Class 514/213.01 - Polycyclo ring system having the seven-membered hetero ring as one of the cyclos

Subclass of Class 514 - Drug, bio-affecting and body treating compositions
Definition: Subject matter wherein the seven-membered hetero ring is
No. of patents: 169
Last issue date: 04/24/2012

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Number	Title	Issue Date
8163732	Tricyclic heteroaryl compounds useful as inhibitors of Janus kinase The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatm...	04/24/2012
8119627	Heterocyclic compounds as inhibitors of 17beta-HSD3 There is provided a compound having Formula (I) wherein each of rings A and B is selected from five or six membered carbon rings optionally containing one or more hetero atoms selected from N, S, and O and optionally having...	02/21/2012
8008290	Compounds A first aspect of the invention relates to a compound of formula (I), or a pharmaceutically acceptable salt, hydrate, complex or pro-drug thereof, wherein: R3 is selected...	08/30/2011
7956050	Aryl- and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin The compounds of the present invention are represented by the following aryl- and heteroaryl-substituted tetrahydrobenzazepine and dihydrobenzazapine derivatives having formulae I(A-E) and formula (II):	06/07/2011
7858613	Substituted benzo-condensed cycloheptanone derivatives and their use for producing drugs The invention relates to substituted benzo-condensed cycloheptanone derivatives, to methods for producing them, to drugs containing said compounds and to the use of said compounds for producing drugs. ...	12/28/2010
7807664	4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepine derivative or salt thereof A novel 4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepine derivative or a pharmaceutically acceptable salt thereof, which is useful as an agent for treating or preventing nocturia and/or diabetes insipidus, is provided. ...	10/05/2010
7790709	Heterocyclic compounds, methods of making them and their use in therapy In part, the present invention is directed to antibacterial compounds of formula (I) wherein A is a bicyclic heteroaryl ring or a tricyclic ring and R2 is an heterocyclic residue; L is a bond, or L is alkyl, alkenyl or cycloalkyl.	09/07/2010
7786108	Compounds and method for treating dyslipidemia Compounds of formula I wherein n, m, p, q, Y, R1 R2, R3a, R3b, R4, R5, and R6 are as defined herein and their pharmaceutical compositions and meth...	08/31/2010
7781425	Guanidine compound and asymmetric reaction using the same A guanidine compound having a biaryl skeleton represented by the following formula (1), which is useful as a catalyst for various asymmetric reactions. (wherein R1, R2 and R3 each independen...	08/24/2010
7772225	N-sulfamoyl-piperidineamides for the treatment or inhibition of obesity and related conditions The present invention relates to novel N-sulfamoyl-piperidineamides of Formula I and their physiologically acceptable acid addition salts, to pharmaceutical compositions comprising them, processes for their preparation, and their use for the treatment of obesity and...	08/10/2010
7749992	Compounds and methods for treating dislipidemia Compounds of formula I wherein n, m, p, q, y, R1 R2, R3, R4, R5, and R6 are as defined herein and their pharmaceutical compositions and methods of use are di...	07/06/2010
7749993	Method for treating severe heart failure and medicament therefor A method for treating severe heart failure, comprising administering to a patient an effective amount of a benzazepine compound (1): wherein R1 is H or halogen, R2 is OH, or —NR5R6 (R5 and R6 are H ...	07/06/2010
7741317	LXR modulators A compound of formula I wherein A, X, q, R1, R2a, R2b, R2c, R3a, and R3b are defined herein. ...	06/22/2010
7704991	Substituted diazabicyclo derivatives and their use as monoamine neurotransmitter re-uptake inhibitors This invention relates to novel substituted diazabicyclo derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions com...	04/27/2010
7700583	11β-hydroxysteroid dehydrogenase type 1 active compounds A novel class of compounds of the general formula (I), their use in therapy, pharmaceutical compositions comprising the compounds, as well as their use in the manufacture of medicaments are described. The present compounds modulate the activity of 11β-hydroxy-stero...	04/20/2010
7674787	Conformationally constrained Smac mimetics and the uses thereof The invention relates to conformationally constrained mimetics of Smac which function as inhibitors of Inhibitor of Apoptosis Proteins. The invention also relates to the use of these mimetics for inducing apoptotic cell death and for sensitizing cells to inducers of...	03/09/2010
7622462	Benzazepine derivatives and uses thereof Compounds of the formula: or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ar, R1 and R2 are defined herein. Also provided are pharmaceutical compositions, methods ...	11/24/2009
7504391	Selective D/Dreceptor antagonists for the treatment of obesity and CNS disorders The present invention provides compounds, which, are novel antagonists for D1/D5 receptors as well as methods for preparing such compounds. In another embodiment, the invention provides pharmaceutical compositions comprising such D1/...	03/17/2009
7488725	Pyrrolidinyl beta-amino amide-based inhibitors of dipeptidyl peptidase IV and methods Compounds are provided having the formula: wherein R1, R2, R2′, R3, R3′, R4, R4′, R5, X, Y and Z are as defined herein. ...	02/10/2009
7423032	Method for treating severe heart failure and medicament therefor A method for treating severe heart failure, comprising administering to a patient an effective amount of a benzazepine compound (1): wherein R1 is H or halogen, R2 is OH, or —NR5R6 (R5 and R6 are H ...	09/09/2008
7375100	2-amino-pyridine derivatives useful for the treatment of diseases The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the ...	05/20/2008
