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| Number | Title | Issue Date |
| 8188071 | Amino substituted pyridines as potent kinase inhibitors The present invention relates to compounds useful as inhibitors of protein kinase of the following structural formula: The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods... | 05/29/2012 |
| 8183237 | Benzenesulfonanilide compounds suitable for treating disorders that respond to modulation of the serotonin 5-HTreceptor The present invention relates to novel benzenesulfonanilide compounds of the formulae I and I′ and physiologically tolerated acid addition salts and the N-oxides thereof. The compounds possess valuable therapeutic properties and are particularly suitable, for trea... | 05/22/2012 |
| 8173640 | Compositions and methods for treating, reducing, ameliorating, or preventing infections Compositions for treating, reducing, ameliorating, or preventing infections comprise a fluoroquinolone having Formulae I-VIII and an additional anti-infective agent. Methods for treating, reducing, ameliorating, or preventing such infection use such compositions. Su... | 05/08/2012 |
| 8173639 | Isoquinolinone derivatives as NK3 antagonists Isoquinolone derivatives of the general formula are provided. The compounds are NK3 antagonists and useful for the treatment of e.g. psychosis and schizophrenia. ... | 05/08/2012 |
| 8148365 | 1,4-diaza-bicyclo[3.2.2]nonyl pyrimidinyl derivative and its medical use This invention relates to a novel 1,4-diaza-bicyclo[3.2.2]nonyl pyrimidinyl derivative and its use in the manufacture of pharmaceutical compositions. The compound of the invention is found to be a cholinergic ligand at the nicotinic acetylcholine receptors. D... | 04/03/2012 |
| 8138175 | Heterocyclyl compounds The invention is concerned with novel heterocyclyl compounds of formula (I): wherein A, X, R3, R4, R5, R6, R7, R8, R9, R10, m, n and p ... | 03/20/2012 |
| 8114866 | Derivatives of 1-piperazine- and 1-homopiperazine-carboxylates, preparation method thereof and use of same as inhibitors of the FAAH enzyme The invention relates to a compound having general formula (I): Wherein m, R1 and R2 are as defined herein. The invention also relates to the use of the compound in therapeutics. More specifically, the... | 02/14/2012 |
| 8097611 | Sulfonyl-derivatives as novel or histone deacetylase This invention comprises the novel compounds of formula (I) wherein n, m, t, R1, R2, R3, R4, L, Q, X, Y, Z and have defined meanings, h... | 01/17/2012 |
| 8093239 | Imidazopyridine kinase inhibitors The present invention provides imidazopyridine compounds, compositions containing the same, as well as processes for the preparation and methods for their use as pharmaceutical agents. ... | 01/10/2012 |
| 8088761 | Enzyme inhibitors Compounds of formula (I), are aurora kinase inhibitors: wherein X is —N—, —CH2-N—, —CH2-CH—, or —CH—; R1 is a radical of formula (IA) wherein Z is —CH2-, —NH—, -0-, —S(O)— —S—, —S(O)2 or a divalent monocyclic carbocyclic or heterocycl... | 01/03/2012 |
| 8084449 | Dual pharmacophores—PDE4-muscarinic antagonistics The present invention is directed to novel compounds of Formula (I) and pharmaceutically acceptable salts thereof, pharmaceutical compositions and their use as dual chromaphores having inhibitory ac... | 12/27/2011 |
| 8076326 | N-phenyl- (piperazinyl or homopiperazinyl)-benzenesulfonamide or benzenesulfonyl-phenl-(piperazine or homopiperazine) compounds suitable for treating disorders that respond to modulation of the serotonin 5-HTreceptor The present invention relates to N-phenyl-(piperazinyl or homopiperazinyl)-benzenesulfonamide or benzenesulfonyl-phenyl-(piperazine or homopiperazine) compounds, pharmaceutical compositions containing them, and their use in therapy. The compounds possess valuable th... | 12/13/2011 |
| 8071589 | Dihydrobenzoindazoles The invention relates to benzoindazole derivatives according to general Formula I or a pharmaceutically acceptable salt thereof. The compounds can be used for the treatment of infertility. ... | 12/06/2011 |
