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| Number | Title | Issue Date |
| 8173641 | 4-amino-1,2,3-benzoxathiazine-derivatives as pesticides The present invention relates to novel benzoxathiazine derivatives of the formula (I) in which R1, R2, R3, R4, R5 and R6 are each as defined in the descripti... | 05/08/2012 |
| 8138176 | Imidazo compounds Heterocyclic compounds of the formula (I) and salts, preferably pharmaceutically acceptable salts thereof, are provided in which R, R1, R2, Q, m and n have the meanings explained in detail in the description. Also provided are a process for the... | 03/20/2012 |
| 8101599 | Pharmaceutical composition containing anti-hypertensive agents The present invention relates to a combination of organic compounds, a pharmaceutical composition and a kit of parts comprising said combination of organic compounds and to a method of treatment or prevention of certain conditions or diseases. ... | 01/24/2012 |
| 8097613 | [1,2,4]thiadiazine 1,1-dioxide compounds The invention is directed to [1,2,4]thiadiazine 1,1-dioxide compounds of formula I wherein A is B is and pharmaceutical compositions co... | 01/17/2012 |
| 7951800 | Anti-infective agents The present invention provides HCV polymerase inhibiting compounds having the formula (I): where R1 is cyclobutyl-N(Ra)—, n is 1, 2, 3 or 4, and at least one R5 is RaSO2 | 05/31/2011 |
| 7820651 | Preparation of antimicrobial formulations using 7-oxa-2-thia-1,5-diazabicyclo[3.3.1]nonane-2,2-dione Use of 7-oxa-2-thia-1,5-diazabicyclo[3.3.1]nonane-2,2-dione (“cyclotaurolidin”) for the preparation of antimicrobial formulations, in particular antimicrobial solutions for technical or medical purposes and of aqueous lock solutions for catheters and port system... | 10/26/2010 |
| 7799776 | Indoleamine 2,3-dioxygenase (IDO) inhibitors Inhibitors of indoleamine 2,3-dioxygenase (IDO) are provided as are pharmaceutical compositions containing such inhibitors as well as the use of such inhibitors and compositions for the treatment of a condition in a mammalian subject characterized by pathology of th... | 09/21/2010 |
| 7763607 | Pharmaceutical compositions comprising CBx cannabinoid receptor modulators and potassium channel modulators Described herein are pharmaceutical compositions comprising therapeutically effective quantities of (i) a KATP channel modulator; and (ii) a CBx modulator. Also described herein are methods of making and using these compositions. ... | 07/27/2010 |
| 7718652 | Substituted benzothiadiazinedioxide derivatives and methods of their use The present invention is directed to substituted benzothiadiazinedioxide derivatives of formula I: or a pharmaceutically acceptable salt, stereoisomer or tautomer thereof, which are monoamine reuptake inhibitors, compositio... | 05/18/2010 |
| 7705000 | Oral suspension comprising meloxicam The present invention relates to an oral suspension comprising meloxicam, its preparation and its use in alleviating inflammation and pain in both acute and chronic musculo-skeletal disorders. ... | 04/27/2010 |
| 7678790 | Platelet ADP receptor inhibitors Novel compounds of formula (I) to (VI), which more particularly include sulfonylurea derivatives, sulfonylthiourea derivatives, sulfonylguanidine derivatives, sulfonylcyanoguanidine derivatives, thioacylsulfonamide derivatives, and acylsulfonamide derivatives which ... | 03/16/2010 |
| 7642253 | Histone deacetylase inhibitors Compounds, pharmaceutical compositions, kits and methods useful for inhibiting HDAC, thereby treating a disease state for which HDAC possess activity that contributes to the pathology and/or symptomology of the disease state. The compound is selected from the group ... | 01/05/2010 |
| 7598239 | Conjugated psychotropic drugs and uses thereof Novel chemical conjugates of psychotropic drugs and organic acids, uses thereof in the treatment of psychotic and/or proliferative disorders and diseases and as chemosensitizing agents, and their syntheses are disclosed. The organic acids are selected to reduce side... | 10/06/2009 |
| 7598238 | Fluorescent fused-ring traizoles that inhibit cell proliferation and uses thereof Fused-ring triazole compounds which inhibit proliferation of cells and exhibit a unique and intense fluorescence are provided. Also provided are methods for synthesizing these compounds and methods for using these compounds to inhibit cell proliferation and infectio... | 10/06/2009 |
| 7538105 | Anti-infective agents Compounds having the formula are hepatitis C(HCV) polymerase inhibitors. Also disclosed are a composition and method for inhibiting hepatitis C(HCV) polymerase, processes for making the compounds, and synthetic intermediate... | 05/26/2009 |
| 7476668 | Thiadiazine derivatives and use thereof as positive AMPA receptor modulators Compounds of formula (I): wherein: A represents thienyl, furyl, pyrrolyl, oxathiol, thiazole, isothiazole, oxazole or imidazole, represents a single bond or a double bond... | 01/13/2009 |
| 7462611 | Pyrro[1,2-b]pyridazinone compounds The invention is directed to pyrro[1,2-b]pyridazinone compounds of Formula I and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus: wherein R4 is se... | 12/09/2008 |
| 7425552 | Pyridazinone compounds The invention is directed to pyridazinone compounds of Formula I and pharmaceutical compositions containing compounds of Formula I wherein R1 and R2 are independently H, alkyl, cycloalkyl, aryl, or het... | 09/16/2008 |
| 7410964 | Cyclohexyl sulphones as gamma-secretase inhibitors Compounds of formula I: inhibit gamma-secretase and hence find use in treatment or prevention of Alzheimer's disease. ... | 08/12/2008 |
| 7365063 | Quinazolinone and benzoxazinone derivatives and uses thereof Compounds of the formula I: and pharmaceutically acceptable salts thereof wherein X is N, Y is S, Z is —(CRaRb)r—, A is —NR3, m is 2, n is 1, q is 2, R2 is optioi... | 04/29/2008 |
