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| Number | Title | Issue Date |
| 8173637 | Stabilized atypical antipsychotic formulation A pharmaceutical composition that contains an atypical antipsychotic drug and succinic acid, fumaric acid or a mixture of succinic acid and fumaric acid. ... | 05/08/2012 |
| 8163731 | Method and dosage regimens for eliminating a chemical substance in blood A method of reducing the concentration of a chemical or drug substance in the blood plasma that targets the same or similar receptors as the normal neurotransmitters in the central or peripheral nervous system includes titrating an initial peak concentration of the ... | 04/24/2012 |
| 8158618 | Dibenzothiazepine derivatives and uses thereof—424 Compounds the following formula: wherein Z is as described in the specification, pharmaceutically acceptable salts thereof, compositions comprising the same, and methods of treating bipolar disorder, an anxiety disorder, a ... | 04/17/2012 |
| 8138169 | Combination therapy for bipolar disorder Treatment regimens for mood disorders that include administration of buprenorphine, alone or in combination with additional pharmacological agents are described. Specifically, treatment regimens that alleviate racing thoughts associated with bipolar disorder, and ph... | 03/20/2012 |
| 8101596 | Loxapine analogs and methods of use thereof The invention relates to novel compounds and methods of using them for modulating sleep. ... | 01/24/2012 |
| 8101597 | Quetiapine salts and their polymorphs The present invention relates to novel and stable salt forms of quetiapine, processes for preparation, pharmaceutical compositions, and method of treating thereof. More particularly, the present invention provides novel acid addition salts of quetiapine wherein the ... | 01/24/2012 |
| 8093237 | Dibenzo[b,f][1,4]oxazapine compounds The present invention relates to 11-(piperazin-1-yl)dibenzo[b,f][1,4 ]oxazapine compounds of the formula: where the variables are as defined herein, their salts and pharmaceutically acceptable compositions thereof. Methods of... | 01/10/2012 |
| 8048876 | Process for preparing quetiapine and quetiapine fumarate The invention comprises a process for preparing quetiapine and/or its salts, including, quetiapine fumarate. The process generally comprises reacting dibenzothiazepinone (dibenzo[bf][1,4]thiazepin-11(10H)-one) with phosphorous oxychloride in the presence of triethyl... | 11/01/2011 |
| 8044039 | Quetiapine hemifumarate purification by crystallization The present invention relates to a process for preparing and purifying crystalline quetiapine hemifumarate, which comprises preparing crystalline quetiapine hemifumarate via a crystalline salt, which is not a salt of fumaric acid. ... | 10/25/2011 |
| 8044038 | Crystallization process of quetiapine hemifumarate The present invention relates to a process for preparing crystalline quetiapine hemifumarate, which comprises crystallizing or re-crystallizing quetiapine hemifumarate from a mixture of water and a water soluble alcohol. ... | 10/25/2011 |
| 8034805 | Methods for the preparation of salts of 2-[2-(4-dibenzo[B,F][1,4]thiazepin-11-yl-1-piperazinyl)ethoxyl]ethanol (quetiapine) and for the purification thereof A method for the preparation of salts of 2-[2-(4-dibenzo[b,fj[1,4]thiazepin-11-yl-1 -piperazinyl)ethoxy]ethanol (quetiapine) from the quetiapine base and the respective acid, wherein the salt is precipitated from a mixture of solvents, the mixture being either a mix... | 10/11/2011 |
| 8003637 | Stabilized atypical antipsychotic formulation A pharmaceutical composition that contains an atypical antipsychotic drug and succinic acid, fumaric acid or a mixture of succinic acid and fumaric acid. ... | 08/23/2011 |
| 7713957 | Pharmaceutical composition containing gabapentin or pregabalin and N-type calcium channel antagonist The present invention relates to a pharmaceutical composition useful for preventing/treating pain, which comprises combination of gabapentin or pregabalin, or pharmaceutically acceptable salts thereof and N-type calcium channel antagonists or pharmaceutically accept... | 05/11/2010 |