| 8071588 | Dual pharmacophores—PDE4-muscarinic antagonistics The present invention relates to novel compounds of Formula (I) and their use in the treatment of respiratory diseases, including anti-inflammatory and allergic diseases such as chronic obstructive pulmonary disease (COPD),... | 12/06/2011 |
| 8067408 | Dual pharmacophores—PDE4-muscarinic antagonistics The present invention is directed to novel compounds of Formula (I), pharmaceutical compositions and their use in therapy, for example as inhibitors of phosphodiesterase type IV (PDE4) and as antagonists of muscarinic acetylcholine receptors (mAChRs), in the treatme... | 11/29/2011 |
| 8048877 | Guanidine derivatives and their medical use This invention relates to novel guanidine derivatives useful as modulators of small-conductance calcium-activated potassium channels (SK channels). In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical com... | 11/01/2011 |
| 8044040 | N-heterocyclic inhibitors of TNF-alpha expression N-heterocyclic compounds that block cytokine production via inhibition of p38 kinase are disclosed. In one embodiment, compounds of the present invention are represented by Formula (I): Methods of production, pharmaceutical... | 10/25/2011 |
| 8044041 | Phthalazine derivatives as inhibitors of protein kinase The present invention relates to novel phthalazine derivatives and, more particularly, to phthalazine derivatives of formula (III) that are useful as protein kinase inhibitors. The invention also relates to methods of preparing the compounds, compositions containing... | 10/25/2011 |
| 8039463 | Piperazine derivatives as inhibitors of stearoyl-CoA desaturase The present invention relates to piperazine derivatives that act as inhibitors of stearoyl-CoA desaturase. The invention also relates to methods of preparing the compounds, compositions containing the compounds, and to methods of treatment using the compounds. ... | 10/18/2011 |
| 8039462 | Methods and compositons for stimulating neurogenesis and inhibiting neuronal degeneration The present invention provides methods and compositions comprising compounds useful for stimulating neurogenesis. The methods and compositions comprising compounds are also useful for inhibiting neuronal degeneration. Thus, the present invention can be used in the t... | 10/18/2011 |
| 8022064 | Phenylpentadienoyl derivatives and their use as PAR 1 antagonists The present invention relates to compounds of general formula (I): wherein: R1 and R2, identical or different, represent: an atom of hydrogen or halogen, CN or NO2, with R1 and R2 not representing hydrogen simul... | 09/20/2011 |
| 8012959 | Diaminopyrimidinecarboxamide derivative A compound which may be used for the prevention or treatment of respiratory diseases in which STAT 6 is concerned, particularly asthma, chronic obstructive pulmonary disease and the like is provided. A pyrimidine derivative or a salt thereof, which has an ary... | 09/06/2011 |
| 8012958 | Methods for treating anxiety related disorders The present invention relates to methods of and compositions for treating and relieving symptoms and disease associated with indications caused by a physiological drive to alleviate a sensation of anxiety. In one treatment method, methods of, and compositions for, m... | 09/06/2011 |
| 8008291 | 3-aminoalkyl-1,4-diazepan-2-one melanocortin-5 receptor antagonists The present invention provides compounds of Formula (I) that are useful for modulating the biological activity of the melanocortin-5 receptor (MC5R). Compounds of this invention can be used to treat diseases and/or conditions in which downregulation of MC5R is benef... | 08/30/2011 |
| 7981883 | Substituted spiro-compounds and the use thereof for producing medicaments The present invention relates to substituted spiro compounds, to processes for preparing them, to medicaments comprising these compounds and to the use of these compounds for producing medicaments. ... | 07/19/2011 |
