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| Number | Title | Issue Date |
| 8188070 | Method of treating neurological diseases and disorders The present invention provides methods for treating neurological diseases and disorders. Compounds that replace or enhance the function of SMN or alleviate or reduce a phenotype of cells with low SMN protein levels are provided. Screening methods and kits for identi... | 05/29/2012 |
| 8039461 | Physical states of a pharmaceutical drug substance An amorphous form of imipramine pamoate, morphologically pure forms, and mixtures of amorphous and morphologically pure imipramine pamoate characterized by differential scanning calorimetry, fourier transform infrared, and powder x-ray diffraction, and pharmaceutica... | 10/18/2011 |
| 7951796 | 9-amino-acridine derivatives and their use for eliminating misfolded proteins The invention relates to compounds according to general formula (1) and/or their enantiomers, diastereomers as well as their pharmaceutically compatible salts, and to the use thereof for producing a medicament suited for treating diseases associated with misfolded p... | 05/31/2011 |
| 7884096 | Method of treating mental disorders using of D4 and 5-HT2A antagonists, inverse agonists or partial agonists The present invention relates to methods of treating the underlying dysregulation of the emotional functionality of mental disorders (i.e. affect instability—hypersensitivity—hyperaesthesia—dissociative phenomena—. . . ) using compounds and compositions of c... | 02/08/2011 |
| 7867999 | Hydroxyamino- and amino-substituted pyridine analogs for treating rho kinase-mediated diseases and conditions Methods for using hydroxyamino- and amino-substituted pyridine analogs are disclosed herein to treat rho kinase-mediated diseases or rho kinase-mediated conditions, including controlling intraocular pressure and treating glaucoma, are disclosed. Ophthalmic pharmaceu... | 01/11/2011 |
| 7855195 | Method of treating mental disorders using D4 and 5-HT2A antagonists, inverse agonists or partial agonists The present invention relates to methods of treating of the underlying dysregulation of the emotional functionality of mental disorders (i.e. affect instability-hypersensitivity-hyperaesthesia-dissociative phenomena- . . . ) using compounds and compositions of compo... | 12/21/2010 |
| 7812015 | Prophylaxis and treatment of infectious diseases The invention relates to the use of inhibitors of acid sphingomyelinase and/or of inhibitors of products of the reaction catalyzed by this enzyme, for the prophylaxis and/or treatment of infectious diseases and/or diseases which are influenced by infections during t... | 10/12/2010 |
| 7763603 | Manipulation of brain CDP-diacylglycerol and uses thereof Provided herein methods of screening for potential antidepressant compounds effective to increase production of cellular CDP-diacylglycerol and synthesis of inositol phospholipid in depression-related areas of the brain. Also, provided are methods of diagnosing and ... | 07/27/2010 |
| 7745426 | Compositions and methods for reducing the risk of epileptic occurrence and/or for treatment of seizure disorders The present invention relates to compounds and compositions useful for reducing the risk of epileptic occurrences and/or for alleviating epileptic phenomena in patients. In accordance with the invention, the compounds and compositions have at least the following two... | 06/29/2010 |
| 7718649 | Physical states of a pharmaceutical drug substance An amorphous form of imipramine pamoate, morphologically pure forms, and mixtures of amorphous and morphologically pure imipramine pamoate characterized by differential scanning calorimetry, fourier transform infrared, and powder x-ray diffraction, and pharmaceutica... | 05/18/2010 |
| 7713960 | Inhibition of the Raf/Mek/P-Erk pathway for treating cancer The invention disclosed herein provides for methods of treating cancer using inhibitors of the Raf/Mek/P-Erk 1/2 pathway. These inhibitors include B2AR agonists (such as ARA-211 (pirbuterol) and isoproterenol), adenylyl cyclase activators, cAMP analogs and Epac acti... | 05/11/2010 |
| 7704992 | Hepatitis C virus inhibitors The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infec... | 04/27/2010 |
