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| Number | Title | Issue Date |
| 8063042 | Heterocyclic compounds The invention is concerned with novel heterocyclyl compounds of formula (I) wherein A, X, Y, R3, R4, R5, R6, R7, R8, R9, R10, m and n a... | 11/22/2011 |
| 8030301 | Treatment of cancers with methylol-containing compounds and at least one electrolyte A method of inhibiting growth of a tumor cell in a mammal may include steps of administering to the mammal a first solution including a tumor-inhibiting methylol-containing compound, the first solution further including a first combination having a plurality of phys... | 10/04/2011 |
| 7973035 | Inhibitors of C-FMS kinase The invention is directed to compounds of Formula I: wherein Z, X, J, R2 and W are set forth in the specification, as well as solvates, hydrates, tautomers and pharmaceutically acceptable salts thereof, that inhi... | 07/05/2011 |
| 7928102 | Irradiated compositions and treatment of cancers with radiation in combination with taurolidine and/or taurultam A composition formed by subjecting to ionizing radiation a combination containing a radiation-protective amount of PVP along with a solution, gel or adhesive including taurolidine, taurultam or a mixture thereof; or an aggregate including collagen-free crystals of t... | 04/19/2011 |
| 7902186 | Substituted 5-phenyl-3,6-dihydro-2-oxo-6H-1,3,4-thiadiazines Compounds of the formula (I), in which R1, R2, m, Q and B have the meanings indicated in Claim 1, are inhibitors of tyrosine kinases, in particular Met kinase, and can be employed, inter alia, for the treatment of tumours. | 03/08/2011 |
| 7834008 | Cyclopropyl derivatives as NK3 receptor antagonists The present invention relates to cyclopropyl derivatives of formula (I) and salt thereof. These compounds are NK3 receptor antagonists and may therefore be useful for treatment of diseases where the NK3 receptor is implicated, e.g. psychotic disorders. | 11/16/2010 |
| 7781428 | Pyrazoline compounds Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I: wherein R1, R2, R3A, R3B, R4, R | 08/24/2010 |
| 7713961 | Substituted 1,2-ethylenediamines, methods for preparing them and uses thereof The present invention relates to substituted 1,2-ethylenediamines of general formula (I) wherein the groups R1 to R15, A, B, L, i as well as X1—X4 are defined as in the specific... | 05/11/2010 |
| 7691849 | Carboxamidine derivatives and their use in the treatment of vascular diseases The subject invention relates to carboxamidine derivatives, to pharmaceutical compositions comprising the same, and the use thereof in the preparation of pharmaceutical compositions for the treatment of vascular diseases. ... | 04/06/2010 |
| 7638511 | Methods and compositions for treating primary and secondary tumors of the central nervous system (CNS) Methods and compositions for the treatment and/or prophylaxis and/or suppression of primary and/or secondary tumors of the central nervous system (brain and spinal cord, eyes) in mammalian subjects are disclosed, wherein an effective dose of a methylol transfer agen... | 12/29/2009 |
| 7550457 | Pharmaceutically effective compounds The subject invention relates to carboxamidine derivatives, to pharmaceutical compositions containing the carboxamidine derivatives of the invention, and the use thereof for the treatment of vascular diseases and in the preparation of pharmaceutical compositions for... | 06/23/2009 |
| 7534785 | 3,6-dihydro-2-oxo-6-1,3,4,-thiadiazine derivatives Compounds of the formula I, in which R1, R2, Q and B have the meanings indicated in claim 1, are inhibitors of tyrosine kinases, in particular Met kinase, and can be employed, inter alia, for the treatment of tumours. ... | 05/19/2009 |
| 7531533 | 6-Membered heterocyclic compound and use thereof A compound represented by the general formula (I) or a salt thereof: [T represents oxygen atom and the like; V represents CH2 and the like; R01 to R04 represent hydrogen atom and the like; A... | 05/12/2009 |
| 7498325 | Modified amino acids, pharmaceuticals containing these compounds and method for their production The present invention relates to modified amino acids of general formula wherein A, Z, X, n, m, R, R2, R3, R4 and R11 are defined as in claims 1 to 5, thei... | 03/03/2009 |
| 7476667 | Indole acetic acids exhibiting CRTH2 receptor antagonism and uses thereof The invention relates to indole acetic acid compounds which function as antagonists of the CRTH2 receptor. The invention also relates to the use of these compounds to inhibit the binding of prostaglandin D2 and its metabolites or certain thromboxane metab... | 01/13/2009 |
| 7442695 | Depeptidized inhibitors of hepatitis C virus NS3 protease The present invention discloses novel depeptidized compounds which have HCV protease inhibitory activity as well as pharmaceutical compositions comprising such compounds and methods of using them to treat disorders associated with the HCV protease. ... | 10/28/2008 |
| 7414050 | Inhibitors of c-fms kinase The invention is directed to compounds of Formula I: wherein Z, X, J, R2 and W are set forth in the specification, as well as solvates, hydrates, tautomers and pharmaceutically acceptable salts thereof, that inhi... | 08/19/2008 |
| 7384936 | Carboxamidine derivatives and their use in the treatment of vascular diseases The invention relates to carboxamidine derivatives to pharmaceutical compositions containing the same and the use thereof in the preparation of pharmaceutical compositions for the treatment of vascular diseases. ... | 06/10/2008 |
| 7371743 | Carboxylic acid amides, the preparation thereof and their use as medicaments The present invention relates to new substituted carboxylic acid amides of general formula wherein A, B and R1 to R5 are defined as in claim 1, the tautomers, the enantiomers, the diastereomers,... | 05/13/2008 |