| 7968539 | Quinoline derivatives and uses thereof This disclosure provides a new class of compounds referred to as “reversed chloroquines” (RCQs), which are highly effective against CQR and CQS malaria parasites. RCQs are hybrid molecules, which include an antimalarial quinoline analog (su... | 06/28/2011 |
| 7968538 | Substituted arylamine compounds and methods of treatment The invention relates to 5-HT6 receptor antagonists. Novel arylamine compounds and use of these compounds and their pharmaceutical compositions, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with serotonin act... | 06/28/2011 |
| 7964591 | Pyridazine derivatives and their use as therapeutic agents Methods of treating an SCD-mediated skin disorder or condition in a mammal, preferably a human include administering to a mammal in need thereof a compound of formula (I): where x, y, W, V, R2 | 06/21/2011 |
| 7951797 | Substituted diazepan orexin receptor antagonists The present invention is directed to substituted diazepan compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The inve... | 05/31/2011 |
| 7939523 | Imidazolidinone and imidazolidinethione derivatives Imidazolidinone and imidazolinethione compounds of formula (I): wherein R1, R2, R3, A1, A2, X, Y, Z, m, n, p, x, and y are defined herein. Also disclosed is a method of... | 05/10/2011 |
| 7932247 | Mmuscarinic acetylcholine receptor antagonists Muscarinic Acetylcholine receptor antagonists and methods of using them are provided. ... | 04/26/2011 |
| 7928100 | Quinolone analogs and methods related thereto The present invention provides novel quinolone compounds and pharmaceutical composition thereof which may inhibit cell proliferation and/or induce cell apoptosis. The present invention also provides methods of preparing such compounds and compositions, and methods o... | 04/19/2011 |
| 7923444 | Alkyl substituted homopiperazine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors This invention relates to novel alkyl substituted homopiperazine derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical composit... | 04/12/2011 |
| 7919489 | Heterocyclyamide-substituted imidazoles The invention relates to heterocyclylamide-substituted imidazoles and methods for their preparation, their use for the treatment and/or prophylaxis of diseases as well as their use for the production of medicaments for the treatment and/or prophylaxis of diseases, i... | 04/05/2011 |
| 7915253 | Sulfonyl-substituted bicyclic compounds as modulators of PPAR Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed. ... | 03/29/2011 |
| 7897596 | Allosteric modulators of the Aadenosine receptor The present invention provides compounds of formula (I) wherein R1, R2, R3, R4 and Q have a meaning as defined herein in the specification. The compounds of formula (I) are allost... | 03/01/2011 |
| 7893052 | CGRP receptor antagonists The present invention is directed to compounds of Formula I: and Formula II: (where variables R1, R2, R3, R4, A, B, G, J, Q, T, U, V, W... | 02/22/2011 |
| 7888348 | 7-membered ring compound and method of production and pharmaceutical application thereof A 7-membered heterocyclic compound having the formula (I), or its salt, or a solvate thereof with a chymase inhibitory action and useful for the prevention or treatment of various diseases, in which chymase is involved: a m... | 02/15/2011 |
| 7884097 | Methods and compositions comprising diamines as new anti-tubercular therapeutics Methods and compositions for treating disease caused by infectious agents, particularly tuberculosis. In particular, methods and compositions comprising novel diamine compositions for the treatment of infectious diseases are provided. In one embodiment, these method... | 02/08/2011 |
| 7858615 | (S)-(-)-1-(4-fluoroisoquinolin-5-Yl)Sulfonyl-2-methyl-1,4-homopiperazine hydrochloride dihydrate The present invention is directed to (S)-(−)-1-(4-fluoroisoquinolin-5-yl)sulfonyl-2-methyl-1,4-homopiperazine hydrochloride dihydrate, to a method producing the dihydrate, and to a drug composition containing the dihydrate. The compound of the present invention ha... | 12/28/2010 |