| 7622461 | Amino substituted diaryl[]cycloheptene analogs as muscarinic agonists and methods of treatment of neuropsychiatric disorders Disclosed herein are analogs of clozapine and pharmaceutically acceptable salts, esters, amides, or prodrugs thereof, methods of synthesizing the analogs; and methods of using the analogs for treating neuropsychiatric disorders. In some embodiments, the analogs are ... | 11/24/2009 |
| 7592333 | Loxapine analogs and methods of use thereof The invention relates to novel compounds and methods of using them for modulating sleep. ... | 09/22/2009 |
| 7563785 | Quetiapine analogs and methods of use thereof The invention relates to novel compounds and methods of using them for modulating sleep. ... | 07/21/2009 |
| 7550454 | Amino substituted diaryl[]cycloheptene analogs as muscarinic agonists and methods of treatment of neuropsychiatric disorders Disclosed herein are analogs of clozapine and pharmaceutically acceptable salts, esters, amides, or prodrugs thereof; methods of synthesizing the analogs; and methods of using the analogs for treating neuropsychiatric disorders. In some embodiments, the analogs are ... | 06/23/2009 |
| 7517871 | Amino substituted diaryl[]cycloheptene analogs as muscarinic agonists and methods of treatment of neuropsychiatric disorders Disclosed herein are analogs of clozapine and pharmaceutically acceptable salts, esters, amides, or prodrugs thereof; methods of synthesizing the analogs; and methods of using the analogs for treating neuorpsychiatric disorders. In some embodiments, the analogs are ... | 04/14/2009 |
| 7429580 | Compositions of an anticonvulsant and an antipsychotic drug and methods of using the same for affecting weight loss Disclosed are compositions for affecting weight loss comprising a first compound and a second compound, where the first compound is a psychotherapeutic agent and the second compound is a anticonvulsant. Also disclosed are methods of affecting weight loss, increasing... | 09/30/2008 |
| 7355042 | Treatment of CNS disorders using CNS target modulators The invention is directed to compositions and methods useful for treating Central Nervous System (CNS) disorders. Furthermore, the invention provides compositions and methods of treating sleep disorders. More specifically, the invention is directed to the compositio... | 04/08/2008 |
| 7338948 | Use of quetiapine A method of treating Attention Deficit Hyperactivity Disorder, Conduct Disorder and related disorders which comprises using the atypical antipychotic agent quetiapine. ... | 03/04/2008 |
| 7304047 | Method of treating substance abuse with quetiapine This invention relates to a method of treating Substance Use such as Substance Abuse or Substance Dependence and in particular to the use of quetiapine in treating such disorders. ... | 12/04/2007 |
| 7299930 | Collecting agent comprising ammoniated compounds (primary, secondary, tertiary amines), for use in the process of grinding and/or floating copper, molybdenum, zinc, and other contained mineral ores The present invention provides a ammoniated collector (amine, azepine, etc.) alone or in combination with other thiol-type collecting reactants, as well as sodium, iron, magnesium, and/or manganese sulfates, sulfurs, oxides, and hydroxides, acrylic acid polymers and... | 11/27/2007 |
| 7238686 | Polymorphs of quetiapine fumarate The present invention relates to novel polymorphic forms of quetiapine fumarate, processes for their preparation and pharmaceutical compositions containing them. ... | 07/03/2007 |
| 7022692 | Quetiapine granules Granule formulation of quetiapine and pharmaceutically acceptable salt thereof are described, as are their preparation and their use in treating diseases of the central nervous system such as psychotic disease conditions including schizophrenia. ... | 04/04/2006 |
| 7022700 | Method of increasing neutrophil production using optically-pure (R)-2,3-benzodiazepines Compounds according to formula I: wherein R1, R2, R3, R4, R5 and n are as defined herein, are administered to increase neutrophil levels in mammels. ... | 04/04/2006 |
