Class 514/215 - Additional hetero atom in the polycyclo ring system

Subclass of Class 514 - Drug, bio-affecting and body treating compositions
Definition: Subject matter wherein the polycyclo ring system contains
No. of patents: 394
Last issue date: 09/06/2011

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Number	Title	Issue Date
8012957	Tetrahydro-1H-1,2,6-triaza-azulene cannabinoid modulators This invention is directed to a tetrahydro-1H-1,2,6-triaza-azulene cannabinoid modulator compound of formula (I): and a method for use in treating, ameliorating or preventing a cannabinoid receptor mediated syndrome, disord...	09/06/2011
7989444	Compounds having affinity for dopamine D3 receptor and uses thereof Compounds of formula (I) wherein A is a 5 or 6 membered heteroaromatic ring or a 5 or 6 membered heterocyclic ring, and which are useful for treating mental disorders such as schizophrenia are set out herein. ...	08/02/2011
7973033	Multi-cyclic cinnamide derivatives The present invention provides a compound represented by the formula (I): or a pharmacologically acceptable salt thereof, wherein Ar1 represents an imidazolyl group that may be substituted with a C1-6 alkyl group, or the li...	07/05/2011
7964590	Cyclopamine lactam analogs and methods of use thereof The present invention relates to steroidal alkaloids useful in the treatment of hedgehog pathway related disorders, particularly cancer. ...	06/21/2011
7960374	Tricyclic compounds, compositions, and methods useful in the treatment or prophylaxis of 5-HTreceptor-related disorders The present invention relates to compounds of the formula (I) wherein A, X and R1 to R9 are as described herein; to pharmaceutical compositions comprising the said compounds; to processes for their pre...	06/14/2011
7939522	Dosage formulations for acetylcholinesterase inhibitors Acetylcholinesterase inhibitors are of use for treating a variety of diseases and conditions including Alzheimer's disease. They also affect circadian rhythms. In order to optimize the use of such compounds, the present invention provides dosage forms and methods of...	05/10/2011
7928099	Pyrimido [4,5-D] azepine derivatives as 5-HTagonists The present invention provides a compound of formula (I): or a pharmaceutically acceptable salt thereof wherein the variables R1, R2, R3a, R3b, R3b, R3d, and...	04/19/2011
7888347	Pyrazolo [3,4-D]azepine derivatives as histamine H3 antagonists The present invention relates to novel pyrazole derivatives of formula I having pharmacological activity as H3 antagonists processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.	02/15/2011
7888346	Method of treating organophosphorous poisoning A method of treating organophosphorous (OP) poisoning comprising administering to a mammal at risk for OP poisoning an OP poisoning-inhibiting amount of galantamine. ...	02/15/2011
7790710	Imidazopyridine derivatives useful as iNOS inhibitors The compounds of formula (I) in which R1, R11 and A have the meanings as given in the description are novel effective iNOS inhibitors. ...	09/07/2010
7749994	Pentacyclic kinase inhibitors The invention provides novel kinase inhibitors that are useful as therapeutic agents for example in the treatment malignancies where the compounds have the general formula I wherein A, X, Y, Z, Ra, Rb, Rc, R1, R	07/06/2010
7727979	Guanidine derivatives and their use as neuropeptide FF receptor antagonists The invention relates to guanidine derivatives of formula (I) where: A represents a chain of 3-6 carbon atoms, one of which can be replaced by —N(R′)— or —O— and R′ is H or a substituent; the ring skeleton only contains both double bonds of the thiazole ...	06/01/2010
7727980	Tricyclic androgen receptor modulator compounds and methods This invention relates to non-steroidal tricyclic compounds that are modulators of androgen receptors and to methods for making and using such compounds. ...	06/01/2010
7718648	Pyridobenzazepine compounds and methods for inhibiting mitotic progression This invention relates to compounds and methods for the treatment of cancer. In particular, the invention provides compounds that inhibit Aurora kinase, pharmaceutical compositions comprising the compounds, and methods of using the compounds for the treatment of can...	05/18/2010
7718647	Substituted azepine derivatives as serotonin receptor modulators The present invention generally relates to a series of compounds, to pharmaceutical compositions containing the compounds, and to use of the compounds and compositions as therapeutic agents. More specifically, compounds of the present invention are hexahydroazepinoi...	05/18/2010
7612059	Pyrrolidine bicyclic compounds and its derivatives, compositions and methods of use N-[1-oxo-(optionally 2-aza)-2-alkyl-3-(carboxyl or thiol or hydroxyaminocarbonyl or N-hydroxyformamido)-propyl]-(aryl or heteroaryl)-azacyclo4-7alkanes or thiazacyclo4-7alkanes, salts or prodrugs thereof have interesting properties, e.g., in th...	11/03/2009
7605153	Use of paullone derivatives for the production of medicaments for the treatment of mucoviscidosis and diseases related to protein addressing errors in cells The invention relates to paullone derivatives for the production of medicaments for the treatment of mucoviscidosis and diseases related to protein addressing errors in cells, said derivatives being of general formula (1): wherein X═C═O, C—S—CH3, ...	10/20/2009
7595311	Azepinoindole derivatives as pharmaceutical agents Compounds, compositions and methods for modulating the activity of receptors are provided. In particular, compounds and compositions are provided for modulating the activity of receptors and for the treatment, prevention, or amelioration of one or more symptoms of d...	09/29/2009
7572784	Compounds and methods for inhibiting mitotic progression This invention relates to compounds and methods for the treatment of cancer. In particular, the invention provides compounds that inhibit Aurora kinase, pharmaceutical compositions comprising the compounds, and methods of using the compounds for the treatment of can...	08/11/2009