| 7691847 | Method of treating neurological diseases and disorders The present invention provides methods for treating neurological diseases and disorders. Compounds that replace or enhance the function of SMN or alleviate or reduce a phenotype of cells with low SMN protein levels are provided. Screening methods and kits for identi... | 04/06/2010 |
| 7638510 | Use of s-10-hydroxy-10,11-dihydro-carbamazepine for the treatment of anxiety and bipolar disorders The present invention relates to the use of a racemate of the compound of formula (1) consisting of at least 85% S-enantiomer and not more than 15% R-enantiomer or of pharmaceutically acceptable salts of said racemate or of the S-enantiomer of formula I or of pharma... | 12/29/2009 |
| 7491715 | Amino substituted diaryl[]cycloheptene analogs as muscarinic agonists and methods of treatment of neuropsychiatric disorders Disclosed herein are analogs of clozapine and pharmaceutically acceptable salts, esters, amides, or prodrugs thereof; methods of synthesizing the analogs; and methods of using the analogs for treating neuropsychiatric disorders. In some embodiments, the analogs are ... | 02/17/2009 |
| 7465723 | Use of carboxamides for the treatment of tinnitus The present invention relates to the use of carbamazepine derivatives in treating tinnitus. ... | 12/16/2008 |
| 7407949 | Benzamide derivatives as oxytocin agonists and vasopressin antagonists Novel compounds according to general formula 1, wherein G1 is NR5R6 or a fused polycyclic group that are specific OT receptor agonists and/or V1a receptor antagonists. Pharmaceutical compositions comprising such compounds ... | 08/05/2008 |
| 7393872 | Sodium channel blocker compositions and the use thereof Methods of treating or preventing chronic pain or convulsion are disclosed by administering to an animal a sodium channel blocker and at least one of gabapentin and pregabalin. Also disclosed are pharmaceutical compositions and kits for the treatment or prevention o... | 07/01/2008 |
| 7365076 | Substituted aryl cycloalkanol derivatives and methods of their use The present invention is directed to substituted aryl cycloalkanoyl derivatives, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor sym... | 04/29/2008 |
| 7355042 | Treatment of CNS disorders using CNS target modulators The invention is directed to compositions and methods useful for treating Central Nervous System (CNS) disorders. Furthermore, the invention provides compositions and methods of treating sleep disorders. More specifically, the invention is directed to the compositio... | 04/08/2008 |
| 7342038 | Substituted diphenyl indanone, indane and indole compounds and analogues thereof useful for the treatment or prevention of diseases characterized by abnormal cell proliferation The present invention provides substituted 3,3-diphenyl indole compounds, as well as analogues thereof, which are specific potent and safe inhibitors of mammalian cell proliferation. The compounds can be used to inhibit mammalian cell proliferation in situ as a ther... | 03/11/2008 |
| 7329653 | Cyclohexylphenyl vasopressin agonists The present invention provides compounds of the general formulas: wherein Y is NR or —(CH2)n; R is H or alkyl; “Z” represents optionally substituted phenyl or a 6-membered aromatic rin... | 02/12/2008 |
| 7326700 | Cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists The present invention provides tricyclic carboxamide compounds and methods and pharmaceutical compositions for their use in treatment, prevention, or suppression of disorders which may be remedied or alleviated by oxytocin antagonist activity, including prevention a... | 02/05/2008 |
| 7265151 | Treatment of neurotic disorders Use of escitalopram (the S-(+)-enantiomer of citalopram) or a pharmaceutically acceptable salt thereof for the preparation of a medicament useful in the treatment of neurotic disorders is provided, including anxiety states, in particular generalised anxiety disorder... | 09/04/2007 |
| 7255866 | Botulinum toxin therapy for fibromyalgia Methods for treating fibromyalgia by administering a therapeutically effective amount of a botulinum toxin to a patient with fibromyalgia. ... | 08/14/2007 |
| 7241886 | Method for preparation of 10,11-dihydro-10-hydroxy-5h-dibenz/b, f/azepine-5-carboxamide and 10,11-dihydro-10-oxo-5h-dibenz/b, f/azepine-5-carboxamide A method for the preparation of 10,11-dihydro-10-hydroxy-5H-dibenz/b,f/azepine-5-carboxamide and 10,11-dihydro-10-oxo-5H-dibenz/b,f/azepine-5-carboxamide from carbamazepine via a three-step process involving (i) epoxidation of carbamazepine; (ii) ring-opening of the... | 07/10/2007 |