| 7358239 | Pyrrolidinyl, piperidinyl or homopiperidinyl substituted (benzodioxan, benzofuran or benzopyran) derivatives The present invention concerns compounds of formula (I) a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof, wherein -Z1-Z2- is... | 04/15/2008 |
| 7339906 | Opening a communications stream between a user terminal and a base station A method and apparatus are provided that allow a communications stream to be quickly opened between two terminals. According to one aspect of the present invention, the invention includes registering the base station and the user terminal with each other by exchangi... | 03/04/2008 |
| 7323460 | N-(substituted benzyl)-8-hydroxy-1,6-naphthyridine-7-carboxamides useful as HIV integrase inhibitors N-(Substituted benzyl)-8-hydroxy-1,6-naphthyridine-7-carboxamides are inhibitors of HIV integrase and inhibitors of HIV replication. The naphthyridine carboxamides are of Formula (I): wherein R1′, R | 01/29/2008 |
| 7273862 | Aminoalkyl substituted (benzodioxan, benzofuran or benzopyran) derivatives The present invention concerns compounds of formula (I) a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof, wherein -Z1-Z... | 09/25/2007 |
| 7253175 | Method for treating athlete's foot A method of treating a patient having a fungal infection comprises administering an effective fungal infection treatment amount of an antiviral agent, such as valacyclovir, to eliminate the symptoms of the fungal infection. ... | 08/07/2007 |
| 7253160 | Depeptidized inhibitors of hepatitis C virus NS3 protease The present invention discloses novel depeptidized compounds which have HCV protease inhibitory activity as well as pharmaceutical compositions comprising such compounds and methods of using them to treat disorders associated with the HCV protease. ... | 08/07/2007 |
| 7235246 | Dermatomycosis vaccine The present invention relates to the preparation of universal inactivated vaccines and their use in preparing compositions for the prophylaxis and therapy of dermatomycosis. Vaccines according to the present invention have the advantage of conferring immunity agains... | 06/26/2007 |
| 7217706 | Propanolamine derivatives This invention relates to new propanolamine derivatives or salts thereof represented by the following formula [I]: Wherein each symbol is as defined in the specification or salts thereof which have gut selective sympatho... | 05/15/2007 |
| 7214701 | Active substance combinations having insecticidal and acaricdal properties The invention relates to insecticidal mixtures for protecting plants against attack by pests comprising (a) compounds of the formula (I) ... | 05/08/2007 |
| 7186749 | Pyrrolo-naphthyl acids and methods for using them The present invention relates to pyrrolo-naphthyl compounds of the formula and methods of using them to modulate PAI-1 expression and to treat PAI-1 related disorders. ... | 03/06/2007 |
| 7186730 | Bicyclic nitrogen-containing heterocyclic derivatives for use as antibacterials Piperidine derivatives and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly man. ... | 03/06/2007 |
| 7186710 | Phthalazinones The compounds of formula I in which R1, R2, R3, R4 and R5 have the meanings as given in the description are PDE4/7 inhibitors. ... | 03/06/2007 |
| 7179773 | Fungicidal composition An improved, long-lasting aqueous-based fungicidal composition is disclosed. ... | 02/20/2007 |
| 7166611 | Pharmaceutical compositions having appetite suppressant activity A pharmaceutical composition contains an extract obtainable from a plant of the genus Trichocaulon or Hoodia containing an appetite suppressant agent having the formula (1). A process for obtaining the extract and a process for synthesizing compound (1... | 01/23/2007 |
| 7151099 | Use of taurolidine and/or taurultam for treatment of abdominal cancer and/or for the prevention of metastases Taurolidine and/or taurultam is administered during and after surgical removal of a cancerous tumor to treat abdominal cancer. ... | 12/19/2006 |
| 7141562 | Substituted benzoxazinones and uses thereof Compound of the Formula: and pharmaceutically acceptable salts or prodrugs thereof, wherein: X is CH or N, Y is C or S, Z is —SO2— or —(CRaRb)r—, n is 1 or 2, R... | 11/28/2006 |
| 7132413 | Anticoagulant/sterilizing compositions and methods Compositions and methods are provided for preventing formation of thrombosis on a liquid-contacting surface of a liquid delivery system, such as a port, catheter or port-catheter system. The liquid delivery system is connected to a patient for delivery of a liquid t... | 11/07/2006 |
| 7122541 | Methods of inhibiting metastases The invention relates to methods for preventing and treating disseminating cancers. Inhibition metastases of a primary tumor to a liver tissue is carried out by directly contacting a liver tissue with Taurolidine. ... | 10/17/2006 |
| 7115640 | Heterocyclic modulators of nuclear receptors Compounds, compositions and methods for modulating the activity of nuclear receptors are provided. In particular, heterocyclic compounds are provided for modulating the activity of farnesoid X receptor (FXR), liver X receptor (LXR) and/or orphan nuclear receptors. I... | 10/03/2006 |
| 7115720 | Therapeutic and diagnostic compounds, compositions, and methods The invention provides a complex comprising a) a compound formula I: wherein R1, X and n have any of the values described in the specification, or a pharmaceutically acceptable salt thereof; and b) a r... | 10/03/2006 |
| 7101557 | Combined tissue factor methods for coagulation and tumor treatment The invention embodies the surprising discovery that Tissue Factor (TF) compositions and variants thereof specifically localize to the blood vessels within a vascularized tumor following systemic administration. The invention therefore provides methods and compositi... | 09/05/2006 |