| 7358239 | Pyrrolidinyl, piperidinyl or homopiperidinyl substituted (benzodioxan, benzofuran or benzopyran) derivatives The present invention concerns compounds of formula (I) a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof, wherein -Z1-Z2- is... | 04/15/2008 |
| 7341749 | Flavopereirine and alstonine combinations in the treatment and prevention of prostate cancer A method and composition for preventing prostate cancer and/or reducing PSA levels and/or alleviating the symptoms of BPH (Benign Prostatic Hyperplasia) or PIN (prostatic intraepithelial neoplasia) by administration of an effective amount of a mixture of flavopereir... | 03/11/2008 |
| 7312212 | Aminopiperidine derivatives Piperidine derivatives and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly in man. ... | 12/25/2007 |
| 7309497 | Injectable pharmaceutical composition for systematic administration of pharmacologically active ingredients The invention relates to novel pharmaceutical compositions for the systemic administration of pharmacologically active ingredients. The invention relates in particular to an injectable pharmaceutical composition comprising (a) a pharmacologically active ingredient i... | 12/18/2007 |
| 7304048 | Indole-type derivatives as inhibitors of p38 kinase The invention is directed to methods to inhibit p38-α kinase using compounds containing an aromatic system coupled through a 7-membered heterocycle to an indole-type system. ... | 12/04/2007 |
| 7262190 | Benzothiazine and benzothiadiazine compounds The invention relates to compounds of formula (I): wherein: R1 represents hydrogen, alkyl or cycloalkyl, R2 represents hydrogen, halogen or hydroxy, A ... | 08/28/2007 |
| 7262189 | Benzothiazine and benzothiadiazine derivatives, method for preparing same and pharmaceutical compositions containing same Compounds of formula (I): wherein: R1 represents aryl or heteroaryl, R2 represents hydrogen, halogen or hydroxy, X represents oxygen or sulphur, ... | 08/28/2007 |
| 7253161 | Benzothiazine and benzothiadiazine derivatives method for preparing same and pharmaceutical compositions containing same Compounds of formula (I): wherein: R1 represents aryl or heteroaryl, R2 represents hydrogen, halogen or hydroxy, A represents CR4R5 | 08/07/2007 |
| 7253163 | Benzothiazine and benzothiadiazine compounds Compounds of formula (I): wherein: R1 represents a heterocycle, R2 represents hydrogen, a halogen or hydroxy, A represents CR4R5 ... | 08/07/2007 |
| 7253162 | Benzothiazine and benzothiadiazine compounds Compounds of formula (I): wherein: R1 represents hydrogen, a halogen or alkyl, R1a represents hydrogen or alkyl, R2 ... | 08/07/2007 |
| 7238712 | Indole-type derivatives as inhibitors of p38 kinase The invention is directed to methods to inhibit p38-α kinase using compounds of the formula and the pharmaceutically acceptable salts thereof, or a pharmaceutical composition thereof, wh... | 07/03/2007 |
| 7232832 | Antibacterial agents Quinoline and naphthyridine derivatives useful in the treatment of bacterial infections in mammals, particularly humans. ... | 06/19/2007 |
| 7220747 | Method for preventing damage to or rejuvenating a cellular blood component using mitochondrial enhancer This invention provides methods for treating cellular blood components and other cells containing mitochondria to improve vital qualities of the cells by contacting the cells with a mitochondrial enhancer to the cells. Mitochondrial enhancers prevent damage to and r... | 05/22/2007 |
| 7189726 | Benzofuran derivatives as inhibitors of p38-α kinase The invention is directed to methods to inhibit p38-α kinase using compounds which contain an aromatic residue coupled to an benzofuran moiety through a piperidine. ... | 03/13/2007 |
| 7183311 | NF-κB inhibitors The present invention provides novel compounds and methods for using them to treat diseases with aminothiophene inhibitors of IKK-β phosphorylation of IκB. In yso doing these aminothiophene inhibitors block pathological activation of transcription factor NF-κB in... | 02/27/2007 |
| 7148236 | Modulators of acetylcholine receptors The present invention relates to compounds that modulate neurotransmission by promoting the release of neurotransmitters such as acetylcholine, dopamine and norepinephrine. More particularly, the present invention relates to thio-bridged aryl compounds that are capa... | 12/12/2006 |
| 7122177 | Preparation and xenotransplantation of porcine islets The invention relates to developments in the treatment of diabetes in mammals. Particularly it relates to a method of preparing a xenotransplantable porcine islet preparation capable upon xenotransplantation of producing porcine insulin in an appropriate recipient m... | 10/17/2006 |
| 7112588 | Use of proteasome inhibitors to treat dry eye disorders Proteasome inhibitors are useful for treating dry eye disorders and other disorders requiring the wetting of the eye. ... | 09/26/2006 |
| 7108997 | Assay for detecting inhibitors of the enzyme myeloperoxidase The invention is an assay for detecting inhibitors of the enzyme myeloperoxdase The assay method comprises reacting myeloperoxdase with hydrogen peroxide and a chloride source to generate hypochlorous acid in the presence of a potential inhibitor of said myeloperoxi... | 09/19/2006 |
| 7105511 | Fluorescent fused-ring triazoles that inhibit cell proliferation and uses thereof Fused-ring triazole compounds which inhibit proliferation of cells and exhibit a unique and intense fluorescence are provided. Also provided are methods for synthesizing these compounds and methods for using these compounds to inhibit cell proliferation and infectio... | 09/12/2006 |