7368444	N-carbamoyl nitrogen-containing fused ring compounds and drugs containing these compounds as the active ingredient The present invention relates to the compound presented by formula (I) (wherein all symbols in formula (I) are the same mean as the description shown in the specification.), mitocondorial benzogeazepin receptor (MBR) antago...	05/06/2008
7335677	Inhibitors of dipeptidyl peptidase IV Novel compounds that are inhibitors of one or most post-proline cleaving proteases, e.g. dipeptidyl peptidase IV, according to general formula (1). R1 is H or CN, X1 is O, S, CH2, CHF, CF2, CH(CH3), C(CH3	02/26/2008
7329653	Cyclohexylphenyl vasopressin agonists The present invention provides compounds of the general formulas: wherein Y is NR or —(CH2)n; R is H or alkyl; “Z” represents optionally substituted phenyl or a 6-membered aromatic rin...	02/12/2008
7326700	Cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists The present invention provides tricyclic carboxamide compounds and methods and pharmaceutical compositions for their use in treatment, prevention, or suppression of disorders which may be remedied or alleviated by oxytocin antagonist activity, including prevention a...	02/05/2008
7323455	7-aryl 1,5-dihydro-4,1-benzoxazepin-2(3)-one derivatives and their use as progesterone receptor modulators This invention provides progesterone receptor modulators having the structure: wherein R1 to R7, X, and Q are as defined in the specification; or a pharmaceutically acceptable salt thereof. ...	01/29/2008
7304050	Antibacterial agents Compounds of formula I and methods for their preparation are disclosed. Further disclosed are methods of making biologically active compounds of formula I as well as pharmaceutically acceptable compositions comprising compounds of formula I. Compounds of formula I a...	12/04/2007
7282496	Allenic aryl sulfonamide hydroxamic acids as matrix metalloproteinase and TACE inhibitors Compounds of the formula are useful in treating disease conditions mediated by TNF-α, such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease, degenera...	10/16/2007
7279493	Therapeutic agents useful for treating pain A compound of formula: wherein A, Ar, R3, R6, and m are disclosed herein, or a pharmaceutically acceptable salt thereof (a “Cyanoiminopiperazine Compound”), compositions comprising an ef...	10/09/2007
7262185	Benzazepine derivative, process for producing the same, and use The present invention provides a novel benzazepine derivative represented by formula: wherein, R1 is a 5- or 6-membered aromatic ring, R2 is lower alkyl group, etc., Y is an optionally subst...	08/28/2007
7226943	Benzothiepine ileal bile acid transport inhibitors The present invention relates to compounds of formula (I) wherein variable groups are as defined within; pharmaceutically acceptable salts, solvates, solvates of such salts and prodrugs thereof and their use as ileal bile acid transport (IBAT) inhibitors for the tre...	06/05/2007
7208508	Use of bradycardiac substances in the treatment of myocardial diseases associated with hypertrophy and novel medicament combinations The present invention relates to the new use of bradycardiac substances such as a Ca++ channel blocker, beta-receptor blocker or if channel blocker, the if channel blockers being preferred, optionally in combination with a cardioacti...	04/24/2007
7202239	Cyclohexylphenyl carboxamides tocolytic oxytocin receptor antagonists The present invention provides novel tricyclic benzodiazepine carboxamides compounds and methods and pharmaceutical compositions utilizing them for the treatment and/or prevention and/or suppression of disorders which may be remedied or alleviated by oxytocin antago...	04/10/2007
7192950	Benzazepines and related heterocyclic derivatives which are useful as orexin receptor antagonists The invention relates to novel benzazepines and related heterocyclic derivatives (I) and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the com...	03/20/2007
7183271	4,4-difluoro-1,2,3,4-tetrahydro-5h-1-benzazepine derivative or salt thereof A novel 4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepine derivative or a pharmaceutically acceptable salt thereof, which is useful as an agent for treating or preventing nocturia and/or diabetes insipidus, is provided. ...	02/27/2007
7183413	Aminoquinoline compounds This invention relates to treating inflammatory and immune diseases with certain aminoquinoline compounds that bind to CXCR3 receptors. The aminoquinoline compounds are covered by the formula (I) shown below. Each variable is defined in the specification.	02/27/2007
7176195	Fused azepine derivatives and their use as antidiuretic agents Compounds according to general formulae (1 and 2), wherein G1 is an azepine derivative and G2 is a group according to general formulae (9–11) are new. Compounds according to the invention are vasopressin V2 receptor agonists. Pharm...	02/13/2007
7169772	4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepine derivatives or salts thereof 4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepine derivatives, which have excellent arginine vasopressin V2 activity and are useful for a drug for the treatment of central diabetes insipidus and/or nocturia. ...	01/30/2007
7169773	Compounds The present invention provides a compound of formula I comprising: a pharmaceutically acceptable salt, solvate, or physiologically functional derivative thereof. ...	01/30/2007
7160876	Fused bicycloheterocycle substituted quinuclidine derivatives Compounds of formula (I) wherein n is 0, 1, or 2; X is O, S, —NH—, and —N-alkyl-; Ar1 is a 6-membered aromatic ring; and Ar2 is a fused bicycloheterocycle. The compounds are useful in ...	01/09/2007

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Class 514/213.01 - Polycyclo ring system having the seven-membered hetero ring as one of the cyclos