| 7202239 | Cyclohexylphenyl carboxamides tocolytic oxytocin receptor antagonists The present invention provides novel tricyclic benzodiazepine carboxamides compounds and methods and pharmaceutical compositions utilizing them for the treatment and/or prevention and/or suppression of disorders which may be remedied or alleviated by oxytocin antago... | 04/10/2007 |
| 7189740 | Methods of using 3-(4-amino-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myelodysplastic syndromes Methods of treating, preventing and/or managing myclodysplastic syndromes are disclosed. Specific methods encompass the administration of an immunomodulatory compound, or a pharmaceutically acceptable salt, solvate, hydrate, stereoisomer, clathrate, or prodrug there... | 03/13/2007 |
| 7189757 | Treatment of sleep disorders using CNS target modulators The invention is directed to compositions used for treating Central Nervous System (CNS) disorders. In addition, the invention provides convenient methods of treatment of a CNS disorder. Furthermore, the invention provides methods of treating sleep disorders using c... | 03/13/2007 |
| 7183272 | Crystal forms of oxcarbazepine and processes for their preparation The present invention provides for new crystal forms of oxcarbazepine, more particularly oxcarbazepine Forms B, C, D and E. The present invention further provides processes for preparation of these forms. Form B is prepared by evaporating the solvents from a solutio... | 02/27/2007 |
| 7163949 | 4-phenyl substituted tetrahydroisoquinolines and use thereof Provided herein are compounds of the formulae IA–IF. These compounds are tetrahydroisoquinolines of the following structure: wherein R1–R8 for compounds of each of the formulae IA, IB, I... | 01/16/2007 |
| 7138393 | Biologically active vasopressin agonist metabolites Novel compounds of Formula (I) and pharmaceutically acceptable salts thereof, and pharmaceutical formulations containing such compounds which are useful as anti-aquaretic agents in the treatment of nocturnal urin... | 11/21/2006 |
| 7132432 | Hydantoin derivatives as inhibitors of tumor necrosis factor-alpha converting enzyme (TACE) The present invention provides compounds of Formula (I): or a stereoisomer or pharmaceutically acceptable salt form thereof, wherein the variables L, Z0, R1, R4, R5, an... | 11/07/2006 |
| 7125987 | Process for the preparation of oxcarbazepine and related intermediates A process for preparing Oxcarbazepine III comprising: a) reacting oximinostilbene IV ... | 10/24/2006 |
| 7115258 | Vesicular monoamine transporter gene therapy in parkinson's disease The present invention provides methods and compositions for the therapeutic intervention of Parkinson's disease. More particularly, methods of making and sequestering dopamine are disclosed. Additionally, methods of genetically modifying donor cells by gene transfer... | 10/03/2006 |
| 7112673 | Dibenzo [b,f]azepine intermediates The invention relates to new processes for the preparation of the pharmaceutical oxcarbazepine, as well as novel intermediates prepared by or used for said processes, and the preparation of said intermediates. ... | 09/26/2006 |
| 7109193 | Tricyclic diazepines tocolytic oxytocin receptor antagonists This invention provides novel tricyclic diazepine compounds as well as methods and pharmaceutical compositions utilizing these compounds for the treatment and/or prevention and/or suppression of disorders which may be remedied or alleviated by oxytocin antagonist ac... | 09/19/2006 |
| RE39265 | Heteroarylpiperidines, and their use as antipsychotics and analgetics Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. The compound... | 09/05/2006 |
| 7091339 | Method of preparing a 5H-dibenz(b,f)azepine-5-carboxamide The present invention provides a method of preparing a 5H-dibenz[b,f]azepine-5-carboxamide of formula (1) wherein R1, R2, R3, and R4 are independently selected from the... | 08/15/2006 |
| 7074833 | Use of the (1S,2R) enantiomer of milnacipran for the preparation of a drug A method for treating or preventing a disorder or a condition by double inhibition of serotonin (5-HT) and noradrenaline (NA) reuptake in a subject in need thereof, while limiting the risks of cardiovascular disturbances and/or organ and/or tissue toxicity, comprisi... | 07/11/2006 |