| 6992065 | Sustained release formulations A composition for sustained release comprises a carrier material containing a non-polymeric, non-water soluble liquid material having a viscosity of at least 5,000 cP at 37° C. that does not crytallize neat under ambient physiological conditions, a multivalent meta... | 01/31/2006 |
| 6936601 | Compositions for treating pain The present invention provides compositions for treating pain using an atypical antipsychotic compound that is seroquel in combination with another Drug Used in the Treatment of Pain. ... | 08/30/2005 |
| 6906046 | Pharmaceutical uses and synthesis of benzobicyclooctanes Benzobicyclooctane compounds, their use in inhibiting cellular events involving TNF-α and IL-8, and in the treatment of inflammation events in general; a combinatorial library of diverse bicyclooctanes and process for their synthesis as a library and as individual ... | 06/14/2005 |
| 6890919 | Atypical antipsychotic agents having low affinity for the D2 receptor The present invention provides novel compounds of Formula I: The invention further relates to pharmaceutical compositions comprising compounds of Formula I and to methods of using compounds of Formula I to treat neurop... | 05/10/2005 |
| 6683072 | Compositions and methods for treatment of irritable bowel syndrome and nonulcer dyspepsia Compounds according to the formula ##STR1## as defined herein are administered for the treatment of irritable bowel syndrome and nonulcer dyspepsia.... | 01/27/2004 |
| 6630462 | Delta agonist analgesics Methods and pharmaceutical compositions for the treatment of pain, preferably with lowered risk of induction of seizure in a patient. The compositions contain active compounds that are tricyclic δ opioid receptor agonists of the general formula (I): ... | 10/07/2003 |
| 6599896 | Use of tianeptine in the production of medicaments to treat neurodegenerative pathologies The invention relates to the use of tianeptine or enantiomers thereof in obtaining medicaments for use in the treatment of neurodegenerative pathologies.... | 07/29/2003 |
| 6599897 | Quetiapine granules Granule formulations of quetiapine and pharmaceutically acceptable salts thereof are described, as are their preparation and their use in treating diseases of the central nervous system such as psychotic disease conditions including schizophrenia.... | 07/29/2003 |
| 6566389 | Therapeutic uses of melatonin A method for treating or preventing symptoms of tardive dyskensia comprises administering melatonin to patient exhibiting or liable to develop such symptoms. The melatonin is administered in an amount effective to ameliorate or prevent symptoms of tardive... | 05/20/2003 |
| 6545057 | Tricyclic antidepressants and their analogues as long-acting local anesthetics and analgesics Methods and compositions of tricyclic antidepressants for inducing local long-lasting anesthesia and analgesia are provided. The methods and compositions are useful for alleviating acute and chronic pain, particularly useful for treating a localized pain.... | 04/08/2003 |
| 6372734 | Crystalline dibenzothiazepine derivative and its use as an antipsychotic agent ##STR1## Crystalline 11-(4-[2-(2-hydroxyethoxy)ethyl]-1-piperazinyl)-dibenzo[b,f][1,4]thiazepin e (I) may be prepared by crystallizing 11-(4-[2-(2-hydroxyethoxy)ethyl]-1-piperazinyl)-dibenzo[b,f][1,4]thiazepin e from a non-aromatic solvent such as ethy... | 04/16/2002 |
| 6214820 | Compounds, their preparation and use The present invention relates to compounds of formula (I) ##STR1## wherein R1, R2, R3, R4, R5, R6, R7, R8, A, X, T, Q, Z, U, Y, Ar, p and n are as defined in the speci... | 04/10/2001 |
| 6211171 | Use of antidepressants for local analgesia When administered locally, tricyclic, second generation and third generation antidepressants, such as amitriptyline and desipramine, have been shown to produce analgesia in a subject having a site of local discomfort. The analgesic effect of such antidepr... | 04/03/2001 |
| 6054458 | Heterocyclic compounds The present invention relates to novel N-substituted azaheterocyclic compounds of the general formula ##STR1## wherein X, Y, Z, R1, R2 and m are as defined in the detailed part of the present description, or salts thereof, to me... | 04/25/2000 |
