical compositions containing them The present invention relates to benzopyran derivatives substituted with secondary amines including imidazole, their preparation, and pharmaceutical compositions containing them. The present invention is pharmacologically useful for the treatment of cancer, rheumato... | 10/09/2007 |
| 7268129 | Fluorinated benzothiadiazine compounds Compounds of formula (I): wherein: RF represents monofluoro- or polyfluoro-alkyl or monofluoro- or polyfluoro-cycloalkylalkyl, R1 represents hydrogen or a group sel... | 09/11/2007 |
| 7268130 | Benzothiadiazine compounds The invention relates to compounds of formula (I): wherein: R1 represents alkyl substituted by one or more halogen atoms, R2 represents hydrogen, halogen or hydroxy... | 09/11/2007 |
| 7262191 | Benzothiadiazine compounds The invention relates to compounds of formula (I): wherein: X represents oxygen or sulphur, R1 represents linear or branched (C1-C6 | 08/28/2007 |
| 7262190 | Benzothiazine and benzothiadiazine compounds The invention relates to compounds of formula (I): wherein: R1 represents hydrogen, alkyl or cycloalkyl, R2 represents hydrogen, halogen or hydroxy, A ... | 08/28/2007 |
| 7250411 | Benzothiazine and benzothiadiazine compounds Compounds of formula (I): wherein: R1 represents hydroxy or RCO—O—, R2 represents hydrogen, halogen, hydroxy or R′CO—O, R, R′, which may be i... | 07/31/2007 |
| 7235548 | Compounds and their use as positive AMPA receptor modulators The invention provides novel compounds represented by the general formula compound represented by the formula: wherein the bond represented by the broken line may be a single, a... | 06/26/2007 |
| 7091200 | Quinazolone derivatives as alpha 1A/B adrenergic receptor antagonists This invention relates to compounds which are generally alpha-1A/B adrenoceptor antagonists and which are represented by Formula I: wherein Z is —C(O)— or —S(O)2—, X is... | 08/15/2006 |
| 7026317 | Pyrazolotriazines as CRF antagonists The present invention relates to pyrazolotriazines according to formula (I) and stereoisomers, isomers and salts thereof wherein R1-R5 are selected from certain alkyl, aryl and heteroaryl species ... | 04/11/2006 |
| 7001907 | Peptide-containing α-ketoamide cysteine and serine protease inhibitors This invention relates to peptide-containing α-ketoamide inhibitors of cysteine and serine proteases, methods for making these compounds, and methods for using the same. ... | 02/21/2006 |
| 6979698 | Method of treating cognitive deficits in learning and memory The treatment of learning, memory, and age-related memory disorders includes administration of a nicotine antagonist. The preferred nicotine antagonists are mecamylamine, a mecamylamine analog, or a mecamylamine stereoisomer. The effective amount of the nicotine ant... | 12/27/2005 |
| 6962922 | Alkynylated quinazoline compounds A compound selected from those of formula (I): wherein W1 represents O, S, or —NR3 in which R3 represents hydrogen, alkyl, OH or CN; W2 represe... | 11/08/2005 |
| 6949651 | Fused bicyclic metalloproteinase inhibitors The present invention relates to fused bicyclic metalloproteinase inhibitors of the formula wherein A, B, X, Y, and R1 are as defined in the specification, and to pharmaceutical compositions and methods of t... | 09/27/2005 |
| 6943159 | Compounds and their use as positive AMPA receptor modulators The invention provides novel compounds represented by general formula (I) wherein the bond represented by the broken line may be a single, double bond or absent; and if the bond is absent, then the nitrogen is substitu... | 09/13/2005 |
| 6939870 | Substituted-3-indolyl-4-piperidino-alkyl heterocycles for the treatment of depression A compound represented by the formula I: wherein A represents the following heterocycles: and R1-9 are as defined herein, a composition containing this compoun... | 09/06/2005 |
| 6919331 | Substituted 2-methyl-benzimidazole respiratory syncytial virus antiviral agents The present invention concerns antiviral compounds, their methods of preparation and their compositions, and use in the treatment of viral infections. More particularly, the invention provides heterocyclic substituted 2-methylbenzimidazole derivatives for the treatm... | 07/19/2005 |
| 6894043 | Benzothiadiazine derivatives, preparation method and pharmaceutical compositions containing same Compound selected from those of formula (I): wherein: X represents flourine, bromine, iodine or methyl, each of R1 and R2, which may be identica... | 05/17/2005 |
| 6858228 | Solid oral dosage forms of valsartan The present invention is concerned with solid oral dosage forms of comprising a) an active agent selected from valsartan and optionally HCTZ, and b) Pharmaceutically acceptable additives suitable for the preparatio... | 02/22/2005 |
| 6737427 | Mucin synthesis inhibitors The claimed invention relates to methods of modulating mucin synthesis and the therapeutic application of compounds in controlling mucin over-production associated with diseases such as chronic obstructive pulmonary diseases (COPD) including asthma and chronic bronc... | 05/18/2004 |
| 6730668 | 6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines The present invention relates to compound which are capable of preventing the extracellular release of inflammatory cytokines, said compounds, including all enantiomeric and diasteriomeric forms and pharmaceutically acceptable salts thereof, have the formula: | 05/04/2004 |
| 6656932 | Benzo thiadiazine matrix metalloproteinase inhibitors Selective MMP-13 inhibitors are benzo thiadiazines of the Formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein R2 is hydrogen or alkyl; R1 and R3 include hydrogen, alkyl, and aryl, with the proviso that ... | 12/02/2003 |
| 6620808 | Endocrine modulation with positive modulators of AMPA type glutamate receptors Methods for modulating the endocrine system of a mammal are provided. In the subject methods, a positive allosteric modulator of AMPA receptors of the hypothalamus are administered to the host. The subject methods find use in applications where it is desi... | 09/16/2003 |
