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Class 514/214.01 - Ring nitrogen of the seven-membered hetero ring is shared by an additional cyclo of the polycyclo ring system


Subclass of Class 514 - Drug, bio-affecting and body treating compositions
Definition: Subject matter wherein the ring nitrogen of the seven-membered
No. of patents: 123
Last issue date: 05/15/2012


1        
NumberTitleIssue Date
8178523Compounds for the treatment of hepatitis C
The disclosure provides compounds of formula (I), including their salts, as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV. ... 		05/15/2012
8143243Compounds for the treatment of hepatitis C
The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV. ... 		03/27/2012
8143244Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors
The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV. ... 		03/27/2012
8138170Immunosuppressive Ningalin compounds
The present invention provides compositions and methods comprising ningalins for use in modulating immune responses to infection, injury, allergy and/or transplantation. ... 		03/20/2012
8138171Dioxolane and dioxolanone fused indolobenzadiazepine HCV NS5B inhibitors
The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV. I. ... 		03/20/2012
8133884Compounds for the treatment of hepatitis C
The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV. ... 		03/13/2012
8129367Compounds for the treatment of Hepatitis C
The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV. ... 		03/06/2012
8124601Compounds for the treatment of Hepatitis C
The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV. ... 		02/28/2012
8039460CGRP receptor antagonists
Compounds of Formula (I): and Formula (II): (where variables R2, R4, A, B, D, W, X, Y and Z are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such... 		10/18/2011
7867998Method of making antitussive medicine and relieving cough
Method for relieving cough using an effective antitussive chemical compound belonging to stemoamide or tuberostemospironine and method for manufacturing pharmaceutical compositions for treating or relieving cough in human and animal subjects which including a stemoa... 		01/11/2011
7842687Cephalotaxane derivatives and their processes of preparation and purification
The present invention concerns a new general process for asymmetric hemisynthesis of harringtonines and their analogs, that are alkaloids used in chemotherapy. This process comprises direct esterification of a natural cephalotaxine with an acylating compound constit... 		11/30/2010
7683050Formulations and methods of administration of cephalotaxines, including homoharringtonine
The present invention is directed to compositions and methods for the treatment of patients with cephalotaxines, for example, homoharringtonine. The invention is also directed to improvements in the purity, manufacturing process, formulation and administration of ho... 		03/23/2010
7652004Compounds for the treatment of hepatitis C
The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV. ... 		01/26/2010
7642251Compounds for the treatment of hepatitis C
The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV. ... 		01/05/2010
7547690Compounds for the treatment of Hepatitis C
The invention encompasses compounds of formula I, including pharmaceutically acceptable salts, as well as compositions and methods of using these compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HC... 		06/16/2009
7541353Compounds for the treatment of hepatitis C
The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV. ... 		06/02/2009
7541351Compounds for the treatment of hepatitis C
The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV. ... 		06/02/2009
7541352Compounds for the treatment of hepatitis C
The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV. ... 		06/02/2009
7538102Compounds for the treatment of Hepatitis C
The invention encompasses compounds of Formula I, pharmaceutically acceptable salts thereof, compositions, and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV. 		05/26/2009
7538103Compounds for the treatment of hepatitis C
The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV. ... 		05/26/2009
7521442Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors
The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV. ... 		04/21/2009
7521443Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors
The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV. ... 		04/21/2009
7521441Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors
The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV. ... 		04/21/2009
7521444Compounds for the treatment of hepatitis C
The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV. ... 		04/21/2009
7517872Compounds for the treatment of hepatitis C
The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV. ... 		04/14/2009
7485633Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors
The invention encompasses compounds of Formula I, pharmaceutically acceptable salts thereof, compositions, and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV. 		02/03/2009
7473688Indolobenzazepine HCV NS5B inhibitors
The invention encompasses compounds and salts of Formulas I, II, III, and IV as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV. 		01/06/2009
74657212-hydroxytetrahydrofuran derivatives and use thereof as medicaments
A hydroxytetrahydrofuran of formula wherein A is with the substituents as defined in the specification, having a calpain inhibiting activity and/or an activity which traps the rea... 		12/16/2008
7456167Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors
The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV. ... 		11/25/2008
7456165HCV NS5B inhibitors
The invention encompasses compounds of Formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV. ... 		11/25/2008
7456166Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors
The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV. ... 		11/25/2008
7452876Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors
The invention encompasses compounds as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV. ... 		11/18/2008
7399758Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors
The invention encompasses compounds of Formula I, pharmaceutically acceptable salts thereof, compositions, and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV. 		07/15/2008
7384933Derivatives of 2-hydroxytetrahydrofuran and their use as medicaments
A hydroxytetrahydrofuran of formula wherein A is with the substituents as defined in the specification, having a calpain inhibiting activity and/or an activity which traps the rea... 		06/10/2008
7348425Inhibitors of HCV replication
Indole compounds of Formula I are described. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV. Different forms and compositions comprising the compounds are also described as well as methods of preparing ... 		03/25/2008
7329663Substituted-triazolopyrimidines as anticancer agents
The invention provides a method of treating or inhibiting the growth of cancerous tumor cells and associated diseases in a mammal in need thereof which comprises administering to said mammal an effective amount of a substituted triazolopyrimidine derivative or a pha... 		02/12/2008
7285546Cephalotaxanes, their method of preparation and their use in treatment of cancers, leukemias, parasites including those resistant to usual chemotherapeutic agents and as reversal agents
The present invention concerns a compound of formula (I) wherein: W represents O or NH, Q represents an unbranched or branched, saturated or unsaturated or arom... 		10/23/2007
7268127Azaindoles having serotonin receptor affinity
Described herein are compounds with affinity for the 5-HT6 receptor, which have the general formula I: Wherein A, B, D, E, R1 to R3 and n are described herein. Also described is t... 		09/11/2007
7250409Ningalin B analogs employable for reversing multidrug resistance
Anlogs of ningalin B lacking inherent cytotoxic activity may be employed to reverse multi-drug resistant (MDR) phenotype and to resensitize transformed cells, including a human colon cancer cell line (HCT116/VM46), with respect to a variety of cytotoxic agents, e.g.... 		07/31/2007
7235550Polycyclic azaindole compounds
The invention relates to compounds of formula (I): wherein: G1 represents an alkylene chain as defined in the description, A represents 		06/26/2007
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