7541354	Bicyclo-pyrazoles Bicyclo-pyrazole compounds of formula (I), as herein defined, are useful for treating diseases linked to disregulated protein kinases. ...	06/02/2009
7531531	Method of treating diseases associated with altered kinase activity with bicyclo-pyrazoles Bicyclo-pyrazole compounds of formula (I), as herein defined, are useful for treating diseases linked to disregulated protein kinases. ...	05/12/2009
7485634	Azepinoindole and pyridoindole derivatives as pharmaceutical agents Compounds, compositions and methods for modulating the activity of receptors are provided. In particular compounds and compositions are provided for modulating the activity of receptors and for the treatment, prevention, or amelioration of one or more symptoms of di...	02/03/2009
7465722	Biphenyl vasopressin agonists A compound of the formulae (I) or (II): wherein: Y is a moiety selected from NR or —(CH2)n; wherein R is hydrogen or (C1-C6) lower alkyl, and n is ...	12/16/2008
7419975	Organic compounds Novel compounds that inhibit the binding of the Smac protein to Inhibitor of Apoptosis Proteins (IAPs) of the formula I ...	09/02/2008
7414046	Gyrase inhibitors and uses thereof The present invention relates to compounds of the formula I: or a pharmaceutically acceptable derivative or prodrug thereof. The compounds are useful as inhibitors of bacterial gyrase activity. The present invention also re...	08/19/2008
7407949	Benzamide derivatives as oxytocin agonists and vasopressin antagonists Novel compounds according to general formula 1, wherein G1 is NR5R6 or a fused polycyclic group that are specific OT receptor agonists and/or V1a receptor antagonists. Pharmaceutical compositions comprising such compounds ...	08/05/2008
7393834	LHRH-antagonists in the treatment of fertility disorders A method of treating infertility disorders by 1) administering an LH-RH antagonist, preferably Cetrorelix, in amounts to selectively suppress endogenous LH but not FSH secretion and 2) inducing follicle growth by administration of exogenous gonadotropin. The selecti...	07/01/2008
7390797	Fused indazole compounds The present invention provides a novel fused indazole compound having an excellent JNK inhibitory action. More specifically, it provides a compound represented by the following formula, a salt thereof or a hydrate of them. ...	06/24/2008
RE40245	Gyrase inhibitors and uses thereof The present invention relates to compounds of the formula I: or a pharmaceutically acceptable derivative or prodrug thereof. The compounds are useful as inhibitors of bacterial gyrase activity. The present invention also relates ...	04/15/2008
7351743	Therapeutic guanidines The present invention provides therapeutically useful substituted guanidines, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more of such guanidines. ...	04/01/2008
7351701	Therapeutic compounds The invention relates to trycyclic lactam indole derivatives and triacyclic lactam benzimodole derivatives and their use in inhibiting the activity of PARP enzyme. The invention also relates to the use of these compounds in the preparation of medicaments. ...	04/01/2008
7348321	Flumazenil for the treatment of alcohol dependency The invention relates to the use of flumazenil in developing a drug used for the sequential administration of small quantities of flumazenil at short intervals, until a therapeutically effective quantity is administered to treat alcohol dependence. ...	03/25/2008
7342028	Medical use for tachykinin antagonists The present invention relates to the use of tachykinin antagonists, including substance P antagonists and other neurokinin antagonists, in the treatment of emesis. Also described are novel tachykinin antagonists of formula (I), processes for their preparation, pharm...	03/11/2008
7342018	Urokinase inhibitors and uses thereof The invention relates to the use of derivatives of 3-amidinophenylalanine as urokinase inhibitors for treating malignant tumors and the formation of metastases. ...	03/11/2008
7338672	Herbal supplement for cognitive related impairment due to estrogen loss Estrogen-deficiency related cognitive dysfunction may be improved by administering a composition comprising an herbal composition to a woman. In a preferred embodiment the herbal composition comprises whole plant extract of Leucojum aestivum. ...	03/04/2008
7329653	Cyclohexylphenyl vasopressin agonists The present invention provides compounds of the general formulas: wherein Y is NR or —(CH2)n; R is H or alkyl; “Z” represents optionally substituted phenyl or a 6-membered aromatic rin...	02/12/2008
7326700	Cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists The present invention provides tricyclic carboxamide compounds and methods and pharmaceutical compositions for their use in treatment, prevention, or suppression of disorders which may be remedied or alleviated by oxytocin antagonist activity, including prevention a...	02/05/2008
7319106	Diazabicyclic central nervous system active agents Compounds of formula I pharmaceutical compositions of these compounds, and use of said compositions to control synaptic transmission in mammals. ...	01/15/2008
7312203	1-aza-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof The present invention relates to 1-aza-dibenzoazulene derivatives, to their pharmacologically acceptable salts and solvates, to processes and intermediates for the preparation thereof as well as to their antiinflammatory effects, especially to the inhibition of tumo...	12/25/2007
7304051	Quinoxaline compounds Amidophenyl-sulfonylamino-quinoxaline compounds of formula (I) are CCK2 modulators useful in the treatment of CCK2 mediated diseases. ...	12/04/2007

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Class 514/215 - Additional hetero atom in the polycyclo ring system